Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Partrick DA et al. | Hypertonic saline activates lipid-primed human neutrophils for enhanced elastase release. | 1998 | J Trauma | pmid:9555828 |
| Cherniad'eva IF et al. | [Characteristics of development of oxidative stress in blood plasma of patients with familial hypercholesterolemia]. | 1998 | Biull Eksp Biol Med | pmid:9559141 |
| Lallès JP et al. | Small intestinal motility disorders in preruminant calves chronically fed a diet based on antigenic soya: characterization and possible mediators. | 1998 Jan-Feb | Vet. Res. | pmid:9559521 |
| Michibayashi T | Neurogenic inhibitory action through platelets of platelet activating factor (PAF) on vasoconstrictive responsiveness to pressor agents. | 1997 | Adv. Exp. Med. Biol. | pmid:9561145 |
| Ishii I et al. | High and low affinity mutants of platelet-activating factor receptor. | 1997 | Adv. Exp. Med. Biol. | pmid:9561146 |
| Heller A et al. | Lipid mediators in inflammatory disorders. | 1998 | Drugs | pmid:9561339 |
| Wei Y et al. | Structure of a microbial homologue of mammalian platelet-activating factor acetylhydrolases: Streptomyces exfoliatus lipase at 1.9 A resolution. | 1998 | Structure | pmid:9562561 |
| Akiyama M et al. | Identification of a major PAF acetylhydrolase in human serum/plasma as a 43 kDa glycoprotein containing about 9 kDa asparagine-conjugated sugar chain(s). | 1998 | J. Biochem. | pmid:9562606 |
| da Silva MB et al. | Effect of ketoprofen on PAF-induced bovine platelet aggregation. | 1998 | Vet. J. | pmid:9564275 |
| Brunet J et al. | In vitro antioxidant properties of calcium dobesilate. | 1998 | Fundam Clin Pharmacol | pmid:9565776 |
| Ezeamuzie CI et al. | The effect of salmeterol on human eosinophils is both stimulus- and response-dependent. | 1997 | Int. J. Immunopharmacol. | pmid:9568547 |
| Ruiz-Ortega M et al. | Overexpression of extracellular matrix proteins in renal tubulointerstitial cells by platelet-activating-factor stimulation. | 1998 | Nephrol. Dial. Transplant. | pmid:9568845 |
| Snapper JR et al. | Effect of platelet-activating factor-receptor antagonism on endotoxin-induced lung dysfunction in sheep. | 1998 | J. Appl. Physiol. | pmid:9572806 |
| Cines DB et al. | Endothelial cells in physiology and in the pathophysiology of vascular disorders. | 1998 | Blood | pmid:9572988 |
| Thijs A and Thijs LG | Pathogenesis of renal failure in sepsis. | 1998 | Kidney Int. Suppl. | pmid:9573570 |
| Kitayama J et al. | The C-C chemokine receptor CCR3 participates in stimulation of eosinophil arrest on inflammatory endothelium in shear flow. | 1998 | J. Clin. Invest. | pmid:9576767 |
| Shindo K and Fukumura M | Oxatomide inhibits synthesis and release of platelet-activating factor in human neutrophils. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9578146 |
| Ereth MH et al. | The relation between the platelet-activated clotting test (HemoSTATUS) and blood loss after cardiopulmonary bypass. | 1998 | Anesthesiology | pmid:9579505 |
| Hüseyinov A et al. | Plasma and urinary platelet activating factor concentrations and leukotriene releasing activity of leukocytes in steroid sensitive nephrotic syndrome of childhood. | 1998 | Acta Paediatr Jpn | pmid:9583202 |
| Takasaki J et al. | Synergistic effect of type II phospholipase A2 and platelet-activating factor on Mac-1 surface expression and exocytosis of gelatinase granules in human neutrophils: evidence for the 5-lipoxygenase-dependent mechanism. | 1998 | J. Immunol. | pmid:9590257 |
| Pietsch P et al. | Effects of platelet-activating factor on intracellular Ca2+ concentration and contractility in isolated cardiomyocytes. | 1998 | J. Cardiovasc. Pharmacol. | pmid:9593076 |
| Jackson JR et al. | The role of platelet activating factor and other lipid mediators in inflammatory angiogenesis. | 1998 | Biochim. Biophys. Acta | pmid:9593866 |
| Colak O et al. | The effect of Ginkgo biloba on the activity of catalase and lipid peroxidation in experimental strangulation ileus. | 1998 | Int. J. Clin. Lab. Res. | pmid:9594365 |
| Wang F et al. | [The effect of platelet activating factor on the biosynthesis of thromboxane A2 and prostaglandin I2 in human placental villi and umbilical artery]. | 1997 | Zhonghua Fu Chan Ke Za Zhi | pmid:9596897 |
| Yamada M et al. | Inhibition of tumor necrosis factor-alpha production by SK&F 98625, a CoA-independent transacylase inhibitor, in cultured rat peritoneal macrophages. | 1998 | Life Sci. | pmid:9600332 |
| Lie WJ et al. | Degranulation of human basophils by picomolar concentrations of IL-3, IL-5, or granulocyte-macrophage colony-stimulating factor. | 1998 | J. Allergy Clin. Immunol. | pmid:9600507 |
| Giménez R and Aguilar J | Effects of CDP-choline administration on brain striatum platelet-activating factor in aging rats. | 1998 | Eur. J. Pharmacol. | pmid:9600649 |
| László F and Whittle BJ | Role of nitric oxide and platelet-activating factor in the initiation of indomethacin-provoked intestinal inflammation in rats. | 1998 | Eur. J. Pharmacol. | pmid:9600654 |
| Gómez FP et al. | The effects of 5-lipoxygenase inhibition by zileuton on platelet-activating-factor-induced pulmonary abnormalities in mild asthma. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9603138 |
| O'Neill C | Autocrine mediators are required to act on the embryo by the 2-cell stage to promote normal development and survival of mouse preimplantation embryos in vitro. | 1998 | Biol. Reprod. | pmid:9603268 |
| Kotelevets L et al. | Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3'-kinase is a critical mediator of tumor invasion. | 1998 | J. Biol. Chem. | pmid:9603913 |
| ZaÄtseva LG et al. | [The role of platelet activating factor in regulation of the phagocytic function of macrophages from different organs]. | 1998 | Biull Eksp Biol Med | pmid:9606554 |
| Nguyen P et al. | [Modulators of leukocytic functions]. | 1998 | J Mal Vasc | pmid:9608925 |
| Nakos G et al. | Bronchoalveolar lavage fluid characteristics of early intermediate and late phases of ARDS. Alterations in leukocytes, proteins, PAF and surfactant components. | 1998 | Intensive Care Med | pmid:9609406 |
| Tsuji F and Shirasawa E | The role of platelet-activating factor in cell infiltration in endotoxin-induced uveitis in guinea pigs. | 1998 | Curr. Eye Res. | pmid:9617545 |
| Shimada A et al. | In situ expression of platelet-activating factor (PAF)-receptor gene in rat skin and effects of PAF on proliferation and differentiation of cultured human keratinocytes. | 1998 | J. Invest. Dermatol. | pmid:9620295 |
| Mollinedo F et al. | Physiological activation of human neutrophils down-regulates CD53 cell surface antigen. | 1998 | J. Leukoc. Biol. | pmid:9620662 |
| Lou YP et al. | Platelet-activating factor induces goblet cell hyperplasia and mucin gene expression in airways. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9620929 |
| Lapchyns'ka II | [Platelet activating factor and its role in the pathogenesis of immune glomerulopathy]. | 1998 Jan-Feb | Lik. Sprava | pmid:9621619 |
| Isumi H et al. | Expression of a 45K subunit of platelet-activating factor acetylhydrolase in the developing mouse cerebellum. | 1998 | Anat. Embryol. | pmid:9623676 |
| Gómez FP et al. | Effect of a platelet-activating factor (PAF) antagonist, SR 27417A, on PAF-induced gas exchange abnormalities in mild asthma. | 1998 | Eur. Respir. J. | pmid:9623685 |
| Werr J et al. | beta1 integrins are critically involved in neutrophil locomotion in extravascular tissue In vivo. | 1998 | J. Exp. Med. | pmid:9625769 |
| Takada Y et al. | Prolonged hepatic warm ischemia in non-heart-beating donors: protective effects of FK506 and a platelet activating factor antagonist in porcine liver transplantation. | 1998 | Surgery | pmid:9626320 |
| Spapen H et al. | The platelet-activating factor antagonist BB-882 does not improve tissue oxygen extraction in endotoxic shock. | 1998 | J Crit Care | pmid:9627275 |
| De Plaen IG et al. | Intestinal NF-kappaB is activated, mainly as p50 homodimers, by platelet-activating factor. | 1998 | Biochim. Biophys. Acta | pmid:9630621 |
| Baker RR and Chang H | MgATP has different inhibitory effects on the use of 1-acyl-lysophosphatidylcholine and lyso platelet-activating factor acceptors by neuronal nuclear acetyltransferase activities. | 1998 | Biochim. Biophys. Acta | pmid:9630721 |
| Beck-Speier I et al. | Pro-inflammatory response of alveolar macrophages induced by sulphite: studies with lucigenin-dependent chemiluminescence. | 1998 Mar-Apr | J. Biolumin. Chemilumin. | pmid:9633012 |
| Grassi S et al. | Role of platelet-activating factor in long-term potentiation of the rat medial vestibular nuclei. | 1998 | J. Neurophysiol. | pmid:9636125 |
| Izuoka T et al. | Role of platelet-activating factor on extravascular lung water after coronary reperfusion in dogs. | 1998 | Jpn. J. Physiol. | pmid:9639551 |
| Mackness B et al. | Lack of protection against oxidative modification of LDL by avian HDL. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9642147 |
| Botitsi E et al. | Metabolic fate of platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and lyso-PAF (1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine) in FRTL5 cells. | 1998 | J. Lipid Res. | pmid:9643362 |
| Jung KY et al. | Magnone A and B, novel anti-PAF tetrahydrofuran lignans from the flower buds of Magnolia fargesii. | 1998 | J. Nat. Prod. | pmid:9644071 |
| Derewenda ZS and Derewenda U | The structure and function of platelet-activating factor acetylhydrolases. | 1998 | Cell. Mol. Life Sci. | pmid:9645224 |
| Shouji K et al. | Platelet-activating factor is a key mediator of pulmonary vasoconstriction and bronchoconstriction after antigen challenge in the perfused sensitized rabbit lung. | 1998 | Shock | pmid:9645492 |
| Qayumi AK et al. | The role of platelet-activating factor in regional myocardial ischemia-reperfusion injury. | 1998 | Ann. Thorac. Surg. | pmid:9647083 |
| Watson F and Edwards SW | Stimulation of primed neutrophils by soluble immune complexes: priming leads to enhanced intracellular Ca2+ elevations, activation of phospholipase D, and activation of the NADPH oxidase. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9647777 |
| Matsumoto K et al. | Proinflammatory cytokine-induced and chemical mediator-induced IL-8 expression in human bronchial epithelial cells through p38 mitogen-activated protein kinase-dependent pathway. | 1998 | J. Allergy Clin. Immunol. | pmid:9648711 |
| Shindo K et al. | Platelet-activating factor increases leukotriene B4 release in stimulated alveolar macrophages from asthmatic patients. | 1998 | Eur. Respir. J. | pmid:9648962 |
| Han BH et al. | In vitro platelet-activating factor receptor binding inhibitory activity of pinusolide derivatives: a structure-activity study. | 1998 | J. Med. Chem. | pmid:9651167 |
| Minamiya Y et al. | Platelet-activating factor mediates intercellular adhesion molecule-1-dependent radical production in the nonhypoxic ischemia rat lung. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9651191 |
| Perry SW et al. | Platelet-activating factor receptor activation. An initiator step in HIV-1 neuropathogenesis. | 1998 | J. Biol. Chem. | pmid:9651362 |
| Roudebush WE and Mathur RS | Presence of platelet-activating factor in squirrel monkey (Saimiri boliviensis) spermatozoa: seasonal differences. | 1998 | Am. J. Primatol. | pmid:9651652 |
| Küçükhüseyin C et al. | On the mechanisms of adenosine induced pulmonary vasoconstriction in rats. | 1997 | J Basic Clin Physiol Pharmacol | pmid:9651801 |
| Ginkgo biloba for dementia. | 1998 | Med Lett Drugs Ther | pmid:9653424 | |
| Itadani K et al. | Inhibition of Na+,K(+)-ATPase by platelet-activating factor in dog submandibular glands. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9653774 |
| Loucks EB et al. | Platelet-activating factor antagonism: a new concept in the management of regional myocardial ischemia-reperfusion injury. | 1997 Nov-Dec | J Invest Surg | pmid:9654389 |
| Schwartz JD et al. | Cardiopulmonary bypass primes polymorphonuclear leukocytes. | 1998 | J. Surg. Res. | pmid:9655092 |
| Rainger GE et al. | Neutrophils rolling on immobilised platelets migrate into homotypic aggregates after activation. | 1998 | Thromb. Haemost. | pmid:9657445 |
| Ahmed A et al. | Localization, quantification, and activation of platelet-activating factor receptor in human endometrium during the menstrual cycle: PAF stimulates NO, VEGF, and FAKpp125. | 1998 | FASEB J. | pmid:9657523 |
| Akisü M et al. | Effect of dietary n-3 fatty acids on hypoxia-induced necrotizing enterocolitis in young mice. n-3 fatty acids alter platelet-activating factor and leukotriene B4 production in the intestine. | 1998 | Biol. Neonate | pmid:9657667 |
| Manya H et al. | Switching of platelet-activating factor acetylhydrolase catalytic subunits in developing rat brain. | 1998 | J. Biol. Chem. | pmid:9660828 |
| Tuder RM and Voelkel NF | Pulmonary hypertension and inflammation. | 1998 | J. Lab. Clin. Med. | pmid:9665367 |
| Barber LA et al. | Expression of the platelet-activating factor receptor results in enhanced ultraviolet B radiation-induced apoptosis in a human epidermal cell line. | 1998 | J. Biol. Chem. | pmid:9668065 |
| Peçanha EP et al. | Synthesis and pharmacological evaluation of a new class of bicyclic phospholipids, designed as platelet activating factor antagonists. | 1998 | Farmaco | pmid:9679282 |
| da Silva MB et al. | Protective effects of WEB 2086 (PAF antagonist) and ketoprofen (NSAID) on PAF-induced changes in the morphological ultrastructure of blood platelets in calves. | 1998 | Vet. Res. Commun. | pmid:9686442 |
| Bussolati B et al. | Platelet-activating factor synthesized by IL-12-stimulated polymorphonuclear neutrophils and NK cells mediates chemotaxis. | 1998 | J. Immunol. | pmid:9686616 |
| Gozal D et al. | Platelet-activating factor modulates cardiorespiratory responses in the conscious rat. | 1998 | Am. J. Physiol. | pmid:9688699 |
| Stolarek R et al. | Effect of various agonists on nitric oxide generation by human polymorphonuclear leukocytes. | 1998 | Int. J. Clin. Lab. Res. | pmid:9689552 |
| Ribaldi E et al. | PAF levels in saliva are regulated by inflammatory cells. | 1998 | J. Periodont. Res. | pmid:9689619 |
| Kaminskaia GO et al. | [Features of oxidative metabolism and level of platelet activating factor in pulmonary and circulating phagocytes of tuberculosis-resistant animals at stages of experimental infection]. | 1998 | Probl Tuberk | pmid:9691697 |
| Li HP et al. | Effect of chinonin on acute hypoxic pulmonary vasoconstriction in Sprague-Dawley rats. | 1998 | Respirology | pmid:9692515 |
| Moro F et al. | The beta and gamma subunits of the human platelet-activating factor acetyl hydrolase isoform Ib (PAFAH1B2 and PAFAH1B3) map to chromosome 11q23 and 19q13.1, respectively. | 1998 | Genomics | pmid:9693049 |
| Napoli C | Familial hypercholesterolaemia and platelet-activating factor acetylhydrolase: difference between the homozygous and heterozygous form. | 1998 | Eur. J. Clin. Invest. | pmid:9693945 |
| Karlsson H et al. | Heparin ameliorates pulmonary hypertension induced by platelet-activating factor in pigs. | 1998 | Thromb. Res. | pmid:9694244 |
| Eakes AT and Olson MS | Regulation of endothelin synthesis in hepatic endothelial cells. | 1998 | Am. J. Physiol. | pmid:9696707 |
| Cruzado JM et al. | Effect of a platelet-activating factor (PAF) receptor antagonist on hyperacute xenograft rejection; evaluation in a pig kidney-human blood xenoperfusion model. | 1998 | Clin. Exp. Immunol. | pmid:9697996 |
| DeCoster MA et al. | Platelet-activating factor is a downstream messenger of kainate-induced activation of mitogen-activated protein kinases in primary hippocampal neurons. | 1998 | J. Neurosci. Res. | pmid:9698157 |
| Alves AC et al. | Effect of selective phosphodiesterase inhibitors on the rat eosinophil chemotactic response in vitro. | 1997 | Mem. Inst. Oswaldo Cruz | pmid:9698934 |
| Koyama S et al. | Human lung fibroblasts release chemokinetic activity for monocytes constitutively. | 1998 | Am. J. Physiol. | pmid:9700081 |
| Andersson R et al. | Effect of a platelet-activating factor antagonist on pancreatitis-associated gut barrier dysfunction in rats. | 1998 | Pancreas | pmid:9700940 |
| Pennings HJ et al. | Tumour necrosis factor-alpha induces hyperreactivity in tracheal smooth muscle of the guinea-pig in vitro. | 1998 | Eur. Respir. J. | pmid:9701413 |
| Akisü M et al. | Platelet-activating factor levels in term and preterm human milk. | 1998 | Biol. Neonate | pmid:9701651 |
| Thakur A and Willcox MD | Cytokine and lipid inflammatory mediator profile of human tears during contact lens associated inflammatory diseases. | 1998 | Exp. Eye Res. | pmid:9702174 |
| Boulay F et al. | Phagocyte chemoattractant receptors. | 1997 | Ann. N. Y. Acad. Sci. | pmid:9704038 |
| Pérez-Arellano JL et al. | BN 52021 (a platelet activating factor-receptor antagonist) decreases alveolar macrophage-mediated lung injury in experimental extrinsic allergic alveolitis. | 1998 | Mediators Inflamm. | pmid:9705608 |
| Pei Y et al. | Activation of the epidermal platelet-activating factor receptor results in cytokine and cyclooxygenase-2 biosynthesis. | 1998 | J. Immunol. | pmid:9712066 |
| Hilliquin P et al. | A double blind, placebo controlled study of a platelet activating factor antagonist in patients with rheumatoid arthritis. | 1998 | J. Rheumatol. | pmid:9712091 |
| Tamaoki J et al. | A human bronchial epithelial cell line releases arginine vasopressin: involvement of Ca2+ -activated K+ channels. | 1998 | Regul. Pept. | pmid:9712168 |
| Tsai IL et al. | Anti-platelet aggregation constituents from Formosan Toddalia asiatica. | 1998 | Phytochemistry | pmid:9720317 |
| Karzai W et al. | [Current aspects of immunomodulatory therapy initiation for sepsis]. | 1998 | Dtsch. Med. Wochenschr. | pmid:9721572 |