Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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MacIntyre DE and Pollock WK | Platelet-activating factor stimulates phosphatidylinositol turnover in human platelets. | 1983 | Biochem. J. | pmid:6411067 |
O'Flaherty JT et al. | 5-L-hydroxy-6,8,11,14-eicosatetraenoate potentiates the human neutrophil degranulating action of platelet-activating factor. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6403011 |
Drapier JC et al. | Lipid-mediator synthesis in peritoneal macrophages from mice injected with immunostimulants. | 1983 | Biochim. Biophys. Acta | pmid:6131693 |
Otsuka A et al. | alpha-Adrenergic blocking action of 1-O-hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine in rats. | 1983 | Clin Exp Hypertens A | pmid:6133661 |
Haddad ZH and Green A | State--and dynamics--of the art: a current review. IgE-mediated immediate hypersensitivity reactions: cellular events and pharmacologic mediators. | 1983 | J Asthma | pmid:6190793 |
Swendsen CL et al. | 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a novel source of arachidonic acid in neutrophils stimulated by the calcium ionophore A23187. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6407484 |
Mueller HW et al. | Biosynthesis of platelet activating factor in rabbit polymorphonuclear neutrophils. | 1983 | J. Biol. Chem. | pmid:6406476 |
Lee TC et al. | Stimulation of calcium uptake by 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) in rabbit platelets: possible involvement of the lipoxygenase pathway. | 1983 | Arch. Biochem. Biophys. | pmid:6407399 |
Billah MM and Johnston JM | Identification of phospholipid platelet-activating factor (1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in human amniotic fluid and urine. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6407483 |
Hartung HP et al. | Platelet activating factor (PAF) induces the oxidative burst in macrophages. | 1983 | Int. J. Immunopharmacol. | pmid:6874164 |
1st International Symposium on Platelet-Activating Factor (PAF-ACETHER, AGEPC) and structurally related ether-lipids. Paris (France) June 26-29, 1983. Abstracts. | 1983 | J Pharmacol | pmid:6876807 | |
Cargill DI et al. | Aggregation, release and desensitization induced in platelets from five species by platelet activating factor (PAF). | 1983 | Thromb. Haemost. | pmid:6879508 |
Blank ML and Snyder F | Improved high-performance liquid chromatographic method for isolation of platelet-activating factor from other phospholipids. | 1983 | J. Chromatogr. | pmid:6863454 |
Simrock R et al. | [Reversible inhibition of thrombocyte stimulation by acetylsalicylic acid and its role in antithrombotic therapy]. | 1983 | Klin. Wochenschr. | pmid:6865264 |
Hadváry P and Baumgartner HR | Activation of human and rabbit blood platelets by synthetic structural analogs of platelet activating factor. | 1983 | Thromb. Res. | pmid:6868019 |
Weksler BB | Platelets and the inflammatory response. | 1983 | Clin. Lab. Med. | pmid:6360503 |
Machin SJ et al. | Defective platelet aggregation to the calcium ionophore A23187 in a patient with a lifelong bleeding disorder. | 1983 | J. Clin. Pathol. | pmid:6413552 |
Alam I et al. | Metabolism of platelet-activating factor by blood platelets and plasma. | 1983 | Lipids | pmid:6413803 |
Pinckard RN | Platelet-activating factor. | 1983 | Hosp. Pract. (Off. Ed.) | pmid:6414941 |
Camussi G et al. | The release of platelet-activating factor from human endothelial cells in culture. | 1983 | J. Immunol. | pmid:6415166 |