Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Ozaki Y et al. | Potentiation of neutrophil biosynthesis of platelet-activating factor by cytochalasin B: evaluation of acetyltransferase activity. | 1987 | Nippon Ketsueki Gakkai Zasshi | pmid:3687329 |
Ramesha CS et al. | Identification and quantitation of PAF from psoriatic scales. | 1987 | Agents Actions | pmid:3687590 |
Ponpipom MM et al. | Structure-activity relationships of kadsurenone analogues. | 1987 | J. Med. Chem. | pmid:3027330 |
Friedlander G et al. | Renal effects of platelet-activating factor in the rat. | 1987 | Agents Actions | pmid:3687594 |
Lagente V et al. | Interference of the PAF-acether antagonist BN 52021 with passive anaphylaxis in the guinea-pig. | 1987 | Prostaglandins | pmid:2438723 |
Pritchard PH | The degradation of platelet-activating factor by high-density lipoprotein in rat plasma. Effect of ethynyloestradiol administration. | 1987 | Biochem. J. | pmid:3689334 |
Hill CE and Olson MS | Stimulation of uric acid release from the perfused rat liver by platelet activating factor or potassium. | 1987 | Biochem. J. | pmid:3689345 |
Sugiyama T et al. | A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and autoimmune thrombocytopenia. | 1987 | Blood | pmid:3580576 |
Agrawal DK and Townley RG | Effect of platelet-activating factor on beta-adrenoceptors in human lung. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3030311 |
Hébert RL et al. | Hemodynamic effects of PAF-acether on the dog kidney. | 1987 | Prostaglandins Leukot Med | pmid:3033688 |
Tysnes OB et al. | Neomycin inhibits agonist-stimulated polyphosphoinositide metabolism and responses in human platelets. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3034251 |
Barnes PJ et al. | The effect of platelet activating factor on pulmonary beta-adrenoceptors. | 1987 | Br. J. Pharmacol. | pmid:3034367 |
Davenas E et al. | Effect of mouse peritoneal macrophages of orally administered very high dilutions of silica. | 1987 | Eur. J. Pharmacol. | pmid:3034632 |
Beijer L et al. | The involvement of platelet activating factor in endotoxin-induced pulmonary platelet recruitment in the guinea-pig. | 1987 | Br. J. Pharmacol. | pmid:2447993 |
Belch JJ et al. | Whole blood white cell aggregation: a novel technique. | 1987 | Thromb. Res. | pmid:2448894 |
Barrio V et al. | Atrial natriuretic peptide inhibits glomerular contraction induced by angiotensin II and platelet activating factor. | 1987 | Eur. J. Pharmacol. | pmid:2952517 |
Camussi G et al. | Receptor antagonist of platelet activating factor inhibits inflammatory injury induced by in situ formation of immune complexes in renal glomeruli and in the skin. | 1987 | J. Lab. Clin. Med. | pmid:2955066 |
Fouque F and Vargaftig BB | Potentiation and inhibition by clonidine of PAF-acether-induced human platelet activation. | 1987 | Eur. J. Pharmacol. | pmid:3582495 |
Lellouch-Tubiana A et al. | Interactions between granulocytes and platelets with the guinea-pig lung in passive anaphylactic shock. Correlations with PAF-acether-induced lesion. | 1987 | Int. Arch. Allergy Appl. Immunol. | pmid:3583412 |
Foegh ML et al. | Leukotrienes, thromboxane, and platelet activating factor in organ transplantation. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959038 |
Patterson R et al. | Evaluation of the effect of a platelet activating factor antagonist on platelet activating factor and Ascaris antigen-induced airway responses in rhesus monkeys. | 1987 | J. Lab. Clin. Med. | pmid:3668360 |
Robertson DN and Smith GM | Role of thromboxane A2, 5-hydroxytryptamine, and platelet activating factor in collagen-induced sudden death in rabbits. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959049 |
Stewart AG and Piper PJ | Actions of platelet-activating factor in the coronary circulation of the guinea pig in vitro. | 1987 | Prog. Clin. Biol. Res. | pmid:3671383 |
Abstracts of the meeting: The role of platelet-activating factors in the immune response. Paris, France, June 25 and 26, 1987. | 1987 | Prostaglandins | pmid:3671731 | |
O'Flaherty JT et al. | 1-O-alkyl-2-N-methylcarbamyl-glycerophosphocholine: a biologically potent, non-metabolizable analog of platelet-activating factor. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2820395 |
Bourgain RH et al. | Arterial obstruction induced by PAF-acether (1-O-alkyl-sn-glycero-3-phosphocholine). | 1987 | Adv. Exp. Med. Biol. | pmid:3673721 |
Myers AK and Bader TJ | Role of adrenal steroids in the recovery from platelet activating factor challenge. | 1987 | Circ. Shock | pmid:3677334 |
Hsueh W et al. | Platelet-activating factor: an endogenous mediator for bowel necrosis in endotoxemia. | 1987 | FASEB J. | pmid:3678700 |
Terasawa M et al. | Antagonistic activity of etizolam on platelet-activating factor in vivo experiments. | 1987 | Jpn. J. Pharmacol. | pmid:3682404 |
Martins MA et al. | Interactions between local inflammatory and systemic haematological effects of PAF-acether in the rat. | 1987 | Eur. J. Pharmacol. | pmid:3609124 |
Mangold HK et al. | Biologically active lipids. Semi-synthesis of 3H-labeled ether glycerophospholipids and ether glyceroglycolipids from ratfish liver oil. | 1987 | FEBS Lett. | pmid:3609315 |
Caffrey E et al. | Aggregation responses to platelet-activating factor in normal subjects. | 1987 | Haemostasis | pmid:3609916 |
Baer PG and Cagen LM | Platelet activating factor vasoconstriction of dog kidney. Inhibition by alprazolam. | 1987 | Hypertension | pmid:3818022 |
Bittman R et al. | Synthesis and biochemical studies of analogs of platelet-activating factor bearing a methyl group at C2 of the glycerol backbone. | 1987 | J. Lipid Res. | pmid:3611974 |
Terashita Z et al. | CV-6209, a highly potent antagonist of platelet activating factor in vitro and in vivo. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3612533 |
Levy JV | Spasmogenic effect of platelet activating factor (PAF) on isolated rat stomach fundus strip. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3619905 |
Huber M and Keppler D | Inhibition of leukotriene D4 catabolism by D-penicillamine. | 1987 | Eur. J. Biochem. | pmid:3622511 |
Egido J et al. | Role of platelet-activating factor in adriamycin-induced nephropathy in rats. | 1987 | Eur. J. Pharmacol. | pmid:3622604 |
Purdon AD et al. | Ionophore-stimulated rat basophilic leukemia cells produce PAF-acether. | 1987 | Int. Arch. Allergy Appl. Immunol. | pmid:3100454 |
Bruijnzeel PL et al. | Platelet-activating factor induces leukotriene C4 synthesis by purified human eosinophils. | 1987 | Prostaglandins | pmid:3118415 |
Sha'afi RI and Molski TF | Signalling for increased cytoskeletal actin in neutrophils. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3036146 |
Adler KB et al. | Platelet activating factor stimulates secretion of mucin by explants of rodent airways in organ culture. | 1987 | Exp. Lung Res. | pmid:3653044 |
Nakayama R et al. | Existence of endogenous inhibitors of platelet-activating factor (PAF) with PAF in rat uterus. | 1987 | J. Biol. Chem. | pmid:3654606 |
Taylor RR et al. | Whole blood platelet aggregation is not affected by cigarette smoking but is sex-related. | 1987 | Clin. Exp. Pharmacol. Physiol. | pmid:3440324 |
Shimazaki N et al. | Diketopiperazines as a new class of platelet-activating factor inhibitors. | 1987 | J. Med. Chem. | pmid:3656347 |
Ruan CG et al. | Studies on monoclonal antibodies against human platelets--a monoclonal antibody to human platelet glycoprotein I--SZ-2. | 1987 | Sci. Sin., Ser. B, Chem. Biol. Agric. Med. Earth Sci. | pmid:3659897 |
Feuerstein G et al. | Protective effect of a PAF-acether antagonist, BN 52021, in trichothecene toxicosis. | 1987 | Toxicol. Lett. | pmid:3660430 |
Heinsohn C et al. | The effect of bovine serum albumin on the synthesis of prostaglandin and incorporation of [3H]acetate into platelet-activating factor. | 1987 | Arch. Biochem. Biophys. | pmid:3662526 |
Sperling RI et al. | Effects of dietary supplementation with marine fish oil on leukocyte lipid mediator generation and function in rheumatoid arthritis. | 1987 | Arthritis Rheum. | pmid:3663263 |
Siess W and Lapetina EG | Phorbol esters sensitize platelets to activation by physiological agonists. | 1987 | Blood | pmid:3663938 |
Casals-Stenzel J et al. | Bronchial and vascular effects of Paf in the rat isolated lung are completely blocked by WEB 2086, a novel specific Paf antagonist. | 1987 | Br. J. Pharmacol. | pmid:3664079 |
Oon SH and Williams N | Immature megakaryocytes in the mouse: synergistic response to megakaryocyte potentiator, thrombopoietic stimulatory factor with interleukin 3. | 1987 | Leukemia | pmid:3500375 |
Pretolani M et al. | Interference by the novel PAF-acether antagonist WEB 2086 with the bronchopulmonary responses to PAF-acether and to active and passive anaphylactic shock in guinea-pigs. | 1987 | Eur. J. Pharmacol. | pmid:3653247 |
Homma H et al. | Some unique features of the metabolic conversion of platelet-activating factor (AGEPC) to alkyl acyl PC by washed rabbit platelets. | 1987 | Arch. Biochem. Biophys. | pmid:3101596 |
Takahashi H et al. | [Blood coagulation disorders in thrombotic thrombocytopenic purpura--with special reference to a von Willebrand factor abnormality]. | 1987 | Rinsho Byori | pmid:3501812 |
Hurst JS et al. | Effects of the lipid peroxidation product 4-hydroxynonenal on the aggregation of human platelets. | 1987 | Chem. Biol. Interact. | pmid:3103933 |
Haroldsen PE et al. | Metabolism of platelet-activating factor in isolated perfused rat lung. | 1987 | J. Clin. Invest. | pmid:3108322 |
Brigham KL | Conference summary: lipid mediators in the pulmonary circulation. | 1987 | Am. Rev. Respir. Dis. | pmid:2820285 |
Morganroth ML et al. | Decreased pulmonary vascular responsiveness in rats raised on an essential fatty acid deficient diet. | 1987 | Prostaglandins | pmid:3108962 |
Lamant V et al. | Inhibition of the metabolism of platelet activating factor (PAF-acether) by three specific antagonists from Ginkgo biloba. | 1987 | Biochem. Pharmacol. | pmid:2820421 |
Haroldsen PE et al. | Quantitation of lyso-platelet activating factor molecular species from human neutrophils by mass spectrometry. | 1987 | J. Lipid Res. | pmid:3104521 |
Bienenstock J et al. | Mast cell involvement in various inflammatory processes. | 1987 | Am. Rev. Respir. Dis. | pmid:3109295 |
Teng CM et al. | Antiplatelet effect of butylidenephthalide. | 1987 | Biochim. Biophys. Acta | pmid:3109495 |
Patrignani P et al. | Platelet-activating factor (PAF) receptor antagonists inhibit mitogen-induced human peripheral blood T-cell proliferation. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2825672 |
Földes-Filep E et al. | Inhibition by BN 52021 (ginkgolide B) of the binding of [3H]-platelet-activating factor to human neutrophil granulocytes. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2825685 |
Kimura Y et al. | Effects of baicalein on leukotriene biosynthesis and degranulation in human polymorphonuclear leukocytes. | 1987 | Biochim. Biophys. Acta | pmid:2825795 |
Braquet P et al. | The role of PAF-acether in anaphylaxis demonstrated with the use of the antagonist BN 52021. | 1987 | Agents Actions Suppl. | pmid:3314418 |
Rubin AH et al. | The bronchoconstrictor properties of platelet-activating factor in humans. | 1987 | Am. Rev. Respir. Dis. | pmid:3314611 |
Vargaftig BB and Braquet PG | PAF-acether today--relevance for acute experimental anaphylaxis. | 1987 | Br. Med. Bull. | pmid:2825900 |
Mathur RS et al. | Current concepts in asthma. | 1987 | J Assoc Physicians India | pmid:3320019 |
Kochanek PM et al. | Platelet activating factor receptor blockade enhances recovery after multifocal brain ischemia. | 1987 | Life Sci. | pmid:2826947 |
Whatley RE et al. | Production of platelet-activating factor by endothelial cells. | 1987 | Semin. Thromb. Hemost. | pmid:3321437 |
Kelton JG and Murphy WG | Acute thrombocytopenia and thrombosis. Heparin-induced thrombocytopenia and thrombotic thrombocytopenic purpura. | 1987 | Ann. N. Y. Acad. Sci. | pmid:3322132 |
Valone FH and Johnson B | Modulation of platelet-activating-factor-induced calcium influx and intracellular calcium release in platelets by phorbol esters. | 1987 | Biochem. J. | pmid:3322269 |
Tou JS | Platelet-activating factor modulates phospholipid acylation in human neutrophils. | 1987 | Lipids | pmid:3110533 |
Caramelo C et al. | Increased levels of platelet-activating factor in blood from patients with cirrhosis of the liver. | 1987 | Eur. J. Clin. Invest. | pmid:3106053 |
Guinot P et al. | Effect of BN 52063, a specific PAF-acether antagonist, on bronchial provocation test to allergens in asthmatic patients. A preliminary study. | 1987 | Prostaglandins | pmid:3432562 |
Ho YS et al. | Chemoattractant-induced activation of c-fos gene expression in human monocytes. | 1987 | J. Exp. Med. | pmid:3108444 |
Hayashi M et al. | Detection of platelet-activating factor in exudates of rats with phorbol myristate acetate-induced pleurisy. | 1987 | Thromb. Res. | pmid:3433255 |
Kurachi M et al. | Suppression of bronchial response to platelet activating factor following taurine administration. | 1987 | Adv. Exp. Med. Biol. | pmid:3434419 |
Matsuno K et al. | [Cytoplasm free calcium ions as a second messenger]. | 1987 | Rinsho Byori | pmid:3437533 |
Kawamura Y et al. | [A simple measurement of plasma platelet-activating factor (PAF) acetylhydrolase, normal level of activity, and distribution among lipoprotein fractions]. | 1987 | Rinsho Byori | pmid:3437547 |
Kertscher HP and Ostermann G | [Synthesis and platelet aggregating activity of structural analogs of platelet-activating factor with a heterocyclic head group]. | 1987 | Pharmazie | pmid:3438334 |
Maudsley DJ and Morris AG | Rapid intracellular calcium changes in U937 monocyte cell line: transient increases in response to platelet-activating factor and chemotactic peptide but not interferon-gamma or lipopolysaccharide. | 1987 | Immunology | pmid:3110054 |
Lianos EA and Zanglis A | Biosynthesis and metabolism of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine in rat glomerular mesangial cells. | 1987 | J. Biol. Chem. | pmid:3110152 |
Riedel A et al. | The effect of the specific PAF antagonist BN 52021 and the calcium blocker diltiazem on PAF induced arrhythmogenicity. | 1987 | Pharmacol Res Commun | pmid:3441484 |
Bussolino F et al. | Intravascular release of platelet activating factor in children with sepsis. | 1987 | Thromb. Res. | pmid:3441909 |
Bull HA and Machin SJ | The haemostatic function of the vascular endothelial cell. | 1987 | Blut | pmid:3111566 |
Parker CW | Lipid mediators produced through the lipoxygenase pathway. | 1987 | Annu. Rev. Immunol. | pmid:3036183 |
Vane J and Botting R | Inflammation and the mechanism of action of anti-inflammatory drugs. | 1987 | FASEB J. | pmid:3111928 |
Riedel A and Mest HJ | The effect of PAF (platelet-activating factor) on experimental cardiac arrhythmias and its inhibition by substances influencing arachidonic acid metabolites. | 1987 | Prostaglandins Leukot Med | pmid:3112804 |
Shimokawa H et al. | Porcine coronary arteries with regenerated endothelium have a reduced endothelium-dependent responsiveness to aggregating platelets and serotonin. | 1987 | Circ. Res. | pmid:3113760 |
Feuerstein G and Hallenbeck JM | Prostaglandins, leukotrienes, and platelet-activating factor in shock. | 1987 | Annu. Rev. Pharmacol. Toxicol. | pmid:3034139 |
Touqui L et al. | The role of Ca2+ in regulating the catabolism of PAF-acether (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in rabbit platelets. | 1987 | Biochem. J. | pmid:3109377 |
Bureau M et al. | Desensitization and antagonism of rat polymorphonuclear leukocytes stimulated with PAF acether. | 1987 | Prostaglandins | pmid:3035615 |
Moodley I and Stuttle A | Evidence for a dual pathway in platelet activating factor-induced aggregation of rat polymorphonuclear leucocytes. | 1987 | Prostaglandins | pmid:3035617 |
Guinot P et al. | Effects of BN 52063 on PAF-acether induced weal and flare in man. | 1987 | Agents Actions Suppl. | pmid:3479000 |
Lang M et al. | Effects of the PAF-antagonist CV-3988 on PAF-induced changes in mucus secretion and in respiratory and circulatory variables in ferrets. | 1987 | Agents Actions Suppl. | pmid:3479001 |
Codde JP et al. | Effects of altered prostanoid and lyso-PAF synthesis by marine oil diets on blood pressure of salt loaded spontaneously hypertensive rats. | 1987 | Agents Actions Suppl. | pmid:3481207 |
Ezra D et al. | Cardiac and coronary consequences of intracoronary platelet activating factor infusion in the domestic pig. | 1987 | Prostaglandins | pmid:3685397 |