Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kono N et al. | Protection against oxidative stress-induced hepatic injury by intracellular type II platelet-activating factor acetylhydrolase by metabolism of oxidized phospholipids in vivo. | 2008 | J. Biol. Chem. | pmid:18024956 |
| Schaefer MB et al. | Peroxisome proliferator-activated receptor-alpha reduces inflammation and vascular leakage in a murine model of acute lung injury. | 2008 | Eur. Respir. J. | pmid:18653653 |
| Samanta U and Bahnson BJ | Crystal structure of human plasma platelet-activating factor acetylhydrolase: structural implication to lipoprotein binding and catalysis. | 2008 | J. Biol. Chem. | pmid:18784071 |
| Beuk RJ et al. | Leucocyte and platelet adhesion in different layers of the small bowel during experimental total warm ischaemia and reperfusion. | 2008 | Br J Surg | pmid:18720462 |
| Kuliszkiewicz-Janus M et al. | Platelet-activating factor changes in phospholipid extracts from the plasma, peripheral blood mononuclear cells and bone marrow mononuclear cells of patients with acute leukemia--a 31P MRS in vitro study. | 2008 | Cell. Mol. Biol. Lett. | pmid:17952375 |
| Bélanger C et al. | Involvement of endogenous leukotriene B4 and platelet-activating factor in polymorphonuclear leucocyte recruitment to dermal inflammatory sites in rats. | 2008 | Immunology | pmid:18217950 |
| Figueiredo MB et al. | Blockades of phospholipase A(2) and platelet-activating factor receptors reduce the hemocyte phagocytosis in Rhodnius prolixus: in vitro experiments. | 2008 | J. Insect Physiol. | pmid:18036540 |
| Adamson RH et al. | Epac/Rap1 pathway regulates microvascular hyperpermeability induced by PAF in rat mesentery. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18178724 |
| Gountopoulou A et al. | TNFalpha is a potent inducer of platelet-activating factor synthesis in adipocytes but not in preadipocytes. Differential regulation by PI3K. | 2008 | Cytokine | pmid:18180165 |
| Kwasniewski FH et al. | Small bowel injury associated to allergy is triggered by platelet-activating factor, mast cells, neutrophils and protected by nitric oxide. | 2008 | Int. Immunopharmacol. | pmid:18182253 |
| Chen Y et al. | Hepatic stellate cells may be potential effectors of platelet activating factor induced portal hypertension. | 2008 | World J. Gastroenterol. | pmid:18186558 |
| Hikiji H et al. | The roles of prostanoids, leukotrienes, and platelet-activating factor in bone metabolism and disease. | 2008 | Prog. Lipid Res. | pmid:18187046 |
| Simonenko VB et al. | [Losartan for the correction of thrombocyte activity in patients suffering from arterial hypertension with metabolic syndrome]. | 2008 | Klin Med (Mosk) | pmid:18326282 |
| Harayama T et al. | Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor. | 2008 | J. Biol. Chem. | pmid:18285344 |
| Mizutani T et al. | Genuine functions of P-glycoprotein (ABCB1). | 2008 | Curr. Drug Metab. | pmid:18288958 |
| Fukunaga A et al. | Dermal dendritic cells, and not Langerhans cells, play an essential role in inducing an immune response. | 2008 | J. Immunol. | pmid:18292528 |
| van Zoelen MA et al. | Platelet-activating factor receptor contributes to host defense against Pseudomonas aeruginosa pneumonia but is not essential for the accompanying inflammatory and procoagulant response. | 2008 | J. Immunol. | pmid:18292561 |
| Knapp S et al. | Lipoteichoic acid-induced lung inflammation depends on TLR2 and the concerted action of TLR4 and the platelet-activating factor receptor. | 2008 | J. Immunol. | pmid:18292574 |
| Mullol J et al. | Rupatadine in allergic rhinitis and chronic urticaria. | 2008 | Allergy | pmid:18339040 |
| Jiang Y et al. | Three-dimensional localization and quantification of PAF-induced gap formation in intact venular microvessels. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18515648 |
| Su J et al. | Natural antibodies against phosphorylcholine as potential protective factors in SLE. | 2008 | Rheumatology (Oxford) | pmid:18522961 |
| McLaughlin NJ et al. | Platelet-activating factor-mediated endosome formation causes membrane translocation of p67phox and p40phox that requires recruitment and activation of p38 MAPK, Rab5a, and phosphatidylinositol 3-kinase in human neutrophils. | 2008 | J. Immunol. | pmid:18523285 |
| Felfernig M et al. | Molecular weight of hydroxyethyl starch molecules influences coagulation profile measured by thrombelastography. | 2008 | J R Nav Med Serv | pmid:18524134 |
| Tsoupras AB et al. | Anti-platelet-activating factor effects of highly active antiretroviral therapy (HAART): a new insight in the drug therapy of HIV infection? | 2008 | AIDS Res. Hum. Retroviruses | pmid:18620493 |
| Corl CM et al. | Platelet activating factor production and proinflammatory gene expression in endotoxin-challenged bovine mammary endothelial cells. | 2008 | J. Dairy Sci. | pmid:18650283 |
| Landgraf RG et al. | Prostaglandins, leukotrienes and PAF selectively modulate lymphocyte subset and eosinophil infiltration into the airways in a murine model of asthma. | 2007 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17923399 |
| Vadnais ML et al. | Current concepts of molecular events during bovine and porcine spermatozoa capacitation. | 2007 May-Jun | Arch. Androl. | pmid:17612869 |
| Rosenwasser L | New insights into the pathophysiology of allergic rhinitis. | 2007 Jan-Feb | Allergy Asthma Proc | pmid:17390750 |
| Hattermann K et al. | The Toll-like receptor 7/8-ligand resiquimod (R-848) primes human neutrophils for leukotriene B4, prostaglandin E2 and platelet-activating factor biosynthesis. | 2007 | FASEB J. | pmid:17264163 |
| Boetkjaer A et al. | Synergism in the repression of COX-2- and TNFalpha-induction in platelet activating factor-stressed human neural cells. | 2007 | Neurosci. Lett. | pmid:17881124 |
| Xu W et al. | Role of platelet activating factor in pathogenesis of acute respiratory distress syndrome. | 2007 | Chin. Med. J. | pmid:18028783 |
| Kawano Y et al. | The effects of platelet-activating factor on the secretion of interleukin-8 and growth-regulated oncogene alpha in human immortalized granulosa cell line (GC1a). | 2007 | Am. J. Reprod. Immunol. | pmid:17922696 |
| Keam SJ and Plosker GL | Rupatadine: a review of its use in the management of allergic disorders. | 2007 | Drugs | pmid:17335300 |
| Van Overloop H et al. | On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase. | 2007 | Biol. Chem. | pmid:17338639 |
| Taheri F and Bazan HE | Platelet-activating factor overturns the transcriptional repressor disposition of Sp1 in the expression of MMP-9 in human corneal epithelial cells. | 2007 | Invest. Ophthalmol. Vis. Sci. | pmid:17460244 |
| Dinubile MJ | Plasma gelsolin: in search of its raison d'etre. Focus on "Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin". | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17428843 |
| Souza LJ et al. | Acute pancreatitis affects non-parenchymal liver cells by a mechanism dependent on platelet-activating factor. | 2007 | Pancreatology | pmid:17449968 |
| Shin CR et al. | Differential platelet-activating factor synthesis by monocytes and polymorphonuclear leukocytes from subjects with localized aggressive periodontitis. | 2007 | J. Periodont. Res. | pmid:17451539 |
| Truffinet V et al. | No effect of platelet-activating factor on the proliferation and apoptosis of immature forms of leukemic blasts. | 2007 | Leuk. Res. | pmid:17350684 |
| Paterson WG et al. | Role of platelet-activating factor in acid-induced esophageal mucosal injury. | 2007 | Dig. Dis. Sci. | pmid:17415649 |
| Tsimikas S et al. | New insights into the role of lipoprotein(a)-associated lipoprotein-associated phospholipase A2 in atherosclerosis and cardiovascular disease. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17626905 |
| Li Y et al. | Direct evidence for the action of phosphatidylinositol (3,4,5)-trisphosphate-mediated signal transduction in the 2-cell mouse embryo. | 2007 | Biol. Reprod. | pmid:17634444 |
| Tsantila N et al. | Antithrombotic and antiatherosclerotic properties of olive oil and olive pomace polar extracts in rabbits. | 2007 | Mediators Inflamm. | pmid:18253466 |
| Takahashi T et al. | Neutrophil-activating activity and platelet-activating factor synthesis in cytokine-stimulated endothelial cells: reduced activity in growth-arrested cells. | 2007 | Microvasc. Res. | pmid:17027041 |
| El Behi M et al. | Changes in self-reactive IgG antibody repertoire after treatment of experimental autoimmune encephalomyelitis with anti-allergic drugs. | 2007 | J. Neuroimmunol. | pmid:17097744 |
| Shindou H et al. | A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase. | 2007 | J. Biol. Chem. | pmid:17182612 |
| Ko HM et al. | Critical role for matrix metalloproteinase-9 in platelet-activating factor-induced experimental tumor metastasis. | 2007 | Int. J. Cancer | pmid:17187368 |
| Bate C et al. | Cholesterol synthesis inhibitors protect against platelet-activating factor-induced neuronal damage. | 2007 | J Neuroinflammation | pmid:17233902 |
| Caini P et al. | Modifications of plasma platelet-activating factor (PAF)-acetylhydrolase/PAF system activity in patients with chronic hepatitis C virus infection. | 2007 | J. Viral Hepat. | pmid:17212640 |
| Callender HL et al. | Quantification of diacylglycerol species from cellular extracts by electrospray ionization mass spectrometry using a linear regression algorithm. | 2007 | Anal. Chem. | pmid:17194150 |