Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hemorrhagic Fever, American D006478 2 associated lipids
Bovine Virus Diarrhea-Mucosal Disease D001912 2 associated lipids
Extravasation of Diagnostic and Therapeutic Materials D005119 3 associated lipids
Enterocolitis, Necrotizing D020345 3 associated lipids
Dyslexia D004410 3 associated lipids
Leukemia, Eosinophilic, Acute D015472 3 associated lipids
Encephalitis, Viral D018792 3 associated lipids
Subacute Sclerosing Panencephalitis D013344 3 associated lipids
Hematoma, Subdural D006408 3 associated lipids
Toxemia D014115 3 associated lipids
Contracture D003286 3 associated lipids
Bronchial Diseases D001982 3 associated lipids
Pneumonia, Pneumococcal D011018 3 associated lipids
Bronchopulmonary Sequestration D001998 3 associated lipids
Ileal Diseases D007077 3 associated lipids
Colitis, Ischemic D017091 3 associated lipids
Platelet Storage Pool Deficiency D010981 3 associated lipids
Hepatitis B, Chronic D019694 4 associated lipids
Lymphoma, T-Cell, Cutaneous D016410 4 associated lipids
Milk Hypersensitivity D016269 4 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

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What functions are associated with Platelet activating factor?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

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What genes are associated with Platelet activating factor?

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What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Page CP et al. An in vivo model for studying platelet aggregation and disaggregation. 1982 Thromb. Haemost. pmid:7051409
Camussi G et al. Platelet-activating factor (PAF) in experimentally-induced rabbit acute serum sickness: role of basophil-derived PAF in immune complex deposition. 1982 J. Immunol. pmid:7054286
Ninio E et al. Biosynthesis of platelet-activating factor. I. Evidence for an acetyl-transferase activity in murine macrophages. 1982 Biochim. Biophys. Acta pmid:7055592
Long MW et al. Immature megakaryocytes in the mouse: physical characteristics, cell cycle status, and in vitro responsiveness to thrombopoietic stimulatory factor. 1982 Blood pmid:7059669
Humphrey DM et al. Vasoactive properties of acetyl glyceryl ether phosphorylcholine and analogues. 1982 Lab. Invest. pmid:7070056
Gimbrone MA Blood vessels and the new mediators of inflammation. 1982 Lab. Invest. pmid:7070058
Prancan A et al. Relaxation of the guinea-pig trachea induced by platelet-activating factor and by serotonin. 1982 Eur. J. Pharmacol. pmid:7095003
Humphrey DM et al. Induction of leukocytic infiltrates in rabbit skin by acetyl glyceryl ether phosphorylcholine. 1982 Lab. Invest. pmid:7109542
Karpatkin S et al. Platelet aggregating material (PAM) of two virally-transformed tumors: SV3T3 mouse fibroblast and PW20 rat renal sarcoma. Role of cell surface sialylation. 1982 Prog. Clin. Biol. Res. pmid:7111309
Voelkel NF et al. Nonimmunological production of leukotrienes induced by platelet-activating factor. 1982 Science pmid:7123233
Kelly GL and Eiseman B Development of a new vascular prosthetic: lessons learned. 1982 Arch Surg pmid:7125901
Sugiura T et al. Ether phospholipids in guinea pig polymorphonuclear leukocytes and macrophages. Occurrence of high levels of 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine. 1982 Biochim. Biophys. Acta pmid:7126622
Vargaftig BB et al. Non-steroidal anti-inflammatory drugs if combined with anti-histamine and anti-serotonin agents interfere with the bronchial and platelet effects of "platelet-activating factor" (PAF-acether). 1982 Eur. J. Pharmacol. pmid:7128682
Namm DH et al. Species specificity of the platelet responses to 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine. 1982 Thromb. Res. pmid:7071810
Keraly CL and Benveniste J Specific desensitization of rabbit platelets by platelet-activating factor (PAF-acether) and derivatives. 1982 Br. J. Haematol. pmid:7082588
Bach MK Mediators of anaphylaxis and inflammation. 1982 Annu. Rev. Microbiol. pmid:6128957
Haslam RJ and Vanderwel M Inhibition of platelet adenylate cyclase by 1-O-alkyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine (platelet-activating factor). 1982 J. Biol. Chem. pmid:6177688
Chilton FH et al. Platelet activating factor. Stimulation of the lipoxygenase pathway in polymorphonuclear leukocytes by 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine. 1982 J. Biol. Chem. pmid:6802816
Sancho J et al. The effect of the injection of a synthetic platelet-activating factor (PAF-acether) on the fate of IgG aggregates in mice. 1982 Immunology pmid:7141463
Sybertz EJ et al. Studies on the interactions of acetyl glycerol ether phosphoryl choline with the sympathetic nervous system in rats. 1982 J. Pharmacol. Exp. Ther. pmid:7143227
Cabot MC et al. Metabolism of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine by cell cultures. 1982 Life Sci. pmid:7162357
Tsien WH et al. Variable responses of human platelets to synthetic platelet activating factor and their modification by epinephrine. 1982 Thromb. Res. pmid:7164038
Vargaftig BB Platelet-activating factor (PAF-acether) 1982 Agents Actions pmid:7164939
Bette P and Bienvenue A Exchange of a spin-labeled analog of PAF-acether between micelles, serum albumin and model membranes. 1982 Agents Actions pmid:7164940
Lartigue-Mattei C et al. Pharmacokinetic study of PAF-acether. Preliminary results after the intravenous administration of a 3H-labelled product to the rabbit. 1982 Agents Actions pmid:7164941
Morgat JL et al. Radio-labelling of 1-O-alkyl, 2-O-acetyl, sn-glycero-3-phosphorylcholine, 1-O-(9,10-di3H)-octadecyl PAF-acether. 1982 Agents Actions pmid:7164942
Convert O et al. 1H NMR of PAF-acether: influence of solvent on its structure. 1982 Agents Actions pmid:7164943
Borrel MC et al. Additional techniques for the total synthesis of PAF-acether. 1982 Agents Actions pmid:7164944
Benveniste J et al. Release of platelet-activating factor (PAF-acether) and 2-lyso PAF-acether from three cell types. 1982 Agents Actions pmid:7164945
Arnoux B et al. Release of PAF-acether from human blood monocytes. 1982 Agents Actions pmid:7164946
Fouque F et al. Platelet-activating factor (PAF-acether): thromboxane-independent synergism with adrenaline on human platelets and recent insights into its mode of action. 1982 Agents Actions pmid:7164947
Lefort J et al. Pharmacological properties of PAF-acether in the guinea-pig: platelet-dependent and independent reactions. 1982 Agents Actions pmid:7164948
Roubin R et al. Release of platelet-activating factor (PAF-acether) and leukotrienes C and D from inflammatory macrophages. 1982 Eur. J. Immunol. pmid:6122581
Lanara E et al. Response of mice and mouse platelets to acetyl glyceryl ether phosphorylcholine. 1982 Biochem. Biophys. Res. Commun. pmid:7168759
O'Flaherty JT Lipid mediators of inflammation and allergy. 1982 Lab. Invest. pmid:6126615
Sánchez-Crespo M et al. Rat serum sickness: possible role of inflammatory mediators allowing deposition of immune complexes in the glomerular basement membrane. 1982 Clin. Exp. Immunol. pmid:7172498
Pinckard RN The "new" chemical mediators of inflammation. 1982 Monogr Pathol pmid:6126808
Ieyasu H et al. A role of calcium-activated, phospholipid-dependent protein kinase in platelet-activating factor-induced serotonin release from rabbit platelets. 1982 Biochem. Biophys. Res. Commun. pmid:7181916
Camussi G et al. The release of platelet-activating factor during phagocytosis by polymorphonuclear neutrophils and monocytes. 1982 Adv. Exp. Med. Biol. pmid:7090917
Robeva R et al. [Changes in blood coagulation in glomerulonephritis]. 1982 Vutr Boles pmid:6219496
Chignard M et al. Inhibition by sulphinpyrazone of the platelet-dependent bronchoconstriction due to platelet-activating factor (PAF-acether) in the guinea pig. 1982 Eur. J. Pharmacol. pmid:6804248
Shukla SD and Hanahan DJ AGEPC (platelet activating factor) induced stimulation of rabbit platelets: effects on phosphatidylinositol, di- and triphosphoinositides and phosphatidic acid metabolism. 1982 Biochem. Biophys. Res. Commun. pmid:6288030
Isobe J and Mizuno A Aspects of PAF (platelet activating factor)-induced aggregation by using rabbit platelets. 1982 Tokushima J. Exp. Med. pmid:7170716
Alonso F et al. Modulatory role of cyclic AMP in the release of platelet-activating factor from human polymorphonuclear leucocytes. 1982 Immunology pmid:6277775
Rao GH et al. Human platelet activation by an alkylacetyl analogue of phosphatidylcholine. 1982 Biochim. Biophys. Acta pmid:6280777
Ingraham LM et al. Metabolic, membrane, and functional responses of human polymorphonuclear leukocytes to platelet-activating factor. 1982 Blood pmid:6282362
Valone FH et al. Specific binding of phospholipid platelet-activating factor by human platelets. 1982 J. Immunol. pmid:6286773
Czarneztki BM Effect of platelet activating factor on leukocytes. II. Enhancement of eosinophil chemotactic factor and beta-glucuronidase release. 1982 Chem. Phys. Lipids pmid:6814773
Aderka D et al. Morphological platelet anomalies in thrombotic thrombocytopenic purpura. 1982 Acta Haematol. pmid:6801893
Benveniste J et al. Biosynthesis of platelet-activating factor (PAF-ACETHER). II. Involvement of phospholipase A2 in the formation of PAF-ACETHER and lyso-PAF-ACETHER from rabbit platelets. 1982 Thromb. Res. pmid:6803388
Roubin R et al. Biosynthesis of platelet-activating factor (PAF-acether). IV. Impairment of acetyl-transferase activity in thioglycollate-elicited mouse macrophages. 1982 J. Immunol. pmid:6806384
Lee TC et al. Activities of enzymes that metabolize platelet-activating factor (1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine) in neutrophils and eosinophils from humans and the effect of a calcium ionophore. 1982 Biochem. Biophys. Res. Commun. pmid:6808993
Yasaka T et al. Monocyte aggregation and superoxide anion release in response to formyl-methionyl-leucyl-phenylalanine (FMLP) and platelet-activating factor (PAF). 1982 J. Immunol. pmid:6278021
Myśliwiec M and Myśliwiec B [Blood platelets, prostaglandin and complement interactions in inflammation]. 1982 Prz. Lek. pmid:6753039
Miller OV et al. Acetyl glycerylphosphorylcholine inhibition of prostaglandin I2-stimulated adenosine 3',5'-cyclic monophosphate levels in human platelets. Evidence for thromboxane A2 dependence. 1982 Biochim. Biophys. Acta pmid:6285985
Miller CL Infection in massively injured patients. 1982 Prog. Clin. Biol. Res. pmid:6757964
Bruni A and Palatini P Biological and pharmacological properties of phospholipids. 1982 Prog Med Chem pmid:6758038
Chesney CM et al. Effect of platelet-activating factor (PAF) on human platelets. 1982 Blood pmid:7037068
Masugi F et al. [Platelet-activating factor and antihypertensive polar renomedullary lipid: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine]. 1982 Tanpakushitsu Kakusan Koso pmid:6758041
Modiano A and Belisario A [Recent information on PAF (Platelet Activating Factor) in hemocoagulative and immuno-allergic processes]. 1982 G Clin Med pmid:6762313
Marcus AJ et al. Arachidonic acid metabolism in endothelial cells and platelets. 1982 Ann. N. Y. Acad. Sci. pmid:6762834
Masugi F et al. Potent hypotensive activity of 1-O-hexadecyl-2-O-acetyl-SN-glycero-3-phosphocholine in spontaneously hypertensive rat. 1982 Biochem. Biophys. Res. Commun. pmid:7041899
Lapetina EG Platelet-activating factor stimulates the phosphatidylinositol cycle. Appearance of phosphatidic acid is associated with the release of serotonin in horse platelets. 1982 J. Biol. Chem. pmid:7045103
Jouvin-Marche E et al. Platelet-activating factor (PAF-acether), an activator of neutrophil functions. 1982 Agents Actions pmid:6299078
Caillard CG et al. Hypotensive activity of PAF-acether in rats. 1982 Agents Actions pmid:6299079
Camussi G et al. Release of platelet-activating factor from HL-60 human leukemic cells following macrophage-like differentiation. 1982 Blood pmid:6947829
Ishii H et al. A platelet aggregating substance contained in xanthine oxidase preparation from cow's milk. 1982 Thromb. Res. pmid:6897588
Smith RJ and Bowman BJ Stimulation of human neutrophil degranulation with 1-O-octadecyl-2-O-acetyl-SN-glyceryl-3-phosphorylcholine: modulation by inhibitors of arachidonic acid metabolism. 1982 Biochem. Biophys. Res. Commun. pmid:6803804
Shukla SD and Hanahan DJ An early transient decrease in phosphatidylinositol 4,5-bisphosphate upon stimulation of rabbit platelets with acetylglycerylether phosphorylcholine (platelet activating factor). 1983 Arch. Biochem. Biophys. pmid:6320731
Larsen GL and Henson PM Mediators of inflammation. 1983 Annu. Rev. Immunol. pmid:6399978
Albert DH and Snyder F Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) from 1-alkyl-2-acyl-sn-glycero-3-phosphocholine by rat alveolar macrophages. Phospholipase A2 and acetyltransferase activities during phagocytosis and ionophore stimulation. 1983 J. Biol. Chem. pmid:6401298
König W et al. On the biological role of lipid chemotactic factors. 1983 Agents Actions Suppl. pmid:6404145
O'Flaherty JT et al. 5-L-hydroxy-6,8,11,14-eicosatetraenoate potentiates the human neutrophil degranulating action of platelet-activating factor. 1983 Biochem. Biophys. Res. Commun. pmid:6403011
Bessin P et al. Acute circulatory collapse caused by platelet-activating factor (PAF-acether) in dogs. 1983 Eur. J. Pharmacol. pmid:6687572
Mueller HW et al. 1-O-alkyl-linked phosphoglycerides of human platelets: distribution of arachidonate and other acyl residues in the ether-linked and diacyl species. 1983 Lipids pmid:6419001
Korth R et al. 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholines: influence on aggregation and [3H]serotonin release of human thrombocytes. 1983 Chem. Phys. Lipids pmid:6627525
Moschidis MC et al. Phosphono-platelet activating factor I. Synthesis of 1-O-hexadecyl-2-O-acetyl-glyceryl-3-(2-trimethyl ammonium-methyl) phosphonate and its platelet activating potency. 1983 Chem. Phys. Lipids pmid:6627527
Heffner JE et al. Acetyl glyceryl ether phosphorylcholine-stimulated human platelets cause pulmonary hypertension and edema in isolated rabbit lungs. Role of thromboxane A2. 1983 J. Clin. Invest. pmid:6822668
Vargaftig BB et al. Convulxin-induced activation of intact and of thrombin-degranulated rabbit platelets: specific crossed desensitisation with collagen. 1983 Eur. J. Pharmacol. pmid:6628537
Keraly CL et al. Effect of structural analogues of PAF-acether on platelet desensitization. 1983 Br. J. Haematol. pmid:6824590
Farr RS et al. Human serum acid-labile factor is an acylhydrolase that inactivates platelet-activating factor. 1983 Fed. Proc. pmid:6628702
Tence M et al. The enantiomer and the positional isomer of platelet-activating factor. 1983 Biochim. Biophys. Acta pmid:6824744
Denjean A et al. Acute effects of intratracheal administration of platelet-activating factor in baboons. 1983 J Appl Physiol Respir Environ Exerc Physiol pmid:6629917
Camussi G et al. Biosynthesis and release of platelet-activating factor from human monocytes. 1983 Int. Arch. Allergy Appl. Immunol. pmid:6826235
Björk J et al. Paf-acether (platelet-activating factor) increases microvascular permeability and affects endothelium-granulocyte interaction in microvascular beds. 1983 Acta Physiol. Scand. pmid:6659994
Björk J and Smedegård G Acute microvascular effects of PAF-acether, as studied by intravital microscopy. 1983 Eur. J. Pharmacol. pmid:6662199
Yamashita M et al. The metabolism of platelet activating factor in platelets and plasma of various animals. 1983 J Toxicol Sci pmid:6663653
Masugi F et al. [Kidney medulla and hypertension, with special reference to antihypertensive lipids]. 1983 Nihon Jinzo Gakkai Shi pmid:6663856
Tanaka S et al. Studies on the hypotensive effects of platelet activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine) in rats, guinea pigs, rabbits, and dogs. 1983 J. Pharmacobio-dyn. pmid:6668545
Saeki S et al. Hypotensive activity of 1-O-hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine in rats with various types of hypertension. 1983 Med J Osaka Univ pmid:6669136
Lee TC et al. Stimulation of calcium uptake by 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) in rabbit platelets: possible involvement of the lipoxygenase pathway. 1983 Arch. Biochem. Biophys. pmid:6407399
Worthen GS et al. Platelet-activating factor causes neutrophil accumulation and edema in rabbit lungs. 1983 Chest pmid:6839840
Heffner JE et al. Platelet-induced pulmonary hypertension and edema. A mechanism involving acetyl glyceryl ether phosphorylcholine and thromboxane A2. 1983 Chest pmid:6839854
Levy JV Calmodulin antagonist W-7 inhibits aggregation of human platelets induced by platelet activating factor. 1983 Proc. Soc. Exp. Biol. Med. pmid:6844347
O'Flaherty JT et al. Platelet-activating factor and analogues: comparative studies with human neutrophils and rabbit platelets. 1983 Res. Commun. Chem. Pathol. Pharmacol. pmid:6844746
Valone FH and Goetzl EJ Specific binding by human polymorphonuclear leucocytes of the immunological mediator 1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphorylcholine. 1983 Immunology pmid:6848449
Chilton FH et al. Metabolic fate of platelet-activating factor in neutrophils. 1983 J. Biol. Chem. pmid:6853486
Stormorken H et al. A new bleeding disorder: lack of platelet aggregatory response to adrenaline and lack of secondary aggregation to ADP and platelet activating factor (PAF). 1983 Thromb. Res. pmid:6857589
Kloprogge E et al. Stimulus-response coupling in human platelets. Evidence against a role of PAF-acether in the "third pathway'. 1983 Thromb. Res. pmid:6857605
Hubbard JW et al. Antihypertensive effects of I-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine on plasma renin activity and catecholamine responses in spontaneously hypertensive rats. 1983 Life Sci. pmid:6337313