| MeSH term | MeSH ID | Detail |
|---|---|---|
| Asphyxia Neonatorum | D001238 | 4 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Pulmonary Atelectasis | D001261 | 1 associated lipids |
| Behcet Syndrome | D001528 | 7 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
| Blister | D001768 | 16 associated lipids |
| Blood Platelet Disorders | D001791 | 12 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Bovine Virus Diarrhea-Mucosal Disease | D001912 | 2 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Brain Injuries | D001930 | 4 associated lipids |
| Bronchial Diseases | D001982 | 3 associated lipids |
| Bronchial Spasm | D001986 | 18 associated lipids |
| Bronchiectasis | D001987 | 7 associated lipids |
| Bronchopulmonary Dysplasia | D001997 | 4 associated lipids |
| Bronchopulmonary Sequestration | D001998 | 3 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Burns, Inhalation | D002059 | 4 associated lipids |
| Carbon Monoxide Poisoning | D002249 | 9 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sugiyama T et al. | A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and autoimmune thrombocytopenia. | 1987 | Blood | pmid:3580576 |
| Hayashi M et al. | Characterization of the activity of a platelet activating factor antagonist, CV-3988. | 1987 | Jpn. J. Pharmacol. | pmid:2888915 |
| Bussolino F et al. | Chick retina generates platelet-activating factor. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2890284 |
| Mikashima H et al. | An antagonistic activity of etizolam on platelet-activating factor (PAF). In vitro effects on platelet aggregation and PAF receptor binding. | 1987 | Jpn. J. Pharmacol. | pmid:2890779 |
| Gautheron PD et al. | A study of PAF-induced ocular inflammation in the rat and its inhibition by the PAF antagonist, L-652,731. | 1987 | J. Pharm. Pharmacol. | pmid:2891830 |
| McFall TL et al. | Effect of group B streptococcal type-specific antigen on polymorphonuclear leukocyte function and polymorphonuclear leukocyte-endothelial cell interaction. | 1987 | Pediatr. Res. | pmid:3037472 |
| Kornecki E et al. | Interactions of the alkyl-ether-phospholipid, platelet activating factor (PAF) with platelets, neural cells, and the psychotropic drugs triazolobenzodiazepines. | 1987 | Adv. Exp. Med. Biol. | pmid:2893525 |
| Kumar R et al. | Metabolism of platelet-activating factor (alkylacetylphosphocholine) by type-II epithelial cells and fibroblasts from rat lungs. | 1987 | Biochim. Biophys. Acta | pmid:3790610 |
| Stewart AG and Piper PJ | Actions of platelet-activating factor in the coronary circulation of the guinea pig in vitro. | 1987 | Prog. Clin. Biol. Res. | pmid:3671383 |
| Abstracts of the meeting: The role of platelet-activating factors in the immune response. Paris, France, June 25 and 26, 1987. | 1987 | Prostaglandins | pmid:3671731 | |
| Criscuoli M and Subissi A | Paf-acether-induced death in mice: involvement of arachidonate metabolites and beta-adrenoceptors. | 1987 | Br. J. Pharmacol. | pmid:2880624 |
| Bourgain RH et al. | Arterial obstruction induced by PAF-acether (1-O-alkyl-sn-glycero-3-phosphocholine). | 1987 | Adv. Exp. Med. Biol. | pmid:3673721 |
| Myers AK and Bader TJ | Role of adrenal steroids in the recovery from platelet activating factor challenge. | 1987 | Circ. Shock | pmid:3677334 |
| Hsueh W et al. | Platelet-activating factor: an endogenous mediator for bowel necrosis in endotoxemia. | 1987 | FASEB J. | pmid:3678700 |
| Terasawa M et al. | Antagonistic activity of etizolam on platelet-activating factor in vivo experiments. | 1987 | Jpn. J. Pharmacol. | pmid:3682404 |
| Sipka S et al. | Atropine is an inhibitor of the chemiluminescence induced by platelet-activating factor in human neutrophils. | 1987 | Acta Biochim. Biophys. Hung. | pmid:3132002 |
| Miwa M et al. | Occurrence of an endogenous inhibitor of platelet-activating factor in rat liver. | 1987 | J. Biol. Chem. | pmid:3804997 |
| Sugiura T et al. | Transacylation of lyso platelet-activating factor and other lysophospholipids by macrophage microsomes. Distinct donor and acceptor selectivities. | 1987 | J. Biol. Chem. | pmid:3805017 |
| Caffrey E et al. | Aggregation responses to platelet-activating factor in normal subjects. | 1987 | Haemostasis | pmid:3609916 |
| Bittman R et al. | Synthesis and biochemical studies of analogs of platelet-activating factor bearing a methyl group at C2 of the glycerol backbone. | 1987 | J. Lipid Res. | pmid:3611974 |
| Terashita Z et al. | CV-6209, a highly potent antagonist of platelet activating factor in vitro and in vivo. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3612533 |
| Levy JV | Spasmogenic effect of platelet activating factor (PAF) on isolated rat stomach fundus strip. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3619905 |
| Huber M and Keppler D | Inhibition of leukotriene D4 catabolism by D-penicillamine. | 1987 | Eur. J. Biochem. | pmid:3622511 |
| Egido J et al. | Role of platelet-activating factor in adriamycin-induced nephropathy in rats. | 1987 | Eur. J. Pharmacol. | pmid:3622604 |
| Kawaguchi H and Yasuda H | Effects of platelet-activating factor on conversion of angiotensin I to II. | 1987 | FEBS Lett. | pmid:3622769 |
| Ninio E et al. | Biosynthesis of paf-acether. IX. Role for a phosphorylation-dependent activation of acetyltransferase in antigen-stimulated mouse mast cells. | 1987 | J. Immunol. | pmid:3584983 |
| Casals-Stenzel J | Triazolodiazepines are potent antagonists of platelet activating factor (PAF) in vitro and in vivo. | 1987 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:3587377 |
| Brambilla A et al. | WEB 2086. A potent PAF antagonist exerts protective effect toward PAF-induced gastric damage. | 1987 | Pharmacol Res Commun | pmid:3588650 |
| Jancar S et al. | Comparative effects of platelet activating factor, leukotriene D4 and histamine on guinea pig trachea, bronchus and lung parenchyma. | 1987 | Prostaglandins | pmid:3588970 |
| Malo PE et al. | Enhancement of leukotriene D4-induced contraction of guinea-pig isolated trachea by platelet activating factor. | 1987 | Prostaglandins | pmid:3588971 |
| Bruijnzeel PL et al. | Platelet-activating factor induces leukotriene C4 synthesis by purified human eosinophils. | 1987 | Prostaglandins | pmid:3118415 |
| Sha'afi RI and Molski TF | Signalling for increased cytoskeletal actin in neutrophils. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3036146 |
| Ruan CG et al. | Studies on monoclonal antibodies against human platelets--a monoclonal antibody to human platelet glycoprotein I--SZ-2. | 1987 | Sci. Sin., Ser. B, Chem. Biol. Agric. Med. Earth Sci. | pmid:3659897 |
| Feuerstein G et al. | Protective effect of a PAF-acether antagonist, BN 52021, in trichothecene toxicosis. | 1987 | Toxicol. Lett. | pmid:3660430 |
| Heinsohn C et al. | The effect of bovine serum albumin on the synthesis of prostaglandin and incorporation of [3H]acetate into platelet-activating factor. | 1987 | Arch. Biochem. Biophys. | pmid:3662526 |
| Sperling RI et al. | Effects of dietary supplementation with marine fish oil on leukocyte lipid mediator generation and function in rheumatoid arthritis. | 1987 | Arthritis Rheum. | pmid:3663263 |
| Siess W and Lapetina EG | Phorbol esters sensitize platelets to activation by physiological agonists. | 1987 | Blood | pmid:3663938 |
| Casals-Stenzel J et al. | Bronchial and vascular effects of Paf in the rat isolated lung are completely blocked by WEB 2086, a novel specific Paf antagonist. | 1987 | Br. J. Pharmacol. | pmid:3664079 |
| Robertson DN and Page CP | Effect of platelet agonists on airway reactivity and intrathoracic platelet accumulation. | 1987 | Br. J. Pharmacol. | pmid:3664082 |
| Whittle BJ et al. | Increased intestinal formation of Paf in endotoxin-induced damage in the rat. | 1987 | Br. J. Pharmacol. | pmid:3664090 |
| Shigenobu K et al. | Potentiation by bovine serum albumin (BSA) of endothelium-dependent vasodilator response to acetyl glyceryl ether phosphorylcholine (AGEPC). | 1987 | J. Pharmacobio-dyn. | pmid:3625454 |
| Jensen NJ et al. | FAB MS/MS for phosphatidylinositol, -glycerol, -ethanolamine and other complex phospholipids. | 1987 | Lipids | pmid:3626775 |
| Cox CP and Wood KL | Selective antagonism of platelet-activating factor (PAF)-induced aggregation and secretion in washed rabbit platelets by CV-3988, L-652731, triazolam and alprazolam. | 1987 | Thromb. Res. | pmid:3629553 |
| Homma H et al. | Some unique features of the metabolic conversion of platelet-activating factor (AGEPC) to alkyl acyl PC by washed rabbit platelets. | 1987 | Arch. Biochem. Biophys. | pmid:3101596 |
| Takahashi H et al. | [Blood coagulation disorders in thrombotic thrombocytopenic purpura--with special reference to a von Willebrand factor abnormality]. | 1987 | Rinsho Byori | pmid:3501812 |
| Haroldsen PE et al. | Metabolism of platelet-activating factor in isolated perfused rat lung. | 1987 | J. Clin. Invest. | pmid:3108322 |
| Tahara T et al. | PAF antagonistic activity of some thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepines. | 1987 | Chem. Pharm. Bull. | pmid:3664818 |
| Hansen JF and Hansen BF | [Unstable angina pectoris, acute myocardial infarct, sudden heart death. Patho-anatomy and pathophysiology]. | 1987 | Ugeskr. Laeg. | pmid:3324429 |
| Haroldsen PE et al. | Quantitation of lyso-platelet activating factor molecular species from human neutrophils by mass spectrometry. | 1987 | J. Lipid Res. | pmid:3104521 |
| Bienenstock J et al. | Mast cell involvement in various inflammatory processes. | 1987 | Am. Rev. Respir. Dis. | pmid:3109295 |
| Beauvais F and Benveniste J | [IgE and anaphylaxis mediators]. | 1987 | Allerg Immunol (Paris) | pmid:2968802 |
| de Almeida PJ et al. | [Biochemical bases of platelet activity in homeostasis and thrombogenesis. III]. | 1987 | Arq. Bras. Cardiol. | pmid:3328601 |
| O'Neill C | Embryo-derived platelet activating factor: a preimplantation embryo mediator of maternal recognition of pregnancy. | 1987 | Domest. Anim. Endocrinol. | pmid:3333935 |
| Teng CM et al. | Antiplatelet effect of butylidenephthalide. | 1987 | Biochim. Biophys. Acta | pmid:3109495 |
| Chabot MC et al. | Reacylation of platelet activating factor with eicosapentaenoic acid in fish-oil-enriched monkey neutrophils. | 1987 | Biochim. Biophys. Acta | pmid:2823907 |
| Whatley RE et al. | Production of platelet-activating factor by endothelial cells. | 1987 | Semin. Thromb. Hemost. | pmid:3321437 |
| Kelton JG and Murphy WG | Acute thrombocytopenia and thrombosis. Heparin-induced thrombocytopenia and thrombotic thrombocytopenic purpura. | 1987 | Ann. N. Y. Acad. Sci. | pmid:3322132 |
| Valone FH and Johnson B | Modulation of platelet-activating-factor-induced calcium influx and intracellular calcium release in platelets by phorbol esters. | 1987 | Biochem. J. | pmid:3322269 |
| HÃ¥kansson L et al. | New method for the measurement of eosinophil migration. | 1987 | J. Leukoc. Biol. | pmid:2445885 |
| Sciberras DG et al. | Inflammatory responses to intradermal injection of platelet activating factor, histamine and prostaglandin E2 in healthy volunteers: a double blind investigation. | 1987 | Br J Clin Pharmacol | pmid:2449904 |
| Tou JS | Platelet-activating factor modulates phospholipid acylation in human neutrophils. | 1987 | Lipids | pmid:3110533 |
| Chen DC | [Phosphoinositide metabolism and platelet activation]. | 1987 | Sheng Li Ke Xue Jin Zhan | pmid:2838899 |
| Touvay C et al. | Gossypol: a potent inhibitor of PAF-acether- and leukotriene-induced contractions of guinea-pig lung parenchyma strips. | 1987 | J. Pharm. Pharmacol. | pmid:2886603 |
| Matsuno K et al. | [Cytoplasm free calcium ions as a second messenger]. | 1987 | Rinsho Byori | pmid:3437533 |
| Kawamura Y et al. | [A simple measurement of plasma platelet-activating factor (PAF) acetylhydrolase, normal level of activity, and distribution among lipoprotein fractions]. | 1987 | Rinsho Byori | pmid:3437547 |
| Kertscher HP and Ostermann G | [Synthesis and platelet aggregating activity of structural analogs of platelet-activating factor with a heterocyclic head group]. | 1987 | Pharmazie | pmid:3438334 |
| Riedel A et al. | The effect of the specific PAF antagonist BN 52021 and the calcium blocker diltiazem on PAF induced arrhythmogenicity. | 1987 | Pharmacol Res Commun | pmid:3441484 |
| Bussolino F et al. | Intravascular release of platelet activating factor in children with sepsis. | 1987 | Thromb. Res. | pmid:3441909 |
| Bossant MJ et al. | Characterization and quantification of PAF-acether (platelet-activating factor) as a heptafluorobutyrate derivative of 1-O-alkyl-2-acetyl-sn-glycerol by capillary column gas chromatography with electron-capture detection. | 1987 | J. Chromatogr. | pmid:3443654 |
| Parker CW | Lipid mediators produced through the lipoxygenase pathway. | 1987 | Annu. Rev. Immunol. | pmid:3036183 |
| Shimizu K et al. | [Actions of platelet activating factor in pulmonary circulation--experimental investigation using rabbit blood vessel smooth muscle preparations]. | 1987 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:3444152 |
| Casals-Stenzel J and Weber KH | Triazolodiazepines: dissociation of their Paf (platelet activating factor) antagonistic and CNS activity. | 1987 | Br. J. Pharmacol. | pmid:2880622 |
| Lagente V et al. | Platelet-activating factor (PAF-acether) and microcirculation: effect of Lyso-PAF and PAF-antagonists. | 1987 | Braz. J. Med. Biol. Res. | pmid:3452452 |
| Gentry PA et al. | Inhibitory effect of trichothecene mycotoxins on bovine platelets stimulated by platelet activating factor. | 1987 | Can. J. Vet. Res. | pmid:3453270 |
| Sugatani J et al. | Potential involvement of vicinal sulfhydryls in stimulus-induced rabbit platelet activation. | 1987 | J. Biol. Chem. | pmid:2824509 |
| Leff AR et al. | Parasympathetic involvement in PAF-induced contraction in canine trachealis in vivo. | 1987 | J. Appl. Physiol. | pmid:2881917 |
| Spinks NR and O'Neill C | Embryo-deprived platelet-activating factor is essential for establishment of pregnancy in the mouse. | 1987 | Lancet | pmid:2432367 |
| Feuerstein G and Hallenbeck JM | Prostaglandins, leukotrienes, and platelet-activating factor in shock. | 1987 | Annu. Rev. Pharmacol. Toxicol. | pmid:3034139 |
| Khandwala A et al. | REV 2871 (CHBZ): a potent antiallergic agent with a novel mechanism of action. I. Activity profile as an inhibitor of mediator release. | 1987 | Biochem. Pharmacol. | pmid:2435293 |
| Alloatti G et al. | Protective effect of verapamil on the cardiac and circulatory alterations induced by platelet-activating factor. | 1987 | J. Cardiovasc. Pharmacol. | pmid:2435996 |
| Kappa JR et al. | Carotid endarterectomy in patients with heparin-induced platelet activation: comparative efficacy of aspirin and iloprost (ZK36374). | 1987 | J. Vasc. Surg. | pmid:2437338 |
| Serafin WE and Austen KF | Mediators of immediate hypersensitivity reactions. | 1987 | N. Engl. J. Med. | pmid:2438554 |
| Avdonin PV et al. | Evidence for the receptor-operated calcium channels in human platelet plasma membrane. | 1987 | Thromb. Res. | pmid:2438805 |
| Terashita Z et al. | A lethal role of platelet activating factor in anaphylactic shock in mice. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3118009 |
| Sperling RI et al. | The effects of N-3 polyunsaturated fatty acids on the generation of platelet-activating factor-acether by human monocytes. | 1987 | J. Immunol. | pmid:2826583 |
| de Arriba G et al. | Changes in glomerular cross-sectional area induced by platelet activating factor. | 1987 | Nephrol. Dial. Transplant. | pmid:3118261 |
| Darius H and Lefer AM | Pharmacologic antagonism of platelet activating factor and peptide leukotrienes inhibits guinea pig anaphylaxis. | 1987 | Prog. Clin. Biol. Res. | pmid:3118384 |
| Musch MW et al. | Antigen-and ionophore-stimulated synthesis of platelet-activating factor by the cloned mast cell line, MC9. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3107564 |
| Sisson JH et al. | Production of platelet-activating factor by stimulated human polymorphonuclear leukocytes. Correlation of synthesis with release, functional events, and leukotriene B4 metabolism. | 1987 | J. Immunol. | pmid:3035016 |
| Michel L et al. | Biologic properties of LTB4 and paf-acether in vivo in human skin. | 1987 | J. Invest. Dermatol. | pmid:3035030 |
| Shalit M et al. | Platelet-activating factor both stimulates and "primes" human polymorphonuclear leukocyte actin filament assembly. | 1987 | Blood | pmid:3118991 |
| Touqui L et al. | The role of Ca2+ in regulating the catabolism of PAF-acether (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in rabbit platelets. | 1987 | Biochem. J. | pmid:3109377 |
| Sheth KJ et al. | Reversal of central nervous system involvement in hemolytic uremic syndrome by use of plasma exchanges. | 1987 | Clin Pediatr (Phila) | pmid:3119270 |
| Bureau M et al. | Desensitization and antagonism of rat polymorphonuclear leukocytes stimulated with PAF acether. | 1987 | Prostaglandins | pmid:3035615 |
| Sage SO and Rink TJ | The kinetics of changes in intracellular calcium concentration in fura-2-loaded human platelets. | 1987 | J. Biol. Chem. | pmid:3119586 |
| Camussi G et al. | Tumor necrosis factor/cachectin stimulates peritoneal macrophages, polymorphonuclear neutrophils, and vascular endothelial cells to synthesize and release platelet-activating factor. | 1987 | J. Exp. Med. | pmid:3119758 |
| Carlson RP et al. | Pharmacologic modulation of PAF-induced mortality in mice. | 1987 | Agents Actions | pmid:3120513 |
| Satouchi K et al. | 1-Acyl-2-acetyl-sn-glycero-3-phosphocholine from stimulated human polymorphonuclear leukocytes. | 1987 | Lipids | pmid:3110532 |
| Bussolino F et al. | Studies on the mechanism of interleukin 1 stimulation of platelet activating factor synthesis in human endothelial cells in culture. | 1987 | Biochim. Biophys. Acta | pmid:3024738 |
| Di Marzo V et al. | Neuropeptides and leukotriene release: effect of peptide histidine isoleucine and secretin in platelet activating factor-stimulated rat lung. | 1987 | Neuropeptides | pmid:3031537 |