| MeSH term | MeSH ID | Detail |
|---|---|---|
| Asphyxia Neonatorum | D001238 | 4 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Pulmonary Atelectasis | D001261 | 1 associated lipids |
| Behcet Syndrome | D001528 | 7 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
| Blister | D001768 | 16 associated lipids |
| Blood Platelet Disorders | D001791 | 12 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Bovine Virus Diarrhea-Mucosal Disease | D001912 | 2 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Brain Injuries | D001930 | 4 associated lipids |
| Bronchial Diseases | D001982 | 3 associated lipids |
| Bronchial Spasm | D001986 | 18 associated lipids |
| Bronchiectasis | D001987 | 7 associated lipids |
| Bronchopulmonary Dysplasia | D001997 | 4 associated lipids |
| Bronchopulmonary Sequestration | D001998 | 3 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Burns, Inhalation | D002059 | 4 associated lipids |
| Carbon Monoxide Poisoning | D002249 | 9 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Madi S et al. | Allergen-induced bronchospasm in passively sensitized guinea pigs: influence of new substances in comparison to reference compounds. | 1991 | Agents Actions | pmid:2058463 |
| Braquet P and Esanu A | New trends in PAF antagonist research: a new series of potent hetrapazine-derived PAF antagonists. | 1991 | Agents Actions | pmid:2058466 |
| Will PC et al. | Platelet activating factor as a proinflammatory mediator in acetic-induced colitis in the rat. | 1991 | Agents Actions | pmid:1793026 |
| Vincent D et al. | Dissociation between LPS-induced bronchial hyperreactivity and airway edema in the guinea-pig. | 1991 | Agents Actions | pmid:1793031 |
| Adolfs MJ et al. | PAF-acether modifies human peritoneal macrophage cAMP levels in a biphasic fashion. | 1989 | Agents Actions | pmid:2540635 |
| Neumann M and Kownatzki E | The effect of adherence on the generation of reactive oxygen species by human neutrophilic granulocytes. | 1989 | Agents Actions | pmid:2540640 |
| Morley J | Platelet activating factor and asthma. | 1986 | Agents Actions | pmid:3099555 |
| Ramesha CS et al. | Identification and quantitation of PAF from psoriatic scales. | 1987 | Agents Actions | pmid:3687590 |
| Friedlander G et al. | Renal effects of platelet-activating factor in the rat. | 1987 | Agents Actions | pmid:3687594 |
| Lauri D et al. | Contribution of ADP to the amplification of primary platelet aggregation by platelet activating factor (PAF): modulatory role of aspirin. | 1986 | Agents Actions | pmid:3706054 |
| Pirotzky E et al. | Vascular permeability induced by Paf-acether (platelet-activating factor) in the isolated perfused rat kidney. | 1985 | Agents Actions | pmid:4003192 |
| Page CP et al. | Platelet activating factor (Paf-acether) may account for late-onset reactions to allergen inhalation. | 1985 | Agents Actions | pmid:4003195 |
| Page CP et al. | Suppression of Paf-acether responses: an anti-inflammatory effect of anti-asthma drugs. | 1985 | Agents Actions | pmid:4003196 |
| Spicer BA et al. | An investigation of the involvement of platelet activating factor in the non-histamine immediate hypersensitivity reaction in the rat peritoneal cavity. | 1985 | Agents Actions | pmid:4003197 |
| Boughton-Smith NK et al. | Actions of nitric oxide on the acute gastrointestinal damage induced by PAF in the rat. | 1992 | Agents Actions | pmid:1279960 |
| Northover AM and Northover BJ | Lectin-induced increase in microvascular permeability to colloidal carbon in vitro may involve protein kinase C activation. | 1994 | Agents Actions | pmid:7942320 |
| Tubaro E et al. | In vitro and in vivo impact of a new glycosphingolipid on neutrophils. | 1994 | Agents Actions | pmid:7879694 |
| Canale P et al. | TCV-309, a novel platelet activating factor antagonist, inhibits leukocyte accumulation and protects against splanchnic artery occlusion shock. | 1994 | Agents Actions | pmid:7879698 |
| Perret BA et al. | Binding of bovine factor VIII-coated colloidal gold particles to receptors on platelet membranes. | 1981 | Agents Actions | pmid:6803540 |
| Denburg JA et al. | Platelet activating factor: regulation by mast cells and aspirin. | 1984 | Agents Actions | pmid:6711391 |
| Lecrubier C et al. | Study of platelet aggregation induced by platelet activating factor (PAF) after administration of ticlopidine or aspirin. | 1983 | Agents Actions | pmid:6858789 |
| Vargaftig BB | Platelet-activating factor (PAF-acether) | 1982 | Agents Actions | pmid:7164939 |
| Bette P and Bienvenue A | Exchange of a spin-labeled analog of PAF-acether between micelles, serum albumin and model membranes. | 1982 | Agents Actions | pmid:7164940 |
| Lartigue-Mattei C et al. | Pharmacokinetic study of PAF-acether. Preliminary results after the intravenous administration of a 3H-labelled product to the rabbit. | 1982 | Agents Actions | pmid:7164941 |
| Morgat JL et al. | Radio-labelling of 1-O-alkyl, 2-O-acetyl, sn-glycero-3-phosphorylcholine, 1-O-(9,10-di3H)-octadecyl PAF-acether. | 1982 | Agents Actions | pmid:7164942 |
| Convert O et al. | 1H NMR of PAF-acether: influence of solvent on its structure. | 1982 | Agents Actions | pmid:7164943 |
| Vargaftig BB et al. | Platelet-tissue interaction: role of platelet-activating factor (PAF-acether). | 1980 | Agents Actions | pmid:7270336 |
| Sullivan MH et al. | Altered platelet responses to P.A.F. in pregnancy-induced hypertension. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825415 |
| Braquet P et al. | From ginkgolides to N-substituted piperidino-thieno diazepines, a new series of highly potent dual antagonists. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825436 |
| Berti F et al. | Opposite effects of PGI2 and PAF generated during acute myocardial ischemia in the perfused rabbit heart. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825437 |
| Takatani M et al. | Platelet activating factor (PAF) antagonists: development of a highly potent PAF antagonist, TCV-309. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825438 |
| Kawabe T et al. | Role of PAF and cytokines in the modulation of Fc epsilon RII/CD23 expression on human eosinophils. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825444 |
| Weber PC and Sellmayer A | Modification of the eicosanoid system and cell signalling by precursor fatty acids. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825543 |
| Balazy M et al. | A novel method for the analysis of PAF and alkyl-ether phospholipids by mass spectrometry. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825562 |
| Magni F et al. | Determination of platelet-activating factor in biological samples by high resolution mass spectrometry. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825563 |
| Robertson DN and Smith GM | Role of thromboxane A2, 5-hydroxytryptamine, and platelet activating factor in collagen-induced sudden death in rabbits. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959049 |
| d'Humieres S et al. | Platelet activating factor acether is involved in thrombin-induced synthesis of prostacyclin by human endothelial cells. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959051 |
| Whittle BJ et al. | Gastric vascular and mucosal damaging actions of platelet activating factor in the canine stomach. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959063 |
| Montrucchio G et al. | In vitro oxytocic activity of platelet-activating factor on human myometrium. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960158 |
| Mallet AI et al. | Platelet activating factor in chronic plaque psoriasis. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960170 |
| Bourgain RH et al. | Effect of ginkgolide PAF-acether antagonists on arterial thrombosis. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960196 |
| Braquet P et al. | Platelet-activating factor: a potential mediator of shock. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960197 |
| Myers A et al. | Pharmacological manipulation of platelet-activating factor toxicity in rodents. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960198 |
| Benveniste J | Biosynthesis and function of PAF-acether (platelet-activating factor). | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936197 |
| Waku K et al. | Metabolism of 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a precursor of platelet-activating factor in macrophages. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936199 |
| Saito K et al. | Determination of AGEPC generated from human neutrophils and rat skin and muscle tissues by a selected ion monitoring technique of GC/MS. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936200 |
| Hanahan DJ et al. | Platelet-activating factor: a unique lipid chemical mediator. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936201 |
| Inoue K et al. | Activation of guinea pig peritoneal macrophages by platelet-activating factor in free form or incorporated into liposomes. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936203 |
| Benveniste J | Paf-acether (platelet-activating factor). | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3159192 |
| Terashita Z et al. | Beneficial effects of (RS)-2-methoxy-3-(octadecylcarbamoyloxy)propyl 2-(3-thiazolio)ethyl phosphate, a specific PAF antagonist, in endotoxin and anaphylactic shock. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3004156 |