Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Asphyxia Neonatorum D001238 4 associated lipids
Asthma D001249 52 associated lipids
Pulmonary Atelectasis D001261 1 associated lipids
Behcet Syndrome D001528 7 associated lipids
Birth Weight D001724 23 associated lipids
Blister D001768 16 associated lipids
Blood Platelet Disorders D001791 12 associated lipids
Body Weight D001835 333 associated lipids
Bovine Virus Diarrhea-Mucosal Disease D001912 2 associated lipids
Brain Diseases D001927 27 associated lipids
Brain Edema D001929 20 associated lipids
Brain Injuries D001930 4 associated lipids
Bronchial Diseases D001982 3 associated lipids
Bronchial Spasm D001986 18 associated lipids
Bronchiectasis D001987 7 associated lipids
Bronchopulmonary Dysplasia D001997 4 associated lipids
Bronchopulmonary Sequestration D001998 3 associated lipids
Burns D002056 34 associated lipids
Burns, Inhalation D002059 4 associated lipids
Carbon Monoxide Poisoning D002249 9 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

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What genes are associated with Platelet activating factor?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Hanss M and Dechavanne M 48740 RP, an antagonist of PAF, does not affect human plasma fibrinolysis before and after venous occlusion. 1988 Thromb. Res. pmid:3126559
Bachelet M et al. Interaction between PAF-acether and drugs that stimulate cyclic AMP in guinea-pig alveolar macrophages. 1988 Eur. J. Pharmacol. pmid:2840303
Dulioust A et al. Immunoregulatory functions of paf-acether. I. Effect of paf-acether on CD4+ cell proliferation. 1988 J. Immunol. pmid:2961808
Acker G et al. Role of platelet-activating factor (PAF) in the ovoimplantation in the rat: effect of the specific PAF-acether antagonist, BN 52021. 1988 Prostaglandins pmid:3129758
Bochner BS et al. Adherence of human basophils to cultured umbilical vein endothelial cells. 1988 J. Clin. Invest. pmid:3130394
López-Farré A et al. Glomeruli from ischemic rat kidneys produce increased amounts of platelet activating factor. 1988 Biochem. Biophys. Res. Commun. pmid:3358756
Kuiper J et al. The induction of glycogenolysis in the perfused liver by platelet activating factor is mediated by prostaglandin D2 from Kupffer cells. 1988 Biochem. Biophys. Res. Commun. pmid:3144970
Valone FH and Epstein LB Biphasic platelet-activating factor synthesis by human monocytes stimulated with IL-1-beta, tumor necrosis factor, or IFN-gamma. 1988 J. Immunol. pmid:3141509
Smith RJ et al. Diacylglycerols modulate human polymorphonuclear neutrophil responsiveness: effects on intracellular calcium mobilization, granule exocytosis, and superoxide anion production. 1988 J. Leukoc. Biol. pmid:2836539
Christman BW et al. Role of circulating platelets and granulocytes in PAF-induced pulmonary dysfunction in awake sheep. 1988 J. Appl. Physiol. pmid:3391901
Greenberg S et al. Extracellular nucleotides mediate Ca2+ fluxes in J774 macrophages by two distinct mechanisms. 1988 J. Biol. Chem. pmid:3392016
Etienne A et al. Possible involvement of platelet-activating factor in endotoxin-induced abortion. 1988 Prog. Clin. Biol. Res. pmid:3393560
Lazanas M et al. PAF of biological fluids in disease: IV. Levels in blood in allergic reactions induced by drugs. 1988 Arch. Dermatol. Res. pmid:3395143
Satoh K et al. Activity of platelet-activating factor (PAF) acetylhydrolase in plasma from patients with ischemic cerebrovascular disease. 1988 Prostaglandins pmid:3399678
Skeaff CM and Holub BJ The effect of fish oil consumption on platelet aggregation responses in washed human platelet suspensions. 1988 Thromb. Res. pmid:3187952
Griffin KJ and Levy JV The thieno-triazolodiazepine WEB 2086 inhibits platelet aggregation and ATP release from porcine platelets induced by platelet activating factor (PAF). 1988 Thromb. Res. pmid:3187959
Dawson J et al. Platelet activating factor as a mediator of equine cell locomotion. 1988 Vet. Res. Commun. pmid:3188378
Gay JC and Stitt ES Enhancement of phorbol ester-induced protein kinase activity in human neutrophils by platelet-activating factor. 1988 J. Cell. Physiol. pmid:3192624
Tamura N et al. Leukotriene C4 production from human eosinophils in vitro. Role of eosinophil chemotactic factors on eosinophil activation. 1988 J. Immunol. pmid:2848892
Smith LJ et al. Mechanism of platelet activating factor-induced bronchoconstriction in humans. 1988 Am. Rev. Respir. Dis. pmid:3195800
Lagarde M Metabolism of fatty acids by platelets and the functions of various metabolites in mediating platelet function. 1988 Prog. Lipid Res. pmid:3060881
Pai JK et al. Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes. 1988 J. Biol. Chem. pmid:3165977
Rosario-Jansen T et al. Phospholipids chiral at phosphorus. Synthesis and stereospecificity of phosphorothioate analogues of platelet-activating factor. 1988 Biochemistry pmid:3167004
Prévost MC et al. Possible origins of PAF-acether and lyso-PAF-acether in rat lung alveoli secondary to hypoxia. 1988 Biochim. Biophys. Acta pmid:3167085
Armstead WM et al. Platelet activating factor: a potent constrictor of cerebral arterioles in newborn pigs. 1988 Circ. Res. pmid:3335052
Bonventre JV et al. PAF and PDGF increase cytosolic [Ca2+] and phospholipase activity in mesangial cells. 1988 Am. J. Physiol. pmid:3337246
Wallace JL and Whittle BJ Gastrointestinal damage induced by platelet-activating factor. Inhibition by the corticoid, dexamethasone. 1988 Dig. Dis. Sci. pmid:3338370
Steel LK et al. Quantitative, functional and biochemical alterations in the peritoneal cells of mice exposed to whole-body gamma-irradiation. I. Changes in cellular protein, adherence properties and enzymatic activities associated with platelet-activating factor formation and inactivation, and arachidonate metabolism. 1988 Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. pmid:3286551
Marquis O et al. [3H]52770 RP, a platelet-activating factor receptor antagonist, and tritiated platelet-activating factor label a common specific binding site in human polymorphonuclear leukocytes. 1988 J. Pharmacol. Exp. Ther. pmid:2831350
Domingo MT et al. Presence of specific binding sites for platelet-activating factor (PAF) in brain. 1988 Biochem. Biophys. Res. Commun. pmid:2831903
Dillon PK et al. Vasoconstrictor effects of platelet-activating factor in the hamster cheek pouch microcirculation: dose-related relations and pathways of action. 1988 Circ. Res. pmid:2832096
Ma YH and Dunham EW Antagonism of the vasodilator effects of a platelet activating factor precursor in anesthetized spontaneously hypertensive rats. 1988 Eur. J. Pharmacol. pmid:2832188
Hellegouarch A et al. Lack of effect of atrial natriuretic factor on the tone induced in rat portal vein by platelet-activating factor. 1988 Eur. J. Pharmacol. pmid:2832190
Chau LY and Jii YJ Characterization of 3H-labelled platelet activating factor receptor complex solubilized from rabbit platelet membranes. 1988 Biochim. Biophys. Acta pmid:2838093
Thelen M et al. Activation of monocytes by interferon-gamma has no effect on the level or affinity of the nicotinamide adenine dinucleotide-phosphate oxidase and on agonist-dependent superoxide formation. 1988 J. Clin. Invest. pmid:2838524
Terashita Z et al. Protective action of prostaglandin E1 (PGE1) against constrictor mediators in isolated rat heart and lung. 1988 Biochem. Pharmacol. pmid:2839198
Morell GP et al. Paf-acether (platelet-activating factor) and interleukin-1-like cytokine production by lipopolysaccharide-stimulated glomeruli. 1988 Clin. Immunol. Immunopathol. pmid:3257432
Pignol B et al. Potentiation of immunosuppressive action of cyclosporine A by platelet-activating factor antagonists: an approach of the mechanism of action of these drugs in the prevention of graft rejection. 1988 Transplant. Proc. pmid:3259039
Leslie CC et al. Properties and purification of an arachidonoyl-hydrolyzing phospholipase A2 from a macrophage cell line, RAW 264.7. 1988 Biochim. Biophys. Acta pmid:3143418
Bussolino F et al. Synthesis and release of platelet-activating factor by human vascular endothelial cells treated with tumor necrosis factor or interleukin 1 alpha. 1988 J. Biol. Chem. pmid:3261295
Schwertschlag US and Whorton AR Platelet-activating factor-induced homologous and heterologous desensitization in cultured vascular smooth muscle cells. 1988 J. Biol. Chem. pmid:3262105
Kosano H and Takatani O Reduction of epidermal growth factor binding in human breast cancer cell lines by an alkyl-lysophospholipid. 1988 Cancer Res. pmid:3262419
Stephens LR et al. Synthesis of myo-inositol 1,3,4,5,6-pentakisphosphate from inositol phosphates generated by receptor activation. 1988 Biochem. J. pmid:2845930
Ukena D and Sybrecht GW [Function of platelet activating factor in asthma]. 1988 Dtsch. Med. Wochenschr. pmid:2846251
Suzuki S et al. [Effect of a specific antagonist of platelet-activating factor, FR-900452, on proteinuria and urinary thromboxane excretion in aminonucleoside nephrotic rats]. 1988 Nihon Jinzo Gakkai Shi pmid:3244194
Sueoka K et al. Platelet activating factor-induced early pregnancy factor activity from the perfused rabbit ovary and oviduct. 1988 Am. J. Obstet. Gynecol. pmid:3207134
Stahl GL et al. Detection of platelet-activating factor during traumatic shock. 1988 Circ. Shock pmid:3208421
Haynes J et al. Platelet-activating factor antagonists increase vascular reactivity in perfused rat lungs. 1988 J. Appl. Physiol. pmid:3209541
Lakin KM et al. [Action of calcium antagonists on thrombocyte aggregation]. 1987 Sep-Oct Farmakol Toksikol pmid:2826225
Berdel WE et al. Lack of correlation between cytotoxicity of agonists and antagonists of platelet activating factor [paf-acether] in neoplastic cells and modulation of [3H]-paf-acether binding to platelets from humans in vitro. 1987 Nov-Dec Anticancer Res. pmid:3442414
Fiedler VB et al. Comparison of cardiac and hemodynamic effects of platelet-activating factor-acether and leukotriene D4 in anesthetized dogs. 1987 Mar-Apr Basic Res. Cardiol. pmid:3606544
Arnoux B et al. Antigenic release of paf-acether and beta-glucuronidase from alveolar macrophages of asthmatics. 1987 Mar-Apr Bull Eur Physiopathol Respir pmid:3607326
Lurie A et al. Exercise- and allergen-induced asthma do not change the production of Paf-acether by neutrophils and platelets. 1987 Jul-Aug Bull Eur Physiopathol Respir pmid:3690021
Auriault C et al. The effector function of platelets is induced and regulated by T lymphocytes. 1987 Jul-Aug Ann. Inst. Pasteur Immunol. pmid:3118905
Liu BN [Neoplastic membrane-toxic activity as one of the pathogenetic factors in blood cell and tumor growth changes]. 1987 Jan-Feb Patol Fiziol Eksp Ter pmid:3550649
Ramesha CS and Pickett WC Human neutrophil platelet-activating factor: molecular heterogeneity in unstimulated and ionophore-stimulated cells. 1987 Biochim. Biophys. Acta pmid:3113489
Kumar R et al. Metabolism of platelet-activating factor (alkylacetylphosphocholine) by type-II epithelial cells and fibroblasts from rat lungs. 1987 Biochim. Biophys. Acta pmid:3790610
Wymann MP et al. Oscillatory motion in human neutrophils responding to chemotactic stimuli. 1987 Biochem. Biophys. Res. Commun. pmid:2820398
Terasawa M et al. Antagonistic activity of etizolam on platelet-activating factor in vivo experiments. 1987 Jpn. J. Pharmacol. pmid:3682404
Sipka S et al. Atropine is an inhibitor of the chemiluminescence induced by platelet-activating factor in human neutrophils. 1987 Acta Biochim. Biophys. Hung. pmid:3132002
Woodard DS et al. The final step in the de novo biosynthesis of platelet-activating factor. Properties of a unique CDP-choline:1-alkyl-2-acetyl-sn-glycerol choline-phosphotransferase in microsomes from the renal inner medulla of rats. 1987 J. Biol. Chem. pmid:3029085
Miwa M et al. Occurrence of an endogenous inhibitor of platelet-activating factor in rat liver. 1987 J. Biol. Chem. pmid:3804997
Egido J et al. Role of platelet-activating factor in adriamycin-induced nephropathy in rats. 1987 Eur. J. Pharmacol. pmid:3622604
Kawaguchi H and Yasuda H Effects of platelet-activating factor on conversion of angiotensin I to II. 1987 FEBS Lett. pmid:3622769
Ninio E et al. Biosynthesis of paf-acether. IX. Role for a phosphorylation-dependent activation of acetyltransferase in antigen-stimulated mouse mast cells. 1987 J. Immunol. pmid:3584983
Casals-Stenzel J Triazolodiazepines are potent antagonists of platelet activating factor (PAF) in vitro and in vivo. 1987 Naunyn Schmiedebergs Arch. Pharmacol. pmid:3587377
Brambilla A et al. WEB 2086. A potent PAF antagonist exerts protective effect toward PAF-induced gastric damage. 1987 Pharmacol Res Commun pmid:3588650
Jancar S et al. Comparative effects of platelet activating factor, leukotriene D4 and histamine on guinea pig trachea, bronchus and lung parenchyma. 1987 Prostaglandins pmid:3588970
Rola-Pleszczynski M et al. Inhibition of human lymphocyte proliferation and interleukin 2 production by platelet activating factor (PAF-acether): reversal by a specific antagonist, BN 52021. 1987 Biochem. Biophys. Res. Commun. pmid:3493773
Knox P et al. Role of plasminogen, plasmin, and plasminogen activators in the migration of fibroblasts into plasma clots. 1987 J. Cell. Physiol. pmid:2958486
Casals-Stenzel J et al. Bronchial and vascular effects of Paf in the rat isolated lung are completely blocked by WEB 2086, a novel specific Paf antagonist. 1987 Br. J. Pharmacol. pmid:3664079
Wilcox RW et al. The degradation of platelet-activating factor and related lipids: susceptibility to phospholipases C and D. 1987 Lipids pmid:3444369
Robertson DN and Page CP Effect of platelet agonists on airway reactivity and intrathoracic platelet accumulation. 1987 Br. J. Pharmacol. pmid:3664082
Kudo I et al. Antitumor activity of synthetic alkylphospholipids with or without PAF activity. 1987 Lipids pmid:3444379
Whittle BJ et al. Increased intestinal formation of Paf in endotoxin-induced damage in the rat. 1987 Br. J. Pharmacol. pmid:3664090
Söling U et al. Effect of synthetic phospholipids on platelet aggregation and serotonin release. 1987 Lipids pmid:3444380
Shigenobu K et al. Potentiation by bovine serum albumin (BSA) of endothelium-dependent vasodilator response to acetyl glyceryl ether phosphorylcholine (AGEPC). 1987 J. Pharmacobio-dyn. pmid:3625454
Schick HD et al. Cytotoxic effects of ether lipids and derivatives in human nonneoplastic bone marrow cells and leukemic cells in vitro. 1987 Lipids pmid:3444383
Danhauser S et al. Structure-cytotoxicity studies on alkyl lysophospholipids and some analogs in leukemic blasts of human origin in vitro. 1987 Lipids pmid:3444384
Jensen NJ et al. FAB MS/MS for phosphatidylinositol, -glycerol, -ethanolamine and other complex phospholipids. 1987 Lipids pmid:3626775
Grigorian GY and Ryan US Platelet-activating factor effects on bovine pulmonary artery endothelial cells. 1987 Circ. Res. pmid:3040294
Beauvais F and Benveniste J [IgE and anaphylaxis mediators]. 1987 Allerg Immunol (Paris) pmid:2968802
Codde JP et al. Can the synthesis of platelet-activating factor, a potent vasodilator and pro-aggregatory agent, be altered by dietary marine oils? 1987 Clin. Exp. Pharmacol. Physiol. pmid:2822306
Di Marzo V et al. Platelet activating factor-mediated leukotriene biosynthesis in rat lungs: effect of prostaglandins E1 and F1 alpha. 1987 Biochem. Biophys. Res. Commun. pmid:2822041
Tamura N et al. Effects of platelet activating factor on the chemotaxis of normodense eosinophils from normal subjects. 1987 Biochem. Biophys. Res. Commun. pmid:3030295
O'Flaherty JT Phospholipid metabolism and stimulus-response coupling. 1987 Biochem. Pharmacol. pmid:3030324
Wymann MP et al. The onset of the respiratory burst in human neutrophils. Real-time studies of H2O2 formation reveal a rapid agonist-induced transduction process. 1987 J. Biol. Chem. pmid:3040727
Bossant MJ et al. Characterization and quantification of PAF-acether (platelet-activating factor) as a heptafluorobutyrate derivative of 1-O-alkyl-2-acetyl-sn-glycerol by capillary column gas chromatography with electron-capture detection. 1987 J. Chromatogr. pmid:3443654
Shimizu K et al. [Actions of platelet activating factor in pulmonary circulation--experimental investigation using rabbit blood vessel smooth muscle preparations]. 1987 Nihon Kyobu Shikkan Gakkai Zasshi pmid:3444152
Lagente V et al. Platelet-activating factor (PAF-acether) and microcirculation: effect of Lyso-PAF and PAF-antagonists. 1987 Braz. J. Med. Biol. Res. pmid:3452452
Gentry PA et al. Inhibitory effect of trichothecene mycotoxins on bovine platelets stimulated by platelet activating factor. 1987 Can. J. Vet. Res. pmid:3453270
Gomez-Cambronero J et al. The diacylglycerol kinase inhibitor R59022 potentiates superoxide production but not secretion induced by fMet-Leu-Phe: effects of leupeptin and the protein kinase C inhibitor H-7. 1987 Biochem. Biophys. Res. Commun. pmid:2823810
Serafin WE and Austen KF Mediators of immediate hypersensitivity reactions. 1987 N. Engl. J. Med. pmid:2438554
Avdonin PV et al. Evidence for the receptor-operated calcium channels in human platelet plasma membrane. 1987 Thromb. Res. pmid:2438805
Bertani T et al. Platelet activating factor (PAF) as a mediator of injury in nephrotoxic nephritis. 1987 Kidney Int. pmid:3039232
Sheth KJ et al. Reversal of central nervous system involvement in hemolytic uremic syndrome by use of plasma exchanges. 1987 Clin Pediatr (Phila) pmid:3119270
Sage SO and Rink TJ The kinetics of changes in intracellular calcium concentration in fura-2-loaded human platelets. 1987 J. Biol. Chem. pmid:3119586
Camussi G et al. Tumor necrosis factor/cachectin stimulates peritoneal macrophages, polymorphonuclear neutrophils, and vascular endothelial cells to synthesize and release platelet-activating factor. 1987 J. Exp. Med. pmid:3119758
Carlson RP et al. Pharmacologic modulation of PAF-induced mortality in mice. 1987 Agents Actions pmid:3120513
Bussolino F et al. Studies on the mechanism of interleukin 1 stimulation of platelet activating factor synthesis in human endothelial cells in culture. 1987 Biochim. Biophys. Acta pmid:3024738