| MeSH term | MeSH ID | Detail |
|---|---|---|
| Asphyxia Neonatorum | D001238 | 4 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Pulmonary Atelectasis | D001261 | 1 associated lipids |
| Behcet Syndrome | D001528 | 7 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
| Blister | D001768 | 16 associated lipids |
| Blood Platelet Disorders | D001791 | 12 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Bovine Virus Diarrhea-Mucosal Disease | D001912 | 2 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Brain Injuries | D001930 | 4 associated lipids |
| Bronchial Diseases | D001982 | 3 associated lipids |
| Bronchial Spasm | D001986 | 18 associated lipids |
| Bronchiectasis | D001987 | 7 associated lipids |
| Bronchopulmonary Dysplasia | D001997 | 4 associated lipids |
| Bronchopulmonary Sequestration | D001998 | 3 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Burns, Inhalation | D002059 | 4 associated lipids |
| Carbon Monoxide Poisoning | D002249 | 9 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kochanek PM et al. | Platelet activating factor antagonists do not alter normal cerebral blood flow or cerebral oxygen consumption. | 1990 | Adv. Exp. Med. Biol. | pmid:2096640 |
| Camussi G et al. | Antiflammins inhibit synthesis of platelet-activating factor and intradermal inflammatory reactions. | 1990 | Adv. Exp. Med. Biol. | pmid:2096695 |
| Droy-Lefaix MT et al. | Effect of the platelet-activating factor (PAF) antagonist, BN 52021, on free radical-induced intestinal ischemia-reperfusion damage in the rat. | 1990 | Adv. Exp. Med. Biol. | pmid:2244522 |
| Damas J et al. | Endotoxin shock, kinin system and PAF-acether in the rat. | 1989 | Adv. Exp. Med. Biol. | pmid:2610092 |
| Bourgain RH et al. | Vivo effects of PAF-acether and arterial thrombosis. | 1986 | Adv. Exp. Med. Biol. | pmid:3799334 |
| Shimizu T et al. | Platelet-activating factor receptor. Gene structure and tissue-specific regulation. | 1996 | Adv. Exp. Med. Biol. | pmid:9131130 |
| Sato S et al. | Up-regulation of the intracellular Ca2+ signaling and mRNA expression of platelet-activating factor receptor by estradiol in human uterine endometrial cells. | 1996 | Adv. Exp. Med. Biol. | pmid:9131133 |
| Dohi T et al. | Functional role of platelet-activating factor receptor in secretory response in adrenal chromaffin cells. | 1996 | Adv. Exp. Med. Biol. | pmid:9131134 |
| Lee T | Acetylation of sphingosine by PAF-dependent transacetylase. | 1996 | Adv. Exp. Med. Biol. | pmid:9131136 |
| Ishii I et al. | High and low affinity mutants of platelet-activating factor receptor. | 1997 | Adv. Exp. Med. Biol. | pmid:9561146 |
| Bazan NG | Bioactive lipids and gene expression in neuronal plasticity. | 1998 | Adv. Exp. Med. Biol. | pmid:10079836 |
| Marshall LA et al. | Respective roles of the 14 kDa and 85 kDa phospholipase A2 enzymes in human monocyte eicosanoid formation. | 1999 | Adv. Exp. Med. Biol. | pmid:10667333 |
| Pirotzky E et al. | Involvement of platelet-activating factor in renal processes. | 1989 | Adv. Lipid Res. | pmid:2698054 |
| Holleran WM | Lipid modulators of epidermal proliferation and differentiation. | 1991 | Adv. Lipid Res. | pmid:1763711 |
| Koltai M et al. | Platelet-activating factor antagonists: scientific background and possible clinical applications. | 1994 | Adv. Pharmacol. | pmid:8080821 |
| Summers JB and Albert DH | Platelet activating factor antagonists. | 1995 | Adv. Pharmacol. | pmid:7748804 |
| Braquet P | Proofs of involvement of PAF-acether in various immune disorders using BN 52021 (ginkgolide B): a powerful PAF-acether antagonist isolated from Ginkgo biloba L. | 1986 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2949548 |
| Foegh ML et al. | Leukotrienes, thromboxane, and platelet activating factor in organ transplantation. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959038 |
| Robertson DN and Smith GM | Role of thromboxane A2, 5-hydroxytryptamine, and platelet activating factor in collagen-induced sudden death in rabbits. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959049 |
| Matsumoto M and Miwa M | Platelet-activating factor-binding protein in human serum. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3004155 |