| MeSH term | MeSH ID | Detail |
|---|---|---|
| Asphyxia Neonatorum | D001238 | 4 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Pulmonary Atelectasis | D001261 | 1 associated lipids |
| Behcet Syndrome | D001528 | 7 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
| Blister | D001768 | 16 associated lipids |
| Blood Platelet Disorders | D001791 | 12 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Bovine Virus Diarrhea-Mucosal Disease | D001912 | 2 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Brain Injuries | D001930 | 4 associated lipids |
| Bronchial Diseases | D001982 | 3 associated lipids |
| Bronchial Spasm | D001986 | 18 associated lipids |
| Bronchiectasis | D001987 | 7 associated lipids |
| Bronchopulmonary Dysplasia | D001997 | 4 associated lipids |
| Bronchopulmonary Sequestration | D001998 | 3 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Burns, Inhalation | D002059 | 4 associated lipids |
| Carbon Monoxide Poisoning | D002249 | 9 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Poeze M et al. | Decreased organ failure in patients with severe SIRS and septic shock treated with the platelet-activating factor antagonist TCV-309: a prospective, multicenter, double-blind, randomized phase II trial. TCV-309 Septic Shock Study Group. | 2000 | Shock | pmid:11049104 |
| Gu M et al. | Pharmacologic graft protection without donor pretreatment in liver transplantation from non-heart-beating donors. | 2000 | Transplantation | pmid:11045637 |
| Mul FP et al. | Sequential migration of neutrophils across monolayers of endothelial and epithelial cells. | 2000 | J. Leukoc. Biol. | pmid:11037975 |
| Lonardoni MV et al. | Essential role of platelet-activating factor in control of Leishmania (Leishmania) amazonensis infection. | 2000 | Infect. Immun. | pmid:11035745 |
| Rowland BL et al. | Elevated circulating concentrations of platelet activating factor in preeclampsia. | 2000 | Am. J. Obstet. Gynecol. | pmid:11035340 |
| Simon HU et al. | Eosinophils maintain their capacity to signal and release eosinophil cationic protein upon repetitive stimulation with the same agonist. | 2000 | J. Immunol. | pmid:11034418 |
| Choi SY et al. | Capsaicin inhibits platelet-activating factor-induced cytosolic Ca2+ rise and superoxide production. | 2000 | J. Immunol. | pmid:11034409 |
| Fraga AG et al. | Synthesis and pharmacological evaluation of novel heterotricyclic acylhydrazone derivatives, designed as PAF antagonists. | 2000 | Eur J Pharm Sci | pmid:11033071 |
| McLarnon JG et al. | Anion channels modulate store-operated calcium influx in human microglia. | 2000 | Cell Calcium | pmid:11032781 |
| De Geest B et al. | Effect of overexpression of human apo A-I in C57BL/6 and C57BL/6 apo E-deficient mice on 2 lipoprotein-associated enzymes, platelet-activating factor acetylhydrolase and paraoxonase. Comparison of adenovirus-mediated human apo A-I gene transfer and human apo A-I transgenesis. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:11031226 |
| Imrie CW and McKay CJ | The possible role of platelet-activating factor antagonist therapy in the management of severe acute pancreatitis. | 1999 | Baillieres Best Pract Res Clin Gastroenterol | pmid:11030612 |
| Brady M et al. | Cytokines and acute pancreatitis. | 1999 | Baillieres Best Pract Res Clin Gastroenterol | pmid:11030606 |
| Ciesla DJ et al. | Hypertonic saline inhibits neutrophil (PMN) priming via attenuation of p38 MAPK signaling. | 2000 | Shock | pmid:11028541 |
| Walther A et al. | Role of platelet-activating factor in leukocyte-independent plasma extravasation and mast cell activation during endotoxemia. | 2000 | J. Surg. Res. | pmid:11027469 |
| Montrucchio G et al. | Role of platelet-activating factor in cardiovascular pathophysiology. | 2000 | Physiol. Rev. | pmid:11015622 |
| Wagner F et al. | Ether lipids in the cell membrane of Mycoplasma fermentans. | 2000 | Eur. J. Biochem. | pmid:11012682 |
| Wratten ML et al. | Hemolipodialysis attenuates oxidative stress and removes hydrophobic toxins. | 2000 | Artif Organs | pmid:11012537 |
| Gastaldello K et al. | Role of complement and platelet-activating factor in the stimulation of phagocytosis and reactive oxygen species production during haemodialysis. | 2000 | Nephrol. Dial. Transplant. | pmid:11007834 |
| Nieswandt B et al. | Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice. | 2000 | Blood | pmid:11001906 |
| Zăgrean L et al. | Preliminary EEG study of protective effects of Tebonin in transient global cerebral ischemia in rats. | 1998 Jan-Jun | Rom J Physiol | pmid:11000876 |
| Klabunde RE and Anderson DE | Obligatory role of nitric oxide in platelet-activating factor-induced microvascular leakage. | 2000 | Eur. J. Pharmacol. | pmid:10996604 |
| Turner PJ et al. | Induction by inhibitors of nitric oxide synthase of hyperresponsiveness in the human nasal airway. | 2000 | Br. J. Pharmacol. | pmid:10991932 |
| Kallan NC and Halcomb RL | Synthesis of the ring system of phomactin D using a Suzuki macrocyclization. | 2000 | Org. Lett. | pmid:10990428 |
| Suzuki T et al. | Thromboxane A(2)-mediated Cl(-) secretion induced by platelet-activating factor in isolated rat colon. | 2000 | Eur. J. Pharmacol. | pmid:10988347 |
| Clark WF et al. | A novel treatment for lupus nephritis: lignan precursor derived from flax. | 2000 | Lupus | pmid:10981647 |
| Denizot Y et al. | Deregulated platelet-activating factor levels and acetylhydrolase activity in patients with idiopathic IgA nephropathy. | 2000 | Nephrol. Dial. Transplant. | pmid:10978389 |
| Tanaka R et al. | Genetics of immunoglobulin A nephropathy. | 2000 | Ann. Acad. Med. Singap. | pmid:10976391 |
| Saito S et al. | Modulatory roles of RANTES in IL-4 production by human blood CD4(+)T cells. | 2000 | Cytokine | pmid:10975998 |
| Taguchi R et al. | Two-dimensional analysis of phospholipids by capillary liquid chromatography/electrospray ionization mass spectrometry. | 2000 | J Mass Spectrom | pmid:10972995 |
| Kim JD et al. | Platelet activating factor acetylhydrolase decreases lung reperfusion injury. | 2000 | Ann. Thorac. Surg. | pmid:10969656 |
| Prescott SM et al. | Platelet-activating factor and related lipid mediators. | 2000 | Annu. Rev. Biochem. | pmid:10966465 |
| Wereszczynska-Siemiatkowska U et al. | Lysosomal activity of pulmonary alveolar macrophages in acute experimental pancreatitis in rats with reference to positive PAF-antagonist (BN 52021) effect. | 2000 | Exp. Toxicol. Pathol. | pmid:10965985 |
| Durán WN et al. | Stimulation of NO production and of eNOS phosphorylation in the microcirculation in vivo. | 2000 | Microvasc. Res. | pmid:10964584 |
| Toró A et al. | Transannular Diels-Alder studies on the asymmetric total synthesis of chatancin: the pyranophane approach. | 2000 | Org. Lett. | pmid:10964353 |
| Jeon SY et al. | Ultrastructural changes in platelet activating factor-induced epithelial damage in rabbit maxillary sinus mucosa. | 2000 | Ann. Otol. Rhinol. Laryngol. | pmid:10961804 |
| Oktar BK et al. | Endothelin-1-induced PMN infiltration and mucosal dysfunction in the rat small intestine. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:10960346 |
| Maniscalco M et al. | The effect of platelet-activating factor (PAF) on nasal airway resistance in healthy subjects is not mediated by nitric oxide. | 2000 | Allergy | pmid:10955702 |
| Gálvez J et al. | Intestinal anti-inflammatory activity of UR-12746, a novel 5-ASA conjugate, on acute and chronic experimental colitis in the rat. | 2000 | Br. J. Pharmacol. | pmid:10952687 |
| Soeki T et al. | Plasma and platelet plasminogen activator inhibitor-1 in patients with acute myocardial infarction. | 2000 | Jpn. Circ. J. | pmid:10952148 |
| Countryman NB et al. | Evidence for involvement of the epidermal platelet-activating factor receptor in ultraviolet-B-radiation-induced interleukin-8 production. | 2000 | J. Invest. Dermatol. | pmid:10951245 |
| Martin M et al. | [Antiretroviral ant anti-inflammatory properties of a novel platelet activation factor antagonist, PMS-601]. | 2000 | Pathol. Biol. | pmid:10949851 |
| Davenpeck KL et al. | Activation of human leukocytes reduces surface P-selectin glycoprotein ligand-1 (PSGL-1, CD162) and adhesion to P-selectin in vitro. | 2000 | J. Immunol. | pmid:10946308 |
| Zhuang Q et al. | Activation via multiple signaling pathways induces down-regulation of platelet-activating factor receptors on human B lymphocytes. | 2000 | J. Immunol. | pmid:10946267 |
| Marathe GK et al. | Bioactive phospholipid oxidation products. | 2000 | Free Radic. Biol. Med. | pmid:10946218 |
| Ueda T et al. | Pancreatitis-associated ascitic fluid increases intracellular Ca(2+) concentration on hepatocytes. | 2000 | J. Surg. Res. | pmid:10945960 |
| Liu JK et al. | Paeonilide, a novel anti-PAF-active monoterpenoid-derived metabolite from Paeonia delavayi. | 2000 | Biosci. Biotechnol. Biochem. | pmid:10945272 |
| Kobayashi Y et al. | [Inhibitory effect of suplatast tosilate on eosinophil migration]. | 2000 | Arerugi | pmid:10944827 |
| Miyao Y et al. | Role of cytokines and adhesion molecules in ischemia and reperfusion in patients with acute myocardial infarction. | 1999 | Jpn. Circ. J. | pmid:10943615 |
| Porta C et al. | Amifostine, a reactive oxigen species scavenger with radiation- and chemo-protective properties, inhibits in vitro platelet activation induced by ADP, collagen or PAF. | 2000 | Haematologica | pmid:10942928 |
| Balestrieri ML and Lee T | Regulation of the biosynthesis of acyl analogs of platelet-activating factor by purinergic agonist in endothlial cells. | 2000 | FEBS Lett. | pmid:10940389 |
| Pávó I et al. | Interactions of pro-inflammatory and vasoactive mediators with nitric oxide in the regulation of rat vascular permeability during laparotomy. | 2000 | Eur. J. Pharmacol. | pmid:10940373 |
| Baskova I et al. | Inhibition of induced and spontaneous platelet aggregation by destabilase from medicinal leech. | 2000 | Platelets | pmid:10938885 |
| Raible DG et al. | Hydrogen peroxide release from human eosinophils on fibronectin: scopoletin enhances eosinophil activation. | 2000 | Free Radic. Biol. Med. | pmid:10938462 |
| Miyatake T et al. | Analysis of cardiac function during hyperacute rejection: effects of PAF antagonist, TXA(2) inhibitor/antagonists, and nitroglycerin. | 2000 | Transplant. Proc. | pmid:10936319 |
| Haribabu B et al. | Targeted disruption of the leukotriene B(4) receptor in mice reveals its role in inflammation and platelet-activating factor-induced anaphylaxis. | 2000 | J. Exp. Med. | pmid:10934231 |
| Henig NR et al. | Effect of recombinant human platelet-activating factor-acetylhydrolase on allergen-induced asthmatic responses. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10934081 |
| Capasso R et al. | Preventive effect of eugenol on PAF and ethanol-induced gastric mucosal damage. | 2000 | Fitoterapia | pmid:10930724 |
| Matsunaga Y et al. | Regulation of lymphocyte proliferation by eosinophils via chymotrypsin-like protease activity and adhesion molecule interaction. | 2000 | Br. J. Pharmacol. | pmid:10928955 |
| Roudebush WE and Purnell ET | Platelet-activating factor content in human spermatozoa and pregnancy outcome. | 2000 | Fertil. Steril. | pmid:10927041 |
| Klyubin IV et al. | The role of reactive oxygen species in membrane potential changes in macrophages and astrocytes. | 2000 | Membr Cell Biol | pmid:10926373 |
| O'Brien JG et al. | Effects of tranexamic acid and aprotinin, two antifibrinolytic drugs, on PAF-induced plasma extravasation in unanesthetized rats. | 2000 | Inflammation | pmid:10921506 |
| Smalley DM et al. | The local effect of PAF on leukocyte adherence to small bowel mesenteric venules following intra-abdominal contamination. | 2000 | Inflammation | pmid:10921505 |
| Choi JH et al. | Selective involvement of reactive oxygen intermediates in platelet-activating factor-mediated activation of NF-kappaB. | 2000 | Inflammation | pmid:10921504 |
| Hu GL and Guo HS | [Progress in platelet-activating factor receptor research]. | 1997 | Sheng Li Ke Xue Jin Zhan | pmid:10921090 |
| Unno N et al. | Plasma platelet-activating factor acetylhydrolase deficiency is associated with atherosclerotic occlusive disease in japan. | 2000 | J. Vasc. Surg. | pmid:10917985 |
| Parrish PR and Larson DF | Pharmacological effect of nitroprusside on platelet aggregation. | 1999 | J Extra Corpor Technol | pmid:10915472 |
| Francescangeli E et al. | Properties and regulation of microsomal PAF-synthesizing enzymes in rat brain cortex. | 2000 | Neurochem. Res. | pmid:10905633 |
| Baker RR | Lipid acetylation reactions and the metabolism of platelet-activating factor. | 2000 | Neurochem. Res. | pmid:10905630 |
| Wang JH and Sun GY | Platelet activating factor (PAF) antagonists on cytokine induction of iNOS and sPLA2 in immortalized astrocytes (DITNC). | 2000 | Neurochem. Res. | pmid:10905622 |
| Clark GD et al. | Neuronal platelet-activating factor receptor signal transduction involves a pertussis toxin-sensitive G-protein. | 2000 | Neurochem. Res. | pmid:10905621 |
| Parkman HP et al. | The contractile action of platelet-activating factor on gallbladder smooth muscle. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:10898747 |
| Hu L et al. | Alkyl and alkoxycarbonyl derivatives of ginkgolide B: synthesis and biological evaluation of PAF inhibitory activity. | 2000 | Bioorg. Med. Chem. | pmid:10896127 |
| Rose F et al. | E. coli hemolysin-induced lipid mediator metabolism in alveolar macrophages: impact of eicosapentaenoic acid. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10893208 |
| Lee YM et al. | Platelet-activating factor contributes to acute lung leak in rats given interleukin-1 intratracheally. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10893205 |
| Bailey SR et al. | Differential activation of platelets from normal and allergic ponies by PAF and ADP. | 2000 | Inflamm. Res. | pmid:10893045 |
| Folch E et al. | H(2)O(2) and PARS mediate lung P-selectin upregulation in acute pancreatitis. | 2000 | Free Radic. Biol. Med. | pmid:10889459 |
| Dent G et al. | Involvement of protein tyrosine kinases in activation of human eosinophils by platelet-activating factor. | 2000 | Immunology | pmid:10886400 |
| Aihara M et al. | Interaction between neurone and microglia mediated by platelet-activating factor. | 2000 | Genes Cells | pmid:10886367 |
| Tektonidou MG et al. | Clinical importance of antibodies against platelet activating factor in antiphospholipid syndrome manifestations. | 2000 | Eur. J. Clin. Invest. | pmid:10886305 |
| Kusuhara H et al. | Y-24180, an antagonist of platelet-activating factor, suppresses interleukin 5 production in cultured murine th(2)cells and human peripheral blood mononuclear cells. | 2000 | Cytokine | pmid:10880261 |
| Viswanath M et al. | Reduction of hypoxic-ischemic brain swelling in the neonatal rat with PAF antagonist WEB 2170: lack of long-term protection. | 2000 | Pediatr. Res. | pmid:10879808 |
| Xu H et al. | Platelet-activating factor acetylhydrolase gene mutation in Japanese children with Escherichia coli O157-associated hemolytic uremic syndrome. | 2000 | Am. J. Kidney Dis. | pmid:10873870 |
| Suzuki S et al. | The roles of platelet-activating factor and endothelin-1 in renal damage after total hepatic ischemia and reperfusion. | 2000 | Transplantation | pmid:10868624 |
| Alappatt C et al. | Acute keratinocyte damage stimulates platelet-activating factor production. | 2000 | Arch. Dermatol. Res. | pmid:10867814 |
| Bae K et al. | Platelet-activating factor (PAF)-dependent transacetylase and its relationship with PAF acetylhydrolases. | 2000 | J. Biol. Chem. | pmid:10867005 |
| Cavallo-Perin P et al. | Increased blood levels of platelet-activating factor in insulin-dependent diabetic patients with microalbuminuria. | 2000 | Nephrol. Dial. Transplant. | pmid:10862637 |
| Huo LJ and Yang ZM | Effects of platelet activating factor on capacitation and acrosome reaction in mouse spermatozoa. | 2000 | Mol. Reprod. Dev. | pmid:10862011 |
| Denizot Y et al. | Effect of cytokines and lipid mediators on the synthesis of interleukin 1 beta by human bone marrow stromal cells. | 2000 | Cytokine | pmid:10857767 |
| Nakajima T et al. | Phospholipase A2-mediated superoxide production of murine peritoneal macrophages induced by chrysotile stimulation. | 2000 | Int. J. Biochem. Cell Biol. | pmid:10856708 |
| Caslake MJ et al. | Lipoprotein-associated phospholipase A(2), platelet-activating factor acetylhydrolase: a potential new risk factor for coronary artery disease. | 2000 | Atherosclerosis | pmid:10856534 |
| Zhu X et al. | A surrogate method for assessment of beta(2)-integrin-dependent adhesion of human eosinophils to ICAM-1. | 2000 | J. Immunol. Methods | pmid:10854610 |
| Fukuyama S et al. | Effect of eotaxin and platelet-activating factor on airway inflammation and hyperresponsiveness in guinea pigs in vivo. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10852755 |
| Poveshchenko AF and Kozlov VA | [The effect of platelet-activating factor and its antagonist--BN 52021--on immune reactions in vivo in mice and in vitro]. | 1999 Jul-Aug | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:10852052 |
| Kobayashi N et al. | Transepithelial migration of activated eosinophils induces a decrease of E-cadherin expression in cultured human nasal epithelial cells. | 2000 | Clin. Exp. Allergy | pmid:10848899 |
| Ma X and Bazan HE | Increased platelet-activating factor receptor gene expression by corneal epithelial wound healing. | 2000 | Invest. Ophthalmol. Vis. Sci. | pmid:10845588 |
| Serradji N et al. | Structure-activity relationships in platelet-activating factor (PAF). 10. From PAF antagonism to inhibition of HIV-1 replication. | 2000 | J. Med. Chem. | pmid:10841793 |
| Mizutani Y et al. | Cloning and expression of rat neutral sphingomyelinase: enzymological characterization and identification of essential histidine residues. | 2000 | Biochim. Biophys. Acta | pmid:10832103 |
| Tokumura A et al. | Structural identification of phosphatidylcholines having an oxidatively shortened linoleate residue generated through its oxygenation with soybean or rabbit reticulocyte lipoxygenase. | 2000 | J. Lipid Res. | pmid:10828088 |
| Asai Y et al. | Characterization of the physicochemical properties of the micelles of platelet-activating factor (C18:0). | 2000 | Drug Dev Ind Pharm | pmid:10826115 |
| Ohishi S | [Evaluation of time course and inter-relationship of inflammatory mediators in experimental inflammatory reaction]. | 2000 | Yakugaku Zasshi | pmid:10825809 |