Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Nagaoka J et al. | Inhibitory effects of the novel platelet activating factor receptor antagonist, 1-ethyl-2-[N-(2-methoxy)benzoyl-N-[(2R)-2-methoxy-3-(4- octadecylcarbamoyloxy) piperidinocarbonyloxypropyloxy]carbonyl] aminomethyl-pyridinium chloride, in several experimentally induced shock models. | 1991 | Arzneimittelforschung | pmid:1663352 |
Tsunoda H et al. | Activity of a novel thienodiazepine derivative as a platelet-activating factor antagonist in guinea pig lungs. Effects on platelet-activating factor and allergen induced eosinophil accumulation. | 1991 | Arzneimittelforschung | pmid:1867658 |
Giudice A et al. | Prevention of platelet-activating factor-induced gastrointestinal lesions in rats by the new specific antagonist N-(2-dimethylaminoethyl)-N-(3-pyridinylmethyl)[4-(2,4,6-triisopropylphe nyl) thiazol-2yl]amine. | 1996 | Arzneimittelforschung | pmid:8740089 |
Akagi M et al. | Inhibitor effect of apafant on bronchopulmonary responses to platelet activating factor and to antigen in rats. | 1997 | Arzneimittelforschung | pmid:9450165 |
David S et al. | Production of platelet activating factor by human neutrophils after backfiltration of endotoxin contaminated dialysate. | 1993 Jul-Sep | ASAIO J. | pmid:8268642 |
Takayama K et al. | Changes in endothelial vasoactive substances under recombinant human erythropoietin therapy in hemodialysis patients. | 1991 Jul-Sep | ASAIO Trans | pmid:1836334 |
Akizawa T et al. | Endothelin and platelet activating factor. Possible indices for biocompatibility of hemodialysis. | 1991 Jul-Sep | ASAIO Trans | pmid:1751199 |
Ando M et al. | Pregnancy suppression by a platelet activating factor antagonist, ONO-6240, in mice. | 1990 | Asia Oceania J Obstet Gynaecol | pmid:2378595 |
Ando M et al. | Pregnancy suppression by a structurally related antagonist for platelet activating factor, CV-6209, in mice. | 1990 | Asia Oceania J Obstet Gynaecol | pmid:2088253 |
Roudebush WE | Role of platelet-activating factor in reproduction: sperm function. | 2001 | Asian J. Androl. | pmid:11404790 |
Tsai JJ et al. | The modulatory effect of antigen- and PAF-induced asthmatic reaction by aerosol administration of OKY-046 in guinea pigs. | 1995 | Asian Pac. J. Allergy Immunol. | pmid:8703249 |
Tsai JJ et al. | Enhanced eosinophil luminol-dependent chemiluminescence and complement receptor expression by platelet-activating factor and interleukin-5. | 1993 | Asian Pac. J. Allergy Immunol. | pmid:8216559 |
Tselepis AD and John Chapman M | Inflammation, bioactive lipids and atherosclerosis: potential roles of a lipoprotein-associated phospholipase A2, platelet activating factor-acetylhydrolase. | 2002 | Atheroscler Suppl | pmid:12573364 |
Feliste R et al. | Protective effect of BN 52021, a specific antagonist of platelet-activating factor (PAF-acether) against diet-induced cholesteryl ester deposition in rabbit aorta. | 1989 | Atherosclerosis | pmid:2783199 |
Caslake MJ et al. | Lipoprotein-associated phospholipase A(2), platelet-activating factor acetylhydrolase: a potential new risk factor for coronary artery disease. | 2000 | Atherosclerosis | pmid:10856534 |
Mügge A et al. | Activation of leukocytes with complement C5a is associated with prostanoid-dependent constriction of large arteries in atherosclerotic monkeys in vivo. | 1992 | Atherosclerosis | pmid:1418094 |
Verouti SN et al. | PAF effects on MCP-1 and IL-6 secretion in U-937 monocytes in comparison with oxLDL and IL-1β effects. | 2011 | Atherosclerosis | pmid:21920519 |
Fiotti N et al. | Atherosclerosis and inflammation. Patterns of cytokine regulation in patients with peripheral arterial disease. | 1999 | Atherosclerosis | pmid:10428295 |
Croft KD et al. | Leukocyte and platelet function and eicosanoid production in subjects with hypercholesterolaemia. | 1990 | Atherosclerosis | pmid:2173612 |
Violi F et al. | Inhibition of cyclooxygenase-independent platelet aggregation by low vitamin E concentration. | 1990 | Atherosclerosis | pmid:2115784 |
Deigner HP et al. | Novel reversible, irreversible and fluorescent inhibitors of platelet-activating factor acetylhydrolase as mechanistic probes. | 1999 | Atherosclerosis | pmid:10381281 |
Hasselwander O et al. | HDL composition and HDL antioxidant capacity in patients on regular haemodialysis. | 1999 | Atherosclerosis | pmid:10208487 |
Bochkov VN et al. | Platelets in patients with homozygous familial hypercholesterolemia are sensitive to Ca(2+)-mobilizing activity of low density lipoproteins. | 1992 | Atherosclerosis | pmid:1334652 |
Imaizumi T et al. | Effect of cigarette smoking on the levels of platelet-activating factor-like lipid(s) in plasma lipoproteins. | 1991 | Atherosclerosis | pmid:1872924 |
Yamada Y et al. | Correlations between plasma platelet-activating factor acetylhydrolase (PAF-AH) activity and PAF-AH genotype, age, and atherosclerosis in a Japanese population. | 2000 | Atherosclerosis | pmid:10781653 |
Pégorier S et al. | Oxidized phospholipid: POVPC binds to platelet-activating-factor receptor on human macrophages. Implications in atherosclerosis. | 2006 | Atherosclerosis | pmid:16386258 |
Tiniakou I et al. | Natural human apoA-I mutations L141RPisa and L159RFIN alter HDL structure and functionality and promote atherosclerosis development in mice. | 2015 | Atherosclerosis | pmid:26363436 |
Narita S and Asakura K | The effects of anti-PAF and other agents on the nasal symptoms in sensitized guinea pigs. | 1993 | Auris Nasus Larynx | pmid:7905260 |
Tachibana F et al. | Platelet-activating factor and leukotrienes in acute otitis media, secretory otitis media, and chronic otitis media on the acute excerbation. | 1996 | Auris Nasus Larynx | pmid:8809319 |
Ogura M et al. | Platelet-activating factor (PAF) induced cytokine production and otitis media with effusion (OME) in the rat middle ear. | 2008 | Auris Nasus Larynx | pmid:17997066 |
Morley J | Asthma mortality and inhaled beta agonist therapy. | 1992 | Aust N Z J Med | pmid:1359864 |
Jackson SP and Salem HH | Platelet aggregating activity in the plasma of patients with established thrombosis. | 1989 | Aust N Z J Med | pmid:2504137 |
Gillin AG | Maintenance of high risk pregnancies: role of prostaglandins and other mediators. | 1994 | Aust N Z J Obstet Gynaecol | pmid:7848215 |
Klopper A and Saunders DM | Signals from the conceptus. | 1994 | Aust N Z J Obstet Gynaecol | pmid:7531434 |
Cooper TM and Ingram DM | Platelet function in the peri-operative period. | 1991 | Aust N Z J Surg | pmid:1829351 |
Jobe LW et al. | Protection from BB rat diabetes by the platelet-activating factor inhibitor BN50730. | 1993 | Autoimmunity | pmid:8025205 |
Beck JC et al. | Effects of ginkgolide B, a platelet-activating factor inhibitor on insulitis in the spontaneously diabetic BB rat. | 1991 | Autoimmunity | pmid:1777555 |
Jauchem JR | The role of autacoids and the autonomic nervous system in cardiovascular responses to radio-frequency energy heating. | 2006 | Auton Autacoid Pharmacol | pmid:16553641 |
Subbotina LA | [Procedure of blood agregation system analysis]. | 2006 Sep-Oct | Aviakosm Ekolog Med | pmid:17357632 |
Brady M et al. | Cytokines and acute pancreatitis. | 1999 | Baillieres Best Pract Res Clin Gastroenterol | pmid:11030606 |
Imrie CW and McKay CJ | The possible role of platelet-activating factor antagonist therapy in the management of severe acute pancreatitis. | 1999 | Baillieres Best Pract Res Clin Gastroenterol | pmid:11030612 |
Harper MJ | The implantation window. | 1992 | Baillieres Clin Obstet Gynaecol | pmid:1424330 |
Ahmed AS and Smith SK | The endometrium: prostaglandins and intracellular signalling at implantation. | 1992 | Baillieres Clin Obstet Gynaecol | pmid:1335852 |
O'Neill C | A consideration of the factors which influence and control the viability and developmental potential of the preimplantation embryo. | 1991 | Baillieres Clin Obstet Gynaecol | pmid:1855338 |
Smith SK | The role of prostaglandins in implantation. | 1991 | Baillieres Clin Obstet Gynaecol | pmid:1855344 |
Bonney RC and Franks S | The endocrinology of implantation and early pregnancy. | 1990 | Baillieres Clin. Endocrinol. Metab. | pmid:1701083 |
Pearson JD | The control of production and release of haemostatic factors in the endothelial cell. | 1993 | Baillieres Clin. Haematol. | pmid:8025346 |
Ranasinghe S and Bolsover S | Microglial calcium responses to platelet-activating factor are inhibited by analogue CAS 99103-16-9 and dihydropyridine PCA 4248 but not by ginkgolide A. | 2004 | Basic Clin. Pharmacol. Toxicol. | pmid:15379786 |
Chu WF et al. | Increasing Intracellular calcium of guinea pig ventricular myocytes induced by platelet activating factor through IP3 pathway. | 2006 | Basic Clin. Pharmacol. Toxicol. | pmid:16433899 |
Droy-Lefaix MT et al. | The amplificative role of PAF-acether in the oxidative stress following reperfusion of ischemic stomach. | 1988 | Basic Life Sci. | pmid:3250539 |
Colton CA and Gilbert DL | An endogenous source of the superoxide anion in the central nervous system. | 1988 | Basic Life Sci. | pmid:2854971 |
Fiedler VB et al. | Comparison of cardiac and hemodynamic effects of platelet-activating factor-acether and leukotriene D4 in anesthetized dogs. | 1987 Mar-Apr | Basic Res. Cardiol. | pmid:3606544 |
Napoli C et al. | Glycosylation enhances oxygen radical-induced modifications and decreases acetylhydrolase activity of human low density lipoprotein. | 1997 | Basic Res. Cardiol. | pmid:9166989 |
Auchampach JA et al. | Effect of the platelet-activating factor antagonist RP 59227 (Tulopafant) on myocardial ischemia/reperfusion injury and neutrophil function. | 1998 | Basic Res. Cardiol. | pmid:9833148 |
Felix SB et al. | Cardiovascular reactions and respiratory events during platelet activating factor-induced shock. | 1990 May-Jun | Basic Res. Cardiol. | pmid:2383216 |
Leprán I and Lefer AM | Ischemia aggravating effects of platelet-activating factor in acute myocardial ischemia. | 1985 Mar-Apr | Basic Res. Cardiol. | pmid:4039929 |
Giessler C et al. | Effects of PAF on cardiac function and eicosanoid release in the isolated perfused rat heart: comparison between normotensive and spontaneously hypertensive rats. | 1995 Jul-Aug | Basic Res. Cardiol. | pmid:8534259 |
Saraf MK et al. | Role of platelet activating factor in triazolobenzodiazepines-induced retrograde amnesia. | 2003 | Behav. Brain Res. | pmid:12798263 |
Jerusalinsky D et al. | Effect of antagonists of platelet-activating factor receptors on memory of inhibitory avoidance in rats. | 1994 | Behav. Neural Biol. | pmid:7945139 |
Agwu DE et al. | Mass determination of receptor-mediated accumulation of phosphatidate and diglycerides in human neutrophils measured by Coomassie blue staining and densitometry. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2466463 |
Catalán RE et al. | Nitric oxide mediates the PAF-stimulated cyclic GMP production in hippocampal slices. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8806587 |
Catalán RE et al. | Platelet-activating factor stimulates protein kinase C translocation in cerebral microvessels. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8484756 |
Rodrigues CO et al. | Platelet-activating factor induction of secreted phosphatase activity in Trypanosoma cruzi. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10581161 |
GarcÃa-Sáinz JA and Hernández-Sotomayor SM | Stimulation of hepatic glycogenolysis by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) via cyclooxygenase products. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3933497 |
Elzi DJ et al. | Receptor-mediated calcium entry is required for maximal effects of platelet activating factor primed responses in human neutrophils. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9398641 |
Lanara E et al. | Response of mice and mouse platelets to acetyl glyceryl ether phosphorylcholine. | 1982 | Biochem. Biophys. Res. Commun. | pmid:7168759 |
Ieyasu H et al. | A role of calcium-activated, phospholipid-dependent protein kinase in platelet-activating factor-induced serotonin release from rabbit platelets. | 1982 | Biochem. Biophys. Res. Commun. | pmid:7181916 |
Hanahan DJ et al. | Potent platelet stimulating activity of enantiomers of acetyl glyceryl ether phosphorylcholine and its methoxy analogues. | 1981 | Biochem. Biophys. Res. Commun. | pmid:7236259 |
Tokuoka SM et al. | Alkylglycerol monooxygenase as a potential modulator for PAF synthesis in macrophages. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23743196 |
Resink TJ et al. | The influence of activating hormones on human platelet membrane Ca2+-ATPase activity. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2943273 |
Hayashi M et al. | Enhanced production of platelet-activating factor in stimulated rat leukocytes pretreated with triacsin C, A novel acyl-coA synthetase inhibitor. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1445360 |
Satouchi K et al. | Evidence for production of 1-acyl-2-acetyl-sn-glyceryl-3-phosphorylcholine concomitantly with platelet-activating factor. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4004866 |
Carveth HJ et al. | Neutrophil activating factor (NAF) induces polymorphonuclear leukocyte adherence to endothelial cells and to subendothelial matrix proteins. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2665743 |
Caramelo C et al. | Presence of platelet-activating factor in blood from humans and experimental animals. Its absence in anephric individuals. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6732788 |
Lenihan DJ and Lee TC | Regulation of platelet activating factor synthesis: modulation of 1-alkyl-2-lyso-sn-glycero-3-phosphocholine:acetyl-CoA acetyltransferase by phosphorylation and dephosphorylation in rat spleen microsomes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6732789 |
Shindou H et al. | Roles of cytosolic phospholipase A(2) and platelet-activating factor receptor in the Ca-induced biosynthesis of PAF. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10814544 |
Palmantier R et al. | Biosynthesis of paf-acether. XIV. Paf-acether output in murine peritoneal macrophages is regulated by the level of acetylhydrolase. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2751666 |
Kato T et al. | Augmentation of DNA synthesis in guinea pig bone marrow cells by platelet-activating factor (PAF). | 1988 | Biochem. Biophys. Res. Commun. | pmid:3202869 |
Takayasu M et al. | Endothelin-induced mobilization of Ca2+ and the possible involvement of platelet activating factor and thromboxane A2. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2655596 |
Mackness B et al. | Lack of protection against oxidative modification of LDL by avian HDL. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9642147 |
Rodrigues CO et al. | Effect of platelet-activating factor on cell differentiation of Trypanosoma cruzi. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8687466 |
Bazan HE et al. | The accumulation of platelet activating factor in the injured cornea may be interrelated with the synthesis of lipoxygenase products. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2827658 |
Ponpipom MM et al. | (+/-)-trans-2-(3-Methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5- trimethoxyphenyl)tetrahydrofuran (L-659,989), a novel, potent PAF receptor antagonist. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2829894 |
Nakayama R et al. | 1-O-hexadec-1'-enyl-2-acetyl-sn-glycero-3-phosphocholine and its biological activity. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3355555 |
Smith CS et al. | Cyclosporin A blocks induction of tumor necrosis factor-alpha in human B lymphocytes. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7524500 |
Diserbo M et al. | Activation of large conductance Ca(2+)-activated K+ channels in N1E-115 neuroblastoma cells by platelet-activating factor. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8579584 |
Iwamoto S et al. | Platelet microparticles: a carrier of platelet-activating factor? | 1996 | Biochem. Biophys. Res. Commun. | pmid:8579618 |
Saxena SP et al. | Histamine formed in stimulated human platelets is cytoplasmic. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2803292 |
Mészáros K | Magnetic field elicits hypotension mediated by platelet activating factor in rats injected with iron beads. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1930228 |
Naoki K et al. | PAF responsiveness in Japanese subjects with plasma PAF acetylhydrolase deficiency. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15047169 |
Randell E et al. | Interaction between rat serum phosphorylcholine binding protein and platelet activating factor. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2322233 |
Dutra PM et al. | A novel ecto-phosphatase activity of Herpetomonas muscarum muscarum inhibited by platelet-activating factor. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9875238 |
Musch MW et al. | Antigen-and ionophore-stimulated synthesis of platelet-activating factor by the cloned mast cell line, MC9. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3107564 |
Lumb RH et al. | PAF-acether transfer activity in HL-60 cells is induced during differentiation. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2169726 |
Müller E et al. | Human PAF receptor gene expression: induction during HL-60 cell differentiation. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1722407 |
Rubin RM and Rosenbaum JT | A platelet-activating factor antagonist inhibits interleukin 1-induced inflammation. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3260779 |
Ye RD et al. | Characterization of a human cDNA that encodes a functional receptor for platelet activating factor. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1656963 |
Combadière C et al. | Staurosporine, a protein kinase inhibitor, up-regulates the stimulation of human neutrophil respiratory burst by N-formyl peptides and platelet activating factor. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2158320 |
Billah MM and Siegel MI | Calmodulin antagonists inhibit formation of platelet-activating factor in stimulated human neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6422930 |
Prevost MC et al. | Platelet activating factor (PAF-acether) is released into rat pulmonary alveolar fluid as a consequence of hypoxia. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6422938 |