Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tselepis AD et al. | Electrocardiographic alterations induced by AGEPC in Wistar rats in relation to its hypotensive and hematologic effects. | 1987 | Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. | pmid:2885139 |
| Hayashi M et al. | Characterization of the activity of a platelet activating factor antagonist, CV-3988. | 1987 | Jpn. J. Pharmacol. | pmid:2888915 |
| Bussolino F et al. | Chick retina generates platelet-activating factor. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2890284 |
| Mikashima H et al. | An antagonistic activity of etizolam on platelet-activating factor (PAF). In vitro effects on platelet aggregation and PAF receptor binding. | 1987 | Jpn. J. Pharmacol. | pmid:2890779 |
| Gautheron PD et al. | A study of PAF-induced ocular inflammation in the rat and its inhibition by the PAF antagonist, L-652,731. | 1987 | J. Pharm. Pharmacol. | pmid:2891830 |
| Kornecki E et al. | Interactions of the alkyl-ether-phospholipid, platelet activating factor (PAF) with platelets, neural cells, and the psychotropic drugs triazolobenzodiazepines. | 1987 | Adv. Exp. Med. Biol. | pmid:2893525 |
| Patterson R et al. | Evaluation of the effect of a platelet activating factor antagonist on platelet activating factor and Ascaris antigen-induced airway responses in rhesus monkeys. | 1987 | J. Lab. Clin. Med. | pmid:3668360 |
| Stewart AG and Piper PJ | Actions of platelet-activating factor in the coronary circulation of the guinea pig in vitro. | 1987 | Prog. Clin. Biol. Res. | pmid:3671383 |
| Abstracts of the meeting: The role of platelet-activating factors in the immune response. Paris, France, June 25 and 26, 1987. | 1987 | Prostaglandins | pmid:3671731 | |
| Bourgain RH et al. | Arterial obstruction induced by PAF-acether (1-O-alkyl-sn-glycero-3-phosphocholine). | 1987 | Adv. Exp. Med. Biol. | pmid:3673721 |
| Myers AK and Bader TJ | Role of adrenal steroids in the recovery from platelet activating factor challenge. | 1987 | Circ. Shock | pmid:3677334 |
| Homma H et al. | Binding and internalization of platelet-activating factor 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine in washed rabbit platelets. | 1987 | J. Biol. Chem. | pmid:3038889 |
| Hsueh W et al. | Platelet-activating factor: an endogenous mediator for bowel necrosis in endotoxemia. | 1987 | FASEB J. | pmid:3678700 |
| Myers A et al. | Pharmacological manipulation of platelet-activating factor toxicity in rodents. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960198 |
| Hannun YA et al. | Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways. | 1987 | J. Biol. Chem. | pmid:3115982 |
| Martin TR et al. | Relative contribution of leukotriene B4 to the neutrophil chemotactic activity produced by the resident human alveolar macrophage. | 1987 | J. Clin. Invest. | pmid:2821074 |
| Mangold HK et al. | Biologically active lipids. Semi-synthesis of 3H-labeled ether glycerophospholipids and ether glyceroglycolipids from ratfish liver oil. | 1987 | FEBS Lett. | pmid:3609315 |
| Caffrey E et al. | Aggregation responses to platelet-activating factor in normal subjects. | 1987 | Haemostasis | pmid:3609916 |
| Brunelleschi S et al. | Platelet-activating factor-acether-induced relaxation of guinea pig airway muscle: role of prostaglandin E2 and the epithelium. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3478474 |
| Bittman R et al. | Synthesis and biochemical studies of analogs of platelet-activating factor bearing a methyl group at C2 of the glycerol backbone. | 1987 | J. Lipid Res. | pmid:3611974 |
| Terashita Z et al. | CV-6209, a highly potent antagonist of platelet activating factor in vitro and in vivo. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3612533 |
| Levy JV | Spasmogenic effect of platelet activating factor (PAF) on isolated rat stomach fundus strip. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3619905 |
| Huber M and Keppler D | Inhibition of leukotriene D4 catabolism by D-penicillamine. | 1987 | Eur. J. Biochem. | pmid:3622511 |
| Ramesha CS and Pickett WC | Fatty acid composition of diacyl, alkylacyl, and alkenylacyl phospholipids of control and arachidonate-depleted rat polymorphonuclear leukocytes. | 1987 | J. Lipid Res. | pmid:3106551 |
| Dallob A et al. | Pharmacological evidence for a role of lipoxygenase products in platelet-activating factor (PAF)-induced hyperalgesia. | 1987 | Biochem. Pharmacol. | pmid:2822047 |
| Shimazaki N et al. | Diketopiperazines as a new class of platelet-activating factor inhibitors. | 1987 | J. Med. Chem. | pmid:3656347 |
| Ruan CG et al. | Studies on monoclonal antibodies against human platelets--a monoclonal antibody to human platelet glycoprotein I--SZ-2. | 1987 | Sci. Sin., Ser. B, Chem. Biol. Agric. Med. Earth Sci. | pmid:3659897 |
| Feuerstein G et al. | Protective effect of a PAF-acether antagonist, BN 52021, in trichothecene toxicosis. | 1987 | Toxicol. Lett. | pmid:3660430 |
| Heinsohn C et al. | The effect of bovine serum albumin on the synthesis of prostaglandin and incorporation of [3H]acetate into platelet-activating factor. | 1987 | Arch. Biochem. Biophys. | pmid:3662526 |
| Sperling RI et al. | Effects of dietary supplementation with marine fish oil on leukocyte lipid mediator generation and function in rheumatoid arthritis. | 1987 | Arthritis Rheum. | pmid:3663263 |
| Siess W and Lapetina EG | Phorbol esters sensitize platelets to activation by physiological agonists. | 1987 | Blood | pmid:3663938 |
| Coëffier E et al. | Platelet-leukocyte interaction: activation of rabbit platelets by FMLP-stimulated neutrophils. | 1987 | Br. J. Pharmacol. | pmid:3118996 |
| Hirafuji M et al. | Regulation of PAF-acether (platelet-activating factor) biosynthesis in cultured human vascular endothelial cells stimulated with thrombin. | 1987 | Biochim. Biophys. Acta | pmid:2888488 |
| Nakamura T et al. | Platelet-activating factor in late asthmatic response. | 1987 | Int. Arch. Allergy Appl. Immunol. | pmid:3804454 |
| Ramesha CS and Pickett WC | Species-specific variations in the molecular heterogeneity of the platelet-activating factor. | 1987 | J. Immunol. | pmid:3100641 |
| Bloom JW et al. | Intravenous platelet activating factor does not affect lung epithelial permeability. | 1987 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:3326081 |
| de Almeida PJ et al. | [Biochemical bases of platelet activity in homeostasis and thrombogenesis. III]. | 1987 | Arq. Bras. Cardiol. | pmid:3328601 |
| O'Neill C | Embryo-derived platelet activating factor: a preimplantation embryo mediator of maternal recognition of pregnancy. | 1987 | Domest. Anim. Endocrinol. | pmid:3333935 |
| Mathur RS et al. | Current concepts in asthma. | 1987 | J Assoc Physicians India | pmid:3320019 |
| Whatley RE et al. | Production of platelet-activating factor by endothelial cells. | 1987 | Semin. Thromb. Hemost. | pmid:3321437 |
| Kelton JG and Murphy WG | Acute thrombocytopenia and thrombosis. Heparin-induced thrombocytopenia and thrombotic thrombocytopenic purpura. | 1987 | Ann. N. Y. Acad. Sci. | pmid:3322132 |
| Valone FH and Johnson B | Modulation of platelet-activating-factor-induced calcium influx and intracellular calcium release in platelets by phorbol esters. | 1987 | Biochem. J. | pmid:3322269 |
| O'Flaherty JT and Nishihira J | Arachidonate metabolites, platelet-activating factor, and the mobilization of protein kinase C in human polymorphonuclear neutrophils. | 1987 | J. Immunol. | pmid:3029224 |
| Henderson WR | Lipid-derived and other chemical mediators of inflammation in the lung. | 1987 | J. Allergy Clin. Immunol. | pmid:3031147 |
| Chen DC | [Phosphoinositide metabolism and platelet activation]. | 1987 | Sheng Li Ke Xue Jin Zhan | pmid:2838899 |
| Matsumoto T et al. | G-protein dissociation, GTP-GDP exchange and GTPase activity in control and PMA treated neutrophils stimulated by fMet-Leu-Phe. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3032170 |
| Kurachi M et al. | Suppression of bronchial response to platelet activating factor following taurine administration. | 1987 | Adv. Exp. Med. Biol. | pmid:3434419 |
| Matsuno K et al. | [Cytoplasm free calcium ions as a second messenger]. | 1987 | Rinsho Byori | pmid:3437533 |
| Kawamura Y et al. | [A simple measurement of plasma platelet-activating factor (PAF) acetylhydrolase, normal level of activity, and distribution among lipoprotein fractions]. | 1987 | Rinsho Byori | pmid:3437547 |
| Kertscher HP and Ostermann G | [Synthesis and platelet aggregating activity of structural analogs of platelet-activating factor with a heterocyclic head group]. | 1987 | Pharmazie | pmid:3438334 |
| Riedel A et al. | The effect of the specific PAF antagonist BN 52021 and the calcium blocker diltiazem on PAF induced arrhythmogenicity. | 1987 | Pharmacol Res Commun | pmid:3441484 |
| Bussolino F et al. | Intravascular release of platelet activating factor in children with sepsis. | 1987 | Thromb. Res. | pmid:3441909 |
| Hwang SB | Specific receptor sites for platelet activating factor on rat liver plasma membranes. | 1987 | Arch. Biochem. Biophys. | pmid:2821908 |
| Chung KF et al. | Effect of a ginkgolide mixture (BN 52063) in antagonising skin and platelet responses to platelet activating factor in man. | 1987 | Lancet | pmid:2880069 |
| Casals-Stenzel J and Weber KH | Triazolodiazepines: dissociation of their Paf (platelet activating factor) antagonistic and CNS activity. | 1987 | Br. J. Pharmacol. | pmid:2880622 |
| Robaut C et al. | PAF binding sites. Characterization by [3H]52770 RP, a pyrrolo[1,2-c]thiazole derivative, in rabbit platelets. | 1987 | Biochem. Pharmacol. | pmid:2822048 |
| Dale MM and Penfield A | Comparison of the effects of indomethacin, RHC80267 and R59022 on superoxide production by 1,oleoyl-2,acetyl glycerol and A23187 in human neutrophils. | 1987 | Br. J. Pharmacol. | pmid:2822195 |
| Leff AR et al. | Parasympathetic involvement in PAF-induced contraction in canine trachealis in vivo. | 1987 | J. Appl. Physiol. | pmid:2881917 |
| Spinks NR and O'Neill C | Embryo-deprived platelet-activating factor is essential for establishment of pregnancy in the mouse. | 1987 | Lancet | pmid:2432367 |
| Livio M et al. | A platelet-activating factor receptor antagonist protects against renal function deterioration in nephrotoxic nephritis. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2823570 |
| Khandwala A et al. | REV 2871 (CHBZ): a potent antiallergic agent with a novel mechanism of action. I. Activity profile as an inhibitor of mediator release. | 1987 | Biochem. Pharmacol. | pmid:2435293 |
| Stenzel H et al. | Effect of the PAF-antagonist SRI 63-441 on the allergic reaction in awake dogs with natural asthma. | 1987 | Agents Actions Suppl. | pmid:2823582 |
| Alloatti G et al. | Protective effect of verapamil on the cardiac and circulatory alterations induced by platelet-activating factor. | 1987 | J. Cardiovasc. Pharmacol. | pmid:2435996 |
| O'Flaherty JT and Wykle RL | Metabolic origin and fate of platelet-activating factor. | 1987 | Agents Actions Suppl. | pmid:2823583 |
| Kappa JR et al. | Carotid endarterectomy in patients with heparin-induced platelet activation: comparative efficacy of aspirin and iloprost (ZK36374). | 1987 | J. Vasc. Surg. | pmid:2437338 |
| Terashita Z et al. | A lethal role of platelet activating factor in anaphylactic shock in mice. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3118009 |
| de Arriba G et al. | Changes in glomerular cross-sectional area induced by platelet activating factor. | 1987 | Nephrol. Dial. Transplant. | pmid:3118261 |
| Darius H and Lefer AM | Pharmacologic antagonism of platelet activating factor and peptide leukotrienes inhibits guinea pig anaphylaxis. | 1987 | Prog. Clin. Biol. Res. | pmid:3118384 |
| Shalit M et al. | Platelet-activating factor both stimulates and "primes" human polymorphonuclear leukocyte actin filament assembly. | 1987 | Blood | pmid:3118991 |
| Krishnamurthi S et al. | Effect of phorbol 12-myristate 13-acetate (PMA) on agonist-induced arachidonate release and 5-hydroxytryptamine secretion in human platelets. Dependence of effects on agonist type and time of incubation with PMA. | 1987 | Biochim. Biophys. Acta | pmid:3101746 |
| Codde JP et al. | Effects of altered prostanoid and lyso-PAF synthesis by marine oil diets on blood pressure of salt loaded spontaneously hypertensive rats. | 1987 | Agents Actions Suppl. | pmid:3481207 |
| Liu BN | [Neoplastic membrane-toxic activity as one of the pathogenetic factors in blood cell and tumor growth changes]. | 1987 Jan-Feb | Patol Fiziol Eksp Ter | pmid:3550649 |
| Lurie A et al. | Exercise- and allergen-induced asthma do not change the production of Paf-acether by neutrophils and platelets. | 1987 Jul-Aug | Bull Eur Physiopathol Respir | pmid:3690021 |
| Auriault C et al. | The effector function of platelets is induced and regulated by T lymphocytes. | 1987 Jul-Aug | Ann. Inst. Pasteur Immunol. | pmid:3118905 |
| Fiedler VB et al. | Comparison of cardiac and hemodynamic effects of platelet-activating factor-acether and leukotriene D4 in anesthetized dogs. | 1987 Mar-Apr | Basic Res. Cardiol. | pmid:3606544 |
| Arnoux B et al. | Antigenic release of paf-acether and beta-glucuronidase from alveolar macrophages of asthmatics. | 1987 Mar-Apr | Bull Eur Physiopathol Respir | pmid:3607326 |
| Berdel WE et al. | Lack of correlation between cytotoxicity of agonists and antagonists of platelet activating factor [paf-acether] in neoplastic cells and modulation of [3H]-paf-acether binding to platelets from humans in vitro. | 1987 Nov-Dec | Anticancer Res. | pmid:3442414 |
| Lakin KM et al. | [Action of calcium antagonists on thrombocyte aggregation]. | 1987 Sep-Oct | Farmakol Toksikol | pmid:2826225 |
| Criscuoli M and Subissi A | Catecholamines released from the adrenal medulla exert a compensatory, protective effect at beta 2-adrenoceptors against Paf-induced death in mice. | 1988 | Br. J. Pharmacol. | pmid:2894872 |
| Vivier E et al. | Immunoregulatory functions of paf-acether. II. Decrease of CD2 and CD3 antigen expression. | 1988 | Eur. J. Immunol. | pmid:2895712 |
| Crouch MF and Lapetina EG | No direct correlation between Ca2+ mobilization and dissociation of Gi during platelet phospholipase A2 activation. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3132162 |
| Ferrell JE et al. | Membrane bilayer balance and platelet shape: morphological and biochemical responses to amphipathic compounds. | 1988 | Biochim. Biophys. Acta | pmid:3355815 |
| There is a case for PAF-acether antagonists. Abstracts of the conference. Paris, France, May 25-27, 1988. | 1988 | Prostaglandins | pmid:3399682 | |
| Valone FH | Platelet-activating factor binding and metabolism during human platelet aggregation. | 1988 | Thromb. Res. | pmid:3400077 |
| O'Neill C et al. | Embryo-derived platelet-activating factor. Its diagnostic and therapeutic future. | 1988 | Ann. N. Y. Acad. Sci. | pmid:3195924 |
| Nagpurkar A et al. | Effect of rat phosphorylcholine-binding protein on platelet aggregation. | 1988 | Biochim. Biophys. Acta | pmid:3167098 |
| Wallace JL | Release of platelet-activating factor (PAF) and accelerated healing induced by a PAF antagonist in an animal model of chronic colitis. | 1988 | Can. J. Physiol. Pharmacol. | pmid:3167675 |
| Benveniste J et al. | Preformed PAF-acether and lyso PAF-acether are bound to blood lipoproteins. | 1988 | FEBS Lett. | pmid:3338565 |
| Barnes PJ et al. | Platelet-activating factor as a mediator of allergic disease. | 1988 | J. Allergy Clin. Immunol. | pmid:3286723 |
| Nakayama R and Saito K | [PAF and its physiological significance in normal tissue]. | 1988 | Seikagaku | pmid:3286791 |
| Valone FH | Identification of platelet-activating factor receptors in P388D1 murine macrophages. | 1988 | J. Immunol. | pmid:2832476 |
| Prpic V et al. | Biochemical and functional responses stimulated by platelet-activating factor in murine peritoneal macrophages. | 1988 | J. Cell Biol. | pmid:2839520 |
| Kroegel C | The potential pathophysiological role of platelet-activating factor in human diseases. | 1988 | Klin. Wochenschr. | pmid:2839728 |
| Egger M et al. | Human platelet electrorotation change induced by activation: inducer specificity and correlation to serotonin release. | 1988 | Biochim. Biophys. Acta | pmid:3143424 |
| Pitcock JA | Morphometric studies of the renomedullary interstitial cells. | 1988 | Am. J. Med. Sci. | pmid:3284348 |
| Berstad A et al. | Effect of platelet-activating factor and its receptor antagonist, SRI 63-675, on gastric bleeding in rats. | 1988 | Scand. J. Gastroenterol. | pmid:3262915 |
| Morley J et al. | Pharmacological evaluation of prophylactic anti-asthma drugs by reference to the pathological sequelae of exposure to allergen or platelet activating factor. | 1988 | Agents Actions Suppl. | pmid:3262989 |
| Ng DS and Wong K | Effect of sulfhydryl reagents on PAF binding to human neutrophils and platelets. | 1988 | Eur. J. Pharmacol. | pmid:2846326 |
| Ryan US et al. | Influence of vasoactive agents on cytoplasmic free calcium in vascular endothelial cells. | 1988 | J. Appl. Physiol. | pmid:3209566 |
| Nogami M et al. | [Effects of a platelet activating factor (PAF) antagonist CV-3988 on acute gastric erosions in rats by water immersion and restrained stress, and by ethanol]. | 1988 | Nihon Shokakibyo Gakkai Zasshi | pmid:3210345 |