Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Flasiński M et al. | Influence of platelet-activating factor, lyso-platelet-activating factor and edelfosine on Langmuir monolayers imitating plasma membranes of cell lines differing in susceptibility to anti-cancer treatment: the effect of plasmalogen level. | 2014 | J R Soc Interface | pmid:24694892 |
Sato A et al. | C-reactive protein specifically enhances platelet-activating factor-induced inflammatory activity in vivo. | 2014 | Eur. J. Pharmacol. | pmid:25455842 |
Wu H et al. | Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. | 2014 | PLoS ONE | pmid:24671173 |
Marathe GK et al. | To hydrolyze or not to hydrolyze: the dilemma of platelet-activating factor acetylhydrolase. | 2014 | J. Lipid Res. | pmid:24859738 |
Zanatta AL et al. | Fish oil supplementation decreases oxidative stress but does not affect platelet-activating factor bioactivity in lungs of asthmatic rats. | 2014 | Lipids | pmid:24858941 |
Mitchell MJ et al. | Fluid shear stress increases neutrophil activation via platelet-activating factor. | 2014 | Biophys. J. | pmid:24853753 |
Carlioglu A et al. | The platelet activating factor acetyl hydrolase, oxidized low-density lipoprotein, paraoxonase 1 and arylesterase levels in treated and untreated patients with polycystic ovary syndrome. | 2014 | Arch. Gynecol. Obstet. | pmid:24840107 |
Yu Y et al. | Epidermal growth factor induces platelet-activating factor production through receptors transactivation and cytosolic phospholipase A2 in ovarian cancer cells. | 2014 | J Ovarian Res | pmid:24721622 |
Forkel S et al. | Inositoylated platelet-activating factor (Ino-C2-PAF) modulates dynamic lymphocyte-endothelial cell interactions and alleviates psoriasis-like skin inflammation in two complementary mouse models. | 2014 | J. Invest. Dermatol. | pmid:24714204 |
Kim SJ et al. | Quantitative determination of major platelet activating factors from human plasma. | 2014 | Anal Bioanal Chem | pmid:24682147 |
Chérifi F et al. | Isolation, functional characterization and proteomic identification of CC2-PLA₂ from Cerastes cerastes venom: a basic platelet-aggregation-inhibiting factor. | 2014 | Protein J. | pmid:24384926 |
Rivera J et al. | Platelet-activating factor contributes to Bacillus anthracis lethal toxin-associated damage. | 2014 | J. Biol. Chem. | pmid:24478317 |
Tarui M et al. | Selective inhibitors of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2. | 2014 | J. Lipid Res. | pmid:24850807 |
Jiao D et al. | Macrophages are the dominant effector cells responsible for IgG-mediated passive systemic anaphylaxis challenged by natural protein antigen in BALB/c and C57BL/6 mice. | 2014 May-Jun | Cell. Immunol. | pmid:24751884 |
Yan W et al. | BN52021 protects rat cardiomyocyte from doxorubicin induced cardiotoxicity. | 2015 | Int J Clin Exp Pathol | pmid:25973059 |
Kim YH et al. | SIRT1 attenuates PAF-induced MMP-2 production via down-regulation of PAF receptor expression in vascular smooth muscle cells. | 2015 | Vascul. Pharmacol. | pmid:25967595 |
Armant DR | Intracellular Ca2+ signaling and preimplantation development. | 2015 | Adv. Exp. Med. Biol. | pmid:25956298 |
Puebla-Osorio N et al. | Platelet-activating factor induces cell cycle arrest and disrupts the DNA damage response in mast cells. | 2015 | Cell Death Dis | pmid:25950475 |
Sahu RP et al. | Systemic chemotherapy is modulated by platelet-activating factor-receptor agonists. | 2015 | Mediators Inflamm. | pmid:25922565 |
Shida-Sakazume T et al. | Lysophosphatidylcholine acyltransferase1 overexpression promotes oral squamous cell carcinoma progression via enhanced biosynthesis of platelet-activating factor. | 2015 | PLoS ONE | pmid:25803864 |
Laidlaw TM and Boyce JA | Platelets in patients with aspirin-exacerbated respiratory disease. | 2015 | J. Allergy Clin. Immunol. | pmid:26051947 |
Lautenschläger I et al. | Quinidine, but not eicosanoid antagonists or dexamethasone, protect the gut from platelet activating factor-induced vasoconstriction, edema and paralysis. | 2015 | PLoS ONE | pmid:25793535 |
Bate C and Williams A | α-Synuclein-induced synapse damage in cultured neurons is mediated by cholesterol-sensitive activation of cytoplasmic phospholipase A2. | 2015 | Biomolecules | pmid:25761116 |
Sahu RP | Expression of the platelet-activating factor receptor enhances benzyl isothiocyanate-induced apoptosis in murine and human melanoma cells. | 2015 | Mol Med Rep | pmid:25695262 |
Reznichenko A and Korstanje R | The role of platelet-activating factor in mesangial pathophysiology. | 2015 | Am. J. Pathol. | pmid:25655028 |
Jeewandara C et al. | Platelet activating factor contributes to vascular leak in acute dengue infection. | 2015 | PLoS Negl Trop Dis | pmid:25646838 |
Valli A et al. | Hypoxia induces a lipogenic cancer cell phenotype via HIF1α-dependent and -independent pathways. | 2015 | Oncotarget | pmid:25605240 |
Yamaguchi M et al. | A platelet-activating factor (PAF) receptor deficiency exacerbates diet-induced obesity but PAF/PAF receptor signaling does not contribute to the development of obesity-induced chronic inflammation. | 2015 | Biochem. Pharmacol. | pmid:25577975 |
Johnson M et al. | Levocetirizine and rupatadine in chronic idiopathic urticaria. | 2015 | Int. J. Dermatol. | pmid:25521304 |
Kim H et al. | Higher plasma platelet-activating factor levels are associated with increased risk of vertebral fracture and lower bone mineral density in postmenopausal women. | 2015 | J. Bone Miner. Metab. | pmid:25501698 |
Kooijman S et al. | Hematopoietic α7 nicotinic acetylcholine receptor deficiency increases inflammation and platelet activation status, but does not aggravate atherosclerosis. | 2015 | J. Thromb. Haemost. | pmid:25345495 |
Jasamai M et al. | Molecular docking study on platelet-activating factor antagonistic activity of bioactive compounds isolated from Guttiferae and Ardisia species. | 2015 | Nat. Prod. Res. | pmid:25332053 |
Detopoulou P et al. | The relation of diet with PAF and its metabolic enzymes in healthy volunteers. | 2015 | Eur J Nutr | pmid:24639073 |
Huang JF et al. | Protective effect of high concentration of BN52021 on retinal contusion in cat eyes. | 2015 | BMC Ophthalmol | pmid:25956877 |
Sun L et al. | PAF receptor antagonist Ginkgolide B inhibits tumourigenesis and angiogenesis in colitis-associated cancer. | 2015 | Int J Clin Exp Pathol | pmid:25755731 |
Wang Y et al. | Aqueous extract of Rabdosia rubescens leaves: forming nanoparticles, targeting P-selectin, and inhibiting thrombosis. | 2015 | Int J Nanomedicine | pmid:26604756 |
Ohshima N et al. | New members of the mammalian glycerophosphodiester phosphodiesterase family: GDE4 and GDE7 produce lysophosphatidic acid by lysophospholipase D activity. | 2015 | J. Biol. Chem. | pmid:25528375 |
van Doorn R and de Gruijl F | Chromatin Modifications and Mast Cell Migration in UV-Induced Immunosuppression, an Epigenetic Piece of The Puzzle. | 2015 | J. Invest. Dermatol. | pmid:26569583 |
Pałgan K and Bartuzi Z | Platelet activating factor in allergies. | 2015 | Int J Immunopathol Pharmacol | pmid:26486136 |
Hergott CB et al. | Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection. | 2015 | J. Clin. Invest. | pmid:26426079 |
Speciani AF and Piuri G | Measuring Biomarkers for an Innovative Personal Food Profile. | 2015 | J Am Coll Nutr | pmid:26400432 |
Pei HX et al. | Ginkgolide B Reduces the Degradation of Membrane Phospholipids to Prevent Ischemia/Reperfusion Myocardial Injury in Rats. | 2015 | Pharmacology | pmid:26382046 |
Tiniakou I et al. | Natural human apoA-I mutations L141RPisa and L159RFIN alter HDL structure and functionality and promote atherosclerosis development in mice. | 2015 | Atherosclerosis | pmid:26363436 |
Vlachogianni IC et al. | Platelet Activating Factor (PAF) biosynthesis is inhibited by phenolic compounds in U-937 cells under inflammatory conditions. | 2015 | Prostaglandins Other Lipid Mediat. | pmid:26358846 |
Sato A et al. | Angiotensin peptides attenuate platelet-activating factor-induced inflammatory activity in rats. | 2015 | Peptides | pmid:26348270 |
Sato A et al. | Biotinylated heptapeptides substituted with a D-amino acid as platelet-activating factor inhibitors. | 2015 | Eur. J. Pharmacol. | pmid:26142829 |
Sala-Cunill A and Cardona V | Biomarkers of anaphylaxis, beyond tryptase. | 2015 | Curr Opin Allergy Clin Immunol | pmid:26110683 |
Gao L et al. | Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition. | 2015 | J. Clin. Invest. | pmid:26098214 |
Gill P et al. | Platelets in the immune response: Revisiting platelet-activating factor in anaphylaxis. | 2015 | J. Allergy Clin. Immunol. | pmid:26051949 |
de Oliveira MC et al. | Platelet-activating factor modulates fat storage in the liver induced by a high-refined carbohydrate-containing diet. | 2015 | J. Nutr. Biochem. | pmid:26013469 |