Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Samples BL et al. | Subcellular localization of enzyme activities involved in the metabolism of platelet-activating factor in rainbow trout leukocytes. | 1999 | Biochim. Biophys. Acta | pmid:10101269 |
Karasawa K et al. | Purification and characterization from rat kidney membranes of a novel platelet-activating factor (PAF)-dependent transacetylase that catalyzes the hydrolysis of PAF, formation of PAF analogs, and C2-ceramide. | 1999 | J. Biol. Chem. | pmid:10085103 |
Kim KA et al. | Pinusolide from the leaves of Biota orientalis as potent platelet activating factor antagonist. | 1999 | Planta Med. | pmid:10083843 |
Takami M and Tsukada W | Effect of DP-1904, a thromboxane synthetase inhibitor, on antigen- and spasmogen-induced bronchoconstriction in rodents. | 1999 | Eur. J. Pharmacol. | pmid:10082207 |
Bazan NG | Bioactive lipids and gene expression in neuronal plasticity. | 1998 | Adv. Exp. Med. Biol. | pmid:10079836 |
Qu XW et al. | Roles of nitric oxide synthases in platelet-activating factor-induced intestinal necrosis in rats. | 1999 | Crit. Care Med. | pmid:10075061 |
Fink MP | Nitric oxide and the gut: one more piece in the puzzle. | 1999 | Crit. Care Med. | pmid:10075038 |
Shohet RV et al. | Plasma platelet-activating factor acetylhydrolase activity is not associated with premature coronary atherosclerosis. | 1999 | Am. J. Cardiol. | pmid:10073795 |
Zeng S and Guo ZG | Mepyramine inhibits platelet activating factor-induced rabbit platelet aggregation: role of intracellular histamine. | 1997 | Zhongguo Yao Li Xue Bao | pmid:10072970 |
Bartemes KR et al. | Endogenous platelet-activating factor is critically involved in effector functions of eosinophils stimulated with IL-5 or IgG. | 1999 | J. Immunol. | pmid:10072549 |
Suzuki T et al. | 2-(3-Pyridyl)thiazolidine-4-carboxamide derivatives. III.) Synthesis of metabolites and metabolism of 2-(3-pyridyl)thiazolidine-4-carboxamides YM461 and YM264 as platelet-activating factor (PAF) receptor antagonists. | 1999 | Chem. Pharm. Bull. | pmid:10071851 |
Oguchi A et al. | Platelet activating factor causes a rapid increase in activity of prior expressed tissue factor on monocyte surface membrane. | 1999 | Int. J. Hematol. | pmid:10071462 |
Hurst J et al. | PAF binding to a single receptor in corneal epithelium plasma membrane. | 1999 | Invest. Ophthalmol. Vis. Sci. | pmid:10067986 |
Kaminskaia GO et al. | [Platelet activating factor in biological fluids of animals with different species-specific resistance at the stage of infective process after inoculation with mycobacterium tuberculosis]. | 1998 | Probl Tuberk | pmid:10067355 |
Stojanov T et al. | In-vitro fertilization and culture of mouse embryos in vitro significantly retards the onset of insulin-like growth factor-II expression from the zygotic genome. | 1999 | Mol. Hum. Reprod. | pmid:10065866 |
Tokumura A et al. | Substrate specificity of lysophospholipase D which produces bioactive lysophosphatidic acids in rat plasma. | 1999 | Biochim. Biophys. Acta | pmid:10064906 |
Satoh N et al. | Plasma platelet-activating factor acetylhydrolase deficiency in Japanese patients with asthma. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10051281 |
Okayama N et al. | Intracellular mechanisms of hydrogen peroxide-mediated neutrophil adherence to cultured human endothelial cells. | 1999 | Microvasc. Res. | pmid:10049654 |
Tsuchiya R et al. | Role of platelet activating factor in development of thrombocytopenia and neutropenia in dogs with endotoxemia. | 1999 | Am. J. Vet. Res. | pmid:10048555 |
Mukherjee PK et al. | Glutamate receptor signaling interplay modulates stress-sensitive mitogen-activated protein kinases and neuronal cell death. | 1999 | J. Biol. Chem. | pmid:10037742 |
Delong P et al. | Bacterial lipopolysaccharide induction of the prostaglandin G/H synthase 2 gene causes thromboxane-dependent pulmonary hypertension in rabbits. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:10030848 |
Zallen G et al. | Postinjury suppression of human neutrophil cytokine production results from the stabilization of inhibitory kappaB. | 1999 | Shock | pmid:10030791 |
Van de Weerdt ML et al. | Ketoprofen and phenylbutazone attenuation of PAF-induced lung inflammation in calves. | 1999 | Vet. J. | pmid:10030127 |
Bussolati B et al. | Interleukin-12 is synthesized by mesangial cells and stimulates platelet-activating factor synthesis, cytoskeletal reorganization, and cell shape change. | 1999 | Am. J. Pathol. | pmid:10027419 |
Tselepis AD et al. | Association of the inflammatory state in active juvenile rheumatoid arthritis with hypo-high-density lipoproteinemia and reduced lipoprotein-associated platelet-activating factor acetylhydrolase activity. | 1999 | Arthritis Rheum. | pmid:10025933 |
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