| MeSH term | MeSH ID | Detail |
|---|---|---|
| Burns | D002056 | 34 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Infertility, Male | D007248 | 11 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Brain Injuries | D001930 | 4 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Osteonecrosis | D010020 | 5 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Acute Kidney Injury | D058186 | 34 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Handa RK et al. | Selective inhibition of vasoconstrictor responses by platelet-activating factor in rat kidney. | 1991 | Am. J. Physiol. | pmid:1907104 |
| Macconi D et al. | PAF mediates neutrophil adhesion to thrombin or TNF-stimulated endothelial cells under shear stress. | 1995 | Am. J. Physiol. | pmid:7631759 |
| Nakao A et al. | cAMP mediates homologous downregulation of PAF receptor mRNA expression in mesangial cells. | 1997 | Am. J. Physiol. | pmid:9321918 |
| Garland A et al. | Activated eosinophils elicit substance P release from cultured dorsal root ganglion neurons. | 1997 | Am. J. Physiol. | pmid:9374740 |
| Rizzo A et al. | Platelet-activating factor increases vascular resistance in rat hindquarters by thromboxane A2. | 1995 | Am. J. Physiol. | pmid:7771545 |
| Olson NC et al. | Pertussis toxin attenuates platelet-activating factor-induced pulmonary hemodynamic alterations in pigs. | 1993 | Am. J. Physiol. | pmid:8460710 |
| Zimmerman BJ et al. | Molecular determinants of lipid mediator-induced leukocyte adherence and emigration in rat mesenteric venules. | 1994 | Am. J. Physiol. | pmid:8160832 |
| Haller H et al. | Endothelin increases [Ca2+]i, protein phosphorylation, and O2-. production in human alveolar macrophages. | 1991 | Am. J. Physiol. | pmid:1662920 |
| Toyofuku T et al. | Pulmonary vascular response to platelet-activating factor in conscious sheep. | 1988 | Am. J. Physiol. | pmid:3414811 |
| Gaboury J et al. | Nitric oxide prevents leukocyte adherence: role of superoxide. | 1993 | Am. J. Physiol. | pmid:8214120 |
| Asako H et al. | Phalloidin prevents leukocyte emigration induced by proinflammatory stimuli in rat mesentery. | 1992 | Am. J. Physiol. | pmid:1362329 |
| Xie J et al. | Dissociation of TNF-alpha from endotoxin-induced nitric oxide and acute-phase hypotension. | 1997 | Am. J. Physiol. | pmid:9249487 |
| MartÃnez-Salgado C et al. | Involvement of phospholipase A2 in gentamicin-induced rat mesangial cell activation. | 1997 | Am. J. Physiol. | pmid:9249592 |
| Yamazaki M et al. | Modulation of leukotriene B4 and platelet-activating factor binding to neutrophils. | 1991 | Am. J. Physiol. | pmid:1653524 |
| Hasunuma K et al. | Endothelin 1 causes pulmonary vasodilation in rats. | 1990 | Am. J. Physiol. | pmid:2115743 |
| Schlondorff D and Neuwirth R | Platelet-activating factor and the kidney. | 1986 | Am. J. Physiol. | pmid:3089026 |
| Sasaki T et al. | Platelet-activating factor increases platelet-dependent glycoconjugate secretion from tracheal submucosal gland. | 1989 | Am. J. Physiol. | pmid:2692465 |
| Buerke M et al. | Isolated cardiac myocytes are sensitized by hypoxia-reoxygenation to neutrophil-released mediators. | 1994 | Am. J. Physiol. | pmid:8304493 |
| Tamaoki J et al. | Effect of azelastine on platelet-activating factor-induced microvascular leakage in rat airways. | 1999 | Am. J. Physiol. | pmid:9950898 |
| Brock TA and Gimbrone MA | Platelet activating factors alters calcium homeostasis in cultured vascular endothelial cells. | 1986 | Am. J. Physiol. | pmid:3717361 |
| Kinnula VL et al. | Release of reactive oxygen species by guinea pig tracheal epithelial cells in vitro. | 1992 | Am. J. Physiol. | pmid:1616055 |
| Mori N et al. | Ischemia-reperfusion induced microvascular responses in LDL-receptor -/- mice. | 1999 | Am. J. Physiol. | pmid:10330250 |
| Owen CA et al. | Cytokines regulate membrane-bound leukocyte elastase on neutrophils: a novel mechanism for effector activity. | 1997 | Am. J. Physiol. | pmid:9124593 |
| Kurtel H et al. | Mechanisms of oxidized chylomicron-induced leukocyte-endothelial cell adhesion. | 1995 | Am. J. Physiol. | pmid:7541957 |
| Ardaillou N et al. | Vasoconstrictor-evoked prostaglandin synthesis in cultured human mesangial cells. | 1985 | Am. J. Physiol. | pmid:3918460 |
| Ferrer-Lopez P et al. | Activation of human platelets by C5a-stimulated neutrophils: a role for cathepsin G. | 1990 | Am. J. Physiol. | pmid:2360620 |
| Wallace JL et al. | Endothelin has potent ulcerogenic and vasoconstrictor actions in the stomach. | 1989 | Am. J. Physiol. | pmid:2650567 |
| Beyer AJ et al. | PAF and CD18 mediate neutrophil infiltration in upper gastrointestinal tract during intra-abdominal sepsis. | 1998 | Am. J. Physiol. | pmid:9724257 |
| Handa RK et al. | Platelet-activating factor is a renal vasodilator in the anesthetized rat. | 1990 | Am. J. Physiol. | pmid:2360650 |
| Eakes AT and Olson MS | Regulation of endothelin synthesis in hepatic endothelial cells. | 1998 | Am. J. Physiol. | pmid:9696707 |
| Koyama S et al. | Human lung fibroblasts release chemokinetic activity for monocytes constitutively. | 1998 | Am. J. Physiol. | pmid:9700081 |
| Zhou W et al. | Role of platelet-activating factor in hepatic responses after bile duct ligation in rats. | 1992 | Am. J. Physiol. | pmid:1443133 |
| Galens S et al. | Assessment of agonist- and cell-mediated responses in airway microsections by computerized videomicrometry. | 1995 | Am. J. Physiol. | pmid:7900832 |
| Feuerstein G et al. | Effect of platelet-activating factor on coronary circulation of the domestic pig. | 1984 | Am. J. Physiol. | pmid:6703081 |
| Bienvenu K et al. | Modulation of leukocyte migration in mesenteric interstitium. | 1994 | Am. J. Physiol. | pmid:7943404 |
| Perico N et al. | Platelet-activating factor alters glomerular barrier size selectivity for macromolecules in rats. | 1991 | Am. J. Physiol. | pmid:1713421 |
| Wang J and Dunn MJ | Platelet-activating factor mediates endotoxin-induced acute renal insufficiency in rats. | 1987 | Am. J. Physiol. | pmid:2827506 |
| Lang CH et al. | Platelet-activating factor-induced increases in glucose kinetics. | 1988 | Am. J. Physiol. | pmid:3348371 |
| Kornecki E and Ehrlich YH | Diminished responsiveness of human platelets to platelet-activating factor during pregnancy. | 1990 | Am. J. Physiol. | pmid:2396687 |
| Rainger GE et al. | Endothelial-borne platelet-activating factor and interleukin-8 rapidly immobilize rolling neutrophils. | 1997 | Am. J. Physiol. | pmid:9038929 |
| Merendino N et al. | Human intestinal epithelial cells express receptors for platelet-activating factor. | 1999 | Am. J. Physiol. | pmid:10516147 |
| Sánchez-Crespo M et al. | Presence in normal human urine of a hypotensive and platelet-activating phospholipid. | 1983 | Am. J. Physiol. | pmid:6859262 |
| Dobrowsky RT et al. | Effect of SRI 63-675 on hemodynamics and blood PAF levels during porcine endotoxemia. | 1991 | Am. J. Physiol. | pmid:2035668 |
| Stahl GL et al. | Eicosanoid production from porcine neutrophils and platelets: differential production with various agonists. | 1997 | Am. J. Physiol. | pmid:9227410 |
| Kubes P et al. | Platelet-activating factor-induced microvascular dysfunction: role of adherent leukocytes. | 1990 | Am. J. Physiol. | pmid:2301577 |
| Chang SW et al. | Beneficial effect of a platelet-activating factor antagonist, WEB 2086, on endotoxin-induced lung injury. | 1990 | Am. J. Physiol. | pmid:2301603 |
| Rainger GE et al. | Adhesion of flowing neutrophils to cultured endothelial cells after hypoxia and reoxygenation in vitro. | 1995 | Am. J. Physiol. | pmid:7485573 |
| Pique JM et al. | Influence of morphine or capsaicin pretreatment on rat gastric microcirculatory response to PAF. | 1990 | Am. J. Physiol. | pmid:2316650 |
| Miller MJ et al. | SOD prevents damage and attenuates eicosanoid release in a rabbit model of necrotizing enterocolitis. | 1988 | Am. J. Physiol. | pmid:2847541 |
| Harris AG et al. | Mechanisms of cell injury in rat mesentery and cremaster muscle. | 1998 | Am. J. Physiol. | pmid:9530215 |