| MeSH term | MeSH ID | Detail |
|---|---|---|
| Burns | D002056 | 34 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Infertility, Male | D007248 | 11 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Brain Injuries | D001930 | 4 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Osteonecrosis | D010020 | 5 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Acute Kidney Injury | D058186 | 34 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sugatani J et al. | Inhibition of rabbit platelet aggregation by nucleoside 5'-alkylphosphates: correlation with inhibition of agonist-induced calcium influx. | 2000 | Biochem. Pharmacol. | pmid:10825464 |
| Luu NT et al. | Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils. | 2000 | J. Immunol. | pmid:10820279 |
| Shindou H et al. | Roles of cytosolic phospholipase A(2) and platelet-activating factor receptor in the Ca-induced biosynthesis of PAF. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10814544 |
| Kulikov VI and Muzya GI | Bioactive amide of prostaglandin E1 and ethanolamine plasmalogen analog of platelet-activating factor inhibits several pathways of human platelet aggregation. | 2000 | Biochemistry Mosc. | pmid:10810178 |
| Kosaka T et al. | Spectrophotometric assay for serum platelet-activating factor acetylhydrolase activity. | 2000 | Clin. Chim. Acta | pmid:10807978 |
| Dearn S et al. | Activation of platelet-activating factor (PAF) receptor stimulates nitric oxide (NO) release via protein kinase C-alpha in HEC-1B human endometrial epithelial cell line. | 2000 | Mol. Med. | pmid:10803407 |
| Balsinde J et al. | Cellular regulation of cytosolic group IV phospholipase A2 by phosphatidylinositol bisphosphate levels. | 2000 | J. Immunol. | pmid:10799904 |
| Asai Y and Watanabe S | Characterization of the physicochemical properties of the micelles by the novel platelet activating factor receptor antagonist E5880. | 2000 | Eur J Pharm Biopharm | pmid:10799812 |
| Oshiro T et al. | Characterization of platelet-activating factor-induced cytosolic calcium mobilization in human eosinophils. | 2000 | Clin. Exp. Allergy | pmid:10792362 |
| Asai Y et al. | A temperature study on critical micellization concentration of the novel platelet-activating factor receptor antagonist E5880 in water by electric conductivity measurements. | 2000 | Drug Dev Ind Pharm | pmid:10789068 |
| Friedman E et al. | Effect of hydrocortisone on platelet activating factor induced lung edema in isolated rabbit lungs. | 2000 | Respir Physiol | pmid:10786645 |
| Smith J et al. | Differences in gene density on chicken macrochromosomes and microchromosomes. | 2000 | Anim. Genet. | pmid:10782207 |
| Yamada Y et al. | Correlations between plasma platelet-activating factor acetylhydrolase (PAF-AH) activity and PAF-AH genotype, age, and atherosclerosis in a Japanese population. | 2000 | Atherosclerosis | pmid:10781653 |
| Hauser CJ et al. | Major trauma enhances store-operated calcium influx in human neutrophils. | 2000 | J Trauma | pmid:10780589 |
| Shute J | Signal transduction mechanisms in human eosinophils. | 1993 | Clin. Exp. Allergy | pmid:10779300 |
| Sehmi R et al. | Interleukin-8 is a chemo-attractant for eosinophils purified from subjects with a blood eosinophilia but not from normal healthy subjects. | 1993 | Clin. Exp. Allergy | pmid:10779297 |
| Lagente V et al. | Effects of the platelet activating factor antagonists BN 52021 and BN 50730 on antigen-induced bronchial hyperresponsiveness and eosinophil infiltration in lung from sensitized guinea-pigs. | 1993 | Clin. Exp. Allergy | pmid:10779293 |
| Bastos da Silva M et al. | In vitro inhibitory effect of SR 27417, a potent platelet-activating factor (PAF) receptor antagonist, on the PAF-induced bovine platelet aggregation. | 2000 Mar-Apr | Vet. Res. | pmid:10779205 |
| Connolly AB and Vernon DR | Manipulations of the metabolic response for management of patients with severe surgical illness: review. | 2000 | World J Surg | pmid:10773122 |
| Munakata M et al. | Nafamostat mesilate modulates the release of platelet-activating factor during left ventricular assistance with hemofiltration in canine heart failure. | 2000 | Jpn. J. Thorac. Cardiovasc. Surg. | pmid:10769990 |
| Emerson M et al. | Characterization and functional significance of calcium transients in the 2-cell mouse embryo induced by an autocrine growth factor. | 2000 | J. Biol. Chem. | pmid:10764773 |
| Triggiani M et al. | Metabolism of lipid mediators in human eosinophils. | 2000 | Chem. Immunol. | pmid:10761306 |
| Kalia N et al. | Mechanisms of Helicobacter pylori-induced rat gastric mucosal microcirculatory disturbances in vivo. | 2000 | Dig. Dis. Sci. | pmid:10759248 |
| Liao CH et al. | Antiplatelet effect of marchantinquinone, isolated from Reboulia hemisphaerica, in rabbit washed platelets. | 2000 | J. Pharm. Pharmacol. | pmid:10757426 |
| Cijevschi I and Cijevschi D | [Ocular immunopathological characteristics and the involvement of the platelet-aggregation factor and the anti-PAF at the level of the eye]. | 1999 Jan-Jun | Rev Med Chir Soc Med Nat Iasi | pmid:10756889 |
| Bailey SR et al. | Actions and interactions of ADP, 5- HT, histamine and PAF on equine platelets. | 2000 | Res. Vet. Sci. | pmid:10756136 |
| Lendvai N et al. | Mechanism for the isotype dependence of antibody-mediated toxicity in Cryptococcus neoformans-infected mice. | 2000 | J. Immunol. | pmid:10754337 |
| Vincent JL et al. | Phase II multicenter clinical study of the platelet-activating factor receptor antagonist BB-882 in the treatment of sepsis. | 2000 | Crit. Care Med. | pmid:10752807 |
| Martin-Chouly CA et al. | Modulation of PAF production by incorporation of arachidonic acid and eicosapentaenoic acid in phospholipids of human leukemic monocyte-like cells THP-1. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10751643 |
| Koyama S et al. | The potential of various lipopolysaccharides to release IL-8 and G-CSF. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10749742 |
| Ibe BO et al. | Platelet-activating factor receptors in lamb lungs are downregulated immediately after birth. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10749711 |
| Ruchaud-Sparagano MH et al. | Soluble E-selectin acts in synergy with platelet-activating factor to activate neutrophil beta 2-integrins. Role of tyrosine kinases and Ca2+ mobilization. | 2000 | J. Biol. Chem. | pmid:10748085 |
| Howard KM and Olson MS | The expression and localization of plasma platelet-activating factor acetylhydrolase in endotoxemic rats. | 2000 | J. Biol. Chem. | pmid:10748027 |
| Wiese A et al. | Structure-dependent effects of glucose-containing analogs of platelet activating factor (PAF) on membrane integrity. | 2000 | Biol. Chem. | pmid:10746745 |
| Tan XD et al. | Platelet-activating factor increases mucosal permeability in rat intestine via tyrosine phosphorylation of E-cadherin. | 2000 | Br. J. Pharmacol. | pmid:10742310 |
| Hagi A et al. | Activation of G-protein coupled fMLP or PAF receptor directly triggers glucose transporter type 1 (GLUT1) translocation in Chinese hamster ovary (CHO) cells stably expressing fMLP or PAF receptor. | 2000 | J. Med. Invest. | pmid:10740976 |
| Boccellino M et al. | Effect of platelet-activating factor receptor expression on CHO cell motility. | 2000 | J. Cell. Physiol. | pmid:10737901 |
| Desplat V et al. | Metabolism and effect of platelet-activating factor on the growth of human myeloma cell lines. | 2000 | Cancer Lett. | pmid:10737702 |
| Berthou C et al. | Interferon-gamma-induced membrane PAF-receptor expression confers tumor cell susceptibility to NK perforin-dependent lysis. | 2000 | Blood | pmid:10733503 |
| Schmidt J et al. | Reduced basal and stimulated leukocyte adherence in tumor endothelium of experimental pancreatic cancer. | 1999 | Int. J. Pancreatol. | pmid:10732294 |
| Iglesias-De La Cruz MC et al. | Phenotypic modifications of human mesangial cells by extracellular matrix: the importance of matrix in the contractile response to reactive oxygen species. | 2000 Mar-Apr | Exp. Nephrol. | pmid:10729749 |
| Ishii S and Shimizu T | Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice. | 2000 | Prog. Lipid Res. | pmid:10729607 |
| Wang WZ et al. | Platelet-activating factor contributes to postischemic vasospasm. | 2000 | J. Surg. Res. | pmid:10729242 |
| Vallee RB et al. | The role of cytoplasmic dynein in the human brain developmental disease lissencephaly. | 2000 | Biochim. Biophys. Acta | pmid:10722879 |
| Sun Z et al. | Beneficial effects of lexipafant, a PAF antagonist on gut barrier dysfunction caused by intestinal ischemia and reperfusion in rats. | 2000 | Dig Surg | pmid:10720833 |
| Manabe H et al. | The inhaled administration of KF19514, a phosphodiesterase 4 and 1 inhibitor, prevents antigen-induced lung inflammation in guinea pigs. | 2000 | Pulm Pharmacol Ther | pmid:10718985 |
| Chen LW et al. | Differential regulation of Ca2+ influx by fMLP and PAF in human neutrophils: possible involvement of store-operated Ca2+ channel. | 2000 | Shock | pmid:10718373 |
| Chen C and Bazan NG | Platelet-activating factor inhibits ionotropic GABA receptor activity in cultured hippocampal neurons. | 1999 | Neuroreport | pmid:10716218 |
| Lo EJ et al. | Bradykinin-induced neurogenic migration of neutrophils into the rat knee joint. | 1999 | Neuroreport | pmid:10716216 |
| Takada Y et al. | Improvement of allograft viability with organs procured from non-heart-beating donors in porcine liver transplantation. | 2000 | Transplant. Proc. | pmid:10715416 |