Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lo CJ et al. | Endotoxin-induced macrophage gene expression depends on platelet-activating factor. | 1997 | Arch Surg | pmid:9403541 |
| Uozumi N et al. | Role of cytosolic phospholipase A2 in allergic response and parturition. | 1997 | Nature | pmid:9403692 |
| Soubeyrand S et al. | Phospholipase A2 from bovine seminal plasma is a platelet-activating factor acetylhydrolase. | 1998 | Biochem. J. | pmid:9405273 |
| Coffer PJ et al. | Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function. | 1998 | Biochem. J. | pmid:9405284 |
| Tabuchi S et al. | Lipid mediators modulate NMDA receptor currents in a Xenopus oocyte expression system. | 1997 | Neurosci. Lett. | pmid:9406868 |
| Adachi T et al. | PAF analogues capable of inhibiting PAF acetylhydrolase activity suppress migration of isolated rat cerebellar granule cells. | 1997 | Neurosci. Lett. | pmid:9406887 |
| Zinchenko VP et al. | [Effect of structural analogs of platelet activating factor on the intracellular signal transduction in murine peritoneal neutrophils and macrophages of P388D1 line]. | 1997 Sep-Oct | Biofizika | pmid:9410037 |
| Camici M et al. | [Platelet activating factor (PAF) and kidney failure progression]. | 1997 | Minerva Med. | pmid:9411309 |
| Kertscher HP | [PAF-antagonists with lipid structure. 6. Alkylpropandiol lipids with acyl- and ether- structures at the C-3 position and heterocyclic head groups; synthesis, characterization and structure-activity relationship]. | 1997 | Pharmazie | pmid:9411454 |
| Bix GJ and Clark GD | Platelet-activating factor receptor stimulation disrupts neuronal migration In vitro. | 1998 | J. Neurosci. | pmid:9412509 |
| Zimmerman GA et al. | Adhesion and signaling in vascular cell-cell interactions. | 1997 | J. Clin. Invest. | pmid:9413392 |
| Sozzani S et al. | Human monocyte-derived and CD34+ cell-derived dendritic cells express functional receptors for platelet activating factor. | 1997 | FEBS Lett. | pmid:9414103 |
| Manabe H et al. | KF19514, a phosphodieterase 4 and 1 inhibitor, inhibits PAF-induced lung inflammatory responses by inhaled administration in guinea pigs. | 1997 | Int. Arch. Allergy Immunol. | pmid:9414145 |
| Maeda T et al. | Hemodynamic depression and microthrombosis in the peripheral areas of cortical contusion in the rat: role of platelet activating factor. | 1997 | Acta Neurochir. Suppl. | pmid:9416292 |
| Prescott SM | Inflammatory actions of platelet-activating factor: control by PAF acetylhydrolase. | 1997 Sep-Oct | J Investig Allergol Clin Immunol | pmid:9416565 |
| Mugnai S et al. | Influence of interleukin 1alpha on superoxide anion, platelet activating factor release and phospholipase A2 activity of naive and sensitized guinea-pig alveolar macrophages. | 1997 | Br. J. Pharmacol. | pmid:9421281 |
| Shamsuddin M et al. | Regulation of leukotriene and platelet-activating factor synthesis in human alveolar macrophages. | 1997 | J. Lab. Clin. Med. | pmid:9422335 |
| Matheson MJ et al. | Role of platelet activating factor, leukotrienes and polymorphs in the FMLP induced increase in microvascular leakage in rabbit trachea. | 1997 | Respirology | pmid:9424405 |
| Hichami A et al. | Modulation of platelet-activating-factor production by incorporation of naturally occurring 1-O-alkylglycerols in phospholipids of human leukemic monocyte-like THP-1 cells. | 1997 | Eur. J. Biochem. | pmid:9428670 |
| Igarashi Y | [Physiology of sphingosine 1-phosphate: regulation of cell motility and platelet function]. | 1997 | Seikagaku | pmid:9431007 |
| Shindo K et al. | Inhibitory effect of azelastine hydrochloride on synthesis and release of platelet activating factor from human alveolar macrophages. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9431823 |
| Stack WA and Hawkey CJ | Specific mediator-directed therapy for gastrointestinal diseases. | 1997 | Eur J Gastroenterol Hepatol | pmid:9431894 |
| Bennett SA and Birnboim HC | Receptor-mediated and protein kinase-dependent growth enhancement of primary human fibroblasts by platelet activating factor. | 1997 | Mol. Carcinog. | pmid:9433481 |
| Dupuis F et al. | Production, metabolism and effect of platelet-activating factor on the growth of the human K562 erythroid cell line. | 1997 | Biochim. Biophys. Acta | pmid:9434130 |
| Li CL and Wong YY | The bioavailability of ginkgolides in Ginkgo biloba extracts. | 1997 | Planta Med. | pmid:9434615 |
| Albert DH et al. | The role of platelet-activating factor (PAF) and the efficacy of ABT-491, a highly potent and selective PAF antagonist, in experimental allergic rhinitis. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9435164 |
| Gamaley IA et al. | Superoxide release is involved in membrane potential changes in mouse peritoneal macrophages. | 1998 | Free Radic. Biol. Med. | pmid:9436627 |
| Tsoukatos DC et al. | Copper-catalyzed oxidation mediates PAF formation in human LDL subspecies. Protective role of PAF:acetylhydrolase in dense LDL. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9437199 |
| Curtin ML et al. | Discovery and evaluation of a series of 3-acylindole imidazopyridine platelet-activating factor antagonists. | 1998 | J. Med. Chem. | pmid:9438024 |
| De Matos IM et al. | Lung oedema induced by Tityus serrulatus scorpion venom in the rat. | 1997 | Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. | pmid:9440240 |
| Kokura S et al. | Effects of rebamipide, a novel anti-ulcer agent, on gastric mucosal injury induced by platelet-activating factor in rats. | 1997 | Dig. Dis. Sci. | pmid:9440637 |
| Lee EK and Kehrli ME | Expression of adhesion molecules on neutrophils of periparturient cows and neonatal calves. | 1998 | Am. J. Vet. Res. | pmid:9442240 |
| Sugimoto Y et al. | Effects of apafant on PAF-induced downregulation of beta-adrenoceptors in guinea pigs. | 1997 | Methods Find Exp Clin Pharmacol | pmid:9442478 |
| Murohara T et al. | Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin. | 1998 Jan 6-13 | Circulation | pmid:9443437 |
| LeVan TD et al. | Platelet-activating factor induction of activator protein-1 signaling in bronchial epithelial cells. | 1998 | Mol. Pharmacol. | pmid:9443941 |
| Nilsson J et al. | Lipoprotein-like phospholipid particles inhibit the smooth muscle cell cytotoxicity of lysophosphatidylcholine and platelet-activating factor. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9445250 |
| Dent G et al. | Protein kinase C inhibition enhances platelet-activating factor-induced eicosanoid production in human eosinophils. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9448055 |
| Moore RM et al. | Effect of platelet-activating factor antagonist L-691,880 on low-flow ischemia-reperfusion injury of the large colon in horses. | 1998 Jan-Feb | Vet Surg | pmid:9449176 |
| van der Bruggen T et al. | Cytokine-induced protein tyrosine phosphorylation is essential for cytokine priming of human eosinophils. | 1998 | J. Allergy Clin. Immunol. | pmid:9449508 |
| Shah BH et al. | Role of phosphatidylinositol 3-kinase in human platelet aggregation. | 1997 | Biochem. Soc. Trans. | pmid:9450028 |
| Akagi M et al. | Inhibitor effect of apafant on bronchopulmonary responses to platelet activating factor and to antigen in rats. | 1997 | Arzneimittelforschung | pmid:9450165 |
| Hirashima Y et al. | Platelet-activating factor and edema surrounding meningiomas. | 1998 | J. Neurosurg. | pmid:9452240 |
| Oancea E et al. | Green fluorescent protein (GFP)-tagged cysteine-rich domains from protein kinase C as fluorescent indicators for diacylglycerol signaling in living cells. | 1998 | J. Cell Biol. | pmid:9456311 |
| Suzuki M et al. | Continuous binding of the PAF molecule to its receptor is necessary for the long-term aggregation of platelets. | 1998 | Am. J. Physiol. | pmid:9458712 |
| Cao Y et al. | Expression of plasma platelet-activating factor acetylhydrolase is transcriptionally regulated by mediators of inflammation. | 1998 | J. Biol. Chem. | pmid:9461591 |
| Kulikov VI and Muzya GI | Ether lipids and platelet-activating factor: evolution and cellular function. | 1997 | Biochemistry Mosc. | pmid:9461631 |
| Sibelius U et al. | Wegener's granulomatosis: anti-proteinase 3 antibodies are potent inductors of human endothelial cell signaling and leakage response. | 1998 | J. Exp. Med. | pmid:9463400 |
| Winkler JD et al. | Beta-lactams SB 212047 and SB 216754 are irreversible, time-dependent inhibitors of coenzyme A-independent transacylase. | 1998 | Mol. Pharmacol. | pmid:9463491 |
| Kruse-Elliott KT et al. | Role of lipid-derived mediators in tumor necrosis factor-induced endothelin-1 release in vivo. | 1998 | Shock | pmid:9466472 |
| Wang HG et al. | The role of endogenous nitric oxide in the sympathetic and hemodynamic response to platelet activating factor-induced hypotension in anesthetized dogs. | 1998 | Shock | pmid:9466475 |