Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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McClenahan DJ et al. | Role of platelet-activating factor in alveolar septal injury associated with experimentally induced pneumonic pasteurellosis in calves. | 2000 | Am. J. Vet. Res. | pmid:10714514 |
Kingston JK et al. | Effects of formaldehyde fixation on equine platelets using flow cytometric methods to evaluate markers of platelet activation. | 2002 | Am. J. Vet. Res. | pmid:12061530 |
Dodam JR et al. | Effect of pertussis toxin and B-oligomer on platelet-activating factor-induced generation of inositol phosphates in porcine alveolar macrophages. | 1996 | Am. J. Vet. Res. | pmid:8712527 |
Weiss DJ and Evanson OA | Detection of activated platelets and platelet-leukocyte aggregates in horses. | 1997 | Am. J. Vet. Res. | pmid:9256963 |
Tsuchiya R et al. | Role of platelet activating factor in development of thrombocytopenia and neutropenia in dogs with endotoxemia. | 1999 | Am. J. Vet. Res. | pmid:10048555 |
Watanabe M et al. | Characterization of platelet-activating factor-induced cutaneous edema and erythema in dogs. | 2016 | Am. J. Vet. Res. | pmid:27580108 |
Lee EK and Kehrli ME | Expression of adhesion molecules on neutrophils of periparturient cows and neonatal calves. | 1998 | Am. J. Vet. Res. | pmid:9442240 |
Wilson DV and Stick JA | Effect of a specific platelet-activating factor antagonist on cardiovascular and peripheral cellular responses to colonic ischemia and reperfusion in anesthetized ponies. | 1993 | Am. J. Vet. Res. | pmid:8498751 |
Tan WC and Bethel RA | The effect of platelet activating factor antagonist on ozone-induced airway inflammation and bronchial hyperresponsiveness in guinea pigs. | 1992 | Am. Rev. Respir. Dis. | pmid:1416419 |
Lohman IC and Halonen M | The effects of combined histamine and platelet-activating factor antagonism on systemic anaphylaxis induced by immunoglobulin E in the rabbit. | 1993 | Am. Rev. Respir. Dis. | pmid:8484635 |
Hamasaki Y et al. | Platelet-activating factor raises airway and vascular pressures and induces edema in lungs perfused with platelet-free solution. | 1984 | Am. Rev. Respir. Dis. | pmid:6547031 |
Boschetto P et al. | Corticosteroid inhibition of airway microvascular leakage. | 1991 | Am. Rev. Respir. Dis. | pmid:2001074 |
Stengel PW et al. | Inhaled A23187 produces a preferential sensitization to substance P. | 1993 | Am. Rev. Respir. Dis. | pmid:7678372 |
Daniel EE and O'Byrne P | Effect of inflammatory mediators on airway nerves and muscle. | 1991 | Am. Rev. Respir. Dis. | pmid:2003686 |
Meade CJ and Heuer H | PAF antagonism as an approach to the treatment of airway hyperreactivity. | 1991 | Am. Rev. Respir. Dis. | pmid:2003696 |
Rylander R and Beijer L | Inhalation of endotoxin stimulates alveolar macrophage production of platelet-activating factor. | 1987 | Am. Rev. Respir. Dis. | pmid:3541718 |
Smith LJ | The role of platelet-activating factor in asthma. | 1991 | Am. Rev. Respir. Dis. | pmid:2018248 |
Henderson WR | Eicosanoids and platelet-activating factor in allergic respiratory diseases. | 1991 | Am. Rev. Respir. Dis. | pmid:1902069 |
Christman BW et al. | Effect of platelet-activating factor on aerosol histamine responsiveness in awake sheep. | 1987 | Am. Rev. Respir. Dis. | pmid:3592402 |
Benveniste J | A role for paf-acether (platelet-activating factor) in bronchial hyperreactivity? | 1987 | Am. Rev. Respir. Dis. | pmid:3592414 |
Halonen M et al. | Differential effects of platelet depletion on the physiologic alterations of IgE anaphylaxis and acetyl glyceryl ether phosphorylcholine infusion in the rabbit. | 1981 | Am. Rev. Respir. Dis. | pmid:7294504 |
Ohar JA et al. | A rabbit model of pulmonary hypertension induced by the synthetic platelet-activating factor acetylglyceryl ether phosphorylcholine. | 1990 | Am. Rev. Respir. Dis. | pmid:2297169 |
Lohman I and Halonen M | Effects of the PAF antagonist WEB 2086 on PAF-induced physiologic alterations and on IgE anaphylaxis in the rabbit. | 1990 | Am. Rev. Respir. Dis. | pmid:2382903 |
Stenmark KR et al. | Potential role of eicosanoids and PAF in the pathophysiology of bronchopulmonary dysplasia. | 1987 | Am. Rev. Respir. Dis. | pmid:3631747 |
Lien DC et al. | Platelet-activating factor causes neutrophil accumulation and neutrophil-mediated increased vascular permeability in canine trachea. | 1992 | Am. Rev. Respir. Dis. | pmid:1546852 |
Oda M et al. | The presence of platelet-activating factor associated with eosinophil and/or neutrophil accumulations in the pleural fluids. | 1990 | Am. Rev. Respir. Dis. | pmid:2350088 |
Nakajima H et al. | CD4+ T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea. | 1992 | Am. Rev. Respir. Dis. | pmid:1362635 |
Henson PM et al. | NHLBI workshop summary. Platelet-activating factor: role in pulmonary injury and dysfunction and blood abnormalities. | 1992 | Am. Rev. Respir. Dis. | pmid:1312316 |
Schellenberg RR | Airway responses to platelet-activating factor. | 1987 | Am. Rev. Respir. Dis. | pmid:3310779 |
Miadonna A et al. | Evidence of PAF-acether metabolic pathway activation in antigen challenge of upper respiratory airways. | 1989 | Am. Rev. Respir. Dis. | pmid:2546468 |
Pretolani M et al. | Protection by nedocromil sodium of active immunization-induced bronchopulmonary alterations in the guinea pig. | 1990 | Am. Rev. Respir. Dis. | pmid:2160213 |
Schleimer RP et al. | Characterization of inflammatory mediator release from purified human lung mast cells. | 1986 | Am. Rev. Respir. Dis. | pmid:3485946 |
Morgan WK et al. | Byssinosis: some unanswered questions. | 1982 | Am. Rev. Respir. Dis. | pmid:6808880 |
Horvath CJ et al. | Role of platelet-activating factor in mediating tumor necrosis factor alpha-induced pulmonary vasoconstriction and plasma-lymph protein transport. | 1991 | Am. Rev. Respir. Dis. | pmid:1741548 |
Zimmerman GA et al. | Production of platelet-activating factor, a biologically active lipid, by vascular endothelial cells. | 1987 | Am. Rev. Respir. Dis. | pmid:3300444 |
Murphy RC and Clay KL | Measurement of platelet-activating factor by physicochemical technique s. | 1987 | Am. Rev. Respir. Dis. | pmid:3300445 |
Page CP | Mechanisms of hyperresponsiveness: platelet-activating factor. | 1992 | Am. Rev. Respir. Dis. | pmid:1734810 |
Halonen M et al. | Respiratory and circulatory alterations induced by acetyl glyceryl ether phosphorylcholine, a mediator of IgE anaphylaxis in the rabbit. | 1980 | Am. Rev. Respir. Dis. | pmid:7458063 |
Scappaticci E et al. | Platelet-activating factor in bronchoalveolar lavage from patients with sarcoidosis. | 1992 | Am. Rev. Respir. Dis. | pmid:1336939 |
Tokuyama K et al. | Mechanism of airway narrowing caused by inhaled platelet-activating factor. Role of airway microvascular leakage. | 1991 | Am. Rev. Respir. Dis. | pmid:2048823 |
Lansing MW et al. | Lipid mediators contribute to oxygen-radical-induced airway responses in sheep. | 1991 | Am. Rev. Respir. Dis. | pmid:1741541 |
Ohar JA et al. | Platelet-activating factor induces selective pulmonary arterial hyperreactivity in isolated perfused rabbit lungs. | 1993 | Am. Rev. Respir. Dis. | pmid:8317792 |
Watson JW et al. | IgG1-mediated acute pulmonary hypersensitivity response in the guinea pig. Involvement of specific lipid mediators. | 1990 | Am. Rev. Respir. Dis. | pmid:2240832 |
Tocker JE et al. | Phospholipase A2-induced pulmonary and hemodynamic responses in the guinea pig. Effects of enzyme inhibitors and mediators antagonists. | 1990 | Am. Rev. Respir. Dis. | pmid:2240843 |
Kidney JC et al. | Inhibition of platelet-activating factor-induced bronchoconstriction by the leukotriene D4 receptor antagonist ICI 204,219. | 1993 | Am. Rev. Respir. Dis. | pmid:8420421 |
Lellouch-Tubiana A et al. | Eosinophil recruitment into guinea pig lungs after PAF-acether and allergen administration. Modulation by prostacyclin, platelet depletion, and selective antagonists. | 1988 | Am. Rev. Respir. Dis. | pmid:3281530 |
Kuitert LM et al. | Effect of the platelet-activating factor antagonist UK-74,505 on the early and late response to allergen. | 1993 | Am. Rev. Respir. Dis. | pmid:8420437 |
Wardlaw AJ et al. | Effects of inhaled PAF in humans on circulating and bronchoalveolar lavage fluid neutrophils. Relationship to bronchoconstriction and changes in airway responsiveness. | 1990 | Am. Rev. Respir. Dis. | pmid:2405759 |
Gulbenkian AR et al. | Anaphylactic challenge causes eosinophil accumulation in bronchoalveolar lavage fluid of guinea pigs. Modulation by betamethasone, phenidone, indomethacin, WEB 2086, and a novel antiallergy agent, SCH 37224. | 1990 | Am. Rev. Respir. Dis. | pmid:2117872 |
Tam FW et al. | Inhaled platelet-activating factor causes pulmonary neutrophil sequestration in normal humans. | 1992 | Am. Rev. Respir. Dis. | pmid:1416388 |