Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Kochanek PM et al. | Platelet activating factor antagonists do not alter normal cerebral blood flow or cerebral oxygen consumption. | 1990 | Adv. Exp. Med. Biol. | pmid:2096640 |
Camussi G et al. | Antiflammins inhibit synthesis of platelet-activating factor and intradermal inflammatory reactions. | 1990 | Adv. Exp. Med. Biol. | pmid:2096695 |
Bussolino F et al. | Role of platelet activating factor in the adhesion process of polymorphonuclear neutrophils to endothelial cells. | 1991 | Adv. Exp. Med. Biol. | pmid:1767755 |
Droy-Lefaix MT et al. | Effect of the platelet-activating factor (PAF) antagonist, BN 52021, on free radical-induced intestinal ischemia-reperfusion damage in the rat. | 1990 | Adv. Exp. Med. Biol. | pmid:2244522 |
Damas J et al. | Endotoxin shock, kinin system and PAF-acether in the rat. | 1989 | Adv. Exp. Med. Biol. | pmid:2610092 |
Vadas P and Pruzanski W | Phospholipase A2 activation is the pivotal step in the effector pathway of inflammation. | 1990 | Adv. Exp. Med. Biol. | pmid:2239447 |
Kornecki E et al. | Interactions of the alkyl-ether-phospholipid, platelet activating factor (PAF) with platelets, neural cells, and the psychotropic drugs triazolobenzodiazepines. | 1987 | Adv. Exp. Med. Biol. | pmid:2893525 |
MacIntyre DE et al. | Agonist-induced inositol phospholipid metabolism and Ca++ flux in human platelet activation. | 1985 | Adv. Exp. Med. Biol. | pmid:3010662 |
Hallam TJ et al. | Control and interrelation of aggregation and secretion; the roles of Ca2+, diacylglycerol and thromboxane with particular reference to ADP stimulation. | 1985 | Adv. Exp. Med. Biol. | pmid:3010663 |
Gerrard JM et al. | Platelet protein phosphorylation. | 1985 | Adv. Exp. Med. Biol. | pmid:3010667 |
Haslam RJ et al. | Receptor-effector coupling in platelets: roles of guanine nucleotides. | 1985 | Adv. Exp. Med. Biol. | pmid:3010668 |
Bourgain RH et al. | Vivo effects of PAF-acether and arterial thrombosis. | 1986 | Adv. Exp. Med. Biol. | pmid:3799334 |
Maes L et al. | In vivo arterial platelet-vessel wall interaction and thrombosis: induction, on-line registration and ultrastructural control. | 1985 | Adv. Exp. Med. Biol. | pmid:3832867 |
Tuffin DP et al. | Specific binding of [3H]-1-O-octadecyl Paf-acether to washed human platelets. | 1985 | Adv. Exp. Med. Biol. | pmid:3834789 |
Kurachi M et al. | Suppression of bronchial response to platelet activating factor following taurine administration. | 1987 | Adv. Exp. Med. Biol. | pmid:3434419 |
Braquet P and Bourgain RH | Anti-anaphylactic properties of BN 52021: a potent platelet activating factor antagonist. | 1987 | Adv. Exp. Med. Biol. | pmid:3314403 |
Proceedings of an International Symposium on Mechanisms of Platelet Activation and Control. London, United Kingdom, April 13-14, 1992. | 1993 | Adv. Exp. Med. Biol. | pmid:7911646 | |
Hanahan DJ | The continuing biochemical challenge of PAF and closely related lipid mediators. | 1996 | Adv. Exp. Med. Biol. | pmid:9131117 |
Snyder F et al. | Biosynthesis of platelet-activating factor and enzyme inhibitors. | 1996 | Adv. Exp. Med. Biol. | pmid:9131118 |
Satoh K et al. | Production of platelet-activating factor by brain microvascular endothelial cells. | 1996 | Adv. Exp. Med. Biol. | pmid:9131120 |
Francescangeli E et al. | PAF-synthesizing enzymes in neural cells during differentiation and in gerbil brain during ischemia. | 1996 | Adv. Exp. Med. Biol. | pmid:9131121 |
Yamada M et al. | Platelet-activating factor production in the stimulated macrophages is enhanced by the cyclooxygenase inhibitors. | 1996 | Adv. Exp. Med. Biol. | pmid:9131122 |
van den Bosch H et al. | The role of peroxisomes in ether lipid synthesis. Back to the roots of PAF. | 1996 | Adv. Exp. Med. Biol. | pmid:9131123 |
Dohi T et al. | Platelet-activating factor synthesis and its role in salivary glands. | 1996 | Adv. Exp. Med. Biol. | pmid:9131124 |
Nakayama R et al. | Physiological action of PAF in yeast Saccharomyces cerevisiae. | 1996 | Adv. Exp. Med. Biol. | pmid:9131125 |
Demopoulos CA and Antonopoulou S | A discovery trip to compounds with PAF-like activity. | 1996 | Adv. Exp. Med. Biol. | pmid:9131127 |
Rementzis J et al. | Biologically active lipids from S. scombrus. | 1996 | Adv. Exp. Med. Biol. | pmid:9131128 |
Orevi M et al. | Purification and partial characterization of the PAF antagonist from the saliva of the leech Hirudo medicinalis. | 1996 | Adv. Exp. Med. Biol. | pmid:9131129 |
Shimizu T et al. | Platelet-activating factor receptor. Gene structure and tissue-specific regulation. | 1996 | Adv. Exp. Med. Biol. | pmid:9131130 |
Sato S et al. | Up-regulation of the intracellular Ca2+ signaling and mRNA expression of platelet-activating factor receptor by estradiol in human uterine endometrial cells. | 1996 | Adv. Exp. Med. Biol. | pmid:9131133 |
Dohi T et al. | Functional role of platelet-activating factor receptor in secretory response in adrenal chromaffin cells. | 1996 | Adv. Exp. Med. Biol. | pmid:9131134 |
Lee T | Acetylation of sphingosine by PAF-dependent transacetylase. | 1996 | Adv. Exp. Med. Biol. | pmid:9131136 |
Muguruma K et al. | The prevention of necrotizing enterocolitis. The role of platelet-activating factor acetylhydrolase. | 1996 | Adv. Exp. Med. Biol. | pmid:9131138 |
Baltas G et al. | Implication of PAF and acetylhydrolase (PAF-AH) activity in periodontal disease. | 1996 | Adv. Exp. Med. Biol. | pmid:9131139 |
Korth RM | Non-specific PAF binding to embryonal F9 cells and prostacyclin synthesis in human umbilical vein endothelial cells. | 1996 | Adv. Exp. Med. Biol. | pmid:9131162 |
Zimmerman GA et al. | Platelet-activating factor (PAF): signalling and adhesion in cell-cell interactions. | 1996 | Adv. Exp. Med. Biol. | pmid:9131163 |
Yang HC et al. | Characterization of plasmalogen-selective phospholipase A2 from bovine brain. | 1996 | Adv. Exp. Med. Biol. | pmid:9131165 |
Ferby I et al. | PAF-induced MAPK activation is inhibited by wortmannin in neutrophils and macrophages. | 1996 | Adv. Exp. Med. Biol. | pmid:9131167 |
Thierse HJ et al. | Evidence for activation of cyclooxygenase-1/-2 by endogenous nitric oxide in adjuvant arthritic Lewis rats. | 1996 | Adv. Exp. Med. Biol. | pmid:9131171 |
Curtis LD | Lexipafant (BB-882), a potent PAF antagonist in acute pancreatitis. | 1996 | Adv. Exp. Med. Biol. | pmid:9131174 |
McKay C et al. | The use of lexipafant in the treatment of acute pancreatitis. | 1996 | Adv. Exp. Med. Biol. | pmid:9131175 |
Tamura G et al. | Effect of a potent platelet-activating factor antagonist, WEB-2086, on asthma. A multicenter, double-blind placebo-controlled study in Japan. | 1996 | Adv. Exp. Med. Biol. | pmid:9131176 |
Albert DH et al. | Ex vivo inhibition of PAF-induced beta-thromboglobulin release in man by ABT-299, a potent PAF antagonist. | 1996 | Adv. Exp. Med. Biol. | pmid:9131177 |
Elizarova EP | Effects of taurine on calcium in platelets and their aggregation. | 1996 | Adv. Exp. Med. Biol. | pmid:8915398 |
Michibayashi T | Neurogenic inhibitory action through platelets of platelet activating factor (PAF) on vasoconstrictive responsiveness to pressor agents. | 1997 | Adv. Exp. Med. Biol. | pmid:9561145 |
Ishii I et al. | High and low affinity mutants of platelet-activating factor receptor. | 1997 | Adv. Exp. Med. Biol. | pmid:9561146 |
Bazan NG | Bioactive lipids and gene expression in neuronal plasticity. | 1998 | Adv. Exp. Med. Biol. | pmid:10079836 |
Marshall LA et al. | Respective roles of the 14 kDa and 85 kDa phospholipase A2 enzymes in human monocyte eicosanoid formation. | 1999 | Adv. Exp. Med. Biol. | pmid:10667333 |
Kato K | Modulation of long-term potentiation in the CA1 area of rat hippocampus by platelet-activating factor. | 1999 | Adv. Exp. Med. Biol. | pmid:10667334 |
Goldman R et al. | Lipid mediators stimulate reactive oxygen species formation in immortalized human keratinocytes. | 1999 | Adv. Exp. Med. Biol. | pmid:10667361 |
Winkler JD et al. | Inhibitors of arachidonate metabolism and effects on PAF production. | 1996 | Adv. Exp. Med. Biol. | pmid:9131119 |
Armant DR | Intracellular Ca2+ signaling and preimplantation development. | 2015 | Adv. Exp. Med. Biol. | pmid:25956298 |
Pirotzky E et al. | Involvement of platelet-activating factor in renal processes. | 1989 | Adv. Lipid Res. | pmid:2698054 |
Holleran WM | Lipid modulators of epidermal proliferation and differentiation. | 1991 | Adv. Lipid Res. | pmid:1763711 |
Koltai M et al. | Platelet-activating factor antagonists: scientific background and possible clinical applications. | 1994 | Adv. Pharmacol. | pmid:8080821 |
Summers JB and Albert DH | Platelet activating factor antagonists. | 1995 | Adv. Pharmacol. | pmid:7748804 |
Sullivan MH et al. | Altered platelet responses to P.A.F. in pregnancy-induced hypertension. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825415 |
Braquet P et al. | From ginkgolides to N-substituted piperidino-thieno diazepines, a new series of highly potent dual antagonists. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825436 |
Berti F et al. | Opposite effects of PGI2 and PAF generated during acute myocardial ischemia in the perfused rabbit heart. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825437 |
Takatani M et al. | Platelet activating factor (PAF) antagonists: development of a highly potent PAF antagonist, TCV-309. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825438 |
Kawabe T et al. | Role of PAF and cytokines in the modulation of Fc epsilon RII/CD23 expression on human eosinophils. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825444 |
Weber PC and Sellmayer A | Modification of the eicosanoid system and cell signalling by precursor fatty acids. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825543 |
Balazy M et al. | A novel method for the analysis of PAF and alkyl-ether phospholipids by mass spectrometry. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825562 |
Magni F et al. | Determination of platelet-activating factor in biological samples by high resolution mass spectrometry. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825563 |
Coceani F et al. | Leukotrienes in cerebrospinal fluid of the conscious cat: effect of platelet-activating factor and pyrogens. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825586 |
Shen TY et al. | Recent development of platelet-activating factor antagonists. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2546389 |
Handley DA et al. | Chemistry and pharmacology of PAF antagonists. Evaluation of changes at potential metabolism sites on activity and duration of activity. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2546390 |
Dray F et al. | Recent studies on icosanoids and PAF-acether modulation of some central neurosecretions in the rat. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2546391 |
Desquand S et al. | Interference of the PAF-acether antagonist BN 52021 with anaphylaxis in the guinea pig. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2445183 |
Benveniste J | PAF-acether (platelet-activating factor). | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526498 |
Hsueh W and Sun XM | Tumor necrosis factor-induced bowel necrosis: the role of platelet-activating factor. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526499 |
Pignol B et al. | Effect of chronic administration of platelet-activating factor (PAF) in the guinea-pig and the rat. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526500 |
Foegh ML et al. | Platelet-activating factor in organ transplant rejection. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526501 |
Pickett WC and Ramesha C | Modulation of mediator precursors by changes in essential fatty acid composition. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526546 |
Bussolino F et al. | Chick retina generates platelet-activating factor. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2890284 |
Braquet P | Proofs of involvement of PAF-acether in various immune disorders using BN 52021 (ginkgolide B): a powerful PAF-acether antagonist isolated from Ginkgo biloba L. | 1986 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2949548 |
Foegh ML et al. | Leukotrienes, thromboxane, and platelet activating factor in organ transplantation. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959038 |
Robertson DN and Smith GM | Role of thromboxane A2, 5-hydroxytryptamine, and platelet activating factor in collagen-induced sudden death in rabbits. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959049 |
d'Humieres S et al. | Platelet activating factor acether is involved in thrombin-induced synthesis of prostacyclin by human endothelial cells. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959051 |
Whittle BJ et al. | Gastric vascular and mucosal damaging actions of platelet activating factor in the canine stomach. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959063 |
Montrucchio G et al. | In vitro oxytocic activity of platelet-activating factor on human myometrium. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960158 |
Mallet AI et al. | Platelet activating factor in chronic plaque psoriasis. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960170 |
Bourgain RH et al. | Effect of ginkgolide PAF-acether antagonists on arterial thrombosis. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960196 |
Braquet P et al. | Platelet-activating factor: a potential mediator of shock. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960197 |
Myers A et al. | Pharmacological manipulation of platelet-activating factor toxicity in rodents. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960198 |
Benveniste J | Biosynthesis and function of PAF-acether (platelet-activating factor). | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936197 |
Waku K et al. | Metabolism of 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a precursor of platelet-activating factor in macrophages. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936199 |
Saito K et al. | Determination of AGEPC generated from human neutrophils and rat skin and muscle tissues by a selected ion monitoring technique of GC/MS. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936200 |
Hanahan DJ et al. | Platelet-activating factor: a unique lipid chemical mediator. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936201 |
Inoue K et al. | Activation of guinea pig peritoneal macrophages by platelet-activating factor in free form or incorporated into liposomes. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936203 |
Benveniste J | Paf-acether (platelet-activating factor). | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3159192 |
Matsumoto M and Miwa M | Platelet-activating factor-binding protein in human serum. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3004155 |
Terashita Z et al. | Beneficial effects of (RS)-2-methoxy-3-(octadecylcarbamoyloxy)propyl 2-(3-thiazolio)ethyl phosphate, a specific PAF antagonist, in endotoxin and anaphylactic shock. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3004156 |
Livio M et al. | A platelet-activating factor receptor antagonist protects against renal function deterioration in nephrotoxic nephritis. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2823570 |
Vargaftig BB et al. | Synergized activation of human platelets by epinephrine and platelet-activating factor-acether is adenosine diphosphate and thromboxane A2-independent. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221558 |
Voelkel NF et al. | Platelet-activating factor causes pulmonary vasoconstriction and edema via platelet-independent leukotriene formation. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221590 |
Izumi T et al. | Regulation and signal transduction of PAF receptor. | 1995 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7732892 |
Bennett SA and Birnboim HC | Platelet activating factor induces transformation of human fibroblasts. | 1995 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7732893 |
Summers JB et al. | ABT-299, a potent antagonist of platelet activating factor. | 1995 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7732895 |
Vincent D et al. | Dissociation between LPS-induced bronchial hyperreactivity and airway edema in the guinea-pig. | 1991 | Agents Actions | pmid:1793031 |