Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yang HQ et al. | PMS777, a new cholinesterase inhibitor with anti-platelet activated factor activity, regulates amyloid precursor protein processing in vitro. | 2009 | Neurochem. Res. | pmid:18758955 |
| Steel HC et al. | Posaconazole attenuates leukotriene B4 release and uptake of calcium by chemoattractant-activated human neutrophils: a potential strategy to control neutrophil-mediated inflammation. | 2009 | J. Antimicrob. Chemother. | pmid:19744985 |
| Seki M et al. | Expression and DNA microarray analysis of a platelet activating factor-related molecule in severe pneumonia in mice due to influenza virus and bacterial co-infection. | 2009 | Jpn. J. Infect. Dis. | pmid:19168951 |
| Schneider DJ and Sobel BE | Streamlining the design of promising clinical trials: in-vitro testing of antithrombotic regimens and multiple agonists of platelet activation. | 2009 | Coron. Artery Dis. | pmid:19194284 |
| Li J et al. | Protection of PMS777, a new AChE inhibitor with PAF antagonism, against amyloid-beta-induced neuronal apoptosis and neuroinflammation. | 2009 | Cell. Mol. Neurobiol. | pmid:19194797 |
| Fité-Mora R | Torsade de pointes associated with rupatadine. | 2009 | Rev Esp Cardiol | pmid:19268083 |
| Kim DD et al. | Independent regulation of periarteriolar and perivenular nitric oxide mechanisms in the in vivo hamster cheek pouch microvasculature. | 2009 | Microcirculation | pmid:19235626 |
| Musio S et al. | Anaphylaxis to a self-peptide in the absence of mast cells or histamine. | 2009 | Lab. Invest. | pmid:19188909 |
| Welch EJ et al. | Opposing effects of platelet-activating factor and lyso-platelet-activating factor on neutrophil and platelet activation. | 2009 | Mol. Pharmacol. | pmid:18931035 |
| Rastogi P and McHowat J | Inhibition of calcium-independent phospholipase A2 prevents inflammatory mediator production in pulmonary microvascular endothelium. | 2009 | Respir Physiol Neurobiol | pmid:19059366 |
| Wen J et al. | Simultaneous determination of rupatadine and its metabolite desloratadine in human plasma by a sensitive LC-MS/MS method: application to the pharmacokinetic study in healthy Chinese volunteers. | 2009 | J Pharm Biomed Anal | pmid:19059745 |
| Rehse K et al. | New 1H-pyrazole-4-carboxamides with antiplatelet activity. | 2009 | Arch. Pharm. (Weinheim) | pmid:19051198 |
| Detopoulou P et al. | Platelet activating factor (PAF) and activity of its biosynthetic and catabolic enzymes in blood and leukocytes of male patients with newly diagnosed heart failure. | 2009 | Clin. Biochem. | pmid:18955040 |
| Giannattasio G et al. | Expression of phospholipases A2 in primary human lung macrophages: role of cytosolic phospholipase A2-alpha in arachidonic acid release and platelet activating factor synthesis. | 2009 | Biochim. Biophys. Acta | pmid:19130898 |
| Coy ED et al. | Macrophyllin-type bicyclo[3.2.1]octanoid neolignans from the leaves of Pleurothyrium cinereum. | 2009 | J. Nat. Prod. | pmid:19548690 |
| Coy-Barrera ED et al. | PAF-antagonistic bicyclo[3.2.1]octanoid neolignans from leaves of Ocotea macrophylla Kunth. (Lauraceae). | 2009 | Phytochemistry | pmid:19674762 |
| Kordan W et al. | Effect of platelet-activating factor on motility, plasmalemma integrity, the process of capacitation and acrosome reaction of fresh and cryopreserved boar spermatozoa. | 2009 | Pol J Vet Sci | pmid:19645346 |
| Poisson C et al. | Caveolae facilitate but are not essential for platelet-activating factor-mediated calcium mobilization and extracellular signal-regulated kinase activation. | 2009 | J. Immunol. | pmid:19620302 |
| Jeong YI et al. | The novel role of platelet-activating factor in protecting mice against lipopolysaccharide-induced endotoxic shock. | 2009 | PLoS ONE | pmid:19652714 |
| Keck M et al. | Pathophysiology of burns. | 2009 | Wien Med Wochenschr | pmid:19652939 |
| Tung JP et al. | Respiratory burst function of ovine neutrophils. | 2009 | BMC Immunol. | pmid:19422720 |
| Penna C et al. | Post-ischaemic activation of kinases in the pre-conditioning-like cardioprotective effect of the platelet-activating factor. | 2009 | Acta Physiol (Oxf) | pmid:19432589 |
| Dutra PM et al. | Stimulation of Leishmania tropica protein kinase CK2 activities by platelet-activating factor (PAF). | 2009 | Acta Trop. | pmid:19433049 |
| Cheng L et al. | HCl-activated neural and epithelial vanilloid receptors (TRPV1) in cat esophageal mucosa. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19389802 |
| He YG et al. | Functional analysis of platelet-activating factor in the retinal pigment epithelial cells and choroidal endothelial cells. | 2009 | Curr. Eye Res. | pmid:19958112 |
| Zhang X et al. | Effect of baicalin on inflammatory mediator levels and microcirculation disturbance in rats with severe acute pancreatitis. | 2009 | Pancreas | pmid:19657312 |
| Guo CJ et al. | The synthesis and biological evaluation of 10-O-dialkylaminoethyl ginkgolide B as platelet-activating factor antagonist. | 2008 Sep-Oct | J Asian Nat Prod Res | pmid:19003620 |
| Kurdiumov IN et al. | [Cerebrovascular and antiaggregative effects of GABA-docosahexaenoyldopamine conjugate]. | 2008 Jul-Aug | Eksp Klin Farmakol | pmid:18819437 |
| Chamogeorgakis TP et al. | Effect of N-acetyl-L-cysteine on lung ischaemia reperfusion injury in a porcine experimental model. | 2008 Jan-Feb | ANZ J Surg | pmid:18199211 |
| Kikuchi M et al. | Platelet-activating factor (PAF) increases NO production in human endothelial cells-real-time monitoring by DAR-4M AM. | 2008 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18502110 |
| Steel HC et al. | Comparison of the anti-inflammatory activities of imidazole antimycotics in relation to molecular structure. | 2008 | Chem Biol Drug Des | pmid:18924285 |
| Shibamoto T et al. | PAF, rather than histamine, participates in mouse anaphylactic hypotension. | 2008 | Pharmacology | pmid:18583921 |
| Penna C et al. | The platelet activating factor triggers preconditioning-like cardioprotective effect via mitochondrial K-ATP channels and redox-sensible signaling. | 2008 | J. Physiol. Pharmacol. | pmid:18441387 |
| Bang UC et al. | Pharmacological approach to acute pancreatitis. | 2008 | World J. Gastroenterol. | pmid:18494044 |
| Kihara Y et al. | Platelet-activating factor production in the spinal cord of experimental allergic encephalomyelitis mice via the group IVA cytosolic phospholipase A2-lyso-PAFAT axis. | 2008 | J. Immunol. | pmid:18802104 |
| Wislet-Gendebien S et al. | Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors. | 2008 | BMC Neurosci | pmid:18808659 |
| Zheng M et al. | (3S)-N-(L-Aminoacyl)-1,2,3,4-tetrahydroisoquinolines, a class of novel antithrombotic agents: synthesis, bioassay, 3D QSAR, and ADME analysis. | 2008 | Bioorg. Med. Chem. | pmid:18835178 |
| Rastogi P et al. | Tryptase activates calcium-independent phospholipase A2 and releases PGE2 in airway epithelial cells. | 2008 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:18790994 |
| Li J et al. | PMS777, a bis-interacting ligand for PAF receptor antagonism and AChE inhibition, attenuates PAF-induced neurocytotoxicity in SH-SY5Y cells. | 2008 | Cell. Mol. Neurobiol. | pmid:17712622 |
| Kasperska-Zajac A et al. | Platelet-activating factor (PAF): a review of its role in asthma and clinical efficacy of PAF antagonists in the disease therapy. | 2008 | Recent Pat Inflamm Allergy Drug Discov | pmid:19075994 |
| XUE M et al. | Relationship between platelet activation related factors and polymorphism of related genes in patients with coronary heart disease of blood-stasis syndrome. | 2008 | Chin J Integr Med | pmid:19082798 |
| Torres MI and Rios A | Current view of the immunopathogenesis in inflammatory bowel disease and its implications for therapy. | 2008 | World J. Gastroenterol. | pmid:18395894 |
| Kim HA et al. | Nitric oxide plays a key role in the platelet-activating factor-induced enhancement of resistance against systemic candidiasis. | 2008 | Immunology | pmid:18397269 |
| Galli SJ and Franco CB | Basophils are back! | 2008 | Immunity | pmid:18400194 |
| Levy JH | Platelet-activating factor, PAF acetylhydrolase, and anaphylaxis. | 2008 | N. Engl. J. Med. | pmid:18385504 |
| Ibe BO et al. | Mechanisms by which S-albuterol induces human bronchial smooth muscle cell proliferation. | 2008 | Int. Arch. Allergy Immunol. | pmid:18362475 |
| Tiemann U | The role of platelet-activating factor in the mammalian female reproductive tract. | 2008 | Reprod. Domest. Anim. | pmid:18363604 |
| Burks AW | Peanut allergy. | 2008 | Lancet | pmid:18456104 |
| Huang GD et al. | Effect of volatile oil of amomum on expressions of platelet activating factor and mastocarcinoma-related peptide in the gastric membrane of chronic gastritis patients with helicobacter-pylori infection. | 2008 | Chin J Integr Med | pmid:18568325 |
| Egea L et al. | Increased production of the ether-lipid platelet-activating factor in intestinal epithelial cells infected by Salmonella enteritidis. | 2008 | Biochim. Biophys. Acta | pmid:18442488 |