Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Bussolino F et al. | Role of platelet activating factor in the adhesion process of polymorphonuclear neutrophils to endothelial cells. | 1991 | Adv. Exp. Med. Biol. | pmid:1767755 |
Kornecki E et al. | Interactions of the alkyl-ether-phospholipid, platelet activating factor (PAF) with platelets, neural cells, and the psychotropic drugs triazolobenzodiazepines. | 1987 | Adv. Exp. Med. Biol. | pmid:2893525 |
Gerrard JM et al. | Platelet protein phosphorylation. | 1985 | Adv. Exp. Med. Biol. | pmid:3010667 |
Haslam RJ et al. | Receptor-effector coupling in platelets: roles of guanine nucleotides. | 1985 | Adv. Exp. Med. Biol. | pmid:3010668 |
Braquet P and Bourgain RH | Anti-anaphylactic properties of BN 52021: a potent platelet activating factor antagonist. | 1987 | Adv. Exp. Med. Biol. | pmid:3314403 |
Proceedings of an International Symposium on Mechanisms of Platelet Activation and Control. London, United Kingdom, April 13-14, 1992. | 1993 | Adv. Exp. Med. Biol. | pmid:7911646 | |
Satoh K et al. | Production of platelet-activating factor by brain microvascular endothelial cells. | 1996 | Adv. Exp. Med. Biol. | pmid:9131120 |
Francescangeli E et al. | PAF-synthesizing enzymes in neural cells during differentiation and in gerbil brain during ischemia. | 1996 | Adv. Exp. Med. Biol. | pmid:9131121 |
Yamada M et al. | Platelet-activating factor production in the stimulated macrophages is enhanced by the cyclooxygenase inhibitors. | 1996 | Adv. Exp. Med. Biol. | pmid:9131122 |
van den Bosch H et al. | The role of peroxisomes in ether lipid synthesis. Back to the roots of PAF. | 1996 | Adv. Exp. Med. Biol. | pmid:9131123 |
Dohi T et al. | Platelet-activating factor synthesis and its role in salivary glands. | 1996 | Adv. Exp. Med. Biol. | pmid:9131124 |
Nakayama R et al. | Physiological action of PAF in yeast Saccharomyces cerevisiae. | 1996 | Adv. Exp. Med. Biol. | pmid:9131125 |
Demopoulos CA and Antonopoulou S | A discovery trip to compounds with PAF-like activity. | 1996 | Adv. Exp. Med. Biol. | pmid:9131127 |
Ferby I et al. | PAF-induced MAPK activation is inhibited by wortmannin in neutrophils and macrophages. | 1996 | Adv. Exp. Med. Biol. | pmid:9131167 |
Thierse HJ et al. | Evidence for activation of cyclooxygenase-1/-2 by endogenous nitric oxide in adjuvant arthritic Lewis rats. | 1996 | Adv. Exp. Med. Biol. | pmid:9131171 |
Curtis LD | Lexipafant (BB-882), a potent PAF antagonist in acute pancreatitis. | 1996 | Adv. Exp. Med. Biol. | pmid:9131174 |
McKay C et al. | The use of lexipafant in the treatment of acute pancreatitis. | 1996 | Adv. Exp. Med. Biol. | pmid:9131175 |
Tamura G et al. | Effect of a potent platelet-activating factor antagonist, WEB-2086, on asthma. A multicenter, double-blind placebo-controlled study in Japan. | 1996 | Adv. Exp. Med. Biol. | pmid:9131176 |
Albert DH et al. | Ex vivo inhibition of PAF-induced beta-thromboglobulin release in man by ABT-299, a potent PAF antagonist. | 1996 | Adv. Exp. Med. Biol. | pmid:9131177 |
Winkler JD et al. | Inhibitors of arachidonate metabolism and effects on PAF production. | 1996 | Adv. Exp. Med. Biol. | pmid:9131119 |