Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Held HD et al. | Characterization of airway and vascular responses in murine lungs. | 1999 | Br. J. Pharmacol. | pmid:10205008 |
Calcerrada MC et al. | Glutamate release is involved in PAF-increased cyclic GMP levels in hippocampus. | 1999 | Biochem. Mol. Biol. Int. | pmid:10204090 |
Wang X et al. | Inhibition of platelet-activating factor, intercellular adhesion molecule 1 and platelet endothelial cell adhesion molecule 1 reduces experimental pancreatitis-associated gut endothelial barrier dysfunction. | 1999 | Br J Surg | pmid:10201790 |
Yamaguchi S et al. | Effects of Y-24180, a receptor antagonist to platelet-activating factor, on allergic cutaneous eosinophilia in mice. | 1999 | Life Sci. | pmid:10201647 |
Park TS et al. | Platelet-activating factor mediates ischemia-induced leukocyte-endothelial adherence in newborn pig brain. | 1999 | J. Cereb. Blood Flow Metab. | pmid:10197511 |
Lim H et al. | Inhibitory effect of sulfur-containing compounds in Scorodocarpus borneensis Becc. on the aggregation of rabbit platelets. | 1999 | Biosci. Biotechnol. Biochem. | pmid:10192909 |
Oh-hashi K et al. | Dietary alpha-linolenate suppresses endotoxin-induced platelet-activating factor production in rat kidney. | 1999 | Lipids | pmid:10188594 |
Uhl E et al. | Influence of platelet-activating factor on cerebral microcirculation in rats: part 2. Local application. | 1999 | Stroke | pmid:10187895 |
Uhl E et al. | Influence of platelet-activating factor on cerebral microcirculation in rats: part 1. Systemic application. | 1999 | Stroke | pmid:10187894 |
Kobayashi K et al. | Platelet-activating factor receptor is not required for long-term potentiation in the hippocampal CA1 region. | 1999 | Eur. J. Neurosci. | pmid:10103126 |