Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Corneal Neovascularization D016510 8 associated lipids
Peripheral Vascular Diseases D016491 8 associated lipids
Helicobacter Infections D016481 21 associated lipids
Lymphoma, T-Cell, Cutaneous D016410 4 associated lipids
Milk Hypersensitivity D016269 4 associated lipids
Blood Loss, Surgical D016063 6 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
HIV Infections D015658 20 associated lipids
AIDS Dementia Complex D015526 4 associated lipids
Leukemia, Eosinophilic, Acute D015472 3 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Glomerulonephritis, Membranous D015433 6 associated lipids
Weight Loss D015431 56 associated lipids
Weight Gain D015430 101 associated lipids
Reperfusion Injury D015427 65 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Dementia, Multi-Infarct D015161 2 associated lipids
Xeroderma Pigmentosum D014983 6 associated lipids
Wounds and Injuries D014947 20 associated lipids
Granulomatosis with Polyangiitis D014890 5 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Viremia D014766 4 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Uveitis, Anterior D014606 11 associated lipids
Uremia D014511 33 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Toxemia D014115 3 associated lipids
Thyroiditis, Autoimmune D013967 9 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Thrombosis D013927 49 associated lipids
Thrombocytosis D013922 4 associated lipids
Thrombocytopenia D013921 15 associated lipids
Thrombasthenia D013915 4 associated lipids
Thalassemia D013789 8 associated lipids
Tangier Disease D013631 8 associated lipids
Subarachnoid Hemorrhage D013345 17 associated lipids
Subacute Sclerosing Panencephalitis D013344 3 associated lipids
Stomatitis D013280 14 associated lipids
Stomach Ulcer D013276 75 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Staphylococcal Infections D013203 15 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Spasm D013035 5 associated lipids
Sneezing D012912 6 associated lipids
Shock, Traumatic D012774 4 associated lipids
Shock, Septic D012772 11 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
O'Flaherty JT et al. Neutrophil-degranulating action of 5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid and 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine. Comparison with other degranulating agents. 1981 Am. J. Pathol. pmid:6274199
Shaw JO et al. Activation of rabbit platelet phospholipase and thromboxane synthesis by 1-O-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (platelet activating factor). 1981 Biochim. Biophys. Acta pmid:7213765
McManus LM et al. Human platelet stimulation by acetyl glyceryl ether phosphorylcholine. 1981 J. Clin. Invest. pmid:7204562
Mencia-Huerta JM et al. Is platelet-activating factor (PAF-acether) synthesis by murine peritoneal cells (PC) a two-step process? 1981 Agents Actions pmid:7053072
Camussi G et al. Release of platelet-activating factor (PAF) and histamine. II. The cellular origin of human PAF: monocytes, polymorphonuclear neutrophils and basophils. 1981 Immunology pmid:6161885
Renooij W and Snyder F Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor and a hypotensive lipid) by cholinephosphotransferase in various rat tissues. 1981 Biochim. Biophys. Acta pmid:6260215
Mencia-Huerta JM and Benveniste J Platelet-activating factor (PAF-acether) and macrophages. II. Phagocytosis-associated release of PAF-acether from rat peritoneal macrophages. 1981 Cell. Immunol. pmid:6260384
Shaw JO et al. Activation of human neutrophils with 1-O-hexadecyl/octadecyl-2-acetyl-sn-glycerol-3-phosphorylcholine (platelet activating factor). 1981 J. Immunol. pmid:6267133
Slauson DO and Sanchez-Vizcaino JM Leukocyte-dependent platelet vasoactive amine release and immune complex deposition in African swine fever. 1981 Vet. Pathol. pmid:6170156
Benveniste J Platelet-activating factor (PAF-acether): present status. 1981 Agents Actions pmid:6176101
Metcalfe DD et al. The mast cell. 1981 Crit. Rev. Immunol. pmid:6178551
O'Flaherty JT et al. Evidence for 5, 12-dihydroxy-6,8,10,14-eicosatetraenoate as a mediator of human neutrophil aggregation. 1981 Biochem. Biophys. Res. Commun. pmid:6277309
Hanahan DJ et al. Potent platelet stimulating activity of enantiomers of acetyl glyceryl ether phosphorylcholine and its methoxy analogues. 1981 Biochem. Biophys. Res. Commun. pmid:7236259
Cox CP et al. The presence of platelet-activating factor (PAF) in normal human mixed saliva. 1981 J. Immunol. pmid:7240750
O'Donnell MC et al. Platelet activating factor: an inhibitor of neutrophil activation? 1981 Clin. Exp. Immunol. pmid:7249391
Findlay SR et al. Contraction of guinea pig ileal smooth muscle by acetyl glyceryl ether phosphorylcholine. 1981 Am. J. Physiol. pmid:7282914
Demopoulos CA et al. Intravascular pathobiology of acetyl glyceryl ether phosphorylcholine (AGEPC), a synthetic platelet-activating factor (PAF). I. Intravenous infusion in guinea pigs. 1981 Immunol. Lett. pmid:7287060
Halonen M et al. Differential effects of platelet depletion on the physiologic alterations of IgE anaphylaxis and acetyl glyceryl ether phosphorylcholine infusion in the rabbit. 1981 Am. Rev. Respir. Dis. pmid:7294504
Wykle RL et al. Stereospecific activity of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine and comparison of analogs in the degranulation of platelets and neutrophils. 1981 Biochem. Biophys. Res. Commun. pmid:7295320
O'Flaherty JT et al. Neutrophil responses to platelet-activating factor. 1981 Inflammation pmid:7298160
Blank ML et al. In vivo metabolism of a new class of biologically active phospholipids: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine, a platelet activating-hypotensive phospholipid. 1981 Life Sci. pmid:7300575
Satouchi K et al. Influence of alkyl ether chain length of acetyl glyceryl ether phosphorylcholine and its ethanolamine analog on biological activity toward rabbit platelets. 1981 Arch. Biochem. Biophys. pmid:7305392
Czarnetzki BM and Muramatsu T Saturated and unsaturated 1-O-alkyl-2-O-acetoyl-sn-glycero-3-phosphocholines derived from ratfish liver oil: effect on human leukocyte migration. 1981 Chem. Phys. Lipids pmid:7318048
Czarnetzki BM and Benveniste J Effect of 1-O-octadecyl-2-O-acetyl-sn-glycero-3-phosphocholine (PAF-acether) on leukocytes I. Analysis of the in vitro migration of human neutrophils. 1981 Chem. Phys. Lipids pmid:7318049
Bonnet J et al. Platelet-activating factor acether (PAF-acether) involvement in acute inflammatory and pain processes. 1981 Agents Actions pmid:7340441
Denjean A et al. Bronchoconstriction induced by intratracheal administration of platelet-activating factor (PAF-acether) in baboons. 1981 Agents Actions pmid:7340444
Marcus AJ et al. Effects of acetyl glyceryl ether phosphorylcholine on human platelet function in vitro. 1981 Blood pmid:6457658
Deguchi K et al. [Blood platelet aggregation]. 1981 Nippon Rinsho pmid:6461781
O'Flaherty JT et al. Role of extracellular calcium and neutrophil degranulation responses to 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine. 1981 Am. J. Pathol. pmid:6271016
Vargaftig BB and Ferreira SH Blockade of the inflammatory effects of platelet-activating factor by cyclo-oxygenase inhibitors. 1981 Braz. J. Med. Biol. Res. pmid:6802210
Perret BA et al. Binding of bovine factor VIII-coated colloidal gold particles to receptors on platelet membranes. 1981 Agents Actions pmid:6803540
Mencia-Huerta JM et al. Release of a slow-reacting substance from rabbit platelets. 1981 J. Clin. Invest. pmid:6119324
Furlan M et al. Binding of colloidal gold granules, coated with bovine factor VIII, to human platelet membranes. 1981 Br. J. Haematol. pmid:6786321
Chap H et al. Biosynthetic labelling of platelet activating factor from radioactive acetate by stimulated platelets. 1981 Nature pmid:7453828
Stimler NP et al. Anaphylactic actions of platelet-activating factor. 1981 Am. J. Pathol. pmid:6975043
Benveniste J et al. Platelet-activating factor (PAF-acether): molecular aspects of its release and pharmacological actions. 1981 Int. Arch. Allergy Appl. Immunol. pmid:7030966
Czarnetzki BM and Benveniste J Effect of synthetic PAF-acether on human neutrophil function. 1981 Agents Actions pmid:7041568
Camussi G et al. Neutropenia induced by platelet-activating factor (PAF-acether) released from neutrophils: the inhibitory effect of prostacyclin (PGI2). 1981 Agents Actions pmid:7041569
Vargaftig BB et al. Present concepts on the mechanisms of platelet aggregation. 1981 Biochem. Pharmacol. pmid:7011325
Colwell JA Studies on the pathogenesis of diabetic vascular disease. 1981 J S C Med Assoc pmid:7022022
Wintroub BU and Soter NA Biology of the mast cell and its role in cutaneous inflammation. 1981 Springer Semin. Immunopathol. pmid:7022722
Heymans F et al. New total synthesis and high resolution 1H NMR spectrum of platelet-activating factor, its enantiomer and racemic mixtures. 1981 Biochim. Biophys. Acta pmid:7306563
Karpatkin S et al. Role of platelets in tumor cell metastases. 1981 Ann. N. Y. Acad. Sci. pmid:6943955
Henson PM and Betz SJ Neutrophil and platelet interactions in "allergic" and inflammatory reactions: a role for acetyl glyceryl ether phosphorylcholine (platelet-activating factor). 1981 Kroc Found Ser pmid:6947075
Chignard M et al. [Platelet aggregation and platelet activating factor (author's transl)]. 1980 Oct-Dec J Pharmacol pmid:7206730
Camussi G et al. Platelet-activating factor (PAF), a mediator of platelet aggregation. Effect of corticosteroids on PAF-induced platelet aggregation. 1980 Oct-Dec Minerva Nefrol pmid:7254682
Suzuki K et al. The influence of 2-mercaptoethanol on von Willebrand factor and bovine platelet aggregating factor. 1980 Feb 1-15 Thromb. Res. pmid:6966083
Check WA A new age in asthma research: study of chemical mediators. 1980 Aug 22-29 JAMA pmid:6104737
Vargaftig BB et al. Platelet-tissue interaction: role of platelet-activating factor (PAF-acether). 1980 Agents Actions pmid:7270336
Polonsky J et al. Release of 1-O-alkylglyceryl 3-phosphorylcholine, O-deacetyl platelet-activating factor, from leukocytes: chemical ionization mass spectrometry of phospholipids. 1980 Proc. Natl. Acad. Sci. U.S.A. pmid:6938950