Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Corneal Neovascularization D016510 8 associated lipids
Peripheral Vascular Diseases D016491 8 associated lipids
Helicobacter Infections D016481 21 associated lipids
Lymphoma, T-Cell, Cutaneous D016410 4 associated lipids
Milk Hypersensitivity D016269 4 associated lipids
Blood Loss, Surgical D016063 6 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
HIV Infections D015658 20 associated lipids
AIDS Dementia Complex D015526 4 associated lipids
Leukemia, Eosinophilic, Acute D015472 3 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Glomerulonephritis, Membranous D015433 6 associated lipids
Weight Loss D015431 56 associated lipids
Weight Gain D015430 101 associated lipids
Reperfusion Injury D015427 65 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Dementia, Multi-Infarct D015161 2 associated lipids
Xeroderma Pigmentosum D014983 6 associated lipids
Wounds and Injuries D014947 20 associated lipids
Granulomatosis with Polyangiitis D014890 5 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Viremia D014766 4 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Uveitis, Anterior D014606 11 associated lipids
Uremia D014511 33 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Toxemia D014115 3 associated lipids
Thyroiditis, Autoimmune D013967 9 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Thrombosis D013927 49 associated lipids
Thrombocytosis D013922 4 associated lipids
Thrombocytopenia D013921 15 associated lipids
Thrombasthenia D013915 4 associated lipids
Thalassemia D013789 8 associated lipids
Tangier Disease D013631 8 associated lipids
Subarachnoid Hemorrhage D013345 17 associated lipids
Subacute Sclerosing Panencephalitis D013344 3 associated lipids
Stomatitis D013280 14 associated lipids
Stomach Ulcer D013276 75 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Staphylococcal Infections D013203 15 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Spasm D013035 5 associated lipids
Sneezing D012912 6 associated lipids
Shock, Traumatic D012774 4 associated lipids
Shock, Septic D012772 11 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Namm DH and High JA Thrombin-induced formation of a polar lipid material within platelets that possesses platelet-activating activity. 1980 Thromb. Res. pmid:7209881
Tencé V et al. Release, purification, and characterization of platelet-activating factor (PAF). 1980 Biochimie pmid:17941181
Bussolino F and Benveniste J Pharmacological modulation of platelet-activating factor (PAF) release from rabbit leucocytes. I. Role of cAMP. 1980 Immunology pmid:6159308
Bussolino F and Camussi G Effect of prostacyclin on platelet-activating factor induced rabbit and platelet aggregation. 1980 Prostaglandins pmid:6258196
Vargaftig BB et al. Platelet-tissue interaction: role of platelet-activating factor (PAF-acether). 1980 Agents Actions pmid:7270336
Godfroid JJ et al. Platelet activating factor (PAF-acether): total synthesis of 1-O-octadecyl 2-O-acetyl sn-glycero-3-phosphoryl choline. 1980 FEBS Lett. pmid:7409144
Clark PO et al. Physical and chemical properties of platelet-activating factor obtained from human neutrophils and monocytes and rabbit neutrophils and basophils. 1980 Biochim. Biophys. Acta pmid:7357030
[Do you know PAF?]. 1980 Nouv Presse Med pmid:7367260
Farr RS et al. Preliminary studies of an acid-labile factor (ALF) in human sera that inactivates platelet-activating factor (PAF). 1980 Clin. Immunol. Immunopathol. pmid:7371225
McManus LM et al. Pathobiology of the intravenous infusion of acetyl glyceryl ether phosphorylcholine (AGEPC), a synthetic platelet-activating factor (PAF), in the rabbit. 1980 J. Immunol. pmid:7373056
Cusack NJ Platelet-activating factor. 1980 Nature pmid:7374771
Hanahan DJ et al. Identification of platelet activating factor isolated from rabbit basophils as acetyl glyceryl ether phosphorylcholine. 1980 J. Biol. Chem. pmid:7380824
Chignard M et al. Platelet-activating factor (PAF-acether) secretion from platelets: effect of aggregating agents. 1980 Br. J. Haematol. pmid:6778498
Vargaftig BB et al. One, two, three or more pathways for platelet aggregation. 1980 Acta Med. Scand. Suppl. pmid:6779505
Arnoux B et al. Release of platelet-activating factor (PAF-acether) from alveolar macrophages by the calcium ionophore A23187 and phagocytosis. 1980 Eur. J. Clin. Invest. pmid:6788561
Halonen M et al. Respiratory and circulatory alterations induced by acetyl glyceryl ether phosphorylcholine, a mediator of IgE anaphylaxis in the rabbit. 1980 Am. Rev. Respir. Dis. pmid:7458063
Kirchmaier CM et al. A platelet stimulating fraction in human and animal tissues. 1980 Artery pmid:6971084
Shaw JO and Henson PM The binding of rabbit basophil-derived platelet-activating factor to rabbit platelets. 1980 Am. J. Pathol. pmid:6987890
Vargaftig BB et al. Platelet-activating factor induces a platelet-dependent bronchoconstriction unrelated to the formation of prostaglandin derivatives. 1980 Eur. J. Pharmacol. pmid:6995139
Pinckard RN et al. Molecular pathobiology of acetyl glyceryl ether phosphorylcholine: evidence for the structural and functional identity with platelet-activating factor. 1980 J Reticuloendothel Soc pmid:7003140
Colwell JA et al. Platelet adhesion and aggregation in diabetes mellitus. 1979 Metab. Clin. Exp. pmid:122293
Benveniste J et al. [Semi-synthesis and proposed structure of platelet-activating factor (P.A.F.): PAF-acether an alkyl ether analog of lysophosphatidylcholine]. 1979 C. R. Acad. Sci., D, Sci. Nat. pmid:121258
pmid:
pmid:3360596
Kelesidis T et al. The Role of Platelet-Activating Factor in Chronic Inflammation, Immune Activation, and Comorbidities Associated with HIV Infection. AIDS Rev pmid:26616844
pmid:9870780