Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Corneal Neovascularization D016510 8 associated lipids
Peripheral Vascular Diseases D016491 8 associated lipids
Helicobacter Infections D016481 21 associated lipids
Lymphoma, T-Cell, Cutaneous D016410 4 associated lipids
Milk Hypersensitivity D016269 4 associated lipids
Blood Loss, Surgical D016063 6 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
HIV Infections D015658 20 associated lipids
AIDS Dementia Complex D015526 4 associated lipids
Leukemia, Eosinophilic, Acute D015472 3 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Glomerulonephritis, Membranous D015433 6 associated lipids
Weight Loss D015431 56 associated lipids
Weight Gain D015430 101 associated lipids
Reperfusion Injury D015427 65 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Dementia, Multi-Infarct D015161 2 associated lipids
Xeroderma Pigmentosum D014983 6 associated lipids
Wounds and Injuries D014947 20 associated lipids
Granulomatosis with Polyangiitis D014890 5 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Viremia D014766 4 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Uveitis, Anterior D014606 11 associated lipids
Uremia D014511 33 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Toxemia D014115 3 associated lipids
Thyroiditis, Autoimmune D013967 9 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Thrombosis D013927 49 associated lipids
Thrombocytosis D013922 4 associated lipids
Thrombocytopenia D013921 15 associated lipids
Thrombasthenia D013915 4 associated lipids
Thalassemia D013789 8 associated lipids
Tangier Disease D013631 8 associated lipids
Subarachnoid Hemorrhage D013345 17 associated lipids
Subacute Sclerosing Panencephalitis D013344 3 associated lipids
Stomatitis D013280 14 associated lipids
Stomach Ulcer D013276 75 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Staphylococcal Infections D013203 15 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Spasm D013035 5 associated lipids
Sneezing D012912 6 associated lipids
Shock, Traumatic D012774 4 associated lipids
Shock, Septic D012772 11 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Song SQ and Hu YM Effects of tetrandrine, Fura 2-AM, and Bay k 8644 on platelet-activating factor release from rat peritoneal macrophages stimulated by lipopolysaccharides. 1996 Zhongguo Yao Li Xue Bao pmid:9812743
Chen SF et al. Three drugs inhibit phospholipase A2-induced high permeability of endothelial monolayers. 1994 Zhongguo Yao Li Xue Bao pmid:7801767
Zeng S et al. Platelet activating factor-induced P-selectin expression in platelets and its related signal transduction. 1999 Zhongguo Yao Li Xue Bao pmid:11270998
Li SH et al. Effects of platelet-activating factor on rat mesenteric microcirculation. 1990 Zhongguo Yao Li Xue Bao pmid:2104488
Zeng GQ and Rui YC [Inhibitory effect of dauricine on platelet activating factor released from calcimycin-induced mouse peritoneal macrophages]. 1990 Zhongguo Yao Li Xue Bao pmid:2104489
Fu Y and Hu YM Prophylactic effects of tetramethyl pyrazine on mice with endotoxemia and its relationship with platelet-activating factor. 1999 Zhongguo Yao Li Xue Bao pmid:10678147
Yi FX and Guo ZG Platelet-released ADP stabilizes PAF-induced rabbit platelet aggregation by stabilizing intracellular calcium. 1998 Zhongguo Yao Li Xue Bao pmid:10375790
Sun DX et al. Specific binding sites of platelet activating factor on the intact bovine cerebral microvascular endothelial cells and antagonism of drugs. 1992 Zhongguo Yao Li Xue Bao pmid:1333718
Li SH et al. Pentoxifylline attenuates platelet activating factor-induced permeable edema in isolated perfused guinea pig lungs. 1994 Zhongguo Yao Li Xue Bao pmid:7976374
Hu JH et al. Platelet adhesion to cultured bovine cerebral microvascular endothelial cells by stimulation of platelet activating factor and antagonism of drugs. 1995 Zhongguo Yao Li Xue Bao pmid:7668100
Zhang M et al. Effects of tetrandrine on rabbit platelet aggregation and platelet activating factor generation. 1995 Zhongguo Yao Li Xue Bao pmid:7660812
Ju DW et al. Inhibitory effects of triazolodiazepine on mouse splenocytes and peritoneal macrophages in vitro. 1994 Zhongguo Yao Li Xue Bao pmid:8010089
Hong JL et al. [Effects of tetrandrine on cytoplasmic free calcium in rat neutrophils]. 1989 Zhongguo Yao Li Xue Bao pmid:2561935
Zeng S and Guo ZG Mepyramine inhibits platelet activating factor-induced rabbit platelet aggregation: role of intracellular histamine. 1997 Zhongguo Yao Li Xue Bao pmid:10072970
Zeng GQ et al. Dauricine and anisodamine inhibited leukotrienes- and platelet activating factor-induced DNA synthesis and proliferation of bovine cerebral microvascular smooth muscle cells in culture. 1993 Zhongguo Yao Li Xue Bao pmid:8249627
Zhang B and Long K Effects of glaucocalyxin A on aggregation and cAMP levels of rabbit platelets in vitro. 1993 Zhongguo Yao Li Xue Bao pmid:8249632
Sun DX et al. Platelet activating factor production in bovine cerebral microvascular endothelial cells and its drug inhibition. 1993 Zhongguo Yao Li Xue Bao pmid:8503282
Zeng S et al. Regulatory role of protein tyrosine phosphorylation in platelet activating factor-induced signal transduction in platelets. 1999 Zhongguo Yao Li Xue Bao pmid:10437164
Shi B et al. [Influence of intensive insulin therapy on the intestinal microcirculatory dysfunction in rats with sepsis]. 2009 Zhongguo Wei Zhong Bing Ji Jiu Yi Xue pmid:19695175
Hao J et al. [Dynamic changes of platelet number in early multiple injury and it is effect on prognosis]. 2003 Zhongguo Wei Zhong Bing Ji Jiu Yi Xue pmid:14552687