Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Ren J et al. | Protective effect of dexmedetomidine against myocardial ischemia-reperfusion injury in rabbits. | 2018 | Acta Cir Bras | pmid:29412230 |
Shi K et al. | Identification and functional analyses of differentially expressed metabolites in early stage endometrial carcinoma. | 2018 | Cancer Sci. | pmid:29436067 |
Hasegawa A et al. | Influence of glucocorticoids on time-of-day-dependent variations in IgE-, histamine-, and platelet-activating factor-mediated systemic anaphylaxis in different mouse strains. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29269296 |
Zhang X et al. | Serum metabolomics of laryngeal cancer based on liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. | 2018 | Biomed. Chromatogr. | pmid:29272549 |
Munoz-Cano R et al. | Effects of Rupatadine on Platelet- Activating Factor-Induced Human Mast Cell Degranulation Compared With Desloratadine and Levocetirizine (The MASPAF Study). | 2017 | J Investig Allergol Clin Immunol | pmid:27758758 |
Moschos MM et al. | Anti-platelet effects of anti-glaucomatous eye drops: an in vitro study on human platelets. | 2017 | Drug Des Devel Ther | pmid:28458520 |
Gale TV et al. | Metabolomics analyses identify platelet activating factors and heme breakdown products as Lassa fever biomarkers. | 2017 | PLoS Negl Trop Dis | pmid:28922385 |
Larrazabal CS et al. | Amiloride interferes with platelet- activating factor-induced respiratory burst and MMP-9 release in bovine neutrophils independent of Na/H exchanger 1. | 2017 | Vet. Immunol. Immunopathol. | pmid:28895869 |
Argyrou C et al. | Postprandial effects of wine consumption on Platelet Activating Factor metabolic enzymes. | 2017 | Prostaglandins Other Lipid Mediat. | pmid:28323197 |
Lecewicz M et al. | Effects of the platelet-activating factor (PAF) supplementation on ATP content of cryopreserved bull spermatozoa (AI). | 2017 | Pol J Vet Sci | pmid:28865217 |
Wang H et al. | Prognostic factors of clinical endpoints in elderly patients with atrial fibrillation during a 2-year follow-up in China: An observational cohort study. | 2017 | Medicine (Baltimore) | pmid:28816946 |
Holdfeldt A et al. | Reactivation of Gαi-coupled formyl peptide receptors is inhibited by Gαq-selective inhibitors when induced by signals generated by the platelet-activating factor receptor. | 2017 | J. Leukoc. Biol. | pmid:28760822 |
Smith LJ | Leukotrienes and sex: strange bedfellows? | 2017 | J. Clin. Invest. | pmid:28737507 |
Lukic A et al. | GM-CSF- and M-CSF-primed macrophages present similar resolving but distinct inflammatory lipid mediator signatures. | 2017 | FASEB J. | pmid:28637652 |
Xanthopoulou MN et al. | Wine consumption reduced postprandial platelet sensitivity against platelet activating factor in healthy men. | 2017 | Eur J Nutr | pmid:26936842 |
Kispert S et al. | Cigarette Smoke Regulates Calcium-Independent Phospholipase A Metabolic Pathways in Breast Cancer. | 2017 | Am. J. Pathol. | pmid:28618256 |
Kelly AM et al. | The effect of variation in donor platelet function on transfusion outcome: a semirandomized controlled trial. | 2017 | Blood | pmid:28487294 |
Meyer AF et al. | Stereochemistry- and concentration-dependent effects of phosphatidylserine enrichment on platelet function. | 2017 | Biochim. Biophys. Acta | pmid:28472616 |
Malavige GN and Ogg GS | Pathogenesis of vascular leak in dengue virus infection. | 2017 | Immunology | pmid:28437586 |
Shindou H et al. | Relief from neuropathic pain by blocking of the platelet-activating factor-pain loop. | 2017 | FASEB J. | pmid:28341636 |
Kispert SE et al. | Cigarette smoke-induced urothelial cell damage: potential role of platelet-activating factor. | 2017 | Physiol Rep | pmid:28270596 |
Noh KT et al. | Platelet-activating Factor Mediates Endotoxin Tolerance by Regulating Indoleamine 2,3-Dioxygenase-dependent Expression of the Suppressor of Cytokine Signaling 3. | 2017 | J. Biol. Chem. | pmid:28077574 |
Liao YR et al. | Bioactive chemical constituents from the root bark of Morus australis. | 2017 | Bioorg. Med. Chem. Lett. | pmid:27908762 |
Sanz-Vicente I et al. | Enzymatic methods for choline-containing water soluble phospholipids based on fluorescence of choline oxidase: Application to lyso-PAF. | 2017 | Anal. Biochem. | pmid:27956151 |
Palur Ramakrishnan AV et al. | Platelet activating factor: A potential biomarker in acute coronary syndrome? | 2017 | Cardiovasc Ther | pmid:27790832 |
Borges AF et al. | Platelet-activating factor increases reactive oxygen species-mediated microbicidal activity of human macrophages infected with Leishmania (Viannia) braziliensis. | 2017 | Pathog Dis | pmid:28830073 |
Moschos MM et al. | In Vitro Effects of Anti-Glaucomatous Eye Drops on Platelet-Activating Factor and its Metabolism. | 2017 | Semin Ophthalmol | pmid:26270771 |
Kulinski JM et al. | Sphingosine-1-phosphate and other lipid mediators generated by mast cells as critical players in allergy and mast cell function. | 2016 | Eur. J. Pharmacol. | pmid:25941085 |
Carretta MD et al. | Butyric acid stimulates bovine neutrophil functions and potentiates the effect of platelet activating factor. | 2016 | Vet. Immunol. Immunopathol. | pmid:27288853 |
Liu R et al. | Pyruvate in oral rehydration salt improves hemodynamics, vasopermeability and survival after burns in dogs. | 2016 | Burns | pmid:27130433 |
Grambow E et al. | Differential effects of endogenous, phyto and synthetic cannabinoids on thrombogenesis and platelet activity. | 2016 | Biofactors | pmid:27151562 |
Eleftheriou K et al. | Comparative Experimental and Computational Study of Monoalkyl Chain Phosphatidylcholine-Containing Thermoresponsive Liposomes. | 2016 | J Phys Chem B | pmid:27280363 |
Megson IL et al. | Lipids and cardiovascular disease: where does dietary intervention sit alongside statin therapy? | 2016 | Food Funct | pmid:27109548 |
Pike DP et al. | Platelet-Activating Factor Quantification Using Reversed Phase Liquid Chromatography and Selected Reaction Monitoring in Negative Ion Mode. | 2016 | Lipids | pmid:27757707 |
Täubel J et al. | Pharmacokinetics, Safety and Cognitive Function Profile of Rupatadine 10, 20 and 40 mg in Healthy Japanese Subjects: A Randomised Placebo-Controlled Trial. | 2016 | PLoS ONE | pmid:27632557 |
Hoenderdos K et al. | Hypoxia upregulates neutrophil degranulation and potential for tissue injury. | 2016 | Thorax | pmid:27581620 |
Watanabe M et al. | Characterization of platelet-activating factor-induced cutaneous edema and erythema in dogs. | 2016 | Am. J. Vet. Res. | pmid:27580108 |
González-Núñez V et al. | Rupatadine: global safety evaluation in allergic rhinitis and urticaria. | 2016 | Expert Opin Drug Saf | pmid:27500993 |
Kamaladasa A et al. | Lipopolysaccharide acts synergistically with the dengue virus to induce monocyte production of platelet activating factor and other inflammatory mediators. | 2016 | Antiviral Res. | pmid:27476044 |
Schauberger E et al. | Lipid Mediators of Allergic Disease: Pathways, Treatments, and Emerging Therapeutic Targets. | 2016 | Curr Allergy Asthma Rep | pmid:27333777 |
Wang JM and Chen J | Damage of vascular endothelial barrier induced by explosive blast and its clinical significance. | 2016 | Chin. J. Traumatol. | pmid:27321288 |
Nel JG et al. | Pneumolysin Mediates Platelet Activation In Vitro. | 2016 | Lung | pmid:27192991 |
Silva-Herdade AS et al. | Erythrocyte deformability - A partner of the inflammatory response. | 2016 | Microvasc. Res. | pmid:27142964 |
Quinn RA et al. | Metabolomics of reef benthic interactions reveals a bioactive lipid involved in coral defence. | 2016 | Proc. Biol. Sci. | pmid:27122568 |
Lecewicz M et al. | Effects of the platelet-activating factor (PAF) on selected quality parameters of cryopreserved bull semen (AI) with reduced sperm motility. | 2016 | Pol J Vet Sci | pmid:27096799 |
Park JH et al. | Glucosamine suppresses platelet-activating factor-induced activation of microglia through inhibition of store-operated calcium influx. | 2016 | Environ. Toxicol. Pharmacol. | pmid:26745504 |
RodrÃguez M et al. | Pharmacological inhibition of eicosanoids and platelet-activating factor signaling impairs zymosan-induced release of IL-23 by dendritic cells. | 2016 | Biochem. Pharmacol. | pmid:26673542 |
Aquino EN et al. | Proteomic Analysis of Neutrophil Priming by PAF. | 2016 | Protein Pept. Lett. | pmid:26631175 |
Anandi VL et al. | Platelet-activating factor promotes motility in breast cancer cells and disrupts non-transformed breast acinar structures. | 2016 | Oncol. Rep. | pmid:26531049 |
Wright NR et al. | Purulent Pericarditis and Abscessed Myocardium with Acute Myocardial Infarction. | 2016 | Am. J. Med. | pmid:26524710 |