Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhou W et al. | Platelet-activating factor as an intercellular signal in neutrophil-dependent platelet activation. | 1992 | J. Immunol. | pmid:1506691 |
| Cooper K et al. | 1,4-Dihydropyridines as antagonists of platelet activating factor. 1. Synthesis and structure-activity relationships of 2-(4-heterocyclyl)phenyl derivatives. | 1992 | J. Med. Chem. | pmid:1507200 |
| Moritoki H et al. | Possible involvement of NO pathway in PAF-induced vasorelaxation. | 1992 | Jpn. J. Pharmacol. | pmid:1507620 |
| Xu Y and Tao YX | Involvement of the NMDA receptor/nitric oxide signal pathway in platelet-activating factor-induced neurotoxicity. | 2004 | Neuroreport | pmid:15076749 |
| Slomiany BL and Slomiany A | Platelet-activating factor mediates Porphyromonas gingivalis lipopolysaccharide interference with salivary mucin synthesis via phosphatidylinositol 3-kinase-dependent constitutive nitric-oxide synthase activation. | 2004 | J. Physiol. Pharmacol. | pmid:15082869 |
| Steel HC and Anderson R | Itraconazole antagonizes store-operated influx of calcium into chemoattractant-activated human neutrophils. | 2004 | Clin. Exp. Immunol. | pmid:15086388 |
| Reeves SR and Gozal D | Platelet-activating factor receptor modulates respiratory adaptation to long-term intermittent hypoxia in mice. | 2004 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:15087283 |
| Hollmann MW et al. | Time-dependent inhibition of G protein-coupled receptor signaling by local anesthetics. | 2004 | Anesthesiology | pmid:15087620 |
| Bate C et al. | The role of platelet activating factor in prion and amyloid-beta neurotoxicity. | 2004 | Neuroreport | pmid:15094513 |
| Northover AM | In vitro effects of PAF on venous endothelial cell actin disposition. | 1992 | Agents Actions | pmid:1509977 |
| Yang YM et al. | Creation of reversed phase high-performance liquid chromatographic technique to assay platelet-activating factor. | 2004 | J. Zhejiang Univ. Sci. | pmid:15101112 |
| Brown GE et al. | Distinct ligand-dependent roles for p38 MAPK in priming and activation of the neutrophil NADPH oxidase. | 2004 | J. Biol. Chem. | pmid:15102856 |
| Wheelan P and Clay KL | Albumin and fatty acid effects on the stimulated production of 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) by human polymorphonuclear leukocytes. | 1992 | Biochim. Biophys. Acta | pmid:1511005 |
| Khreiss T et al. | Activation of extracellular signal-regulated kinase couples platelet-activating factor-induced adhesion and delayed apoptosis of human neutrophils. | 2004 | Cell. Signal. | pmid:15115659 |
| Ninio E et al. | Platelet-activating factor-acetylhydrolase and PAF-receptor gene haplotypes in relation to future cardiovascular event in patients with coronary artery disease. | 2004 | Hum. Mol. Genet. | pmid:15115767 |
| Schreiber S et al. | The role of the mucosal immune system in inflammatory bowel disease. | 1992 | Gastroenterol. Clin. North Am. | pmid:1512051 |
| Hirafuji M and Shinoda H | Antagonism of platelet-activating factor-induced increase in cytosolic free calcium concentration in human endothelial cells. | 1992 | Jpn. J. Pharmacol. | pmid:1513073 |
| Poli G et al. | Oxidative stress and cell signalling. | 2004 | Curr. Med. Chem. | pmid:15134513 |
| Yang Y et al. | Increased hepatic platelet activating factor (PAF) and PAF receptors in carbon tetrachloride induced liver cirrhosis. | 2004 | Gut | pmid:15138217 |
| Burgos RA et al. | Determination of specific receptor sites for platelet activating factor in bovine neutrophils. | 2004 | Am. J. Vet. Res. | pmid:15141884 |
| Wang J et al. | [Effect of Radix notoginseng saponins on platelet activating molecule expression and aggregation in patients with blood hyperviscosity syndrome]. | 2004 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:15143716 |
| Schauer U et al. | Enhanced production of platelet activating factor by peripheral granulocytes from children with asthma. | 1992 | Allergy | pmid:1514664 |
| Ekholm J et al. | The human platelet as a reproducible and sensitive cell for the detection and assay of platelet-activating factor. | 1992 | Anal. Biochem. | pmid:1514698 |
| Fu H et al. | The mechanism for activation of the neutrophil NADPH-oxidase by the peptides formyl-Met-Leu-Phe and Trp-Lys-Tyr-Met-Val-Met differs from that for interleukin-8. | 2004 | Immunology | pmid:15147563 |
| Beaudeux JL et al. | Activation of PAF receptor by oxidised LDL in human monocytes stimulates chemokine releases but not urokinase-type plasminogen activator expression. | 2004 | Clin. Chim. Acta | pmid:15149885 |
| Lee SH et al. | Role of messenger RNA expression of platelet activating factor and its receptor in porcine in vitro-fertilized and cloned embryo development. | 2004 | Biol. Reprod. | pmid:15151927 |
| Ishii S et al. | Platelet-activating factor receptor develops airway hyperresponsiveness independently of airway inflammation in a murine asthma model. | 2004 | J. Immunol. | pmid:15153532 |
| Tokiwano T et al. | Biosynthesis of phomactins: common intermediate phomactatriene and taxadiene. | 2004 | Chem. Commun. (Camb.) | pmid:15154058 |
| Zhang C et al. | The effect of Ginkgo biloba extract (EGb 761) on hepatic sinusoidal endothelial cells and hepatic microcirculation in CCl4 rats. | 2004 | Am. J. Chin. Med. | pmid:15154282 |
| Saint-Martin F et al. | A randomized, double-blind, parallel-group study, comparing the efficacy and safety of rupatadine (20 and 10 mg), a new PAF and H1 receptor-specific histamine antagonist, to loratadine 10 mg in the treatment of seasonal allergic rhinitis. | 2004 | J Investig Allergol Clin Immunol | pmid:15160440 |
| Stephens CJ et al. | Plasma platelet activating factor degradation and serum lipids after coronary bypass surgery. | 1992 | Cardiovasc. Res. | pmid:1516109 |
| Weinberg JR | Fever, cytokines and shock. | 1992 | Cent Afr J Med | pmid:1516118 |
| Ruiz J et al. | Effects of inhaled platelet activating factor on bronchial responsiveness in patients with symptomatic and asymptomatic pulmonary embolism. | 1992 | Chest | pmid:1516409 |
| Hla T | Prostaglandins & other lipid mediators: a new phase, a new team. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15165026 |
| Ruan Z et al. | Effects of platelet-activating factor and thromboxane A2 on isolated perfused guinea pig liver. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15165033 |
| Nomikos TN et al. | Application of a TCA-precipitation method for the determination of 1-alkyl-sn-glycero-3-phosphate: Acetyl-CoA acetyltransferase in human renal tissue. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15165037 |
| Kato M et al. | Dual signaling and effector pathways mediate human eosinophil activation by platelet-activating factor. | 2004 | Int. Arch. Allergy Immunol. | pmid:15166482 |
| Pédrono F et al. | Natural 1-O-alkylglycerols reduce platelet-activating factor-induced release of [3H]-serotonin in rabbit platelets. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15172680 |
| Watanabe M et al. | Preparation of immunoaffinity mini-columns for the analysis of platelet activating factor (PAF) in biological samples. | 1992 | J. Chromatogr. | pmid:1517334 |
| Zimmerman GA and McIntyre TM | PAF, ceramide and pulmonary edema: alveolar flooding and a flood of questions. | 2004 | Trends Mol Med | pmid:15177186 |
| Leong LL et al. | The effects of a PAF antagonist on ischemic myocardial damage and arrhythmia in the dog. | 1992 | J. Mol. Cell. Cardiol. | pmid:1518080 |
| Besana A et al. | Activation of protein kinase C epsilon inhibits the two-pore domain K+ channel, TASK-1, inducing repolarization abnormalities in cardiac ventricular myocytes. | 2004 | J. Biol. Chem. | pmid:15184378 |
| Michail S and Abernathy F | A new model for studying eosinophil migration across cultured intestinal epithelial monolayers. | 2004 | J. Pediatr. Gastroenterol. Nutr. | pmid:15187782 |
| Lu H and Xue XD | [Platelet-activating factor and neonatal necrotizing enterocolitis]. | 2004 | Zhonghua Er Ke Za Zhi | pmid:15189692 |
| Seyffarth G et al. | Lipopolysaccharide induces nitric oxide synthase expression and platelet-activating factor increases nitric oxide production in human fetal membranes in culture. | 2004 | Reprod. Biol. Endocrinol. | pmid:15191613 |
| Tsironis LD et al. | Effect of lipoprotein (a) on platelet activation induced by platelet-activating factor: role of apolipoprotein (a) and endogenous PAF-acetylhydrolase. | 2004 | Cardiovasc. Res. | pmid:15194469 |
| Warren JS | Relationship between interleukin-1 beta and platelet-activating factor in the pathogenesis of acute immune complex alveolitis in the rat. | 1992 | Am. J. Pathol. | pmid:1519663 |
| Arima M et al. | [Platelet activating factor (PAF)-induced late asthmatic response in sensitized but not in non-sensitized guinea pigs]. | 1992 | Arerugi | pmid:1520069 |
| Bate C et al. | Phospholipase A2 inhibitors or platelet-activating factor antagonists prevent prion replication. | 2004 | J. Biol. Chem. | pmid:15210691 |
| Jakubowski A et al. | Involvement of platelet activating factor in immediate heart response to lipopolysaccharide. | 2004 | J. Physiol. Pharmacol. | pmid:15213362 |
| Tranquille N and Emeis JJ | The involvement of products of the phospholipase pathway in the acute release of tissue-type plasminogen activator from perfused rat hindlegs. | 1992 | Eur. J. Pharmacol. | pmid:1521562 |
| Ma YQ et al. | P-selectin binding to P-selectin glycoprotein ligand-1 induces an intermediate state of alphaMbeta2 activation and acts cooperatively with extracellular stimuli to support maximal adhesion of human neutrophils. | 2004 | Blood | pmid:15217824 |
| Du YM et al. | Effects of platelet activating factor on action potentials and potassium channels in guinea-pig ventricular myocytes. | 2004 | Sheng Li Xue Bao | pmid:15224138 |
| Wang C and Tai HH | A sensitive and specific radioimmunoassay for platelet-activating factor. | 1992 | Lipids | pmid:1522765 |
| Vrzheshch PV et al. | Cell response kinetics: the phenomenon of supercooperativity in aggregation of human platelets. | 1992 | Thromb. Res. | pmid:1523610 |
| Teng CM et al. | Antiplatelet actions of some coumarin compounds isolated from plant sources. | 1992 | Thromb. Res. | pmid:1523611 |
| Roudebush WE et al. | Platelet-activating factor significantly enhances intrauterine insemination pregnancy rates in non-male factor infertility. | 2004 | Fertil. Steril. | pmid:15236989 |
| Zhelev DV et al. | Controlled pseudopod extension of human neutrophils stimulated with different chemoattractants. | 2004 | Biophys. J. | pmid:15240502 |
| Shio MT et al. | PAF is involved in the Mycoplasma arthritidis superantigen-triggering pathway for iNOS and COX-2 expression in murine peritoneal cells. | 2004 | Exp. Cell Res. | pmid:15242784 |
| Al-Darmaki S et al. | Delineation of the role of platelet-activating factor in the immunoglobulin G2 antibody response. | 2004 | Clin. Diagn. Lab. Immunol. | pmid:15242947 |
| PAF symposium on allergic, respiratory and cardiovascular diseases, Tokyo, 13-15 February 1991. Selected papers--symposium proceedings. | 1992 Jun-Jul | J Lipid Mediat | pmid:1525348 | |
| Bussolino F et al. | Protein kinase C activation in murine endothelioma cell lines containing middle T antigen stimulated by platelet-activating factor. | 1992 Jun-Jul | J Lipid Mediat | pmid:1525349 |
| Oh-ishi S et al. | Production of platelet-activating factor in inflammatory exudate. | 1992 Jun-Jul | J Lipid Mediat | pmid:1525350 |
| Yukawa T et al. | Sensitization primes platelet-activating factor (PAF)-induced accumulation of eosinophils in mouse skin lesions: contribution of cytokines to the response. | 1992 Jun-Jul | J Lipid Mediat | pmid:1525351 |
| Tokumura A et al. | Formation of PAF-like compounds by peroxidation of phospholipids from bovine brain. | 1992 Jun-Jul | J Lipid Mediat | pmid:1525352 |
| Uda H et al. | PAF-induced production of M-CSF in guinea-pig bone marrow. | 1992 Jun-Jul | J Lipid Mediat | pmid:1525353 |
| Saito H et al. | PAF-induced eosinophilic and basophilic differentiation in human hematopoietic precursor cells. | 1992 Jun-Jul | J Lipid Mediat | pmid:1525354 |
| Fukuda T et al. | Platelet-activating factor (PAF)-induced chemotaxis and PAF binding to human eosinophils. | 1992 Jun-Jul | J Lipid Mediat | pmid:1525356 |
| Barnes PJ | PAF, eosinophils and asthma. | 1992 Jun-Jul | J Lipid Mediat | pmid:1525357 |
| Lefort J et al. | Is platelet-activating factor involved in bronchopulmonary hyperresponsiveness? | 1992 Jun-Jul | J Lipid Mediat | pmid:1525358 |
| Minoguchi K et al. | The mechanism of airway hyperresponsiveness following immediate asthmatic response in ovalbumin-sensitized guinea-pigs. | 1992 Jun-Jul | J Lipid Mediat | pmid:1525359 |
| Inoue H et al. | Effect of a potent PAF antagonist, Y-24180, on an allergen-induced late asthmatic response in guinea-pigs. | 1992 Jun-Jul | J Lipid Mediat | pmid:1525360 |
| Ohno S et al. | The roles of platelet-activating factor (PAF) in pulmonary vasoconstriction during venous air embolism in anesthetized mongrel dogs. | 1992 Jun-Jul | J Lipid Mediat | pmid:1525361 |
| Furukawa M et al. | PAF in human respiratory diseases. | 1992 Jun-Jul | J Lipid Mediat | pmid:1525362 |
| Nakamura T et al. | Platelet-activating factor in Japanese cedar pollinosis. | 1992 Jun-Jul | J Lipid Mediat | pmid:1525363 |
| Lai CK et al. | Should PAF inhalation challenge be used as an experimental model of bronchial hyperresponsiveness in man? | 1992 Jun-Jul | J Lipid Mediat | pmid:1525364 |
| Seo KH et al. | Essential role for platelet-activating factor-induced NF-kappaB activation in macrophage-derived angiogenesis. | 2004 | Eur. J. Immunol. | pmid:15259010 |
| Ebiike H et al. | Lipase-catalyzed enantioselective hydrolysis of 4-alkyl-1,4-dihydropyridine derivatives: synthesis of (+)- and (-)-methyl 2-(phenylthio)ethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate (PCA 4248). | 1992 | Chem. Pharm. Bull. | pmid:1525941 |
| Misso NL and Thompson PJ | Xanthines inhibit human platelet aggregation induced by platelet-activating factor. | 1992 | Clin. Exp. Pharmacol. Physiol. | pmid:1526066 |
| Mita M and Ueta N | Fatty chains of alkenylacyl, alkylacyl and diacyl phospholipids in sea urchin spermatozoa. | 1992 | Comp. Biochem. Physiol., B | pmid:1526122 |
| Zhu P et al. | Interplay among platelet-activating factor, oxidative stress, and group I metabotropic glutamate receptors modulates neuronal survival. | 2004 | J. Neurosci. Res. | pmid:15264222 |
| Sarchielli P et al. | Platelet-activating factor (PAF) in internal jugular venous blood of migraine without aura patients assessed during migraine attacks. | 2004 | Cephalalgia | pmid:15265050 |
| Frenkel RA and Johnston JM | Metabolic conversion of platelet-activating factor into ethanolamine plasmalogen in an amnion-derived cell line. | 1992 | J. Biol. Chem. | pmid:1527040 |
| Chami O et al. | Components of a platelet-activating factor-signaling loop are assembled in the ovine endometrium late in the estrous cycle. | 2004 | Am. J. Physiol. Endocrinol. Metab. | pmid:15271646 |
| Fourcade O et al. | Propofol inhibits human platelet aggregation induced by proinflammatory lipid mediators. | 2004 | Anesth. Analg. | pmid:15271713 |
| Rasheed H and Saeed SA | Involvement of thromboxane A2 and tyrosine kinase in the synergistic interaction of platelet activating factor and calcium ionophore A23187 in human platelet aggregation. | 2004 | Exp. Mol. Med. | pmid:15272233 |
| Sumita C et al. | Pioglitazone induces plasma platelet activating factor-acetylhydrolase and inhibits platelet activating factor-mediated cytoskeletal reorganization in macrophage. | 2004 | Biochim. Biophys. Acta | pmid:15279882 |
| Corcoran PC et al. | Platelet activating factor antagonist enhances lung preservation. | 1992 | J. Surg. Res. | pmid:1528038 |
| Llodrá J et al. | Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15280540 |
| Kato M et al. | Apafant, a potent platelet-activating factor antagonist, blocks eosinophil activation and is effective in the chronic phase of experimental allergic conjunctivitis in guinea pigs. | 2004 | J. Pharmacol. Sci. | pmid:15286429 |
| Zinchuk O et al. | Dynamics of PAF-induced conjunctivitis reveals differential expression of PAF receptor by macrophages and eosinophils in the rat. | 2004 | Cell Tissue Res. | pmid:15290234 |
| Dulioust A et al. | Paf-acether acetylhydrolase activity is increased in patients with rheumatic diseases. | 1992 | Scand. J. Rheumatol. | pmid:1529281 |
| Xu Y et al. | Targeted disruption of PSD-93 gene reduces platelet-activating factor-induced neurotoxicity in cultured cortical neurons. | 2004 | Exp. Neurol. | pmid:15296832 |
| Wanten G et al. | Lipid effects on neutrophil calcium signaling induced by opsonized particles: platelet activating factor is only part of the story. | 2004 | Clin Nutr | pmid:15297099 |
| Tabor BL et al. | Platelet-activating factor antagonists decrease lung protein leak in preterm ventilated rabbits. | 1992 | Am. J. Obstet. Gynecol. | pmid:1530043 |
| Berdeli A et al. | Meconium enhances platelet-activating factor and tumor necrosis factor production by rat alveolar macrophages. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15301793 |
| Triggiani M et al. | Factors that influence the proportions of platelet-activating factor and 1-acyl-2-acetyl-sn-glycero-3-phosphocholine synthesized by the mast cell. | 1992 | Biochem. J. | pmid:1530582 |
| Ma X et al. | [Corneal epithelial wound healing is delayed by platelet activating factor treatment]. | 2004 | Zhonghua Yan Ke Za Zhi | pmid:15307983 |
| Venkatesha RT et al. | Platelet-activating factor-induced chemokine gene expression requires NF-kappaB activation and Ca2+/calcineurin signaling pathways. Inhibition by receptor phosphorylation and beta-arrestin recruitment. | 2004 | J. Biol. Chem. | pmid:15308653 |
| Buke AC et al. | Tumor necrosis factor alpha and interleukin 6 productions in response to platelet-activating factor in chronic hepatitis B virus infection. | 2004 Sep-Oct | Med Princ Pract | pmid:15316260 |