| MeSH term | MeSH ID | Detail |
|---|---|---|
| Tumor Virus Infections | D014412 | 8 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Wounds and Injuries | D014947 | 20 associated lipids |
| Pleurisy | D010998 | 20 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Grigoriadis G and Stewart AG | Human monocytes maintained in culture acquire functional responsiveness to platelet-activating factor that is independent of increases in protein tyrosine phosphorylation. | 1997 | Clin. Exp. Pharmacol. Physiol. | pmid:9269528 |
| Gaumond F et al. | Differential signaling pathways in platelet-activating factor-induced proliferation and interleukin-6 production by rat vascular smooth muscle cells. | 1997 | J. Cardiovasc. Pharmacol. | pmid:9269943 |
| Klouche M et al. | Endocytosis, storage, and release of IgE by human platelets: differences in patients with type I allergy and nonatopic subjects. | 1997 | J. Allergy Clin. Immunol. | pmid:9275146 |
| Chen D and Chen W | Changes of distribution of platelet activating factor in the lung of rats with hypoxic pulmonary hypertension. | 1996 | Chin. Med. J. | pmid:9275354 |
| Cheng D and Chen W | Effects of ginkgolide B on isobaric hypoxic pulmonary hypertension in rats. | 1996 | Chin. Med. J. | pmid:9275375 |
| Ren G and Ye R | [Changes in urinary excretion of platelet activating factor and its significance in patients with primary nephrotic syndrome]. | 1996 | Zhonghua Nei Ke Za Zhi | pmid:9275622 |
| Yamashita A et al. | Acyltransferases and transacylases involved in fatty acid remodeling of phospholipids and metabolism of bioactive lipids in mammalian cells. | 1997 | J. Biochem. | pmid:9276665 |
| Bkaily G et al. | The use of confocal microscopy in the investigation of cell structure and function in the heart, vascular endothelium and smooth muscle cells. | 1997 | Mol. Cell. Biochem. | pmid:9278244 |
| Kume K and Shimizu T | Platelet-activating factor (PAF) induces growth stimulation, inhibition, and suppression of oncogenic transformation in NRK cells overexpressing the PAF receptor. | 1997 | J. Biol. Chem. | pmid:9278453 |
| Oh SO et al. | Platelet-activating factor in plasma of patients with sickle cell disease in steady state. | 1997 | J. Lab. Clin. Med. | pmid:9280146 |
| RodrÃguez Roisin R | [Platelet activating factor and bronchial asthma. Is it relevant?]. | 1997 | Arch. Bronconeumol. | pmid:9280556 |
| Kintner DB et al. | Hyperglycemic damage to mitochondrial membranes during cerebral ischemia: amelioration by platelet-activating factor antagonist BN 50739. | 1997 | J. Neurochem. | pmid:9282946 |
| Roudebush WE et al. | Evidence for the presence of the platelet-activating factor receptor in the CFW mouse preimplantation two-cell-stage embryo. | 1997 | Biol. Reprod. | pmid:9282993 |
| Xie XQ et al. | Differential scanning calorimetry and small angle x-ray diffraction study of the interaction of (R)-PAF, (R)-ET-18-OME and (R)-Lyso-PAF with model membranes. | 1997 | Life Sci. | pmid:9284084 |
| Bastos da Silva M et al. | Combined effect of Web 2086 (Paf antagonist) and ketoprofen (Nsaid) on Paf-induced ex vivo platelet aggregation in bovine. | 1997 | Zentralbl Veterinarmed A | pmid:9284631 |
| Edwards CM et al. | Effects of the co-polymer surfactant, Pluronic F-68, on platelet aggregation in human whole blood. | 1997 | Artif Cells Blood Substit Immobil Biotechnol | pmid:9285052 |
| Karzai W and Reinhart K | Immune modulation and sepsis. | 1997 | Int. J. Clin. Pract. | pmid:9287265 |
| Partrick DA et al. | Nitric oxide attenuates platelet-activating factor priming for elastase release in human neutrophils via a cyclic guanosine monophosphate-dependent pathway. | 1997 | Surgery | pmid:9288123 |
| Van de Weerdt ML et al. | Effect of platelet-activating factor on bovine pulmonary function. | 1997 | Vet. Rec. | pmid:9290195 |
| Partrick DA et al. | Lipid mediators up-regulate CD11b and prime for concordant superoxide and elastase release in human neutrophils. | 1997 | J Trauma | pmid:9291376 |
| Bozza PT et al. | Eosinophil lipid bodies: specific, inducible intracellular sites for enhanced eicosanoid formation. | 1997 | J. Exp. Med. | pmid:9294145 |
| Perico N et al. | Platelet-activating factor mediates angiotensin II-induced proteinuria in isolated perfused rat kidney. | 1997 | J. Am. Soc. Nephrol. | pmid:9294830 |
| Albert DH et al. | ABT-491, a highly potent and selective PAF antagonist, inhibits nasal vascular permeability associated with experimental allergic rhinitis in brown Norway rats. | 1997 | Inflamm. Res. | pmid:9297547 |
| O'Brien JG et al. | Effects of tranexamic acid and aprotinin on PAF-induced vascular permeability in normal, thrombocytopenic or neutropenic rats. | 1997 | Inflamm. Res. | pmid:9297553 |
| Stewart A et al. | The regulation by phosphorylation of 'priming' of phospholipase A2 activity in the neutrophil model system, differentiated HL60 cells. | 1997 | Br. J. Pharmacol. | pmid:9298523 |
| Manabe H et al. | Anti-inflammatory and bronchodilator properties of KF19514, a phosphodiesterase 4 and 1 inhibitor. | 1997 | Eur. J. Pharmacol. | pmid:9298930 |
| Marr KA et al. | Effect of antigen challenge on the activation of peripheral blood neutrophils from horses with chronic obstructive pulmonary disease. | 1997 May-Jun | Res. Vet. Sci. | pmid:9300544 |
| Kimura M et al. | Effects of fluvastatin on leukocyte-endothelial cell adhesion in hypercholesterolemic rats. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9301630 |
| Herbert JM et al. | Pharmacological evidence for the putative existence of two different subtypes of PAF receptors on platelets and leukocytes; studies with yangambin. | 1997 | J Lipid Mediat Cell Signal | pmid:9302650 |
| Bialasiewicz P et al. | Altered intracellular calcium signalling after PAF stimulations in polymorphonuclear leukocytes from asthmatic patients. | 1997 | J Lipid Mediat Cell Signal | pmid:9302652 |
| Balsa D et al. | Effect of endotoxin and platelet-activating factor on rat vascular permeability: role of vasoactive mediators. | 1997 | J Lipid Mediat Cell Signal | pmid:9302653 |
| Ablett JM et al. | Influence of antigen challenge on platelet responsiveness in horses with chronic obstructive pulmonary disease. | 1997 | Equine Vet. J. | pmid:9306066 |
| Oh-ishi S | [Analysis of chemical mediators involved in acute inflammatory reaction with the rat pleurisy model]. | 1997 | Nippon Yakurigaku Zasshi | pmid:9306414 |
| Tailor A et al. | Dexamethasone inhibits leukocyte emigration in rat mesenteric post-capillary venules: an intravital microscopy study. | 1997 | J. Leukoc. Biol. | pmid:9307068 |
| Cortijo J et al. | Pharmacological activity of PF-904 in guinea pig in vivo, and on human bronchus and neutrophils in vitro. | 1997 | Eur. J. Pharmacol. | pmid:9311663 |
| Teixeira MM et al. | Chemokine-induced eosinophil recruitment. Evidence of a role for endogenous eotaxin in an in vivo allergy model in mouse skin. | 1997 | J. Clin. Invest. | pmid:9312163 |
| Cepinskas G et al. | Transendothelial neutrophil migration. Role of neutrophil-derived proteases and relationship to transendothelial protein movement. | 1997 | Circ. Res. | pmid:9314844 |
| Wan S et al. | Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies. | 1997 | Chest | pmid:9315800 |
| Nakao A et al. | cAMP mediates homologous downregulation of PAF receptor mRNA expression in mesangial cells. | 1997 | Am. J. Physiol. | pmid:9321918 |
| Shimizu T and Mutoh H | Structure and regulation of platelet activating factor receptor gene. | 1997 | Adv. Exp. Med. Biol. | pmid:9321953 |
| Mori M et al. | Localization of platelet-activating factor receptor in the rat brain. | 1997 | Adv. Exp. Med. Biol. | pmid:9321976 |
| Erickson KL et al. | Alteration of platelet activating factor-induced macrophage tumoricidal response, IA expression, and signal transduction by N-3 fatty acids. | 1997 | Adv. Exp. Med. Biol. | pmid:9321978 |
| Muguruma K et al. | The central role of PAF in necrotizing enterocolitis development. | 1997 | Adv. Exp. Med. Biol. | pmid:9321979 |
| Aoki Y et al. | A simple, rapid and specific radioreceptor assay for platelet-activating factor. | 1997 | Adv. Exp. Med. Biol. | pmid:9321990 |
| Si Y et al. | The change in plasma PAF activity before and after delivery. | 1997 | Adv. Exp. Med. Biol. | pmid:9322006 |
| Murray J et al. | Regulation of neutrophil apoptosis by tumor necrosis factor-alpha: requirement for TNFR55 and TNFR75 for induction of apoptosis in vitro. | 1997 | Blood | pmid:9326245 |
| DeLano FA et al. | Attenuation of oxygen free radical formation and tissue injury during experimental inflammation by P-selectin blockade. | 1997 | Microcirculation | pmid:9329011 |
| Weber C and Springer TA | Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor. | 1997 | J. Clin. Invest. | pmid:9329974 |
| Ohkuni H et al. | Purification and partial characterization of a novel human platelet aggregation factor in the extracellular products of Streptococcus mitis, strain Nm-65. | 1997 | Adv. Exp. Med. Biol. | pmid:9331745 |
| Knight D et al. | Adenosine A3 receptor stimulation inhibits migration of human eosinophils. | 1997 | J. Leukoc. Biol. | pmid:9335316 |