| MeSH term | MeSH ID | Detail |
|---|---|---|
| Tumor Virus Infections | D014412 | 8 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Wounds and Injuries | D014947 | 20 associated lipids |
| Pleurisy | D010998 | 20 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Getting SJ et al. | Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9336316 |
| Greiff L et al. | Effects of topical platelet activating factor on the guinea-pig tracheobronchial mucosa in vivo. | 1997 | Acta Physiol. Scand. | pmid:9338520 |
| Ohashi Y et al. | Platelet activating factor compromises airway epithelial defense functions. | 1997 | J. Allergy Clin. Immunol. | pmid:9338547 |
| Hirashima Y et al. | Elevation of platelet activating factor, inflammatory cytokines, and coagulation factors in the internal jugular vein of patients with subarachnoid hemorrhage. | 1997 | Neurochem. Res. | pmid:9342729 |
| Francescangeli E et al. | Activities of enzymes involved in the metabolism of platelet-activating factor in neural cell cultures during proliferation and differentiation. | 1997 | Neurochem. Res. | pmid:9342735 |
| Bastos da Silva M et al. | Morphological alterations of blood platelets induced by platelet activating factor (PAF) and partial inhibition by ketoprofen in calves. | 1997 Sep-Oct | Vet. Res. | pmid:9342825 |
| Rezaul K et al. | Platelet-activating factor stimulates calcium-dependent activation of protein-tyrosine kinase Syk in a human B cell line. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9345263 |
| Iwamoto S et al. | The release mechanism of platelet-activating factor during shear-stress induced platelet aggregation. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9345277 |
| Bastos da Silva MB et al. | The effect of intravenous administration of WEB 2086 on PAF-induced platelet aggregation in healthy Friesian calves. | 1997 | Vet. Res. Commun. | pmid:9345719 |
| Million M et al. | Effects of neuropeptide FF on intestinal motility and temperature changes induced by endotoxin and platelet-activating factor. | 1997 | Eur. J. Pharmacol. | pmid:9346330 |
| Aspey BS et al. | Effects of combined glutamate and platelet-activating factor inhibition on the outcome of focal cerebral ischaemia - an initial screening study. | 1997 | Metab Brain Dis | pmid:9346472 |
| Bzeizi KI et al. | Primary graft dysfunction after liver transplantation: from pathogenesis to prevention. | 1997 | Liver Transpl Surg | pmid:9346727 |
| Denham W et al. | Gene targeting demonstrates additive detrimental effects of interleukin 1 and tumor necrosis factor during pancreatitis. | 1997 | Gastroenterology | pmid:9352880 |
| Howarth PH | Mediators of nasal blockage in allergic rhinitis. | 1997 | Allergy | pmid:9353555 |
| Nagaoka H et al. | 2-(3-Pyridyl)thiazolidine-4-carboxamides. 1. Novel orally active antagonists of platelet-activating factor (PAF). | 1997 | Chem. Pharm. Bull. | pmid:9353894 |
| Liu B et al. | Prolonged activation of phospholipase D in Chinese hamster ovary cells expressing platelet-activating-factor receptor lacking cytoplasmic C-terminal tail. | 1997 | Biochem. J. | pmid:9355758 |
| Silomon M et al. | Role of platelet-activating factor in hepatocellular Ca2+ alterations during hemorrhagic shock. | 1997 | J. Surg. Res. | pmid:9356229 |
| Wang H et al. | Platelet-activating factor (PAF) up-regulates plasma and tissue PAF-acetylhydrolase activity in the rat: effect of cycloheximide. | 1997 | Pediatr. Res. | pmid:9357930 |
| May JA et al. | Platelet responses to several agonists and combinations of agonists in whole blood: a placebo controlled comparison of the effects of a once daily dose of plain aspirin 300 mg, plain aspirin 75 mg and enteric coated aspirin 300 mg, in man. | 1997 | Thromb. Res. | pmid:9361371 |
| Radonjic-Lazovic G and Roudebush WE | The effect of short- vs. long-term platelet-activating factor exposure on mouse preimplantation embryo development. | 1995 | Early Pregnancy | pmid:9363251 |
| Hershkowitz M and Adunsky A | Binding of platelet-activating factor to platelets of Alzheimer's disease and multiinfarct dementia patients. | 1996 Nov-Dec | Neurobiol. Aging | pmid:9363797 |
| Kishimoto S et al. | Comparison of platelet-activating factor receptor mRNA levels in peripheral blood eosinophils from normal subjects and atopic asthmatic patients. | 1997 | Int. Arch. Allergy Immunol. | pmid:9363928 |
| Manna SK et al. | Hamycin inhibits IL-8-induced biologic response by modulating its receptor in human polymorphonuclear neutrophils. | 1997 | J. Immunol. | pmid:9366432 |
| Saeed SA et al. | Anti-thrombotic and anti-inflammatory activities of protopine. | 1997 | Pharmacol. Res. | pmid:9368908 |
| Snyder F | CDP-choline:alkylacetylglycerol cholinephosphotransferase catalyzes the final step in the de novo synthesis of platelet-activating factor. | 1997 | Biochim. Biophys. Acta | pmid:9370322 |
| Nagase T et al. | Airway responsiveness in transgenic mice overexpressing platelet-activating factor receptor. Roles of thromboxanes and leukotrienes. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9372685 |
| Tetta C et al. | Relevance of platelet-activating factor in inflammation and sepsis: mechanisms and kinetics of removal in extracorporeal treatments. | 1997 | Am. J. Kidney Dis. | pmid:9372980 |
| Garland A et al. | Activated eosinophils elicit substance P release from cultured dorsal root ganglion neurons. | 1997 | Am. J. Physiol. | pmid:9374740 |
| Miyahara T et al. | Role of circulating blood components and thromboxane in anaphylactic vasoconstriction in isolated canine lungs. | 1997 | J. Appl. Physiol. | pmid:9375313 |
| Bazan HE et al. | Platelet-activating factor induces cyclooxygenase-2 gene expression in corneal epithelium. Requirement of calcium in the signal transduction pathway. | 1997 | Invest. Ophthalmol. Vis. Sci. | pmid:9375567 |
| Mori M et al. | Localization of platelet-activating factor receptor messenger RNA in the rat eye. | 1997 | Invest. Ophthalmol. Vis. Sci. | pmid:9375587 |
| Okada S et al. | Migration of eosinophils through basement membrane components in vitro: role of matrix metalloproteinase-9. | 1997 | Am. J. Respir. Cell Mol. Biol. | pmid:9376127 |
| Mantovani A | The interplay between primary and secondary cytokines. Cytokines involved in the regulation of monocyte recruitment. | 1997 | Drugs | pmid:9378074 |
| Kagoshima M et al. | Effect of Y-24180, a long-acting antagonist to platelet-activating factor (PAF), on PAF-induced reactions: a relationship between the partial structure of the compound and its duration of the action. | 1997 | Pharmacology | pmid:9380772 |
| Kozai T et al. | Platelet activating factor causes hyperconstriction at the inflammatory coronary lesions in pigs in vivo. | 1997 | Coron. Artery Dis. | pmid:9383603 |
| Wang HG et al. | Effect of platelet-activating factor on hepatic capillary pressure in isolated dog liver. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9384519 |
| Sapir T et al. | Reduction of microtubule catastrophe events by LIS1, platelet-activating factor acetylhydrolase subunit. | 1997 | EMBO J. | pmid:9384577 |
| Yu P et al. | [A study on changes and its mechanisms of intestinal mucosal permeability after severe burn]. | 1996 | Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi | pmid:9387456 |
| Zhou X et al. | [Monocellular quantitative study on the adhesive ability of eosinophils in the course of eosinophils activation]. | 1996 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:9387483 |
| Cheng D et al. | [The level of platelet activating factor in blood of rats with hypoxic pulmonary hypertension]. | 1996 | Hua Xi Yi Ke Da Xue Xue Bao | pmid:9389027 |
| Cheng D and Chen W | [The role of platelet activating factor in chronic pulmonary hypertension]. | 1996 | Hua Xi Yi Ke Da Xue Xue Bao | pmid:9389061 |
| Hu DH and Ma CT | [Effect of platelet activating factor on TxA2, PGI2 and Ca(2+)-ATPase activity in the intra-pulmonary artery smooth muscle cells]. | 1996 | Sheng Li Xue Bao | pmid:9389196 |
| Bellamy MC et al. | Changes in inflammatory mediators during orthotopic liver transplantation. | 1997 | Br J Anaesth | pmid:9389852 |
| Nathan N et al. | Cytokine and lipid mediator blood concentrations after coronary artery surgery. | 1997 | Anesth. Analg. | pmid:9390587 |
| Im SY et al. | Involvement of nuclear factor-kappa B in platelet-activating factor-mediated tumor necrosis factor-alpha expression. | 1997 | Eur. J. Immunol. | pmid:9394802 |
| Negro Alvarez JM et al. | Platelet-activating factor antagonists. | 1997 Sep-Oct | Allergol Immunopathol (Madr) | pmid:9395010 |
| Elzi DJ et al. | Receptor-mediated calcium entry is required for maximal effects of platelet activating factor primed responses in human neutrophils. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9398641 |
| el-Shazly AE et al. | Mechanisms involved in activation of human eosinophil exocytosis by substance P: an in vitro model of sensory neuroimmunomodulation. | 1997 Aug-Dec | Immunol. Invest. | pmid:9399104 |
| Erickson KL et al. | Induction and modulation of macrophage Ia antigen expression by platelet-activating factor. | 1997 | J. Leukoc. Biol. | pmid:9400826 |
| Bix GJ and Clark GD | Elvax as a slow-release delivery agent for a platelet-activating factor receptor agonist and antagonist. | 1997 | J. Neurosci. Methods | pmid:9402559 |