Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hepatitis C, Chronic D019698 12 associated lipids
Coronary Stenosis D023921 6 associated lipids
Aggressive Periodontitis D010520 8 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Arteriosclerosis Obliterans D001162 8 associated lipids
Encephalitis D004660 15 associated lipids
Thyroiditis, Autoimmune D013967 9 associated lipids
Cholestasis, Intrahepatic D002780 4 associated lipids
Contracture D003286 3 associated lipids
Stomatitis D013280 14 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Cheng NN and Ma YM [A hypotensive analog of platelet-activating factor (PAF) in pheretima]. 1993 Zhongguo Zhong Yao Za Zhi pmid:8011088
Shi W et al. [Study on composing mechanism by effect of disassembled compositions of Yiqi Huoxue decoction on platelet aggregation of health adults]. 2007 Zhongguo Zhong Yao Za Zhi pmid:18309677
Li SH et al. [Effect of an extract from the cauline of Piper kadsura ohwi on endotoxin-induced hypotension and lung injury in rats]. 1989 Zhongguo Zhong Yao Za Zhi pmid:2619897
Chen ZN et al. [Anti-platelet activating factor constituents, 2,5-diaryltetrahydrofuran type lignans, from Piper futokadsura Sied. et Zucc]. 1993 Zhongguo Zhong Yao Za Zhi pmid:8216803
Chen ZN [Recent progress in the study of anti-PAF (platelet activating factor) constituents of medicinal herbs]. 1993 Zhongguo Zhong Yao Za Zhi pmid:8274205
Dong JC et al. [Experimental study on antagonism of ginkgolides against effect of platelet-activating factor on lung strip of guinea pigs]. 1997 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:10322836
Yang AP and Chen Q [Correlation between blood-stasis tongue figure and platelet activating factor (PAF) and acetyl hydrolase of PAF (PAF-AH) in patients with primary dysmenorrhea]. 2011 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:21485072
Dong JC et al. [Ginkgolides antagonizing some effects of platelet-activating factor in vitro]. 1995 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:8704427
Zhang J et al. [Experimental study on effect of Buyang Huanwu decoction on arterial blood platelet activating factor content pre- and post-arterial thrombosis of rats]. 1998 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:11475720
Shao P et al. [Research on relationship of syndrome type and parameters of hemorheology and platelet activation in patients with acute gout arthritis of dampness-heat blockage type and stasis-heat accumulate type]. 2006 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:17186728
Wang J et al. [Effect of Radix notoginseng saponins on platelet activating molecule expression and aggregation in patients with blood hyperviscosity syndrome]. 2004 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:15143716
Chen WM et al. [Experimental study on inhibitory effect of rutin against platelet activation induced by platelet activating factor in rabbits]. 2002 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:12584792
Zhao W et al. [Expression and regulation of pituitary adenylate cyclase-activating polypeptide mRNA in pregnant rat corpus luteum]. 2010 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21038678
Di Y et al. [Effect of ginkgolide B on plasma levels of interleukin-12 and PAF in severe acute pancreatitis in rats]. 2008 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21141514
Zhao W et al. [Effect of PAF on the expression of PACAP mRNA in the granulosa cells of rat ovary]. 2007 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21180114
Dong J et al. [Effect of platelet-activating factor on long-term potentiation in rat hippocampal slices]. 2005 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21171322
Liu SH et al. [Effects of p38 mitogen-activated protein kinase in protection of carbon monoxide against lipopolysaccharide induced rat small intestine injury]. 2009 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21189571
Shen ZQ et al. Effect of protopine on cytosolic Ca2+ in rabbit platelets. 1999 Zhongguo Yao Li Xue Bao pmid:10452120
Zeng GQ and Rui YC [Inhibitory effect of dauricine on platelet activating factor released from calcimycin-induced mouse peritoneal macrophages]. 1990 Zhongguo Yao Li Xue Bao pmid:2104489
Zeng S and Guo ZG Mepyramine inhibits platelet activating factor-induced rabbit platelet aggregation: role of intracellular histamine. 1997 Zhongguo Yao Li Xue Bao pmid:10072970