| MeSH term | MeSH ID | Detail |
|---|---|---|
| Malaria, Falciparum | D016778 | 22 associated lipids |
| Liver Failure | D017093 | 5 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Helicobacter Infections | D016481 | 21 associated lipids |
| Gastroesophageal Reflux | D005764 | 10 associated lipids |
| Mucositis | D052016 | 7 associated lipids |
| Ileitis | D007079 | 2 associated lipids |
| Carcinoma, Embryonal | D018236 | 8 associated lipids |
| Postoperative Hemorrhage | D019106 | 7 associated lipids |
| Neoplastic Cells, Circulating | D009360 | 5 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Detopoulou P et al. | PAF and its metabolic enzymes in healthy volunteers: interrelations and correlations with basic characteristics. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:22079887 |
| Steil AA et al. | Platelet-activating factor and eicosanoids are mediators of local and systemic changes induced by immune-complexes in mice. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10367295 |
| Fujimura M et al. | No involvement of lipid mediators in a guinea pig model of ultrasonically nebulized distilled water-induced bronchoconstriction. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10680775 |
| MartÃnez L et al. | Nitroprusside stimulates contractility and the synthesis of 14C-acetylated PAF-like substances in estrogen primed-mouse uterine horns. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10367296 |
| Miguel BG et al. | Increase of phosphoinositide hydrolysis and diacylglycerol production by PAF in isolated rat liver nuclei. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11444588 |
| Travers JB et al. | Identification and pharmacological characterization of platelet-activating factor and related 1-palmitoyl species in human inflammatory blistering diseases. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9990675 |
| Balestrieri ML et al. | Types of purinoceptors and phospholipase A2 involved in the activation of the platelet-activating factor-dependent transacetylase activity and arachidonate release by ATP in endothelial cells. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9990678 |
| Li L et al. | Estrogen effects on platelet-activating factor and platelet-activating factor acetylhydrolase activity in rat uterus during the late stages of pregnancy. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10402216 |
| Tiemann U et al. | Influence of ovarian steroid hormones or platelet-activating factor on mRNA of platelet-activating factor receptor in endometrial explant perfusion cultures from ovariectomized bovine. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15967160 |
| Kudolo GB and DeFronzo RA | Urinary platelet-activating factor excretion is elevated in non-insulin dependent diabetes mellitus. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10410380 |
| Martin-Chouly CA et al. | Modulation of PAF production by incorporation of arachidonic acid and eicosapentaenoic acid in phospholipids of human leukemic monocyte-like cells THP-1. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10751643 |
| Tsutsumi T et al. | Movement of monoglyceride derived from hydrolysis of fluorescence-labeled lyso platelet-activating factor by lysophospholipase C through plasma membranes of porcine kidney epithelial cell line LLC-PK1. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17259070 |
| Benito E and Bosch MA | Role of platelet-activating factor in phosphatidylcholine secretion in primary cultures of rat type II pneumocytes. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12013527 |
| Sakellariou M et al. | Intravenous infusion of PAF affects ovulation, fertilization and preimplantation embryonic development in NZB x NZW F1 hybrid mice. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18248752 |
| Chen C and Bazan NG | Lipid signaling: sleep, synaptic plasticity, and neuroprotection. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099392 |
| Itadani K et al. | Inhibition of Na+,K(+)-ATPase by platelet-activating factor in dog submandibular glands. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9653774 |
| Fallani A et al. | Platelet-activating factor (PAF) is the effector of IFN gamma-stimulated invasiveness and motility in a B16 melanoma line. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:17085325 |
| Arai H | Platelet-activating factor acetylhydrolase. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12432911 |
| Fallani A et al. | Synthesis of platelet-activating factor (PAF) in transformed cell lines of a different origin. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12428690 |
| Ishii S et al. | Platelet-activating factor receptor. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12432946 |
| Hla T | Prostaglandins & other lipid mediators: a new phase, a new team. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15165026 |
| Ruan Z et al. | Effects of platelet-activating factor and thromboxane A2 on isolated perfused guinea pig liver. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15165033 |
| Nomikos TN et al. | Application of a TCA-precipitation method for the determination of 1-alkyl-sn-glycero-3-phosphate: Acetyl-CoA acetyltransferase in human renal tissue. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15165037 |
| Beck-Speier I et al. | Sulfur-related air pollutants induce the generation of platelet-activating factor, 5-lipoxygenase- and cyclooxygenase-products in canine alveolar macrophages via activation of phospholipases A2. | 2003 | Prostaglandins Other Lipid Mediat. | pmid:14518563 |
| Ishiura Y et al. | In vivo PAF-induced airway eosinophil accumulation reduces bronchial responsiveness to inhaled histamine. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15789611 |
| Gaudreault E et al. | Involvement of leukotriene B4 receptor 1 signaling in platelet-activating factor-mediated neutrophil degranulation and chemotaxis. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15789613 |
| Calcerrada MC et al. | Selective translocation of protein kinase c isozymes by PAF in rabbit platelets. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15789614 |
| Tiano L et al. | Oxidative response and membrane modification of diabetic platelets challenged with PAF. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:11060899 |
| Argyrou C et al. | Postprandial effects of wine consumption on Platelet Activating Factor metabolic enzymes. | 2017 | Prostaglandins Other Lipid Mediat. | pmid:28323197 |
| Calcerrada MC et al. | Modulation of protein kinase C isoforms by PAF in cerebral cortex. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10482284 |
| Nakasaki T et al. | Effects of PAF on histamine H1 receptor mRNA expression in rat trigeminal ganglia. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10482285 |
| Hiran T et al. | Evidence for the involvement of the NADPH oxidase enzyme complex in the optimal accumulation of Platelet-activating factor in the human cell line PLB-985. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11785782 |
| Cui S et al. | Effects of platelet-activating factor, thromboxane A2 and leukotriene D4 on isolated perfused rat liver. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16846785 |
| Menezes-de-Lima O et al. | Lipoxin A4 inhibits acute edema in mice: implications for the anti-edematogenic mechanism induced by aspirin. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16939877 |
| Vlachogianni IC et al. | Platelet Activating Factor (PAF) biosynthesis is inhibited by phenolic compounds in U-937 cells under inflammatory conditions. | 2015 | Prostaglandins Other Lipid Mediat. | pmid:26358846 |
| Besana A et al. | Lipids and two-pore domain K+ channels in excitable cells. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099395 |
| Shibamoto T et al. | Involvement of platelet-activating factor and leukotrienes in anaphylactic segmental venoconstriction in ovalbumin sensitized guinea pig livers. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16303618 |
| Shindo K et al. | Inhibitory effect of azelastine hydrochloride on synthesis and release of platelet activating factor from human alveolar macrophages. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9431823 |
| Akisu M et al. | Selective head cooling with hypothermia suppresses the generation of platelet-activating factor in cerebrospinal fluid of newborn infants with perinatal asphyxia. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12878450 |
| Landgraf RG et al. | Prostaglandins, leukotrienes and PAF selectively modulate lymphocyte subset and eosinophil infiltration into the airways in a murine model of asthma. | 2007 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17923399 |
| Hardy P et al. | New insights into the retinal circulation: inflammatory lipid mediators in ischemic retinopathy. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15850712 |
| Galli C et al. | Modulation of lipid derived mediators by polyunsaturated fatty acids. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8424123 |
| Evans RD et al. | Platelet-activating factor and its metabolic effects. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1946557 |
| Viossat I et al. | Effects of platelet activating factor (PAF) and its receptor antagonist BN 52021 on isolated perfused guinea-pig heart. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2622972 |
| Shindo K and Fukumura M | Azelastine hydrochloride inhibits platelet activating factor-like activity in human eosinophils. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8951989 |
| González E et al. | A novel enhancing effect of platelet activating factor (PAF) on glucose oxidation in uteri from pregnant rats. Participation of prostaglandins and leukotrienes. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2399270 |
| Peplow PV and Mikhailidis DP | Platelet-activating factor (PAF) and its relation to prostaglandins, leukotrienes and other aspects of arachidonate metabolism. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2274568 |
| Jeremy JY et al. | Eicosanoids and septicaemia. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7938078 |
| Peplow PV | Regulation of platelet-activating factor (PAF) activity in human diseases by phospholipase A2 inhibitors, PAF acetylhydrolases, PAF receptor antagonists and free radical scavengers. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10509861 |
| Shindo K and Fukumura M | Oxatomide inhibits synthesis and release of platelet-activating factor in human neutrophils. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9578146 |