| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Experimental | D007942 | 42 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lenshof A and Laurell T | Emerging clinical applications of microchip-based acoustophoresis. | 2011 | J Lab Autom | pmid:22093301 |
| Michelotto PV et al. | Pulmonary inflammation due to exercise-induced pulmonary haemorrhage in Thoroughbred colts during race training. | 2011 | Vet. J. | pmid:22108190 |
| Howard KM et al. | Lipopolysaccharide and platelet-activating factor stimulate expression of platelet-activating factor acetylhydrolase via distinct signaling pathways. | 2011 | Inflamm. Res. | pmid:21432021 |
| Jönsson F et al. | Mouse and human neutrophils induce anaphylaxis. | 2011 | J. Clin. Invest. | pmid:21436586 |
| Côrte-Real R et al. | The activity of platelet activating factor-acetyl hydrolase (PAF-AH) in the salivary glands of Rhodnius prolixus. | 2011 | J. Insect Physiol. | pmid:21439293 |
| Li XJ et al. | [Expression of platelet-activating factor in necrotizing enterocolitis and its clinical significance]. | 2011 | Zhonghua Bing Li Xue Za Zhi | pmid:21426810 |
| Leistad L et al. | Multiple phospholipase A2 enzymes participate in the inflammatory process in osteoarthritic cartilage. | 2011 | Scand. J. Rheumatol. | pmid:21417548 |
| Xu LF et al. | Disruption of the F-actin cytoskeleton and monolayer barrier integrity induced by PAF and the protective effect of ITF on intestinal epithelium. | 2011 | Arch. Pharm. Res. | pmid:21380808 |
| Aktan I et al. | PKC isoenzymes in equine platelets and stimulus induced activation. | 2011 | Vet. Immunol. Immunopathol. | pmid:21513989 |
| Jiang W et al. | [Effects and mechanisms of platelet-activating factor on the invasiveness of ovarian cancer cells in vitro]. | 2011 | Zhonghua Fu Chan Ke Za Zhi | pmid:22333285 |
| Kang NI et al. | Protein kinase CK2/PTEN pathway plays a key role in platelet-activating factor-mediated murine anaphylactic shock. | 2011 | J. Immunol. | pmid:21531890 |
| Tang WZ et al. | Dimeric prenylated C6-C3 compounds from the stem bark of Illicium oligandrum. | 2011 | J. Nat. Prod. | pmid:21524101 |
| Ma SG et al. | Four new phenolic diglycosides from the roots of Illicium oligandrum. | 2011 | Carbohydr. Res. | pmid:21524732 |
| Orlando RC et al. | Esophageal disease: updated information on inflammation. | 2011 | Ann. N. Y. Acad. Sci. | pmid:21950828 |
| Frisardi V et al. | Glycerophospholipids and glycerophospholipid-derived lipid mediators: a complex meshwork in Alzheimer's disease pathology. | 2011 | Prog. Lipid Res. | pmid:21703303 |
| Zimmermann LT et al. | Effects of platelet-activating factor on the interaction of Trypanosoma cruzi with Rhodnius prolixus. | 2011 | Parasitol. Res. | pmid:21161276 |
| Musto AE and Samii M | Platelet-activating factor receptor antagonism targets neuroinflammation in experimental epilepsy. | 2011 | Epilepsia | pmid:21204830 |
| Liao HJ et al. | Two new ginkgolides from the leaves of Ginkgo biloba. | 2011 | Planta Med. | pmid:21614751 |
| Penna C et al. | Platelet activating factor: the good and the bad in the ischemic/reperfused heart. | 2011 | Exp. Biol. Med. (Maywood) | pmid:21378031 |
| Kennedy MA et al. | Srf1 is a novel regulator of phospholipase D activity and is essential to buffer the toxic effects of C16:0 platelet activating factor. | 2011 | PLoS Genet. | pmid:21347278 |
| Kim HA et al. | Mechanisms of platelet-activating factor-induced enhancement of VEGF expression. | 2011 | Cell. Physiol. Biochem. | pmid:21325822 |
| Saihkay HN et al. | Validating 123I-metaiodobenzylguanidine as a platelet marker for non-invasive imaging in rabbits. | 2011 Jan-Feb | J Pharmacol Toxicol Methods | pmid:20646985 |
| Cingi C et al. | The histopathological effect of thymoquinone on experimentally induced rhinosinusitis in rats. | 2011 Nov-Dec | Am J Rhinol Allergy | pmid:22185737 |
| Detopoulou P et al. | PAF and its metabolic enzymes in healthy volunteers: interrelations and correlations with basic characteristics. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:22079887 |
| Ding DD et al. | [Changes of platelet α-particle membrane protein, platelet activating factor and platelet parameters in patients with hyperuricemia]. | 2012 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:22541106 |
| Camuesco D et al. | The intestinal anti-inflammatory effect of dersalazine sodium is related to a down-regulation in IL-17 production in experimental models of rodent colitis. | 2012 | Br. J. Pharmacol. | pmid:21790535 |
| Sahu RP et al. | The environmental stressor ultraviolet B radiation inhibits murine antitumor immunity through its ability to generate platelet-activating factor agonists. | 2012 | Carcinogenesis | pmid:22542595 |
| Sato A et al. | Synthetic biotinylated peptide compounds derived from Asp-hemolysin: novel potent inhibitors of platelet-activating factor. | 2012 | Eur. J. Pharmacol. | pmid:22542654 |
| Bachi AL et al. | Apoptotic cells contribute to melanoma progression and this effect is partially mediated by the platelet-activating factor receptor. | 2012 | Mediators Inflamm. | pmid:22577252 |
| Neerhof MG et al. | The significance of endothelin in platelet-activating factor-induced fetal growth restriction. | 2012 | Reprod Sci | pmid:22534337 |
| Muehlmann LA et al. | PAF increases phagocytic capacity and superoxide anion production in equine alveolar macrophages and blood neutrophils. | 2012 | Res. Vet. Sci. | pmid:21820686 |
| Kim HA et al. | Glutamine inhibits platelet-activating factor-mediated pulmonary tumour metastasis. | 2012 | Eur. J. Cancer | pmid:21889331 |
| Werner J et al. | Multidrug strategies are effective in the treatment of severe experimental pancreatitis. | 2012 | Surgery | pmid:21982067 |
| Conejeros I et al. | 2-Aminoethoxydiphenyl borate (2-APB) reduces respiratory burst, MMP-9 release and CD11b expression, and increases l-selectin shedding in bovine neutrophils. | 2012 | Res. Vet. Sci. | pmid:21071047 |
| López-Sagaseta J et al. | sPLA2-V inhibits EPCR anticoagulant and antiapoptotic properties by accommodating lysophosphatidylcholine or PAF in the hydrophobic groove. | 2012 | Blood | pmid:22167755 |
| Park J et al. | Females with angina pectoris have altered lipoprotein metabolism with elevated cholesteryl ester transfer protein activity and impaired high-density lipoproteins-associated antioxidant enzymes. | 2012 | Int. J. Mol. Med. | pmid:22211242 |
| Bae R et al. | Albuterol isomers modulate platelet-activating factor synthesis and receptor signaling in human bronchial smooth muscle cells. | 2012 | Int. Arch. Allergy Immunol. | pmid:22212397 |
| Widgerow AD and Kalaria S | Pain mediators and wound healing--establishing the connection. | 2012 | Burns | pmid:22738827 |
| Altomare A et al. | Platelet-activating factor and distinct chemokines are elevated in mucosal biopsies of erosive compared with non-erosive reflux disease patients and controls. | 2012 | Neurogastroenterol. Motil. | pmid:22734465 |
| Akbarshahi H et al. | Acute lung injury in acute pancreatitis--awaiting the big leap. | 2012 | Respir Med | pmid:22749752 |
| Kolovou V et al. | Platelet activating factor levels and metabolism in Tangier disease: a case study. | 2012 | Lipids Health Dis | pmid:22769014 |
| Jia XQ et al. | [Changes in coagulation and fibrinolysis in the patients with coronary heart disease in acute period and effect of drug intervention]. | 2012 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:22464576 |
| Liu M et al. | Group A Streptococcus secreted esterase hydrolyzes platelet-activating factor to impede neutrophil recruitment and facilitate innate immune evasion. | 2012 | PLoS Pathog. | pmid:22496650 |
| Kim HA et al. | PTEN/MAPK pathways play a key role in platelet-activating factor-induced experimental pulmonary tumor metastasis. | 2012 | FEBS Lett. | pmid:23137704 |
| Jiang Z et al. | The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in Aspergillus fumigatus sensitized mice. | 2012 | Respir. Res. | pmid:23140447 |
| Senbagavalli P et al. | Immune complexes isolated from patients with pulmonary tuberculosis modulate the activation and function of normal granulocytes. | 2012 | Clin. Vaccine Immunol. | pmid:23100480 |
| Zhang J et al. | Traumatic brain injury-associated coagulopathy. | 2012 | J. Neurotrauma | pmid:23020190 |
| Zia-Ul-Haq M et al. | Report: Platelet aggregation inhibition activity of selected legumes of Pakistan. | 2012 | Pak J Pharm Sci | pmid:23010006 |
| Petho G and Reeh PW | Sensory and signaling mechanisms of bradykinin, eicosanoids, platelet-activating factor, and nitric oxide in peripheral nociceptors. | 2012 | Physiol. Rev. | pmid:23073630 |
| Tsoupras AB et al. | Platelet-activating factor and its basic metabolic enzymes in blood of naive HIV-infected patients. | 2012 | Angiology | pmid:21948973 |