| MeSH term | MeSH ID | Detail |
|---|---|---|
| Corneal Neovascularization | D016510 | 8 associated lipids |
| Xeroderma Pigmentosum | D014983 | 6 associated lipids |
| Shock, Cardiogenic | D012770 | 5 associated lipids |
| Hypertrophy, Right Ventricular | D017380 | 4 associated lipids |
| Strongylida Infections | D017206 | 5 associated lipids |
| Enterocolitis, Necrotizing | D020345 | 3 associated lipids |
| Milk Hypersensitivity | D016269 | 4 associated lipids |
| Hematoma, Subdural | D006408 | 3 associated lipids |
| Venous Thrombosis | D020246 | 11 associated lipids |
| Blood Loss, Surgical | D016063 | 6 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chand N et al. | Effect of PAF-antagonists on aeroallergen-induced bronchial eosinophilia in guinea pigs: a therapeutic approach. | 1994 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:7850258 |
| Dupuis F et al. | Production and metabolism of platelet-activating factor by human bone marrow cells. | 1997 | Res. Immunol. | pmid:9226766 |
| Denizot Y et al. | Modulation of gut wall paf-acether and precursors by intestinal microflora. | 1990 Mar-Apr | Res. Immunol. | pmid:2218055 |
| Denizot Y et al. | Effects of platelet-activating factor on human T and B cells--an overview. | 1994 | Res. Immunol. | pmid:8079043 |
| Alviano DS et al. | Differentiation of Fonsecaea pedrosoi mycelial forms into sclerotic cells is induced by platelet-activating factor. | 2003 | Res. Microbiol. | pmid:14643407 |
| Muehlmann LA et al. | PAF increases phagocytic capacity and superoxide anion production in equine alveolar macrophages and blood neutrophils. | 2012 | Res. Vet. Sci. | pmid:21820686 |
| Conejeros I et al. | 2-Aminoethoxydiphenyl borate (2-APB) reduces respiratory burst, MMP-9 release and CD11b expression, and increases l-selectin shedding in bovine neutrophils. | 2012 | Res. Vet. Sci. | pmid:21071047 |
| Fairbairn SM et al. | Effects of platelet activating factor on the distribution of radiolabelled leucocytes and platelets in normal horses and asymptomatic horses with chronic obstructive pulmonary disease. | 1996 | Res. Vet. Sci. | pmid:8880978 |
| Foster AP et al. | Platelet activating factor is a mediator of equine neutrophil and eosinophil migration in vitro. | 1992 | Res. Vet. Sci. | pmid:1332153 |
| Bailey SR et al. | Actions and interactions of ADP, 5- HT, histamine and PAF on equine platelets. | 2000 | Res. Vet. Sci. | pmid:10756136 |
| Hammond A et al. | Platelets in equine recurrent airway obstruction. | 2007 | Res. Vet. Sci. | pmid:17107696 |
| Jarvis GE and Evans RJ | Endotoxin-induced platelet aggregation in heparinised equine whole blood in vitro. | 1994 | Res. Vet. Sci. | pmid:7871251 |
| Marr KA et al. | Effect of antigen challenge on the activation of peripheral blood neutrophils from horses with chronic obstructive pulmonary disease. | 1997 May-Jun | Res. Vet. Sci. | pmid:9300544 |
| Akbarshahi H et al. | Acute lung injury in acute pancreatitis--awaiting the big leap. | 2012 | Respir Med | pmid:22749752 |
| Echazarreta AL et al. | Lack of systemic oxidative stress during PAF challenge in mild asthma. | 2005 | Respir Med | pmid:15823446 |
| Kroegel C et al. | Cytokines, platelet activating factor and eosinophils in asthma. | 1992 | Respir Med | pmid:1462017 |
| Barnes NC | New developments in the treatment of asthma and chronic obstructive pulmonary disease. | 1993 | Respir Med | pmid:7901879 |
| Inoue T and Kannan MS | Platelet-activating factor-induced functional changes in the guinea pig trachea in vitro. | 1989 | Respir Physiol | pmid:2781159 |
| Marcano H et al. | Effect of dopamine on platelet activating factor induced-pulmonary edema in isolated and perfused rabbit lungs. | 2001 | Respir Physiol | pmid:11348642 |
| Pesce L et al. | Effect of Fenoterol on PAF-induced lung edema in isolated and perfused rabbit lungs. | 1998 | Respir Physiol | pmid:9865589 |
| Friedman E et al. | Effect of hydrocortisone on platelet activating factor induced lung edema in isolated rabbit lungs. | 2000 | Respir Physiol | pmid:10786645 |
| Steer ML | Relationship between pancreatitis and lung diseases. | 2001 | Respir Physiol | pmid:11535257 |
| Raj JU et al. | Effects of endothelin, platelet activating factor and thromboxane A2 in ferret lungs. | 1992 Apr-May | Respir Physiol | pmid:1626132 |
| Rastogi P and McHowat J | Inhibition of calcium-independent phospholipase A2 prevents inflammatory mediator production in pulmonary microvascular endothelium. | 2009 | Respir Physiol Neurobiol | pmid:19059366 |
| Machado GB et al. | Pseudomonas aeruginosa toxin ExoU induces a PAF-dependent impairment of alveolar fibrin turnover secondary to enhanced activation of coagulation and increased expression of plasminogen activator inhibitor-1 in the course of mice pneumosepsis. | 2011 | Respir. Res. | pmid:21819560 |
| Jiang Z et al. | The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in Aspergillus fumigatus sensitized mice. | 2012 | Respir. Res. | pmid:23140447 |
| Gebremichael I and Leuenberger P | Platelet-activating factor does not induce bronchial hyperreactivity in nonasthmatic subjects. | 1992 | Respiration | pmid:1485002 |
| Block LH et al. | PAF-dependent phosphatidylinositol turnover in platelets: differences between asthmatics and normal individuals. | 1990 | Respiration | pmid:2099571 |
| Tohda Y et al. | Role of chemical mediators in airway hyperresponsiveness in an asthmatic model. | 2001 | Respiration | pmid:11223734 |
| Matheson MJ et al. | Role of platelet activating factor, leukotrienes and polymorphs in the FMLP induced increase in microvascular leakage in rabbit trachea. | 1997 | Respirology | pmid:9424405 |
| Li HP et al. | Effect of chinonin on acute hypoxic pulmonary vasoconstriction in Sprague-Dawley rats. | 1998 | Respirology | pmid:9692515 |
| Ruchaud-Sparagano MH et al. | Effect of granulocyte-macrophage colony-stimulating factor on neutrophil function in idiopathic bronchiectasis. | 2013 | Respirology | pmid:23730995 |
| Hosford D et al. | Platelet-activating factor and cytokine interactions in shock. | 1989 | Resuscitation | pmid:2555874 |
| Gedeborg R and Wiklund L | Experimental model of cardiovascular post-resuscitation syndrome--no effect of platelet activating factor antagonism. | 1998 Oct-Nov | Resuscitation | pmid:9918458 |
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| Santos OF et al. | [Platelet activating factor in nephrology: physiopathologic and therapeutic perspectives]. | 1988 Jul-Aug | Rev Paul Med | pmid:3076976 |
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| Romero A et al. | [Effect of corticosteroids, quinacrine and L-652, 731 on experimental aggregation of polymorphonuclear leukocytes induced by complement and platelet activating factor (PAF)]. | 1988 | Rev. Esp. Fisiol. | pmid:3072620 |
| Santos JC et al. | Effect of intrarenal infusion of synthetic PAF-acether in dogs. | 1988 | Rev. Esp. Fisiol. | pmid:3231880 |
| Brochet B et al. | [Pilot study of Ginkgolide B, a PAF-acether specific inhibitor in the treatment of acute outbreaks of multiple sclerosis]. | 1992 | Rev. Neurol. (Paris) | pmid:1439458 |
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