| MeSH term | MeSH ID | Detail |
|---|---|---|
| Corneal Neovascularization | D016510 | 8 associated lipids |
| Xeroderma Pigmentosum | D014983 | 6 associated lipids |
| Shock, Cardiogenic | D012770 | 5 associated lipids |
| Hypertrophy, Right Ventricular | D017380 | 4 associated lipids |
| Strongylida Infections | D017206 | 5 associated lipids |
| Enterocolitis, Necrotizing | D020345 | 3 associated lipids |
| Milk Hypersensitivity | D016269 | 4 associated lipids |
| Hematoma, Subdural | D006408 | 3 associated lipids |
| Venous Thrombosis | D020246 | 11 associated lipids |
| Blood Loss, Surgical | D016063 | 6 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Leslie CC and Detty DM | Arachidonic acid turnover in response to lipopolysaccharide and opsonized zymosan in human monocyte-derived macrophages. | 1986 | Biochem. J. | pmid:3098232 |
| Lewis RE and Granger HJ | Neutrophil-dependent mediation of microvascular permeability. | 1986 | Fed. Proc. | pmid:3510911 |
| DeFeudis FV | Studies on endothelium-dependent vasorelaxation. | 1986 | Gen. Pharmacol. | pmid:3512363 |
| Wardlow ML et al. | Substrate specificity and partial characterization of the PAF-acylhydrolase in human serum that rapidly inactivates platelet-activating factor. | 1986 | J. Immunol. | pmid:3514760 |
| Böhm R and Giessler AJ | [Thrombocyte aggregation inhibitors. A new class of active substances]. | 1986 | Pharmazie | pmid:3515372 |
| Touvay C et al. | Characterization of platelet activating factor (PAF)-acether-induced contractions of guinea-pig lung strips by selected inhibitors of arachidonic acid metabolism and by PAF-acether antagonists. | 1986 | Immunopharmacology | pmid:3021651 |
| Siffert W et al. | Inhibition of platelet aggregation by amiloride. | 1986 | Thromb. Res. | pmid:3787567 |
| Whittle BJ et al. | Microvascular actions of platelet-activating factor on rat gastric mucosa and submucosa. | 1986 | Am. J. Physiol. | pmid:3789144 |
| Suemune H et al. | Enzymatic synthesis of 2,3-O-isopropylidene-sn-glycerol, a chiral building block for platelet-activating factor. | 1986 | Chem. Pharm. Bull. | pmid:3791517 |
| Silva PM et al. | Platelet involvement in rat paw edema induced by 2-methoxy-PAF. | 1986 | Inflammation | pmid:3793206 |
| Wu MS et al. | Inhibition of the platelet activating factor (PAF)-induced in vivo responses in rats by trans-2,5-(3,4,5-trimethoxyphenyl) tetrahydrofuran (L-652,731), a PAF receptor antagonist. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3795043 |
| Page CP et al. | Inflammatory mediators of asthma. | 1986 | Eur J Respir Dis Suppl | pmid:3527737 |
| Mlczoch J | [Disorders of thrombocyte function and/or endothelial cell damage as a cause of primary pulmonary hypertension?]. | 1986 | Herz | pmid:3530927 |
| Lovett DH and Sterzel RB | Cell culture approaches to the analysis of glomerular inflammation. | 1986 | Kidney Int. | pmid:3531678 |
| Muirhead EE et al. | Renal medullary system of blood pressure control. | 1986 | J Hypertens Suppl | pmid:3534182 |
| Foegh ML et al. | The causal role of PAF and leukotrienes in acute cardiac allograft rejection in rats. | 1986 | Pharmacol Res Commun | pmid:3534895 |
| Zimmerman GA and Klein-Knoeckel D | Human endothelial cells inhibit granulocyte aggregation in vitro. | 1986 | J. Immunol. | pmid:3009611 |
| Sage SO and Rink TJ | Effects of ionic substitution on [Ca2+]i rises evoked by thrombin and PAF in human platelets. | 1986 | Eur. J. Pharmacol. | pmid:3758190 |
| Chignard M et al. | Use of steroidal antiinflammatory drug provides further evidence for a potential role of PAF-acether in bronchial anaphylaxis. | 1986 | Int. Arch. Allergy Appl. Immunol. | pmid:3759260 |
| Ohno M et al. | Molecular design toward biologically significant compounds based on platelet activating factor: a highly selective agonist as a potential antihypertensive agent. | 1986 | J. Med. Chem. | pmid:3761300 |
| Parnham MJ and Bittner C | Pharmacological analysis of guinea-pig macrophage chemiluminescence responses to platelet activating factor and opsonized zymosan. | 1986 | Int. J. Immunopharmacol. | pmid:3804536 |
| Handley DA et al. | Vascular responses of platelet-activating factor in the Cebus apella primate and inhibitory profiles of antagonists SRI 63-072 and SRI 63-119. | 1986 | Immunopharmacology | pmid:3733419 |
| Issekutz AC and Szpejda M | Evidence that platelet activating factor may mediate some acute inflammatory responses. Studies with the platelet-activating factor antagonist, CV3988. | 1986 | Lab. Invest. | pmid:3951199 |
| Shukla SD | Action of phosphatidylinositol specific phospholipase C on platelets: nonlytic release of acetylcholinesterase, effect on thrombin and PAF induced aggregation. | 1986 | Life Sci. | pmid:3951330 |
| Benveniste J | Paf-acether (platelet-activating factor). | 1986 | Bull Eur Physiopathol Respir | pmid:3955269 |
| Phillips ML and Bonjouklian R | Cyclic platelet-activating factor analogues derived from 2-deoxy-D-erythro-pentose. | 1986 | Carbohydr. Res. | pmid:3955572 |
| Schneider E et al. | Transbilayer reorientation of platelet-activating factor in the erythrocyte membrane. | 1986 | FEBS Lett. | pmid:3956740 |
| Thomas MJ et al. | Desorption chemical ionization mass spectrometry of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholines and analogues. | 1986 | J. Lipid Res. | pmid:3958619 |
| Becker EL et al. | Pertussis toxin as a probe of neutrophil activation. | 1986 | Fed. Proc. | pmid:3011523 |
| Ozaki Y et al. | Oxygen radical production by neutrophils from patients with bacterial infection and rheumatoid arthritis. Measurement of hydrogen peroxide may most accurately represent enhancement of oxygen radical production during infection. | 1986 | Inflammation | pmid:3011666 |
| Doebber TW et al. | Platelet-activating factor (PAF) mediation of rat anaphylactic responses to soluble immune complexes. Studies with PAF receptor antagonist L-652,731. | 1986 | J. Immunol. | pmid:3011900 |
| Tokumura A et al. | Alkylacetylglycerophosphocholine effects on the metabolism of phospholipids in rabbit platelets: effects of extracellular Ca2+ and prostacyclin. | 1986 | Arch. Biochem. Biophys. | pmid:3013094 |
| Houslay MD et al. | Platelet activating factor and U44069 stimulate a GTPase activity in human platelets which is distinct from the guanine nucleotide regulatory proteins, Ns and Ni. | 1986 | Biochem. J. | pmid:3013161 |
| Ban C et al. | Metabolism of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in human fetal membranes and decidua vera. | 1986 | Arch. Biochem. Biophys. | pmid:3963833 |
| Cerletti C et al. | Platelet-aggregation response to single or paired aggregating stimuli after low-dose aspirin. | 1986 | N. Engl. J. Med. | pmid:3941724 |
| Parente L et al. | The effect of glucocorticoids on lyso-PAF formation in vitro and in vivo. | 1986 | Agents Actions | pmid:3962774 |
| Tarayre JP et al. | Inflammatory action of PAF-acether in the rat pleural cavity. | 1986 | Agents Actions | pmid:3962789 |
| Blank ML et al. | Metabolism of platelet activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and 1-alkyl-2-acetyl-sn-glycerol by human endothelial cells. | 1986 | Biochim. Biophys. Acta | pmid:3707974 |
| Tarayre JP et al. | Exudative, cellular and humoral reactions to platelet-activating factor (PAF-acether) in the pleural cavity of rats. | 1986 | Eur. J. Pharmacol. | pmid:3755401 |
| Kikawa Y et al. | Leukotriene B4 biosynthesis in polymorphonuclear leukocytes from blood of umbilical cord, infants, children, and adults. | 1986 | Pediatr. Res. | pmid:3012451 |
| Bussolino F et al. | Production of platelet-activating factor by chick retina. | 1986 | J. Biol. Chem. | pmid:3023352 |
| Mossmann H et al. | Effect of platelet-activating factor on human polymorphonuclear leukocyte enhancement of chemiluminescence and antibody-dependent cellular cytotoxicity. | 1986 | J. Leukoc. Biol. | pmid:3455715 |
| Haye-Legrand I et al. | Production of PAF-acether and leukotrienes by cultured mouse macrophages. | 1986 | Pharmacol Res Commun | pmid:3774848 |
| Dupont L et al. | Crystal and molecular structure of BN 52021, a PAF-acether antagonist. Comparison with the conformation of Kadsurenone and related compounds. | 1986 | Pharmacol Res Commun | pmid:3774849 |
| Bruynzeel PL et al. | Platelet-activating factor (PAF-acether) induced leukotriene C4 formation and luminol dependent chemiluminescence by human eosinophils. | 1986 | Pharmacol Res Commun | pmid:3774850 |
| Etienne A et al. | The relative role of PAF-acether and icosanoids in septic shock. | 1986 | Pharmacol Res Commun | pmid:3774851 |
| Maes L et al. | Endogenic PAF-acether production by guinea pig endothelial cells in experimental arterial thrombosis. | 1986 | Pharmacol Res Commun | pmid:3774852 |
| Lee TC et al. | A new de novo pathway for the formation of 1-alkyl-2-acetyl-sn-glycerols, precursors of platelet activating factor. Biochemical characterization of 1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase in rat spleen. | 1986 | J. Biol. Chem. | pmid:3007498 |
| Handley DA et al. | Inhibition of PAF-induced systemic responses in the rat, guinea pig, dog and primate by the receptor antagonist SRI 63-441. | 1986 | Thromb. Haemost. | pmid:3775689 |
| Hwang SB and Lam MH | Species difference in the specific receptors of platelet activating factor. | 1986 | Biochem. Pharmacol. | pmid:3024653 |