| MeSH term | MeSH ID | Detail |
|---|---|---|
| Corneal Neovascularization | D016510 | 8 associated lipids |
| Xeroderma Pigmentosum | D014983 | 6 associated lipids |
| Shock, Cardiogenic | D012770 | 5 associated lipids |
| Hypertrophy, Right Ventricular | D017380 | 4 associated lipids |
| Strongylida Infections | D017206 | 5 associated lipids |
| Enterocolitis, Necrotizing | D020345 | 3 associated lipids |
| Milk Hypersensitivity | D016269 | 4 associated lipids |
| Hematoma, Subdural | D006408 | 3 associated lipids |
| Venous Thrombosis | D020246 | 11 associated lipids |
| Blood Loss, Surgical | D016063 | 6 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Am. J. Physiol., Cell Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Detopoulou P et al. | PAF and its metabolic enzymes in healthy volunteers: interrelations and correlations with basic characteristics. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:22079887 |
| López-Sagaseta J et al. | sPLA2-V inhibits EPCR anticoagulant and antiapoptotic properties by accommodating lysophosphatidylcholine or PAF in the hydrophobic groove. | 2012 | Blood | pmid:22167755 |
| Jiang Z et al. | The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in Aspergillus fumigatus sensitized mice. | 2012 | Respir. Res. | pmid:23140447 |
| Cingi C et al. | The histopathological effect of thymoquinone on experimentally induced rhinosinusitis in rats. | 2011 Nov-Dec | Am J Rhinol Allergy | pmid:22185737 |
| Saihkay HN et al. | Validating 123I-metaiodobenzylguanidine as a platelet marker for non-invasive imaging in rabbits. | 2011 Jan-Feb | J Pharmacol Toxicol Methods | pmid:20646985 |
| Sánchez FA et al. | Functional significance of cytosolic endothelial nitric-oxide synthase (eNOS): regulation of hyperpermeability. | 2011 | J. Biol. Chem. | pmid:21757745 |
| Dombrowsky H et al. | Ingestion of (n-3) fatty acids augments basal and platelet activating factor-induced permeability to dextran in the rat mesenteric vascular bed. | 2011 | J. Nutr. | pmid:21775525 |
| Tsuda M et al. | Platelet-activating factor and pain. | 2011 | Biol. Pharm. Bull. | pmid:21804199 |
| Chan MV et al. | Optical multichannel (optimul) platelet aggregometry in 96-well plates as an additional method of platelet reactivity testing. | 2011 | Platelets | pmid:21806492 |
| Zhou X and He P | Temporal and spatial correlation of platelet-activating factor-induced increases in endothelial [Ca²âº]i, nitric oxide, and gap formation in intact venules. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21873500 |
| Alarcón P et al. | D-lactic acid interferes with the effects of platelet activating factor on bovine neutrophils. | 2011 | Vet. Immunol. Immunopathol. | pmid:21816488 |
| Machado GB et al. | Pseudomonas aeruginosa toxin ExoU induces a PAF-dependent impairment of alveolar fibrin turnover secondary to enhanced activation of coagulation and increased expression of plasminogen activator inhibitor-1 in the course of mice pneumosepsis. | 2011 | Respir. Res. | pmid:21819560 |
| Drolet AM et al. | Platelet-activating factor induces Th17 cell differentiation. | 2011 | Mediators Inflamm. | pmid:22013287 |
| Janakiram NB et al. | Role of lipoxins, resolvins, and other bioactive lipids in colon and pancreatic cancer. | 2011 | Cancer Metastasis Rev. | pmid:22015691 |
| Verouti SN et al. | PAF effects on MCP-1 and IL-6 secretion in U-937 monocytes in comparison with oxLDL and IL-1β effects. | 2011 | Atherosclerosis | pmid:21920519 |
| Yu Y et al. | Homosecoiridoids from the flower buds of Lonicera japonica. | 2011 | J. Nat. Prod. | pmid:21942812 |
| Ajiro Y et al. | Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21949111 |
| Ma J et al. | ATP: a mediator for HCl-induced TRPV1 activation in esophageal mucosa. | 2011 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:21960521 |
| Bragado MJ et al. | Platelet-activating factor in Iberian pig spermatozoa: receptor expression and role as enhancer of the calcium-induced acrosome reaction. | 2011 | Reprod. Domest. Anim. | pmid:22023717 |
| Tsantila N et al. | In vitro and in vivo effects of statins on platelet-activating factor and its metabolism. | 2011 | Angiology | pmid:20805097 |
| Rastogi P et al. | Urothelial cell platelet-activating factor production mediated by calcium-independent phospholipase A2γ. | 2011 | Urology | pmid:21094990 |
| Uriarte SM et al. | Granule exocytosis contributes to priming and activation of the human neutrophil respiratory burst. | 2011 | J. Immunol. | pmid:21642540 |
| Frelinger AL et al. | Intrinsic platelet reactivity before P2Y12 blockade contributes to residual platelet reactivity despite high-level P2Y12 blockade by prasugrel or high-dose clopidogrel. Results from PRINCIPLE-TIMI 44. | 2011 | Thromb. Haemost. | pmid:21713327 |
| Smit JJ et al. | Contribution of classic and alternative effector pathways in peanut-induced anaphylactic responses. | 2011 | PLoS ONE | pmid:22194949 |
| Byrne SN et al. | The immune-modulating cytokine and endogenous Alarmin interleukin-33 is upregulated in skin exposed to inflammatory UVB radiation. | 2011 | Am. J. Pathol. | pmid:21703403 |
| Semini G et al. | Impact of alkylphospholipids on the gene expression profile of HaCaT cells. | 2011 | Pharmacogenet. Genomics | pmid:21681147 |
| Khan BQ and Kemp SF | Pathophysiology of anaphylaxis. | 2011 | Curr Opin Allergy Clin Immunol | pmid:21659865 |
| Parrill AL et al. | Computational identification and experimental characterization of substrate binding determinants of nucleotide pyrophosphatase/phosphodiesterase 7. | 2011 | BMC Biochem. | pmid:22177013 |
| Lacy P et al. | Agonist activation of f-actin-mediated eosinophil shape change and mediator release is dependent on Rac2. | 2011 | Int. Arch. Allergy Immunol. | pmid:21576984 |
| Howard KM et al. | Lipopolysaccharide and platelet-activating factor stimulate expression of platelet-activating factor acetylhydrolase via distinct signaling pathways. | 2011 | Inflamm. Res. | pmid:21432021 |
| Jönsson F et al. | Mouse and human neutrophils induce anaphylaxis. | 2011 | J. Clin. Invest. | pmid:21436586 |
| Côrte-Real R et al. | The activity of platelet activating factor-acetyl hydrolase (PAF-AH) in the salivary glands of Rhodnius prolixus. | 2011 | J. Insect Physiol. | pmid:21439293 |
| Li XJ et al. | [Expression of platelet-activating factor in necrotizing enterocolitis and its clinical significance]. | 2011 | Zhonghua Bing Li Xue Za Zhi | pmid:21426810 |
| Leistad L et al. | Multiple phospholipase A2 enzymes participate in the inflammatory process in osteoarthritic cartilage. | 2011 | Scand. J. Rheumatol. | pmid:21417548 |
| Xu LF et al. | Disruption of the F-actin cytoskeleton and monolayer barrier integrity induced by PAF and the protective effect of ITF on intestinal epithelium. | 2011 | Arch. Pharm. Res. | pmid:21380808 |
| Orlando RC et al. | Esophageal disease: updated information on inflammation. | 2011 | Ann. N. Y. Acad. Sci. | pmid:21950828 |
| Fang W et al. | Platelet activating factor induces blood brain barrier permeability alteration in vitro. | 2011 | J. Neuroimmunol. | pmid:20870297 |
| Fragel-Madeira L et al. | Platelet activating factor blocks interkinetic nuclear migration in retinal progenitors through an arrest of the cell cycle at the S/G2 transition. | 2011 | PLoS ONE | pmid:21298035 |
| Garland RC et al. | Noninvasive molecular imaging reveals role of PAF in leukocyte-endothelial interaction in LPS-induced ocular vascular injury. | 2011 | FASEB J. | pmid:21257713 |
| Mushtaq N et al. | Adhesion of Streptococcus pneumoniae to human airway epithelial cells exposed to urban particulate matter. | 2011 | J. Allergy Clin. Immunol. | pmid:21247619 |
| Singh TP et al. | Platelet-activating factor blockade inhibits the T-helper type 17 cell pathway and suppresses psoriasis-like skin disease in K5.hTGF-β1 transgenic mice. | 2011 | Am. J. Pathol. | pmid:21281802 |
| Metz M and Maurer M | Rupatadine for the treatment of allergic rhinitis and urticaria. | 2011 | Expert Rev Clin Immunol | pmid:21162645 |
| Cureton EL et al. | Endothelin-1 attenuates increases in hydraulic conductivity due to platelet-activating factor via prostacyclin release. | 2011 | J. Appl. Physiol. | pmid:21183623 |
| Liu J et al. | Circulating platelet-activating factor is primarily cleared by transport, not intravascular hydrolysis by lipoprotein-associated phospholipase A2/ PAF acetylhydrolase. | 2011 | Circ. Res. | pmid:21183738 |
| Soares PM et al. | Role of platelet-activating factor in the pathogenesis of 5-fluorouracil-induced intestinal mucositis in mice. | 2011 | Cancer Chemother. Pharmacol. | pmid:21153821 |
| Zimmermann LT et al. | Effects of platelet-activating factor on the interaction of Trypanosoma cruzi with Rhodnius prolixus. | 2011 | Parasitol. Res. | pmid:21161276 |
| Musto AE and Samii M | Platelet-activating factor receptor antagonism targets neuroinflammation in experimental epilepsy. | 2011 | Epilepsia | pmid:21204830 |
| Lowry P | 1-O-alkenyl-sn-glyceryl-3-phosphorylcholine may be a novel posttranslational modification used by the placenta. | 2011 | Biopolymers | pmid:20564011 |
| Kennedy MA et al. | Srf1 is a novel regulator of phospholipase D activity and is essential to buffer the toxic effects of C16:0 platelet activating factor. | 2011 | PLoS Genet. | pmid:21347278 |
| Kim HA et al. | Mechanisms of platelet-activating factor-induced enhancement of VEGF expression. | 2011 | Cell. Physiol. Biochem. | pmid:21325822 |