| MeSH term | MeSH ID | Detail |
|---|---|---|
| Purpura, Thrombotic Thrombocytopenic | D011697 | 6 associated lipids |
| Platelet Storage Pool Deficiency | D010981 | 3 associated lipids |
| Thrombophilia | D019851 | 6 associated lipids |
| Hepatitis B, Chronic | D019694 | 4 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
| Dementia, Multi-Infarct | D015161 | 2 associated lipids |
| Leukocyte-Adhesion Deficiency Syndrome | D018370 | 1 associated lipids |
| Neoplasms, Germ Cell and Embryonal | D009373 | 4 associated lipids |
| Bronchopulmonary Sequestration | D001998 | 3 associated lipids |
| Colitis, Ischemic | D017091 | 3 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cook VL et al. | The effect of lidocaine on in vitro adhesion and migration of equine neutrophils. | 2009 | Vet. Immunol. Immunopathol. | pmid:19136156 |
| Liu SH et al. | [Effects of p38 mitogen-activated protein kinase in protection of carbon monoxide against lipopolysaccharide induced rat small intestine injury]. | 2009 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21189571 |
| McIntyre TM et al. | The emerging roles of PAF acetylhydrolase. | 2009 | J. Lipid Res. | pmid:18838739 |
| Liu J et al. | New vernocuminosides from the stem barks of Vernonia cumingiana Benth. | 2009 | Steroids | pmid:18840454 |
| Brooks AC et al. | Regulation of platelet activating factor-induced equine platelet activation by intracellular kinases. | 2009 | J. Vet. Pharmacol. Ther. | pmid:19290950 |
| Eckels PC et al. | Amantadine inhibits platelet-activating factor induced clathrin-mediated endocytosis in human neutrophils. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19295175 |
| Melnikova VO and Bar-Eli M | Inflammation and melanoma metastasis. | 2009 | Pigment Cell Melanoma Res | pmid:19368690 |
| Sánchez FA et al. | Internalization of eNOS and NO delivery to subcellular targets determine agonist-induced hyperpermeability. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19342481 |
| Marotta DM et al. | Mechanisms underlying the nociceptive responses induced by platelet-activating factor (PAF) in the rat paw. | 2009 | Biochem. Pharmacol. | pmid:19283893 |
| Yost CC et al. | Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates. | 2009 | Blood | pmid:19221037 |
| Tsoupras AB et al. | The implication of platelet activating factor in cancer growth and metastasis: potent beneficial role of PAF-inhibitors and antioxidants. | 2009 | Infect Disord Drug Targets | pmid:19689381 |
| Ereso AQ et al. | Lipoxin a(4) attenuates microvascular fluid leak during inflammation. | 2009 | J. Surg. Res. | pmid:19524267 |
| Plager DA et al. | Pimecrolimus reduces eosinophil activation associated with calcium mobilization. | 2009 | Int. Arch. Allergy Immunol. | pmid:19127068 |
| Severino DN et al. | Edematogenic activity of scorpion venoms from the Buthidae family and the role of platelet-activating factor and nitric oxide in paw edema induced by Tityus venoms. | 2009 | Inflammation | pmid:19096919 |
| Mukai K et al. | New insights into the roles for basophils in acute and chronic allergy. | 2009 | Allergol Int | pmid:19153532 |
| Eigenmann PA | Mechanisms of food allergy. | 2009 | Pediatr Allergy Immunol | pmid:19154253 |
| Knezevic II et al. | Tiam1 and Rac1 are required for platelet-activating factor-induced endothelial junctional disassembly and increase in vascular permeability. | 2009 | J. Biol. Chem. | pmid:19095647 |
| Rigat B et al. | GM2 activator protein inhibits platelet activating factor signaling in rats. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19486886 |
| Liu SX et al. | Platelet-activating factor induces the processing of nuclear factor-kappaB p105 into p50, which mediates acute bowel injury in mice. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19460845 |
| Kovacova E et al. | General changes in hemostasis in gastric cancer. | 2009 | Bratisl Lek Listy | pmid:19507648 |
| Sharif NA et al. | Human conjunctival epithelial cell responses to platelet-activating factor (PAF): signal transduction and release of proinflammatory cytokines. | 2009 | Mol. Vis. | pmid:19513187 |
| Tang WZ et al. | Rearranged prenylated C6-C3 compounds and a highly oxygenated seco-prezizaane-type sesquiterpene from the stem bark of Illicium oligandrum. | 2009 | J. Nat. Prod. | pmid:19496609 |
| Chang W et al. | Common pathways for activation of proinflammatory gene expression by G protein-coupled receptors in primary lung epithelial and endothelial cells. | 2009 | Exp. Lung Res. | pmid:19415549 |
| Yamamura K et al. | Intracellular protein phosphorylation in eosinophils and the functional relevance in cytokine production. | 2009 | Int. Arch. Allergy Immunol. | pmid:19494504 |
| Keating FK and Schneider DJ | The influence of platelet activating factor on the effects of platelet agonists and antiplatelet agents in vitro. | 2009 | J. Thromb. Thrombolysis | pmid:18574670 |
| Zhang Q et al. | Involvement of platelet-activating factor in ultraviolet B-induced hyperalgesia. | 2009 | J. Invest. Dermatol. | pmid:18580961 |
| Guo CJ et al. | The synthesis and biological evaluation of 10-O-dialkylaminoethyl ginkgolide B as platelet-activating factor antagonist. | 2008 Sep-Oct | J Asian Nat Prod Res | pmid:19003620 |
| Kurdiumov IN et al. | [Cerebrovascular and antiaggregative effects of GABA-docosahexaenoyldopamine conjugate]. | 2008 Jul-Aug | Eksp Klin Farmakol | pmid:18819437 |
| Chamogeorgakis TP et al. | Effect of N-acetyl-L-cysteine on lung ischaemia reperfusion injury in a porcine experimental model. | 2008 Jan-Feb | ANZ J Surg | pmid:18199211 |
| Kikuchi M et al. | Platelet-activating factor (PAF) increases NO production in human endothelial cells-real-time monitoring by DAR-4M AM. | 2008 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18502110 |
| Schaefer MB et al. | Peroxisome proliferator-activated receptor-alpha reduces inflammation and vascular leakage in a murine model of acute lung injury. | 2008 | Eur. Respir. J. | pmid:18653653 |
| Samanta U and Bahnson BJ | Crystal structure of human plasma platelet-activating factor acetylhydrolase: structural implication to lipoprotein binding and catalysis. | 2008 | J. Biol. Chem. | pmid:18784071 |
| Beuk RJ et al. | Leucocyte and platelet adhesion in different layers of the small bowel during experimental total warm ischaemia and reperfusion. | 2008 | Br J Surg | pmid:18720462 |
| Konger RL et al. | Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18555720 |
| Leong HS et al. | Vimentin autoantibodies induce platelet activation and formation of platelet-leukocyte conjugates via platelet-activating factor. | 2008 | J. Leukoc. Biol. | pmid:17974709 |
| Gountopoulou A et al. | TNFalpha is a potent inducer of platelet-activating factor synthesis in adipocytes but not in preadipocytes. Differential regulation by PI3K. | 2008 | Cytokine | pmid:18180165 |
| Kwasniewski FH et al. | Small bowel injury associated to allergy is triggered by platelet-activating factor, mast cells, neutrophils and protected by nitric oxide. | 2008 | Int. Immunopharmacol. | pmid:18182253 |
| Chen Y et al. | Hepatic stellate cells may be potential effectors of platelet activating factor induced portal hypertension. | 2008 | World J. Gastroenterol. | pmid:18186558 |
| Hikiji H et al. | The roles of prostanoids, leukotrienes, and platelet-activating factor in bone metabolism and disease. | 2008 | Prog. Lipid Res. | pmid:18187046 |
| Zhang Q et al. | UVB radiation-mediated inhibition of contact hypersensitivity reactions is dependent on the platelet-activating factor system. | 2008 | J. Invest. Dermatol. | pmid:18200048 |
| Lu YY et al. | Synthesis of platelet-activating factor and its receptor expression in Kupffer cells in rat carbon tetrachloride-induced cirrhosis. | 2008 | World J. Gastroenterol. | pmid:18205269 |
| Nomura DK et al. | Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification. | 2008 | Toxicol. Appl. Pharmacol. | pmid:18164358 |
| Fukunaga A et al. | Dermal dendritic cells, and not Langerhans cells, play an essential role in inducing an immune response. | 2008 | J. Immunol. | pmid:18292528 |
| van Zoelen MA et al. | Platelet-activating factor receptor contributes to host defense against Pseudomonas aeruginosa pneumonia but is not essential for the accompanying inflammatory and procoagulant response. | 2008 | J. Immunol. | pmid:18292561 |
| Knapp S et al. | Lipoteichoic acid-induced lung inflammation depends on TLR2 and the concerted action of TLR4 and the platelet-activating factor receptor. | 2008 | J. Immunol. | pmid:18292574 |
| Mullol J et al. | Rupatadine in allergic rhinitis and chronic urticaria. | 2008 | Allergy | pmid:18339040 |
| Claud EC et al. | Platelet-activating factor-induced chloride channel activation is associated with intracellular acidosis and apoptosis of intestinal epithelial cells. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18339705 |
| Shindou H | [Lysophospholipid acyltransferase and platelet-activating factor (PAF) biosynthetic enzyme]. | 2008 | Seikagaku | pmid:18341030 |
| Tsujimura Y et al. | Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. | 2008 | Immunity | pmid:18342553 |
| Corl CM et al. | Platelet activating factor production and proinflammatory gene expression in endotoxin-challenged bovine mammary endothelial cells. | 2008 | J. Dairy Sci. | pmid:18650283 |