| MeSH term | MeSH ID | Detail |
|---|---|---|
| Purpura, Thrombotic Thrombocytopenic | D011697 | 6 associated lipids |
| Platelet Storage Pool Deficiency | D010981 | 3 associated lipids |
| Thrombophilia | D019851 | 6 associated lipids |
| Hepatitis B, Chronic | D019694 | 4 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
| Dementia, Multi-Infarct | D015161 | 2 associated lipids |
| Leukocyte-Adhesion Deficiency Syndrome | D018370 | 1 associated lipids |
| Neoplasms, Germ Cell and Embryonal | D009373 | 4 associated lipids |
| Bronchopulmonary Sequestration | D001998 | 3 associated lipids |
| Colitis, Ischemic | D017091 | 3 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hertelendy F and Zakár T | Prostaglandins and the myometrium and cervix. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:14683694 |
| Herron D et al. | Inhibition of PAF-induced human platelet aggregation by antithrombotic nipecotomides. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7630919 |
| Gáti I et al. | Effects of the PAF-analog and -antagonist CV-6209 on cultured human glioma cell lines. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1886907 |
| Mózes T et al. | Protective effect of diclofenac sodium against endotoxic shock in anaesthetized pigs. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8446657 |
| Shindo K et al. | Inhibitory effect of azelastine hydrochloride on synthesis and release of platelet activating factor from human alveolar macrophages. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9431823 |
| Akisu M et al. | Selective head cooling with hypothermia suppresses the generation of platelet-activating factor in cerebrospinal fluid of newborn infants with perinatal asphyxia. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12878450 |
| Landgraf RG et al. | Prostaglandins, leukotrienes and PAF selectively modulate lymphocyte subset and eosinophil infiltration into the airways in a murine model of asthma. | 2007 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17923399 |
| Sugatani J et al. | The role of platelet activating factor (PAF) in the pathogenesis of gastric ulcers. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1808623 |
| Cui S et al. | L-NAME augments PAF-induced venoconstriction in isolated perfused livers of rat and guinea pig, but not mouse. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17395449 |
| Becker K et al. | Influence of some prostaglandins and prostaglandin analogues on PAF-induced shock in mice. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1696744 |
| Hardy P et al. | New insights into the retinal circulation: inflammatory lipid mediators in ischemic retinopathy. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15850712 |
| Mentz P et al. | Interactions of prostanoids with the platelet activating factors. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1279731 |
| Richter M et al. | Endothelin, PAF and thromboxane A2 in allergic pulmonary hyperreactivity in mice. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17448648 |
| Louis NA et al. | Lipid mediator networks and leukocyte transmigration. | 2005 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15979294 |
| Akisu M et al. | The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the generation of platelet-activating factor and leukotriene B4 in hypoxic-ischemic brain in young mice. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12468264 |
| de Lima WT et al. | Studies on the mechanism of PAF-induced vasopermeability in rat lungs. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7784472 |
| Hughes H et al. | PAF formation by H2O2-stimulated perfused canine carotid arteries. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846103 |
| Albertini M and Clement MG | In pigs, inhaled nitric oxide (NO) counterbalances PAF-induced pulmonary hypertension. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846107 |
| Galli C et al. | Modulation of lipid derived mediators by polyunsaturated fatty acids. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8424123 |
| Tsunoda H et al. | Involvement of leukotriene C4 in PAF-induced death in mice. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2353029 |
| Ichimaru T and Tai HH | Alteration of platelet activating factor (PAF) metabolism in rat pulmonary alveolar macrophages and plasma by cigarette smoking. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1461922 |
| Becker K et al. | PAF effects on eicosanoid release in neonatal rat cardiomyocytes. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7480082 |
| Evans RD et al. | Platelet-activating factor and its metabolic effects. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1946557 |
| Salamonsen LA | Effect of platelet activating factor on prostaglandin release from ovine endometrial cells in culture. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1946564 |
| Travis SP and Jewell DP | The role of platelet-activating factor in the pathogenesis of gastrointestinal disease. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8208748 |
| Evangelou AM | Platelet-activating factor (PAF): implications for coronary heart and vascular diseases. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8146205 |
| Shindo K and Fukumura M | Azelastine hydrochloride inhibits platelet activating factor-like activity in human eosinophils. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8951989 |
| Peplow PV and Mikhailidis DP | Platelet-activating factor (PAF) and its relation to prostaglandins, leukotrienes and other aspects of arachidonate metabolism. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2274568 |
| Jeremy JY et al. | Eicosanoids and septicaemia. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7938078 |
| Berdeli A et al. | Meconium enhances platelet-activating factor and tumor necrosis factor production by rat alveolar macrophages. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15301793 |
| Shindo K et al. | Effect of azelastine hydrochloride on release and production of platelet activating factor in human neutrophils. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9175174 |
| Clement MG et al. | PAF and the role of the vagus nerve in the breathing pattern of the pig. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1561234 |
| Saito M et al. | Role of leukotrienes and platelet activating factor in allergic bronchoconstriction and their interactions in guinea pig airway in vivo. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8415807 |
| Arribas I et al. | Direct interactions between platelets and cultured rat mesangial cells. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8415809 |
| Plante GE et al. | Platelet activating factor antagonism with BN52021 protects the kidney against acute ischemic injury. | 1988 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:3231663 |
| Becker K et al. | PAF-induced death in NMRI mice--a suitable shock model for testing new PAF receptor antagonists. Correlation with eicosanoid related substances. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8385779 |
| Wise H | Activation of the prostaglandin EP4-receptor subtype is highly coupled to inhibition of N-formyl-methionyl-leucyl-phenylalanine-stimulated rat neutrophil aggregation. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9482170 |
| Peplow PV | Regulation of platelet-activating factor (PAF) activity in human diseases by phospholipase A2 inhibitors, PAF acetylhydrolases, PAF receptor antagonists and free radical scavengers. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10509861 |
| Shindo K and Fukumura M | Oxatomide inhibits synthesis and release of platelet-activating factor in human neutrophils. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9578146 |
| MartÃnez L et al. | Nitroprusside stimulates contractility and the synthesis of 14C-acetylated PAF-like substances in estrogen primed-mouse uterine horns. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10367296 |
| Miguel BG et al. | Increase of phosphoinositide hydrolysis and diacylglycerol production by PAF in isolated rat liver nuclei. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11444588 |
| Travers JB et al. | Identification and pharmacological characterization of platelet-activating factor and related 1-palmitoyl species in human inflammatory blistering diseases. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9990675 |
| Balestrieri ML et al. | Types of purinoceptors and phospholipase A2 involved in the activation of the platelet-activating factor-dependent transacetylase activity and arachidonate release by ATP in endothelial cells. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9990678 |
| Tiemann U et al. | Influence of ovarian steroid hormones or platelet-activating factor on mRNA of platelet-activating factor receptor in endometrial explant perfusion cultures from ovariectomized bovine. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15967160 |
| Kudolo GB and DeFronzo RA | Urinary platelet-activating factor excretion is elevated in non-insulin dependent diabetes mellitus. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10410380 |
| Tsutsumi T et al. | Movement of monoglyceride derived from hydrolysis of fluorescence-labeled lyso platelet-activating factor by lysophospholipase C through plasma membranes of porcine kidney epithelial cell line LLC-PK1. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17259070 |
| Benito E and Bosch MA | Role of platelet-activating factor in phosphatidylcholine secretion in primary cultures of rat type II pneumocytes. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12013527 |
| Itadani K et al. | Inhibition of Na+,K(+)-ATPase by platelet-activating factor in dog submandibular glands. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9653774 |
| Fallani A et al. | Platelet-activating factor (PAF) is the effector of IFN gamma-stimulated invasiveness and motility in a B16 melanoma line. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:17085325 |
| Argyrou C et al. | Postprandial effects of wine consumption on Platelet Activating Factor metabolic enzymes. | 2017 | Prostaglandins Other Lipid Mediat. | pmid:28323197 |