| MeSH term | MeSH ID | Detail |
|---|---|---|
| Purpura, Thrombotic Thrombocytopenic | D011697 | 6 associated lipids |
| Platelet Storage Pool Deficiency | D010981 | 3 associated lipids |
| Thrombophilia | D019851 | 6 associated lipids |
| Hepatitis B, Chronic | D019694 | 4 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
| Dementia, Multi-Infarct | D015161 | 2 associated lipids |
| Leukocyte-Adhesion Deficiency Syndrome | D018370 | 1 associated lipids |
| Neoplasms, Germ Cell and Embryonal | D009373 | 4 associated lipids |
| Bronchopulmonary Sequestration | D001998 | 3 associated lipids |
| Colitis, Ischemic | D017091 | 3 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ogundaini A et al. | Isolation of two new antiinflammatory biflavanoids from Sarcophyte piriei. | 1996 | J. Nat. Prod. | pmid:8786365 |
| Baker RR | Enzymes of platelet activating factor synthesis in brain. | 1995 | Neurochem. Res. | pmid:8786821 |
| Yoshii H et al. | Neurotropin inhibits accumulation of eosinophils induced by allergen through the suppression of sensitized T-cells. | 1995 | Int. J. Immunopharmacol. | pmid:8788117 |
| Battye KM et al. | Ovine endometrium synthesizes and releases platelet-activating factor, which can cause the release of prostaglandin F2 alpha by the uterus in situ. | 1996 | Biol. Reprod. | pmid:8788186 |
| Hirafuji M et al. | Involvement of platelet cyclic GMP but not cyclic AMP suppression in leukocyte-dependent platelet adhesion to endothelial cells induced by platelet-activating factor in vitro. | 1996 | Br. J. Pharmacol. | pmid:8789382 |
| Bazan NG and Allan G | Platelet-activating factor is both a modulator of synaptic function and a mediator of cerebral injury and inflammation. | 1996 | Adv Neurol | pmid:8790822 |
| Naraba H et al. | Inhibitory effect of arachidonic acid on platelet-activating factor production in rat neutrophils. | 1996 | Eur. J. Pharmacol. | pmid:8790999 |
| Aïssa J et al. | Biochemical and cellular effects of heparin-protamine injection in rabbits are partially inhibited by a PAF-acether receptor antagonist. | 1996 | Eur. J. Pharmacol. | pmid:8791000 |
| Weikert LF and Bernard GR | Pharmacotherapy of sepsis. | 1996 | Clin. Chest Med. | pmid:8792067 |
| Takeda H et al. | Release of fructose and hexose phosphates from perivascular cells induced by low density lipoprotein and acceleration of protein glycation in vitro. | 1996 | Diabetes Res. Clin. Pract. | pmid:8792096 |
| Abebe W et al. | Platelet-activating factor-induced inositol 1,4,5-trisphosphate generation in undifferentiated and differentiated U937 cells: role of tyrosine kinase. | 1996 | Int. J. Immunopharmacol. | pmid:8796445 |
| Parent JL et al. | Identification of transmembrane domain residues determinant in the structure-function relationship of the human platelet-activating factor receptor by site-directed mutagenesis. | 1996 | J. Biol. Chem. | pmid:8798529 |
| Marcheselli VL and Bazan NG | Sustained induction of prostaglandin endoperoxide synthase-2 by seizures in hippocampus. Inhibition by a platelet-activating factor antagonist. | 1996 | J. Biol. Chem. | pmid:8798751 |
| van Rossem K et al. | The role of PAF and the effect of a specific PAF antagonist on local tissue PO2 and neuronal integrity during and after photothrombotic brain infarction in unanesthetised rabbits. | 1996 | Adv. Exp. Med. Biol. | pmid:8798843 |
| Westmoreland SV et al. | Toxicity of TNF alpha and platelet activating factor for human NT2N neurons: a tissue culture model for human immunodeficiency virus dementia. | 1996 | J. Neurovirol. | pmid:8799203 |
| Civelli M et al. | The involvement of the release of nitric oxide in the pharmacological activity of the new furoxan derivative CHF 2363. | 1996 | Br. J. Pharmacol. | pmid:8799563 |
| Noguchi K et al. | Involvement of nitric oxide and eicosanoids in platelet-activating factor-induced haemodynamic and haematological effects in dogs. | 1996 | Br. J. Pharmacol. | pmid:8799566 |
| Marrakchi N et al. | [Biochemical and pharmacologic properties of platelet aggregants and platelet antiaggregants of viper venoms in Tunisia]. | 1994 Jul-Oct | Arch Inst Pasteur Tunis | pmid:8801850 |
| Catalán RE et al. | Nitric oxide mediates the PAF-stimulated cyclic GMP production in hippocampal slices. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8806587 |
| Baskin SI et al. | The effects of EDRF/NO releasers or calcium ionophore A23187 on cyanide toxicity in mice. | 1996 | Toxicol. Appl. Pharmacol. | pmid:8806852 |
| Dunlop ME et al. | Production of hyaluronan by glomerular mesangial cells in response to fibronectin and platelet-derived growth factor. | 1996 | Kidney Int. | pmid:8807570 |
| Arima S et al. | Platelet-activating factor dilates efferent arterioles through glomerulus-derived nitric oxide. | 1996 | J. Am. Soc. Nephrol. | pmid:8808114 |
| Tachibana F et al. | Platelet-activating factor and leukotrienes in acute otitis media, secretory otitis media, and chronic otitis media on the acute excerbation. | 1996 | Auris Nasus Larynx | pmid:8809319 |
| Yasugahira H et al. | [The changes of blood gas analysis values and platelet aggregability on acute phase in the experimental model of pulmonary embolism prepared by sephadex G-75 (SG-75) injection]. | 1996 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:8810754 |
| Durán WN et al. | Platelet-activating factor modulates leukocyte adhesion to endothelium in ischemia-reperfusion. | 1996 | Microvasc. Res. | pmid:8812764 |
| Tao Y et al. | Platelet-activating factor enhances urokinase-type plasminogen activator gene expression in corneal epithelium. | 1996 | Invest. Ophthalmol. Vis. Sci. | pmid:8814143 |
| Erger RA and Casale TB | Eosinophil migration in response to three molecular species of platelet activating factor. | 1996 | Inflamm. Res. | pmid:8814455 |
| Sato E et al. | Bradykinin stimulates alveolar macrophages to release neutrophil, monocyte, and eosinophil chemotactic activity. | 1996 | J. Immunol. | pmid:8816423 |
| Bauldry SA and Wooten RE | Leukotriene B4 and platelet activating factor production in permeabilized human neutrophils: role of cytosolic PLA2 in LTB4 and PAF generation. | 1996 | Biochim. Biophys. Acta | pmid:8816854 |
| Le Texier L et al. | Structure-activity relationships in platelet-activating factor (PAF). 7. Tetrahydrofuran derivatives as dual PAF antagonists and acetylcholinesterase inhibitors. Synthesis and PAF-antagonistic activity. | 1996 | J Lipid Mediat Cell Signal | pmid:8816984 |
| Le Texier L et al. | Structure-activity relationships in platelet-activating factor (PAF). 8. Tetrahydrofuran derivatives as dual PAF antagonists and acetylcholinesterase inhibitors: anti-acetylcholinesterase activity and comparative SAR. | 1996 | J Lipid Mediat Cell Signal | pmid:8816985 |
| Le Solleu H et al. | A pharmacophore for high affinity PAF antagonists. I. Electronic model using molecular electrostatic potential. | 1996 | J Lipid Mediat Cell Signal | pmid:8816988 |
| Abu-Zidan FM and Walther S | Platelet activating factor antagonism improves cardiovascular function in non-hypotensive sepsis in pigs. | 1996 | Eur J Surg | pmid:8817228 |
| Lin J et al. | Effects of platelet-activating factor (PAF) receptor blockage on mucous glycoprotein secretion in cultured chinchilla middle ear epithelium. | 1996 | Acta Otolaryngol. | pmid:8820353 |
| Kuitert L and Barnes NC | PAF and asthma--time for an appraisal? | 1995 | Clin. Exp. Allergy | pmid:8821294 |
| Miguélez R et al. | Anti-inflammatory effect of a PAF receptor antagonist and a new molecule with antiproteinase activity in an experimental model of acute urate crystal arthritis. | 1996 | J Lipid Mediat Cell Signal | pmid:8821809 |
| Murakami K et al. | A novel platelet activating factor antagonist, SM-12502, attenuates endotoxin-induced disseminated intravascular coagulation and acute pulmonary vascular injury by inhibiting TNF production in rats. | 1996 | Thromb. Haemost. | pmid:8822594 |
| Yang HO et al. | Biological and pharmacological effects of pinusolide, a novel platelet activating factor antagonist. | 1995 | Planta Med. | pmid:8824945 |
| Predescu D et al. | The vascular distribution of the platelet-activating factor receptor. | 1996 | Eur. J. Cell Biol. | pmid:8825027 |
| Burt RP et al. | The role of diacylglycerol and activation of protein kinase C in alpha 1A-adrenoceptor-mediated contraction to noradrenaline of rat isolated epididymal vas deferens. | 1996 | Br. J. Pharmacol. | pmid:8825367 |
| Grinyó JM et al. | The role of platelet-activating factor antagonists in the prophylaxis of posttransplant acute tubular necrosis. | 1996 | Ren Fail | pmid:8827990 |
| López-Novoa JM et al. | The role of platelet-activating factor and the effect of PAF blocking receptors on the outcome of ARF. | 1996 | Ren Fail | pmid:8827995 |
| Spangelo BL and Jarvis WD | Lysophosphatidylcholine stimulates interleukin-6 release from rat anterior pituitary cells in vitro. | 1996 | Endocrinology | pmid:8828503 |
| Galloway SW and Kingsnorth AN | Lung injury in the microembolic model of acute pancreatitis and amelioration by lexipafant (BB-882), a platelet-activating factor antagonist. | 1996 | Pancreas | pmid:8829181 |
| Sandoval D et al. | The role of neutrophils and platelet-activating factor in mediating experimental pancreatitis. | 1996 | Gastroenterology | pmid:8831604 |
| Ribaldi E et al. | Inhibition of PAF synthesis by stimulated human polymorphonuclear leucocytes with cloricromene, an inhibitor of phospholipase A2 activation. | 1996 | Br. J. Pharmacol. | pmid:8832056 |
| Savu SR et al. | Determination of 1-O-acyl-2-acetyl-sn-glyceryl-3-phosphorylcholine, platelet-activating factor and related phospholipids in biological samples by high-performance liquid chromatography--tandem mass spectrometry. | 1996 | J. Chromatogr. B, Biomed. Appl. | pmid:8832423 |
| Tsukioka K et al. | Increased plasma level of platelet-activating factor (PAF) and decreased serum PAF acetylhydrolase (PAFAH) activity in adults with bronchial asthma. | 1996 Jan-Feb | J Investig Allergol Clin Immunol | pmid:8833165 |
| Matsuo Y et al. | Role of platelet-activating factor and thromboxane A2 in radical production during ischemia and reperfusion of the rat brain. | 1996 | Brain Res. | pmid:8833766 |
| Gabryelewicz A | Etiology and pathogenesis of acute pancreatitis--current view. | 1995 | Rocz. Akad. Med. Bialymst. | pmid:8834603 |