| MeSH term | MeSH ID | Detail |
|---|---|---|
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ulrich CD | Lexipafant in severe acute pancreatitis: the final word? | 2001 | Curr Gastroenterol Rep | pmid:11276374 |
| Ishizuka S et al. | Acid exposure stimulates the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells: effects on platelet-activating factor receptor expression. | 2001 | Am. J. Respir. Cell Mol. Biol. | pmid:11306440 |
| Gu M et al. | Role of platelet-activating factor in hepatectomy with Pringle's maneuver. | 2001 | J. Surg. Res. | pmid:11266278 |
| Gujrati VR and Sastry BV | Metabolic fate of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine by human spermatozoa: biosynthesis and biodegradation. | 2001 | Life Sci. | pmid:11270625 |
| Lee T et al. | Differential regulation of three catalytic activities of platelet-activating factor (PAF)-dependent transacetylase. | 2001 | Arch. Biochem. Biophys. | pmid:11368182 |
| Iwase M et al. | Cardiac functional and structural alterations induced by endotoxin in rats: importance of platelet-activating factor. | 2001 | Crit. Care Med. | pmid:11373429 |
| Jehle R et al. | Platelet-activating factor (PAF)-acetylhydrolase and PAF-like compounds in the lung: effects of hyperoxia. | 2001 | Biochim. Biophys. Acta | pmid:11420174 |
| Kulikov VI and Muzya GI | Inhibition of human platelet aggregation by amides and ester of salicylic acid with platelet-activating factor analogs. | 2001 | Biochemistry Mosc. | pmid:11421815 |
| Virchow JC et al. | Effect of a specific cysteinyl leukotriene-receptor 1-antagonist (montelukast) on the transmigration of eosinophils across human umbilical vein endothelial cells. | 2001 | Clin. Exp. Allergy | pmid:11422147 |
| Wang H et al. | Platelet-activating factor and endotoxin activate CCAAT/enhancer binding protein in rat small intestine. | 2001 | Br. J. Pharmacol. | pmid:11429396 |
| Miguel BG et al. | Increase of phosphoinositide hydrolysis and diacylglycerol production by PAF in isolated rat liver nuclei. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11444588 |
| Hirashima Y et al. | Effect of a platelet-activating factor receptor antagonist, E5880, on cerebral vasospasm after aneurysmal subarachnoid hemorrhage--open clinical trial to investigate efficacy and safety. | 2001 | Neurol. Med. Chir. (Tokyo) | pmid:11381675 |
| Liu XH et al. | Platelet-activating factor antagonist BN 50730 attenuates hypoxic-ischemic brain injury in neonatal rats. | 2001 | Pediatr. Res. | pmid:11385142 |
| Mi B and Maleczka RE | A Nozaki-Hiyama-Kishi Ni(II)/Cr(II) coupling approach to the phomactins. | 2001 | Org. Lett. | pmid:11388849 |
| Elzi DJ et al. | Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11401859 |
| Tiemann U et al. | Platelet-activating factor (PAF)-like activity, localization of PAF receptor (PAF-R) and PAF-acetylhydrolase (PAF-AH) activity in bovine endometrium at different stages of the estrous cycle and early pregnancy. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11403499 |
| Tong N et al. | Activation of glycogen synthase kinase 3 beta (GSK-3beta) by platelet activating factor mediates migration and cell death in cerebellar granule neurons. | 2001 | Eur. J. Neurosci. | pmid:11403684 |
| Ferland C et al. | Eotaxin promotes eosinophil transmigration via the activation of the plasminogen-plasmin system. | 2001 | J. Leukoc. Biol. | pmid:11358986 |
| Tavakoli S et al. | Prostaglandin E(2)-induced interleukin-6 release by a human airway epithelial cell line. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11133502 |
| Rodrigo L et al. | Hydrolysis of platelet-activating factor by human serum paraoxonase. | 2001 | Biochem. J. | pmid:11171072 |
| Del Sorbo L et al. | Tat-induced platelet-activating factor synthesis contributes to the angiogenic effect of HIV-1 Tat. | 2001 | Eur. J. Immunol. | pmid:11180101 |
| Petty HR and Kindzelskii AL | Dissipative metabolic patterns respond during neutrophil transmembrane signaling. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11248046 |
| Zhang J et al. | Effect of buyang huanwu decoction on platelet activating factor content in arterial blood pre- and post-arterial thrombosis in rats. | 2001 | J Tradit Chin Med | pmid:12014136 |
| Kwan ML et al. | Airway vasculature after mycoplasma infection: chronic leakiness and selective hypersensitivity to substance P. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11159008 |
| Komori M et al. | PAF mediates cigarette smoke-induced goblet cell metaplasia in guinea pig airways. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11159026 |
| McManus LM et al. | Agonist-dependent failure of neutrophil function in diabetes correlates with extent of hyperglycemia. | 2001 | J. Leukoc. Biol. | pmid:11527989 |
| Stojanov T and O'Neill C | In vitro fertilization causes epigenetic modifications to the onset of gene expression from the zygotic genome in mice. | 2001 | Biol. Reprod. | pmid:11159375 |
| Qian C et al. | Anti-inflammatory activities of LDP-392, a dual PAF receptor antagonist and 5-lipoxygenase inhibitor. | 2001 | Pharmacol. Res. | pmid:11529688 |
| Persidsky Y et al. | Reduction in glial immunity and neuropathology by a PAF antagonist and an MMP and TNFalpha inhibitor in SCID mice with HIV-1 encephalitis. | 2001 | J. Neuroimmunol. | pmid:11240016 |
| Bachert C | Decongestant efficacy of desloratadine in patients with seasonal allergic rhinitis. | 2001 | Allergy | pmid:11243500 |
| Roudebush WE et al. | Impact of blood serum insulin-like growth factor I on platelet-activating factor in bull spermatozoa. | 2001 | Domest. Anim. Endocrinol. | pmid:11164329 |
| Giménez R and Aguilar J | Cytidine (5') diphosphocholine-induced decrease in cerebral platelet activating factor is due to inactivation of its synthesizing enzyme cholinephosphotransferase in aged rats. | 2001 | Neurosci. Lett. | pmid:11165772 |
| Goudevenos J et al. | Platelet-associated and secreted PAF-acetylhydrolase activity in patients with stable angina: sequential changes of the enzyme activity after angioplasty. | 2001 | Eur. J. Clin. Invest. | pmid:11168434 |
| Galimi F et al. | Hepatocyte growth factor is a regulator of monocyte-macrophage function. | 2001 | J. Immunol. | pmid:11145707 |
| Arese M et al. | HIV-1 Tat protein stimulates in vivo vascular permeability and lymphomononuclear cell recruitment. | 2001 | J. Immunol. | pmid:11145723 |
| Rabinowitz SS et al. | Platelet-activating factor in infants at risk for necrotizing enterocolitis. | 2001 | J. Pediatr. | pmid:11148517 |
| Gandhi CR et al. | A23187 causes release of inositol phosphates from cultured rat Kupffer cells. | 2001 | Eur. J. Pharmacol. | pmid:11245846 |
| Kawaguchi A et al. | Preventive effect of platelet-activating factor antagonist, Y-24180, against cyclosporine-induced acute nephrotoxicity. | 2001 | Life Sci. | pmid:11228102 |
| Denis MA et al. | Increased response of blood eosinophils to various chemotactic agents in quiescent Crohn disease. | 2001 | Scand. J. Gastroenterol. | pmid:11252412 |
| Storey RF et al. | Effects of P2Y(1) and P2Y(12) receptor antagonists on platelet aggregation induced by different agonists in human whole blood. | 2001 | Platelets | pmid:11674863 |
| Camici M and Sagripanti A | Plasma platelet activating factor in nephrotic syndrome. | 2001 | Minerva Med. | pmid:11675576 |
| Kohno S and Nabe T | [Inflammatory mediators (leukotrienes, thromboxane A2, tachykinins and others)]. | 2001 | Nippon Rinsho | pmid:11676130 |
| Pettorossi VE and Grassi S | Different contributions of platelet-activating factor and nitric oxide in long-term potentiation of the rat medial vestibular nuclei. | 2001 | Acta Otolaryngol Suppl | pmid:11677732 |
| Rosa MS et al. | Platelet-activating factor (PAF) modulates peritoneal mouse macrophage infection by Leishmania amazonensis. | 2001 | Curr. Microbiol. | pmid:11375661 |
| Bernatchez PN et al. | Regulation of VEGF-induced endothelial cell PAF synthesis: role of p42/44 MAPK, p38 MAPK and PI3K pathways. | 2001 | Br. J. Pharmacol. | pmid:11704645 |
| Ibe BO et al. | Maturational changes in ovine pulmonary metabolism of platelet-activating factor: implications for postnatal adaptation. | 2001 | Mol. Genet. Metab. | pmid:11708870 |
| Suwaki T et al. | Modification of eosinophil function by suplatast tosilate (IPD), a novel anti-allergic drug. | 2001 | Int. Immunopharmacol. | pmid:11710545 |
| Macphee CH | Lipoprotein-associated phospholipase A2: a potential new risk factor for coronary artery disease and a therapeutic target. | 2001 | Curr Opin Pharmacol | pmid:11714085 |
| Khoo C et al. | Inhibition of store-operated Ca(2+) influx by acidic extracellular pH in cultured human microglia. | 2001 | Glia | pmid:11571781 |
| Mariano F et al. | Hemofiltration reduces the serum priming activity on neutrophil chemiluminescence in septic patients. | 2001 | Kidney Int. | pmid:11576379 |
| Fazal N et al. | PAF receptor antagonist modulates neutrophil responses with thermal injury in vivo. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11546669 |
| Beales IL | Effect of platelet-activating factor on gastrin release from cultured rabbit G-cells. | 2001 | Dig. Dis. Sci. | pmid:11284466 |
| McHowat J et al. | Endothelial cell PAF synthesis following thrombin stimulation utilizes Ca(2+)-independent phospholipase A(2). | 2001 | Biochemistry | pmid:11732912 |
| Sirolli V et al. | Platelet activation and platelet-erythrocyte aggregates in end-stage renal disease patients on hemodialysis. | 2001 | Thromb. Haemost. | pmid:11583316 |
| Fukunaga K et al. | Single nucleotide polymorphism of human platelet-activating factor receptor impairs G-protein activation. | 2001 | J. Biol. Chem. | pmid:11560941 |
| Zhao L et al. | Effects of combining three different antiplatelet agents on platelets and leukocytes in whole blood in vitro. | 2001 | Br. J. Pharmacol. | pmid:11564653 |
| Bhatia M et al. | Inflammatory mediators as therapeutic targets in acute pancreatitis. | 2001 | Curr Opin Investig Drugs | pmid:11566005 |
| Emingil G et al. | Levels of platelet-activating factor in gingival crevicular fluid and gingival tissue in specific periodontal diseases. | 2001 | J. Periodontol. | pmid:11525434 |
| Thomet OA et al. | Differential inhibition of inflammatory effector functions by petasin, isopetasin and neopetasin in human eosinophils. | 2001 | Clin. Exp. Allergy | pmid:11529903 |
| Watanabe S et al. | Suppression of platelet-activating factor generation and modulation of arachidonate metabolism by dietary enrichment with (n-9) eicosatrienoic acid or docosahexaenoic acid in mouse peritoneal cells. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11534547 |
| Johnson CD et al. | Double blind, randomised, placebo controlled study of a platelet activating factor antagonist, lexipafant, in the treatment and prevention of organ failure in predicted severe acute pancreatitis. | 2001 | Gut | pmid:11115824 |
| Hu LH et al. | Synthesis and biological activity of amide derivatives of ginkgolide A. | 2001 | J Asian Nat Prod Res | pmid:11491398 |
| Alvarez A and Sanz MJ | Reactive oxygen species mediate angiotensin II-induced leukocyte-endothelial cell interactions in vivo. | 2001 | J. Leukoc. Biol. | pmid:11493611 |
| Raggers RJ et al. | Multidrug-resistance P-glycoprotein (MDR1) secretes platelet-activating factor. | 2001 | Biochem. J. | pmid:11463358 |
| Hollmann MW et al. | Local anesthetic effects on priming and activation of human neutrophils. | 2001 | Anesthesiology | pmid:11465548 |
| Lane JS et al. | Platelet activating factor antagonism reduces the systemic inflammatory response in a murine model of acute pancreatitis. | 2001 | J. Surg. Res. | pmid:11469912 |
| Thom SR et al. | Roles for platelet-activating factor and *NO-derived oxidants causing neutrophil adherence after CO poisoning. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11454599 |
| Grosman N | Similar effects of ether phospholipids, PAF and lyso-PAF on the Ca(2+)-ATPase activity of rat brain synaptosomes and leukocyte membranes. | 2001 | Int. Immunopharmacol. | pmid:11460312 |
| Marathe GK et al. | Lysophosphatidylcholine and lyso-PAF display PAF-like activity derived from contaminating phospholipids. | 2001 | J. Lipid Res. | pmid:11518762 |
| Thomet OA et al. | Role of petasin in the potential anti-inflammatory activity of a plant extract of petasites hybridus. | 2001 | Biochem. Pharmacol. | pmid:11286996 |
| Smith DG et al. | Quinolinic acid is produced by macrophages stimulated by platelet activating factor, Nef and Tat. | 2001 | J. Neurovirol. | pmid:11519483 |
| Hoenstein R et al. | Interleukin-2 activates human peripheral blood eosinophils. | 2001 | Cell. Immunol. | pmid:11520078 |
| Carceller E et al. | Novel azo derivatives as prodrugs of 5-aminosalicylic acid and amino derivatives with potent platelet activating factor antagonist activity. | 2001 | J. Med. Chem. | pmid:11520209 |
| Bernatchez PN et al. | VEGF stimulation of endothelial cell PAF synthesis is mediated by group V 14 kDa secretory phospholipase A2. | 2001 | Br. J. Pharmacol. | pmid:11522612 |
| Hourton D et al. | Oxidized low density lipoproteins downregulate LPS-induced platelet-activating factor receptor expression in human monocyte-derived macrophages: implications for LPS-induced nuclear factor-kappaB binding activity. | 2001 | Eur. J. Biochem. | pmid:11502209 |
| Velasquez LA et al. | PAF receptor and PAF acetylhydrolase expression in the endosalpinx of the human Fallopian tube: possible role of embryo-derived PAF in the control of embryo transport to the uterus. | 2001 | Hum. Reprod. | pmid:11473946 |
| Akisu M et al. | The role of recombinant human erythropoietin in lipid peroxidation and platelet-activating factor generation in a rat model of necrotizing enterocolitis. | 2001 | Eur J Pediatr Surg | pmid:11475112 |
| Burke JR et al. | BMS-229724 is a tight-binding inhibitor of cytosolic phospholipase A2 that acts at the lipid/water interface and possesses anti-inflammatory activity in skin inflammation models. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11408565 |
| Murakami M et al. | Distinct arachidonate-releasing functions of mammalian secreted phospholipase A2s in human embryonic kidney 293 and rat mastocytoma RBL-2H3 cells through heparan sulfate shuttling and external plasma membrane mechanisms. | 2001 | J. Biol. Chem. | pmid:11106649 |
| Ottino P and Bazan HE | Corneal stimulation of MMP-1, -9 and uPA by platelet-activating factor is mediated by cyclooxygenase-2 metabolites. | 2001 | Curr. Eye Res. | pmid:11840344 |
| Uhlmann D et al. | Importance of microcirculatory disturbances in the pathogenesis of pancreatitis. | 2001 | Zentralbl Chir | pmid:11753796 |
| Closa D et al. | Absorption and effects of 3-(N-phenylamino)-1,2-propanediol esters in relation to toxic oil syndrome. | 2001 | Lipids | pmid:11768157 |
| Hiran T et al. | Evidence for the involvement of the NADPH oxidase enzyme complex in the optimal accumulation of Platelet-activating factor in the human cell line PLB-985. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11785782 |
| Binisti C et al. | Structure-activity relationships in platelet-activating factor (PAF). 11-From PAF-antagonism to phospholipase A(2) inhibition: syntheses and structure-activity relationships in 1-arylsulfamido-2-alkylpiperazines. | 2001 | Eur J Med Chem | pmid:11738488 |
| Biffl WL et al. | Neutrophil apoptosis is delayed by trauma patients' plasma via a mechanism involving proinflammatory phospholipids and protein kinase C. | 2001 | Surg Infect (Larchmt) | pmid:12593704 |
| Tohda Y et al. | Role of chemical mediators in airway hyperresponsiveness in an asthmatic model. | 2001 | Respiration | pmid:11223734 |
| Tsai MH et al. | Effect of platelet activating factor and butyrate on the expression of interleukin-2 receptor alpha in nasopharyngeal carcinoma cells. | 2001 | Int. J. Oncol. | pmid:11605008 |
| Jin Y et al. | [The effect of autocrine factors on development of early embryos of mouse]. | 2001 | Shi Yan Sheng Wu Xue Bao | pmid:12549014 |
| Fabi F et al. | Nitric oxide (NO) modulation of PAF-induced cardiopulmonary action: interaction between NO synthase and cyclo-oxygenase-2 pathways. | 2001 | Br. J. Pharmacol. | pmid:11606318 |
| Añel RL and Kumar A | Experimental and emerging therapies for sepsis and septic shock. | 2001 | Expert Opin Investig Drugs | pmid:11772263 |
| Min JH et al. | Platelet-activating factor acetylhydrolases: broad substrate specificity and lipoprotein binding does not modulate the catalytic properties of the plasma enzyme. | 2001 | Biochemistry | pmid:11294621 |
| Richardson RM et al. | RGS4 inhibits platelet-activating factor receptor phosphorylation and cellular responses. | 2001 | Biochemistry | pmid:11297424 |
| Kuijpers TW et al. | The impact of platelet-activating factor (PAF)-like mediators on the functional activity of neutrophils: anti-inflammatory effects of human PAF-acetylhydrolase. | 2001 | Clin. Exp. Immunol. | pmid:11298128 |
| Teeling JL et al. | Intravenous immunoglobulin preparations induce mild activation of neutrophils in vivo via triggering of macrophages--studies in a rat model. | 2001 | Br. J. Haematol. | pmid:11298603 |
| Teather LA et al. | Differential interaction of platelet-activating factor and NMDA receptor function in hippocampal and dorsal striatal memory processes. | 2001 | Neurobiol Learn Mem | pmid:11300737 |
| Aiboshi J et al. | Blood transfusion and the two-insult model of post-injury multiple organ failure. | 2001 | Shock | pmid:11303730 |
| Ilveskero S et al. | Procoagulant activity on platelets adhered to collagen or plasma clot. | 2001 | Arterioscler. Thromb. Vasc. Biol. | pmid:11304482 |
| Hattar K et al. | Cell density regulates neutrophil IL-8 synthesis: role of IL-1 receptor antagonist and soluble TNF receptors. | 2001 | J. Immunol. | pmid:11342652 |
| Berdyshev EV et al. | Activation of PAF receptors results in enhanced synthesis of 2-arachidonoylglycerol (2-AG) in immune cells. | 2001 | FASEB J. | pmid:11641243 |
| Alam N et al. | Additional bioactive Lyso-PAF congeners from the sponge Spirastrella abata. | 2001 | J. Nat. Prod. | pmid:11325244 |