| MeSH term | MeSH ID | Detail |
|---|---|---|
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Am. J. Physiol., Cell Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lee T et al. | Increased biosynthesis of platelet-activating factor in activated human eosinophils. | 1984 | J. Biol. Chem. | pmid:6425292 |
| Hallam TJ et al. | Stimulus-response coupling in human platelets. Changes evoked by platelet-activating factor in cytoplasmic free calcium monitored with the fluorescent calcium indicator quin2. | 1984 | Biochem. J. | pmid:6426464 |
| Hopkins NK et al. | Acetyl glyceryl ether phosphorylcholine (PAF-acether) and leukotriene B4-mediated neutrophil chemotaxis through an intact endothelial cell monolayer. | 1984 | Biochim. Biophys. Acta | pmid:6089913 |
| Krishnamurthi S et al. | Regulation of human platelet activation--analysis of cyclooxygenase and cyclic AMP-dependent pathways. | 1984 | Biochem. Pharmacol. | pmid:6091666 |
| Tokumura A et al. | Contractile effect of 1-O-hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine on strips of isolated rat intestine. | 1984 | J. Pharm. Pharmacol. | pmid:6144763 |
| Pirotzky E et al. | Release of platelet-activating factor, slow-reacting substance, and vasoactive amines from isolated rat kidneys. | 1984 | Kidney Int. | pmid:6144811 |
| Gómez-Cambronero J et al. | The role of calcium ions in the process of acetyltransferase activation during the formation of platelet-activating factor (PAF-acether). | 1984 | Biochem. J. | pmid:6146309 |
| Morley J et al. | The platelet in asthma. | 1984 | Lancet | pmid:6150192 |
| Kloprogge E and Akkerman JW | Binding kinetics of PAF-acether (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) to intact human platelets. | 1984 | Biochem. J. | pmid:6150705 |
| Hanahan DJ and Nelson DR | Phospholipids as dynamic participants in biological processes. | 1984 | J. Lipid Res. | pmid:6152281 |
| Rao AK et al. | Platelet-activating factor is a weak platelet agonist: evidence from normal human platelets and platelets with congenital secretion defects. | 1984 | Am. J. Hematol. | pmid:6431801 |
| Colditz IG and Movat HZ | Desensitization of acute inflammatory lesions to chemotaxins and endotoxin. | 1984 | J. Immunol. | pmid:6088633 |
| Siess W et al. | Activation of phospholipase C is dissociated from arachidonate metabolism during platelet shape change induced by thrombin or platelet-activating factor. Epinephrine does not induce phospholipase C activation or platelet shape change. | 1984 | J. Biol. Chem. | pmid:6429141 |
| Malpass TW et al. | The effect of prostacyclin infusion on platelet hemostatic function in patients undergoing cardiopulmonary bypass. | 1984 | J. Thorac. Cardiovasc. Surg. | pmid:6231433 |
| Willoughby WF and Willoughby JB | Immunologic mechanisms of parenchymal lung injury. | 1984 | Environ. Health Perspect. | pmid:6234162 |
| Lartigue-Mattei C et al. | Pharmacokinetic study of 3H-labelled PAF-acether II. Comparison with 3H-labelled lyso-PAF-acether after intravenous administration in the rabbit and protein binding. | 1984 | Agents Actions | pmid:6532184 |
| Kulikov VI et al. | [Incorporation of 1-0-alkyl-2-acetyl-sn-glycerol-3-phosphocholine into human plasma lipoproteins in vitro. Effect of the lecithin:cholesterol acyltransferase activity of plasma]. | 1984 | Biokhimiia | pmid:6542803 |
| Nagata K et al. | [Thrombotic thrombocytopenic purpura (TTP) with a remission following splenectomy after the failure of antiplatelet therapy and plasmapheresis]. | 1984 | Rinsho Ketsueki | pmid:6542941 |
| Pirotzky E et al. | PAF-acether-induced plasma exudation in rat skin is independent of platelets and neutrophils. | 1984 | Microcirc Endothelium Lymphatics | pmid:6546141 |
| Bussolino F et al. | Platelet-activating factor phosphatidate, but not platelet-activating factor, is a powerful calcium ionophore in the human red cell. | 1984 | Cell Calcium | pmid:6549153 |
| Pirotzky E et al. | Biosynthesis of platelet-activating factor. VI. Precursor of platelet-activating factor and acetyltransferase activity in isolated rat kidney cells. | 1984 | Lab. Invest. | pmid:6492758 |
| Colditz IG and Movat HZ | Kinetics of neutrophil accumulation in acute inflammatory lesions induced by chemotaxins and chemotaxinigens. | 1984 | J. Immunol. | pmid:6470487 |
| Patterson R et al. | Airway responses to sequential challenges with platelet-activating factor and leukotriene D4 in rhesus monkeys. | 1984 | J. Lab. Clin. Med. | pmid:6470563 |
| Ludwig JC et al. | Modulation of platelet-activating factor (PAF) synthesis and release from human polymorphonuclear leukocytes (PMN): role of extracellular Ca2+. | 1984 | Arch. Biochem. Biophys. | pmid:6430234 |
| Kasuya Y et al. | Hypotensive actions of some analogues of platelet-activating factor (PAF) with higher potencies than natural PAF. | 1984 | Can. J. Physiol. Pharmacol. | pmid:6733593 |
| Page CP et al. | Platelets and bronchospasm. | 1984 | Int. Arch. Allergy Appl. Immunol. | pmid:6735490 |
| Söling HD et al. | Acetylcholine-like effects of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine ('platelet-activating factor') and its analogues in exocrine secretory glands. | 1984 | Eur. J. Biochem. | pmid:6207023 |
| Jouvin-Marche E et al. | Biosynthesis of Paf-acether (platelet-activating factor). VII. Precursors of Paf-acether and acetyl-transferase activity in human leukocytes. | 1984 | J. Immunol. | pmid:6736649 |
| Renal syndromes and nonsteroidal antiinflammatory drugs. | 1984 | N. Engl. J. Med. | pmid:6738607 | |
| Hoffman DR et al. | Cytotoxicity of ether-linked phytanyl phospholipid analogs and related derivatives in human HL-60 leukemia cells and polymorphonuclear neutrophils. | 1984 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:6739956 |
| Mohanty D and Hilgard P | A new platelet aggregating material (PAM) in an experimentally induced rat fibrosarcoma. | 1984 | Thromb. Haemost. | pmid:6740552 |
| O'Neill C and Saunders DM | Assessment of embryo quality. | 1984 | Lancet | pmid:6149413 |
| Nishihira J et al. | Mass spectrometric evidence for the presence of platelet-activating factor (1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in human amniotic fluid during labor. | 1984 | Lipids | pmid:6527609 |
| Lefer AM et al. | Pathophysiological mechanisms of sudden death induced by platelet activating factor. | 1984 | Br. J. Pharmacol. | pmid:6435705 |
| Billah MM and Siegel MI | Calmodulin antagonists inhibit formation of platelet-activating factor in stimulated human neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6422930 |
| Prevost MC et al. | Platelet activating factor (PAF-acether) is released into rat pulmonary alveolar fluid as a consequence of hypoxia. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6422938 |
| Wodzinowska B and Krajewski T | [Role of blood platelets and their membrane in the process of hemostasis]. | 1984 Jan-Feb | Postepy Hig Med Dosw | pmid:6093087 |
| Vemulapalli S et al. | Cardiovascular and renal action of platelet-activating factor in anesthetized dogs. | 1984 Jul-Aug | Hypertension | pmid:6378787 |
| Cox CP et al. | VIP elevates platelet cyclic AMP (cAMP) levels and inhibits in vitro platelet activation induced by platelet-activating factor (PAF). | 1984 Mar-Apr | Peptides | pmid:6206481 |
| Michel L and Dubertret L | A simple method for studying chemotaxis, vascular permeability and histological modifications induced by mediators of inflammation in vivo in man. | 1985 | Br. J. Dermatol. | pmid:2990519 |
| Pfeilschifter J et al. | Inhibition of renin secretion by platelet activating factor (acetylglyceryl ether phosphorylcholine) in cultured rat renal juxtaglomerular cells. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2985064 |
| Hwang SB et al. | Specific binding sites for platelet activating factor in human lung tissues. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2986633 |
| Weber N and Mangold HK | Semi-synthetic preparation of 1-O-[1'-14C]hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) using plant cell cultures. | 1985 | J. Lipid Res. | pmid:3891896 |
| Hanahan DJ and Weintraub ST | Platelet-activating factor isolation, identification, and assay. | 1985 | Methods Biochem Anal | pmid:3894881 |
| Kumar R et al. | Occurrence of glyceryl ethers in the phosphatidylcholine fraction of surfactant from dog lungs. | 1985 | Biochim. Biophys. Acta | pmid:3839684 |
| Hallam TJ et al. | Control and interrelation of aggregation and secretion; the roles of Ca2+, diacylglycerol and thromboxane with particular reference to ADP stimulation. | 1985 | Adv. Exp. Med. Biol. | pmid:3010663 |
| Gerrard JM et al. | Platelet protein phosphorylation. | 1985 | Adv. Exp. Med. Biol. | pmid:3010667 |
| Shigenobu K et al. | Platelet activating factor analogues: lack of correlation between their activities to produce hypotension and endothelium-mediated vasodilation. | 1985 | J. Pharmacobio-dyn. | pmid:4009403 |
| Saeki S et al. | Effects of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) on cardiac function in perfused guinea-pig heart. | 1985 | Life Sci. | pmid:4010479 |
| Mushayakarara EC and Mantsch HH | Thermotropic phase behavior of the platelet-activating factor: an infrared spectroscopic study. | 1985 | Can. J. Biochem. Cell Biol. | pmid:4075223 |