| MeSH term | MeSH ID | Detail |
|---|---|---|
| Capillary Leak Syndrome | D019559 | 2 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Hepatitis B, Chronic | D019694 | 4 associated lipids |
| Hepatitis C, Chronic | D019698 | 12 associated lipids |
| Thrombophilia | D019851 | 6 associated lipids |
| Brain Hemorrhage, Traumatic | D020201 | 1 associated lipids |
| Optic Nerve Injuries | D020221 | 4 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Venous Thrombosis | D020246 | 11 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nagase T et al. | Platelet-activating factor mediates acid-induced lung injury in genetically engineered mice. | 1999 | J. Clin. Invest. | pmid:10525045 |
| Prescott SM et al. | Two of the usual suspects, platelet-activating factor and its receptor, implicated in acute lung injury. | 1999 | J. Clin. Invest. | pmid:10525039 |
| Monteiro HS et al. | Glomerular effects of cholera toxin in isolated perfused rat kidney: a potential role for platelet activating factor. | 1999 | Pharmacol. Toxicol. | pmid:10522748 |
| Hocke M et al. | Platelet activating factor in stool from patients with ulcerative colitis and Crohn's disease. | 1999 Jul-Aug | Hepatogastroenterology | pmid:10521992 |
| Sugiura T et al. | Occurrence of lysophosphatidic acid and its alkyl ether-linked analog in rat brain and comparison of their biological activities toward cultured neural cells. | 1999 | Biochim. Biophys. Acta | pmid:10521703 |
| Bernatchez PN et al. | Vascular endothelial growth factor effect on endothelial cell proliferation, migration, and platelet-activating factor synthesis is Flk-1-dependent. | 1999 | J. Biol. Chem. | pmid:10521504 |
| Greenberg SG and Clark KE | Hemodynamic effects of platelet-activating factor in nonpregnant and pregnant sheep. | 1999 | Am. J. Physiol. | pmid:10516237 |
| Merendino N et al. | Human intestinal epithelial cells express receptors for platelet-activating factor. | 1999 | Am. J. Physiol. | pmid:10516147 |
| Peplow PV | Regulation of platelet-activating factor (PAF) activity in human diseases by phospholipase A2 inhibitors, PAF acetylhydrolases, PAF receptor antagonists and free radical scavengers. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10509861 |
| Tiemann U et al. | Influence of inhibitors on increase in intracellular free calcium and proliferation induced by platelet-activating factor in bovine oviductal cells. | 1999 | J. Reprod. Fertil. | pmid:10505057 |
| Min JH et al. | Membrane-bound plasma platelet activating factor acetylhydrolase acts on substrate in the aqueous phase. | 1999 | Biochemistry | pmid:10504265 |
| Imrie CW and McKay CJ | The scientific basis of medical therapy of acute pancreatitis. Could it work, and is there a role for lexipafant? | 1999 | Gastroenterol. Clin. North Am. | pmid:10503138 |
| Sakaguchi T et al. | Participation of platelet-activating factor in the lipopolysaccharide-induced liver injury in partially hepatectomized rats. | 1999 | Hepatology | pmid:10498648 |
| Marathe GK et al. | Inflammatory platelet-activating factor-like phospholipids in oxidized low density lipoproteins are fragmented alkyl phosphatidylcholines. | 1999 | J. Biol. Chem. | pmid:10497200 |
| Mitidieri F and de Meis L | Ca(2+) release and heat production by the endoplasmic reticulum Ca(2+)-ATPase of blood platelets. Effect of the platelet activating factor. | 1999 | J. Biol. Chem. | pmid:10497193 |
| Dekkers PE et al. | Divergent roles of tumor necrosis factor and platelet-activating factor in endotoxin-induced release of monocyte chemoattractant protein 1 and macrophage inflammatory protein 1beta in chimpanzees. | 1999 | Infect. Immun. | pmid:10496934 |
| GamaleÄ IA et al. | [Post-receptor formation of active forms of oxygen in nonphagocytic cells]. | 1999 | Tsitologiia | pmid:10496012 |
| Comellas A et al. | Effect of platelet activating factor (PAF) on pulmonary circulation in isolated rabbit lung. | 1999 | J. Physiol. Biochem. | pmid:10494654 |
| Blackstone MO | ICAM-1 in cerulein-induced pancreatitis. | 1999 | Gastroenterology | pmid:10490367 |
| Triggiani M et al. | Inhibition of platelet-activating factor synthesis in human neutrophils and platelets by propionyl-L-carnitine. | 1999 | Biochem. Pharmacol. | pmid:10487538 |
| Piccolo MT et al. | Chemotactic mediator requirements in lung injury following skin burns in rats. | 1999 | Exp. Mol. Pathol. | pmid:10486240 |
| Koyama N and Ogawa Y | Elevated platelet activating factor in the tracheal aspirate at birth and signs of intra-uterine inflammation in infants with neonatal pulmonary emphysema. | 1999 | Eur. J. Pediatr. | pmid:10486094 |
| Kültürsay N et al. | Platelet-activating factor concentrations in healthy and septic neonates. | 1999 | Eur. J. Pediatr. | pmid:10485307 |
| Shah BH et al. | Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling. | 1999 | Biochem. Pharmacol. | pmid:10484074 |
| Kapui Z et al. | Experimental studies on guanosine 3',5'-cyclic monophosphate levels and airway responsiveness of the novel phosphodiesterase type 5 inhibitor SR 265579 in guinea-pigs. | 1999 | Arzneimittelforschung | pmid:10483515 |
| Nakasaki T et al. | Effects of PAF on histamine H1 receptor mRNA expression in rat trigeminal ganglia. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10482285 |
| Calcerrada MC et al. | Modulation of protein kinase C isoforms by PAF in cerebral cortex. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10482284 |
| Foitzik T et al. | Therapy for microcirculatory disorders in severe acute pancreatitis: effectiveness of platelet-activating factor receptor blockade vs. endothelin receptor blockade. | 1999 May-Jun | J. Gastrointest. Surg. | pmid:10481117 |
| Casale TB et al. | Eosinophils isolated by magnetic cell sorting respond poorly to lipid chemoattractants. | 1999 | Ann. Allergy Asthma Immunol. | pmid:10480585 |
| Oku H and Ishiguro K | Screening method for PAF antagonist substances: on the phenolic compounds from Impatients balsamina L. | 1999 | Phytother Res | pmid:10479766 |
| Baker KE and Curtis MJ | Protection against ventricular fibrillation by the PAF antagonist, BN-50739, involves an ischaemia-selective mechanism. | 1999 | J. Cardiovasc. Pharmacol. | pmid:10470998 |
| Denham W and Norman J | The potential role of therapeutic cytokine manipulation in acute pancreatitis. | 1999 | Surg. Clin. North Am. | pmid:10470326 |
| Ho YS et al. | Probing the substrate specificity of the intracellular brain platelet-activating factor acetylhydrolase. | 1999 | Protein Eng. | pmid:10469831 |
| Conroy DM and Sirois P | Early bronchial hyperresponsiveness following injection of sephadex beads in the guinea pig: involvement of platelet activating factor and thromboxane A2. | 1999 | Inflammation | pmid:10466580 |
| Kaminski JJ et al. | Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine. | 1999 | Bioorg. Med. Chem. | pmid:10465415 |
| Hsueh W et al. | Necrotizing enterocolitis of the newborn: pathogenetic concepts in perspective. | 1998 Jan-Feb | Pediatr. Dev. Pathol. | pmid:10463267 |
| Zardini DM et al. | Release of O2- by human umbilical cord blood-derived eosinophils: role of intra- and extracellular calcium. | 1999 | Cell Calcium | pmid:10463102 |
| Rengan R and Omann GM | Regulation of oscillations in filamentous actin content in polymorphonuclear leukocytes stimulated with leukotriene B(4) and platelet-activating factor. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10462500 |
| Downing SJ et al. | Effect of inflammatory mediators on the electrophysiology of the human oviduct. | 1999 | Biol. Reprod. | pmid:10456842 |
| Yaffe MB et al. | Priming of the neutrophil respiratory burst is species-dependent and involves MAP kinase activation. | 1999 | Surgery | pmid:10455891 |
| Subbanagounder G et al. | Evidence that phospholipid oxidation products and/or platelet-activating factor play an important role in early atherogenesis : in vitro and In vivo inhibition by WEB 2086. | 1999 | Circ. Res. | pmid:10455059 |
| Nikbakht-Sangari M et al. | Platelet-activating factor plays a role in the mechanism of major histocompatibility complex in T lymphocytes. | 1999 | Immunol. Invest. | pmid:10454000 |
| Dervenis C et al. | Diagnosis, objective assessment of severity, and management of acute pancreatitis. Santorini consensus conference. | 1999 | Int. J. Pancreatol. | pmid:10453421 |
| Sakaguchi T et al. | Acute portal hypertension increases ileal vulnerability to platelet-activating factor in rats. | 1999 | J. Surg. Res. | pmid:10452877 |
| Partrick DA et al. | Cardiopulmonary bypass renders patients at risk for multiple organ failure via early neutrophil priming and late neutrophil disability. | 1999 | J. Surg. Res. | pmid:10452867 |
| Shen ZQ et al. | Effect of protopine on cytosolic Ca2+ in rabbit platelets. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10452120 |
| Birk-Sørensen L et al. | Platelet activating factor antagonism in pure skin flaps exposed to ischaemia-reperfusion injury. | 1999 | Scand J Plast Reconstr Surg Hand Surg | pmid:10450571 |
| Wang H et al. | Platelet-activating factor receptor mRNA is localized in eosinophils and epithelial cells in rat small intestine: regulation by dexamethasone and gut flora. | 1999 | Immunology | pmid:10447766 |
| Alvi SA et al. | The production of interleukin-1beta from human fetal membranes is not obligatory for increased prostaglandin output. | 1999 | Immunology | pmid:10447739 |
| Davies D et al. | VCAM-1 contributes to rapid eosinophil accumulation induced by the chemoattractants PAF and LTB4: evidence for basal expression of functional VCAM-1 in rat skin. | 1999 | Immunology | pmid:10447726 |