| MeSH term | MeSH ID | Detail |
|---|---|---|
| Mouth, Edentulous | D009066 | 1 associated lipids |
| Pelvic Pain | D017699 | 7 associated lipids |
| Amnesia, Anterograde | D020324 | 2 associated lipids |
| Encephalitis, Viral | D018792 | 3 associated lipids |
| Capillary Leak Syndrome | D019559 | 2 associated lipids |
| Uveitis, Anterior | D014606 | 11 associated lipids |
| Chromoblastomycosis | D002862 | 2 associated lipids |
| Migraine without Aura | D020326 | 1 associated lipids |
| Peanut Hypersensitivity | D021183 | 2 associated lipids |
| Egg Hypersensitivity | D021181 | 1 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yamazaki H | [Recent medical topics on platelets in hemorrhagic and thrombotic diseases]. | 1986 | Nippon Naika Gakkai Zasshi | pmid:3027214 |
| Prunieras M | Melanocytes, melanogenesis, and inflammation. | 1986 | Int. J. Dermatol. | pmid:2433237 |
| Schleimer RP et al. | Selective inhibition of arachidonic acid metabolite release from human lung tissue by antiinflammatory steroids. | 1986 | J. Immunol. | pmid:3082976 |
| Etienne A et al. | In vivo inhibition of plasma protein leakage and Salmonella enteritidis-induced mortality in the rat by a specific paf-acether antagonist: BN 52021. | 1986 | Agents Actions | pmid:3515870 |
| Nunez D et al. | Specific inhibition of PAF-acether-induced platelet activation by BN 52021 and comparison with the PAF-acether inhibitors kadsurenone and CV 3988. | 1986 | Eur. J. Pharmacol. | pmid:3086108 |
| Oxholm P and Winther K | Thrombocyte involvement in immune inflammatory reactions. | 1986 | Allergy | pmid:3515999 |
| DeFeudis FV | Possible relationship between the syntheses of endothelium-derived relaxing factor (EDRF) and PAF-acether. | 1986 | Gen. Pharmacol. | pmid:3516791 |
| Camussi G | Potential role of platelet-activating factor in renal pathophysiology. | 1986 | Kidney Int. | pmid:3517457 |
| Mastacchi R et al. | Interaction of a new low molecular weight heparin (OP/LMWH) with human platelets. | 1986 | Agents Actions | pmid:3518359 |
| Zanetti A et al. | The effect of AD6 (8-monochloro-3-beta-diethylamino-ethyl-4-methyl-7-ethoxy- carbonylmethoxycoumarin) on washed human platelet aggregation induced by platelet activating factor (PAF) and epinephrine. | 1986 | Eur. J. Pharmacol. | pmid:2944757 |
| Tetta C et al. | Platelet-activating factor contracts human myometrium in vitro. | 1986 | Proc. Soc. Exp. Biol. Med. | pmid:3797421 |
| Montrucchio G et al. | In vitro contractile effect of platelet-activating factor on guinea-pig myometrium. | 1986 | Prostaglandins | pmid:3797692 |
| Bourgain RH et al. | Vivo effects of PAF-acether and arterial thrombosis. | 1986 | Adv. Exp. Med. Biol. | pmid:3799334 |
| Kloprogge E et al. | PAF-acether (1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphocholine)-induced fibrinogen binding to platelets depends on metabolic energy. | 1986 | Biochem. J. | pmid:3800968 |
| Panchenko EP et al. | [Free cytoplasmic calcium and thrombocyte aggregation in patients with ischemic heart disease. The effect of ADP, thrombocyte activation factor and serotonin]. | 1986 | Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR | pmid:3801147 |
| Wardlaw AJ et al. | Platelet-activating factor. A potent chemotactic and chemokinetic factor for human eosinophils. | 1986 | J. Clin. Invest. | pmid:3023451 |
| O'Flaherty JT | Age dependency of the inflammatory response. | 1986 | Lab. Invest. | pmid:3537520 |
| Sybertz EJ et al. | AGEPC, a vasodilator phospholipid with profound circulatory actions. | 1986 | Prog. Clin. Biol. Res. | pmid:3538024 |
| McGowan HM et al. | Increased aortic PGI2 and plasma lyso-PAF in the unclipped one-kidney hypertensive rat. | 1986 | Am. J. Physiol. | pmid:3538908 |
| Hemmendinger S et al. | [Methods of studying platelet function. Biological markers of the activation of human platelets in vivo and in vitro]. | 1986 | Ann. Biol. Clin. (Paris) | pmid:3538949 |
| Malavasi F et al. | Fc receptor triggering induces expression of surface activation antigens and release of platelet-activating factor in large granular lymphocytes. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3085094 |
| Orozco C et al. | Platelet-activating factor induces the expression of early pregnancy factor activity in female mice. | 1986 | J. Reprod. Fertil. | pmid:3806515 |
| Wissner A et al. | Analogues of platelet activating factor. 5. Multiple oxygen substitution of the alkoxy chain. | 1986 | J. Med. Chem. | pmid:3806583 |
| Simpson AW et al. | Low concentrations of the stable prostaglandin endoperoxide U44069 stimulate shape change in quin2-loaded platelets without a measurable increase in [Ca2+]i. | 1986 | FEBS Lett. | pmid:3086128 |
| Nakaya H and Tohse N | Electrophysiological effects of acetyl glyceryl ether phosphorylcholine on cardiac tissues: comparison with lysophosphatidylcholine and long chain acyl carnitine. | 1986 | Br. J. Pharmacol. | pmid:3814909 |
| Alloatti G et al. | Effect of platelet-activating factor (PAF) on human cardiac muscle. | 1986 | Int. Arch. Allergy Appl. Immunol. | pmid:3941007 |
| Stimler-Gerard NP | Parasympathetic stimulation as a mechanism for platelet-activating factor-induced contractile responses in the lung. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3958964 |
| Wade PJ et al. | Effect of calcium and calcium antagonists on [3H]-Paf-acether binding to washed human platelets. | 1986 | Thromb. Res. | pmid:3961730 |
| Schlondorff D et al. | Different concentrations of pertussis toxin have opposite effects on agonist-induced PGE2 formation in mesangial cells. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3099783 |
| Okayasu T et al. | Metabolism of platelet-activating factor in primary cultured adult rat hepatocytes by a new pathway involving phospholipase C and alkyl monooxygenase. | 1986 | Biochim. Biophys. Acta | pmid:3947669 |
| Fechter M et al. | Experimental eosinophilia and inflammation--the effect of various inflammatory mediators and chemoattractants. | 1986 | Exp Pathol | pmid:3013671 |
| Fisher RA et al. | Effects of beta-adrenergic stimulation on 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine-mediated vasoconstriction and glycogenolysis in the perfused rat liver. | 1986 | J. Biol. Chem. | pmid:3013865 |
| Darius H et al. | Inhibition of the platelet activating factor mediated component of guinea pig anaphylaxis by receptor antagonists. | 1986 | Int. Arch. Allergy Appl. Immunol. | pmid:3015804 |
| Kloprogge E et al. | Kinetics of platelet-activating factor 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine-induced fibrinogen binding to human platelets. | 1986 | J. Biol. Chem. | pmid:3015954 |
| O'Flaherty JT et al. | Binding and metabolism of platelet-activating factor by human neutrophils. | 1986 | J. Clin. Invest. | pmid:3016027 |
| Cox CP | Effects of CV-3988, an antagonist of platelet-activating factor (PAF), on washed rabbit platelets. | 1986 | Thromb. Res. | pmid:2421432 |
| Schleimer RP et al. | Characterization of inflammatory mediator release from purified human lung mast cells. | 1986 | Am. Rev. Respir. Dis. | pmid:3485946 |
| Okamoto M et al. | Studies of platelet activating factor (PAF) antagonists from microbial products. I. Bisdethiobis(methylthio)gliotoxin and its derivatives. | 1986 | Chem. Pharm. Bull. | pmid:2421923 |
| Okamoto M et al. | Studies of platelet activating factor (PAF) antagonists from microbial products. II. Pharmacological studies of FR-49175 in animal models. | 1986 | Chem. Pharm. Bull. | pmid:2421924 |
| Robertson DN and Smith GM | CV3988 inhibits in vivo platelet aggregation induced by PAF-acether and collagen. | 1986 | Eur. J. Pharmacol. | pmid:3709663 |
| Ostermann G et al. | Stimulation and desensitization of human and rabbit platelets by 1-O-hexadecyl-2-O-methyl-rac-glycero-3-phosphocholine and analogues. | 1986 | Thromb. Res. | pmid:3764811 |
| McIntyre TM et al. | Leukotrienes C4 and D4 stimulate human endothelial cells to synthesize platelet-activating factor and bind neutrophils. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3457383 |
| Oh S et al. | Inflammatory effects of acetylglycerylether phosphorylcholine: vascular permeability increase and induction of pleurisy in rats. | 1986 | Prostaglandins Leukot Med | pmid:3459197 |
| Newhouse MT and Sears MR | Platelet activating factor, ketotifen and asthma. | 1986 | N. Z. Med. J. | pmid:3462569 |
| Chignard M et al. | Direct evidence for the existence of a neutrophil-derived platelet activator (neutrophilin). | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3464972 |
| Kloprogge E and Akkerman JW | Platelet-activating factor (PAF-acether) induces high- and low-affinity binding of fibrinogen to human platelets via independent mechanisms. | 1986 | Biochem. J. | pmid:3101672 |
| Koltai M et al. | Effect of BN 52021, a specific PAF-acether antagonist, on cardiac anaphylaxis in Langendorff hearts isolated from passively sensitized guinea-pigs. | 1986 | Eur. J. Pharmacol. | pmid:3780855 |
| Montrucchio G et al. | Cardiovascular alterations in the rabbit infused with platelet activating factor (PAF): effect of kadsurenone, a PAF-receptor antagonist. | 1986 | Int J Tissue React | pmid:3025124 |
| Salari H | Solid-phase extraction and reversed-phase high-performance liquid chromatographic technique for isolation and estimation of platelet activating factor in plasma. | 1986 | J. Chromatogr. | pmid:3782417 |
| Ng DS and Wong K | GTP regulation of platelet-activating factor binding to human neutrophil membranes. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3026378 |