| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lee T et al. | Increased biosynthesis of platelet-activating factor in activated human eosinophils. | 1984 | J. Biol. Chem. | pmid:6425292 |
| Hallam TJ et al. | Stimulus-response coupling in human platelets. Changes evoked by platelet-activating factor in cytoplasmic free calcium monitored with the fluorescent calcium indicator quin2. | 1984 | Biochem. J. | pmid:6426464 |
| Hillmar I et al. | Effects of a thio analog of platelet-activating factor on platelet aggregation and adenosine 3',5'-monophosphate concentration in hepatocyte suspensions and in platelets. A comparison with the naturally occurring compound. | 1984 | Hoppe-Seyler's Z. Physiol. Chem. | pmid:6325321 |
| Valone FH | Isolation of a platelet membrane protein which binds the platelet-activating factor 1-0-hexadecyl-2-acetyl-SN-glycero-3-phosphorylcholine. | 1984 | Immunology | pmid:6325330 |
| Kramp W et al. | Observations on the critical micellar concentration of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine and a series of its homologs and analogs. | 1984 | Chem. Phys. Lipids | pmid:6744496 |
| Smith RJ et al. | Effects of an anion channel blocker, 4, 4'-diisothiocyano-2,2'-disulfonic acid stilbene (DIDS), on human neutrophil function. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6329191 |
| Lefort J et al. | The platelet-independent release of thromboxane A2 by Paf-acether from guinea-pig lungs involves mechanisms distinct from those for leukotriene. | 1984 | Br. J. Pharmacol. | pmid:6430375 |
| Hamasaki Y et al. | Platelet-activating factor raises airway and vascular pressures and induces edema in lungs perfused with platelet-free solution. | 1984 | Am. Rev. Respir. Dis. | pmid:6547031 |
| Pirotzky E et al. | Release of platelet-activating factor, slow-reacting substance, and vasoactive amines from isolated rat kidneys. | 1984 | Kidney Int. | pmid:6144811 |
| Gómez-Cambronero J et al. | The role of calcium ions in the process of acetyltransferase activation during the formation of platelet-activating factor (PAF-acether). | 1984 | Biochem. J. | pmid:6146309 |
| Morley J et al. | The platelet in asthma. | 1984 | Lancet | pmid:6150192 |
| Kloprogge E and Akkerman JW | Binding kinetics of PAF-acether (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) to intact human platelets. | 1984 | Biochem. J. | pmid:6150705 |
| Hanahan DJ and Nelson DR | Phospholipids as dynamic participants in biological processes. | 1984 | J. Lipid Res. | pmid:6152281 |
| Lewis AJ et al. | The effects of antiallergic and bronchodilator drugs on platelet-activating factor (PAF-acether) induced bronchospasm and platelet aggregation. | 1984 | Agents Actions | pmid:6152379 |
| Dahlbäck M et al. | Bronchial anaphylaxis in actively sensitized Sprague Dawley rats: studies on mediators involved. | 1984 | Acta Pharmacol Toxicol (Copenh) | pmid:6431753 |
| Rao AK et al. | Platelet-activating factor is a weak platelet agonist: evidence from normal human platelets and platelets with congenital secretion defects. | 1984 | Am. J. Hematol. | pmid:6431801 |
| Wasserman SI | The human lung mast cell. | 1984 | Environ. Health Perspect. | pmid:6428878 |
| Clay KL et al. | Structure elucidation of platelet activating factor derived from human neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6430285 |
| Siess W et al. | Activation of phospholipase C is dissociated from arachidonate metabolism during platelet shape change induced by thrombin or platelet-activating factor. Epinephrine does not induce phospholipase C activation or platelet shape change. | 1984 | J. Biol. Chem. | pmid:6429141 |
| Nishihira J et al. | Production and characterization of specific antibodies against 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a potent hypotensive and platelet-activating ether-linked phospholipid). | 1984 | J. Biochem. | pmid:6430883 |
| Feuerstein G et al. | Hypotension produced by platelet-activating factor is reversed by thyrotropin-releasing hormone. | 1984 | Circ. Shock | pmid:6432359 |
| Malpass TW et al. | The effect of prostacyclin infusion on platelet hemostatic function in patients undergoing cardiopulmonary bypass. | 1984 | J. Thorac. Cardiovasc. Surg. | pmid:6231433 |
| Willoughby WF and Willoughby JB | Immunologic mechanisms of parenchymal lung injury. | 1984 | Environ. Health Perspect. | pmid:6234162 |
| White GC | Effect of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine on calcium fluxes by human platelet microsomes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6428395 |
| Goldstein BM et al. | Effect of platelet activating factor (PAF) on blood flow distribution in the spontaneously hypertensive rat. | 1984 | Life Sci. | pmid:6482659 |
| Baldo BA and Tovey ER | Allergy, allergens and allergen standardization. | 1984 | Med. J. Aust. | pmid:6482786 |
| Saeki S et al. | Effect of 1-hexadecyl-2-acetyl-sn-glycero-3-phosphorylcholine on blood pressure by intra-lateral ventricular injection in the rat. | 1984 | Med J Osaka Univ | pmid:6482814 |
| Nishizawa EE and Della-Coletta AA | The formation of a thrombin-like material (TLM) following stimulation of leukocytes. | 1984 | Thromb. Res. | pmid:6484896 |
| Satouchi K et al. | Metabolism of 1-O-alkyl-2-acetyl-sn-glycerol by washed rabbit platelets: formation of platelet activating factor. | 1984 | Arch. Biochem. Biophys. | pmid:6486825 |
| Nakamura N et al. | Synthesis and biological activities of bioisosteric O-carba-analogues of platelet activating factor (PAF). | 1984 | Chem. Pharm. Bull. | pmid:6488414 |
| Kasuya Y et al. | Hypotensive actions of some analogues of platelet-activating factor (PAF) with higher potencies than natural PAF. | 1984 | Can. J. Physiol. Pharmacol. | pmid:6733593 |
| Page CP et al. | Platelets and bronchospasm. | 1984 | Int. Arch. Allergy Appl. Immunol. | pmid:6735490 |
| Jouvin-Marche E et al. | Biosynthesis of Paf-acether (platelet-activating factor). VII. Precursors of Paf-acether and acetyl-transferase activity in human leukocytes. | 1984 | J. Immunol. | pmid:6736649 |
| Renal syndromes and nonsteroidal antiinflammatory drugs. | 1984 | N. Engl. J. Med. | pmid:6738607 | |
| Hoffman DR et al. | Cytotoxicity of ether-linked phytanyl phospholipid analogs and related derivatives in human HL-60 leukemia cells and polymorphonuclear neutrophils. | 1984 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:6739956 |
| Mohanty D and Hilgard P | A new platelet aggregating material (PAM) in an experimentally induced rat fibrosarcoma. | 1984 | Thromb. Haemost. | pmid:6740552 |
| Lalau Keraly C et al. | Inhibition by ticlopidine of Paf-acether-induced in vitro aggregation of rabbit and human platelets. | 1984 | Thromb. Res. | pmid:6740569 |
| Blank ML et al. | A new class of antihypertensive neutral lipid: 1-alkyl-2-acetyl-sn-glycerols, a precursor of platelet activating factor. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6696762 |
| Williams KA and Haslam RJ | Effects of NaCl and GTP on the inhibition of platelet adenylate cyclase by 1-O-octadecyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine (synthetic platelet-activating factor). | 1984 | Biochim. Biophys. Acta | pmid:6696908 |
| Hoffman DR et al. | Cytotoxicity of platelet activating factor and related alkyl-phospholipid analogs in human leukemia cells, polymorphonuclear neutrophils, and skin fibroblasts. | 1984 | Blood | pmid:6696992 |
| Basran GS et al. | Platelet-activating factor: a possible mediator of the dual response to allergen? | 1984 | Clin. Allergy | pmid:6697475 |
| Roubin R et al. | The role of immunomodulators in the production of lipid mediators by macrophages (M phi). | 1984 | Int J Tissue React | pmid:6596298 |
| Archer CB et al. | Inflammatory characteristics of platelet activating factor (PAF-acether) in human skin. | 1984 | Br. J. Dermatol. | pmid:6581831 |
| Andreesen R et al. | Tumor cytotoxicity of human macrophages after incubation with synthetic analogues of 2-lysophosphatidylcholine. | 1984 | J. Natl. Cancer Inst. | pmid:6582303 |
| Prescott SM et al. | Human endothelial cells in culture produce platelet-activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when stimulated with thrombin. | 1984 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6587368 |
| Iñarrea P et al. | Characteristics of the binding of platelet-activating factor to platelets of different animal species. | 1984 | Eur. J. Pharmacol. | pmid:6510472 |
| O'Neill C and Saunders DM | Assessment of embryo quality. | 1984 | Lancet | pmid:6149413 |
| Lian EC et al. | Purification and some properties of a protein obtained from normal human plasma which inhibits the platelet aggregation induced by thrombotic thrombocytopenic purpura plasma. | 1984 | Thromb. Res. | pmid:6420930 |
| Billah MM and Siegel MI | Calmodulin antagonists inhibit formation of platelet-activating factor in stimulated human neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6422930 |
| Prevost MC et al. | Platelet activating factor (PAF-acether) is released into rat pulmonary alveolar fluid as a consequence of hypoxia. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6422938 |