| MeSH term | MeSH ID | Detail |
|---|---|---|
| Amnesia, Anterograde | D020324 | 2 associated lipids |
| Migraine without Aura | D020326 | 1 associated lipids |
| Enterocolitis, Necrotizing | D020345 | 3 associated lipids |
| Osteoarthritis, Knee | D020370 | 13 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Fetal Weight | D020567 | 12 associated lipids |
| Hypoxia-Ischemia, Brain | D020925 | 22 associated lipids |
| Egg Hypersensitivity | D021181 | 1 associated lipids |
| Peanut Hypersensitivity | D021183 | 2 associated lipids |
| Coronary Stenosis | D023921 | 6 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Am. J. Physiol., Cell Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Diven WF et al. | Expression of acute otitis media after receptor blockade of platelet activating factor, thromboxane, and leukotrienes in the chinchilla. | 1998 | Ann. Otol. Rhinol. Laryngol. | pmid:9525240 |
| Jeon SY et al. | Nitric oxide mediates platelet activating factor-induced microvascular leakage in rat airways. | 2001 | Ann. Otol. Rhinol. Laryngol. | pmid:11201815 |
| Ganbo T et al. | Effects of platelet activating factor on mucociliary clearance of the eustachian tube. | 1996 | Ann. Otol. Rhinol. Laryngol. | pmid:8659935 |
| Lin J et al. | Effect of lipoxygenase inhibition on mucous glycoprotein secretion from chinchilla middle ear epithelial cells in vitro. | 1996 | Ann. Otol. Rhinol. Laryngol. | pmid:8916869 |
| Rhee CK et al. | Experimental otitis media with effusion induced by platelet activating factor. | 1993 | Ann. Otol. Rhinol. Laryngol. | pmid:8352483 |
| Jung TT et al. | Effect of platelet activating factor with and without receptor antagonist (WEB2170) on morphology of isolated cochlear outer hair cells. | 2004 | Ann. Otol. Rhinol. Laryngol. | pmid:14994775 |
| Jeon SY et al. | Ultrastructural changes in platelet activating factor-induced epithelial damage in rabbit maxillary sinus mucosa. | 2000 | Ann. Otol. Rhinol. Laryngol. | pmid:10961804 |
| Price JE et al. | In vitro platelet aggregability studies: lack of evidence for platelet hyperactivity in systemic sclerosis. | 1991 | Ann. Rheum. Dis. | pmid:1888199 |
| Hilliquin P et al. | Presence of paf-acether in rheumatic diseases. | 1992 | Ann. Rheum. Dis. | pmid:1540032 |
| Herrero-Beaumont G and Egido J | PAF, a potent proinflammatory mediator, looking for its role in the pathogenesis of joint damage. | 1997 | Ann. Rheum. Dis. | pmid:9165991 |
| Hilliquin P et al. | Treatment of carrageenan induced arthritis by the platelet activating factor antagonist BN 50730. | 1995 | Ann. Rheum. Dis. | pmid:7702404 |
| Eggleton P et al. | Differences in oxidative response of subpopulations of neutrophils from healthy subjects and patients with rheumatoid arthritis. | 1995 | Ann. Rheum. Dis. | pmid:7492242 |
| Kaminski DL et al. | The role of prostanoids in the production of acute acalculous cholecystitis by platelet-activating factor. | 1990 | Ann. Surg. | pmid:2171443 |
| Fletcher JR et al. | Platelet activating factor receptor antagonist improves survival and attenuates eicosanoid release in severe endotoxemia. | 1990 | Ann. Surg. | pmid:2178565 |
| Yamakawa Y et al. | Interaction of platelet activating factor, reactive oxygen species generated by xanthine oxidase, and leukocytes in the generation of hepatic injury after shock/resuscitation. | 2000 | Ann. Surg. | pmid:10714632 |
| Heinrich S et al. | Evidence-based treatment of acute pancreatitis: a look at established paradigms. | 2006 | Ann. Surg. | pmid:16432347 |
| Spitzer AL et al. | Applying Ockham's razor to pancreatitis prognostication: a four-variable predictive model. | 2006 | Ann. Surg. | pmid:16495704 |
| Ontell SJ et al. | Pharmacologic modulation of experimental postischemic hepatic function. | 1989 | Ann. Surg. | pmid:2916864 |
| Makowka L et al. | Prolongation of pig-to-dog renal xenograft survival by modification of the inflammatory mediator response. | 1987 | Ann. Surg. | pmid:3310931 |
| Unno N et al. | Association of a G994 -->T missense mutation in the plasma platelet-activating factor acetylhydrolase gene with risk of abdominal aortic aneurysm in Japanese. | 2002 | Ann. Surg. | pmid:11807372 |
| Nathan N and Denizot Y | Platelet-activating factor antagonist and cardiopulmonary bypass. | 1995 | Ann. Thorac. Surg. | pmid:7677525 |
| Zehr KJ et al. | Platelet activating factor inhibition reduces lung injury after cardiopulmonary bypass. | 1995 | Ann. Thorac. Surg. | pmid:7847945 |
| Taggart DP | Effects of a platelet-activating factor antagonist on lung injury and ventilation after cardiac operation. | 2001 | Ann. Thorac. Surg. | pmid:11216754 |
| Qayumi AK et al. | The role of platelet-activating factor in regional myocardial ischemia-reperfusion injury. | 1998 | Ann. Thorac. Surg. | pmid:9647083 |
| Kim JD et al. | Platelet activating factor acetylhydrolase decreases lung reperfusion injury. | 2000 | Ann. Thorac. Surg. | pmid:10969656 |
| Corcoran PC et al. | Reduction of conjugated dienes in lung transplantation: effect of BN 52021. | 1993 | Ann. Thorac. Surg. | pmid:8267425 |
| Qayumi AK et al. | Effects of platelet-activating factor antagonist CV-3988 in preservation of heart and lung for transplantation. | 1991 | Ann. Thorac. Surg. | pmid:1929620 |
| Nathan N and Denizot Y | Tumor necrosis factor and platelet-activating factor during cardiopulmonary bypass. | 1993 | Ann. Thorac. Surg. | pmid:8494455 |
| Zhang J et al. | Strategies of myocardial protection for operation in chronic model of cyanotic heart disease. | 1998 | Ann. Thorac. Surg. | pmid:9875743 |
| Hanahan DJ | Platelet activating factor: a biologically active phosphoglyceride. | 1986 | Annu. Rev. Biochem. | pmid:3017194 |
| Prescott SM et al. | Platelet-activating factor and related lipid mediators. | 2000 | Annu. Rev. Biochem. | pmid:10966465 |
| Larsen GL and Henson PM | Mediators of inflammation. | 1983 | Annu. Rev. Immunol. | pmid:6399978 |
| Parker CW | Lipid mediators produced through the lipoxygenase pathway. | 1987 | Annu. Rev. Immunol. | pmid:3036183 |
| Bach MK | Mediators of anaphylaxis and inflammation. | 1982 | Annu. Rev. Microbiol. | pmid:6128957 |
| Saunders RN and Handley DA | Platelet-activating factor antagonists. | 1987 | Annu. Rev. Pharmacol. Toxicol. | pmid:3555317 |
| Feuerstein G and Hallenbeck JM | Prostaglandins, leukotrienes, and platelet-activating factor in shock. | 1987 | Annu. Rev. Pharmacol. Toxicol. | pmid:3034139 |
| Vanhoutte PM et al. | Modulation of vascular smooth muscle contraction by the endothelium. | 1986 | Annu. Rev. Physiol. | pmid:2871807 |
| Semini G et al. | Glycosidated phospholipids - a promising group of anti-tumour lipids. | 2014 | Anticancer Agents Med Chem | pmid:24628240 |
| Zimmermann A and Keller H | Shape changes and chemokinesis of Walker carcinosarcoma cells: effects of protein kinase inhibitors (HA-1004, polymyxin B, sangivamycin and tamoxifen) and an inhibitor of diacylglycerol kinase (R 59022). | 1993 Mar-Apr | Anticancer Res. | pmid:8390801 |
| Adamson LM et al. | Release of anti-PAF activity from PAF-binding human ovarian cancer cells in culture. | 1992 Mar-Apr | Anticancer Res. | pmid:1580546 |
| Berdel WE et al. | Lack of correlation between cytotoxicity of agonists and antagonists of platelet activating factor [paf-acether] in neoplastic cells and modulation of [3H]-paf-acether binding to platelets from humans in vitro. | 1987 Nov-Dec | Anticancer Res. | pmid:3442414 |
| Torley LW et al. | Studies of the effect of a platelet-activating factor antagonist, CL 184,005, in animal models of gram-negative bacterial sepsis. | 1992 | Antimicrob. Agents Chemother. | pmid:1416889 |
| Nunn B et al. | Effect of temocillin and moxalactam on platelet responsiveness and bleeding time in normal volunteers. | 1985 | Antimicrob. Agents Chemother. | pmid:4015075 |
| Lang F et al. | Mechanisms and significance of eryptosis. | 2006 Jul-Aug | Antioxid. Redox Signal. | pmid:16910766 |
| Cao YZ et al. | Selenium modulates 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) biosynthesis in bovine aortic endothelial cells. | 2001 | Antioxid. Redox Signal. | pmid:11813988 |
| Kamaladasa A et al. | Lipopolysaccharide acts synergistically with the dengue virus to induce monocyte production of platelet activating factor and other inflammatory mediators. | 2016 | Antiviral Res. | pmid:27476044 |
| Chamogeorgakis TP et al. | Effect of N-acetyl-L-cysteine on lung ischaemia reperfusion injury in a porcine experimental model. | 2008 Jan-Feb | ANZ J Surg | pmid:18199211 |
| Steel HC et al. | Platelet-activating factor and lyso-PAF possess direct antimicrobial properties in vitro. | 2002 | APMIS | pmid:12064871 |
| Ginesta MM et al. | Modulation of the pathology of late xenograft rejection by PAF-antagonist UR-12670 in the hamster-to-rat liver xenotransplant model. | 2003 | APMIS | pmid:12752216 |
| Marrakchi N et al. | [Biochemical and pharmacologic properties of platelet aggregants and platelet antiaggregants of viper venoms in Tunisia]. | 1994 Jul-Oct | Arch Inst Pasteur Tunis | pmid:8801850 |