| MeSH term | MeSH ID | Detail |
|---|---|---|
| Soft Tissue Injuries | D017695 | 2 associated lipids |
| Optic Nerve Injuries | D020221 | 4 associated lipids |
| Hyperuricemia | D033461 | 4 associated lipids |
| Pneumonia, Pneumococcal | D011018 | 3 associated lipids |
| Dictyocaulus Infections | D004022 | 1 associated lipids |
| Bovine Virus Diarrhea-Mucosal Disease | D001912 | 2 associated lipids |
| Jaundice, Obstructive | D041781 | 2 associated lipids |
| Lymphoma, T-Cell, Cutaneous | D016410 | 4 associated lipids |
| Leukostasis | D018921 | 1 associated lipids |
| Pulmonary Atelectasis | D001261 | 1 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lad PM et al. | A step sensitive to pertussis toxin and phorbol ester in human neutrophils regulates chemotaxis and capping but not phagocytosis. | 1986 | FEBS Lett. | pmid:3699167 |
| Viero P et al. | Defective platelet aggregation induced by platelet activating factor in myeloproliferative disorders: deficiency of an aspirin-independent mechanism? | 1986 | Haemostasis | pmid:3699584 |
| Wallace JL and Whittle BJ | Picomole doses of platelet-activating factor predispose the gastric mucosa to damage by topical irritants. | 1986 | Prostaglandins | pmid:3726156 |
| Eche N et al. | Platelet aggregating and procoagulant activities of cultured human breast cancer cells (FAM). | 1986 | Thromb. Res. | pmid:3726808 |
| Hoffman DR et al. | The role of platelet-activating factor in human fetal lung maturation. | 1986 | Am. J. Obstet. Gynecol. | pmid:3728606 |
| Handley DA et al. | Inhibition and reversal of endotoxin-, aggregated IgG- and paf-induced hypotension in the rat by SRI 63-072, a paf receptor antagonist. | 1986 | Immunopharmacology | pmid:3019921 |
| Hwang SB et al. | Specific binding of [3H]dihydrokadsurenone to rabbit platelet membranes and its inhibition by the receptor agonists and antagonists of platelet-activating factor. | 1986 | J. Biol. Chem. | pmid:3020044 |
| Biftu T et al. | Conformation and activity of tetrahydrofuran lignans and analogues as specific platelet activating factor antagonists. | 1986 | J. Med. Chem. | pmid:3020247 |
| Valone FH and Ruis NM | Platelet-activating factor binding to human platelet membranes. | 1986 | Biotechnol. Appl. Biochem. | pmid:3021183 |
| Naccache PH et al. | Biochemical events associated with the stimulation of rabbit neutrophils by platelet-activating factor. | 1986 | J. Leukoc. Biol. | pmid:3021882 |
| Buxton DB et al. | Specific antagonists of platelet activating factor-mediated vasoconstriction and glycogenolysis in the perfused rat liver. | 1986 | Biochem. Pharmacol. | pmid:3754140 |
| Toyofuku T et al. | Effects of ONO-6240, a platelet-activating factor antagonist, on endotoxin shock in unanesthetized sheep. | 1986 | Prostaglandins | pmid:3754344 |
| Touvay C et al. | Inhibition of antigen-induced lung anaphylaxis in the guinea-pig by BN 52021 a new specific paf-acether receptor antagonist isolated from Ginkgo biloba. | 1986 | Agents Actions | pmid:3754380 |
| Sugatani J and Hanahan DJ | Characterization of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (AGEPC)-induced protein phosphorylation in rabbit platelets: inhibitory effects of AGEPC analogs. | 1986 | Arch. Biochem. Biophys. | pmid:3754710 |
| Hsueh W et al. | Platelet activating factor-induced ischemic bowel necrosis: the effect of PAF antagonists. | 1986 | Eur. J. Pharmacol. | pmid:3754817 |
| Kloprogge E et al. | Stimulus-aggregation coupling in platelets activated with PAF-acether. | 1986 | Biochim. Biophys. Acta | pmid:3089297 |
| Porcellini G | [Platelet-activating factor: a new biochemical and pharmacologic frontier]. | 1986 | Clin Ter | pmid:3720244 |
| Wallace JL and Whittle BJ | Prevention of endotoxin-induced gastrointestinal damage by CV-3988, an antagonist of platelet-activating factor. | 1986 | Eur. J. Pharmacol. | pmid:3720841 |
| Oh-ishi S et al. | Suppression of phorbol myristate acetate-induced pleurisy by CV-3988, an antagonist of platelet-activating factor. | 1986 | Chem. Pharm. Bull. | pmid:3829203 |
| Gillespie MN and Bowdy BD | Impact of platelet activating factor on vascular responsiveness in isolated rat lungs. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3944767 |
| Flower RJ | Background and discovery of lipocortins. | 1986 | Agents Actions | pmid:2938452 |
| Viero P et al. | Thrombotic thrombocytopenic purpura and high-dose immunoglobulin treatment. | 1986 | Ann. Intern. Med. | pmid:3946966 |
| Ramesha CS and Pickett WC | Measurement of sub-picogram quantities of platelet activating factor (AGEPC) by gas chromatography/negative ion chemical ionization mass spectrometry. | 1986 | Biomed. Environ. Mass Spectrom. | pmid:2938649 |
| Siafaka-Kapadai A et al. | Biological activity of lipids of pine pollen on platelet aggregation in correlation with the platelet activating factor. | 1986 | Biochem. Int. | pmid:3947373 |
| McNamara PJ et al. | Autacoid binding to serum proteins. Interaction of platelet activating factor (PAF) with human serum alpha-1-acid glycoprotein (AAG). | 1986 | Biochem. Pharmacol. | pmid:3947392 |
| Resink TJ et al. | The influence of activating hormones on human platelet membrane Ca2+-ATPase activity. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2943273 |
| Gay JC et al. | Modulation of neutrophil oxidative responses to soluble stimuli by platelet-activating factor. | 1986 | Blood | pmid:3006836 |
| McManus LM | Pathobiology of platelet-activating factors. | 1986 | Pathol Immunopathol Res | pmid:3543915 |
| Davis RB and Johnson MF | Effects of bacterial endotoxin and platelet activating factor (PAF) on human platelet aggregation in native whole blood. | 1986 | Thromb. Res. | pmid:3544327 |
| Piper PJ and Stewart AG | Coronary vasoconstriction in the rat, isolated perfused heart induced by platelet-activating factor is mediated by leukotriene C4. | 1986 | Br. J. Pharmacol. | pmid:3091131 |
| Raaijmakers JA et al. | Phospholipase A2 products induce pulmonary beta-adrenoceptor deviations. | 1986 | Eur. J. Pharmacol. | pmid:3019725 |
| Foegh ML et al. | Fatty acids and eicosanoids in organ transplantation. | 1986 | Prog. Lipid Res. | pmid:3321095 |
| Hsueh W et al. | Platelet-activating factor-induced ischemic bowel necrosis. An investigation of secondary mediators in its pathogenesis. | 1986 | Am. J. Pathol. | pmid:3080895 |
| Darius H et al. | Role of platelet-activating factor-acether in mediating guinea pig anaphylaxis. | 1986 | Science | pmid:3082008 |
| Kohayakawa M and Inoue K | Augmentation of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine (PAF)-induced human platelet activation by C-reactive protein. | 1986 | Thromb. Res. | pmid:3083530 |
| Morley J et al. | Effects of ketotifen upon responses to platelet activating factor: a basis for asthma prophylaxis. | 1986 | Ann Allergy | pmid:3083731 |
| McKean ML et al. | Formation of diacyl- and alkylacylphosphatidylcholine by the membranes of human platelets. | 1986 | FEBS Lett. | pmid:3943622 |
| Hackenthal E and Taugner R | Hormonal signals and intracellular messengers for renin secretion. | 1986 | Mol. Cell. Endocrinol. | pmid:2875004 |
| Swingle KF and Reiter MJ | Inhibition of Paf-acether-induced edema of the rat's paw. | 1986 | Agents Actions | pmid:2875631 |
| Ghezzi E | Autacoids and some mediators in allergic and non allergic forms. | 1986 | Boll Ist Sieroter Milan | pmid:2877678 |
| Homburger HA | Diagnosis of allergy: in vitro testing. | 1986 | Crit Rev Clin Lab Sci | pmid:2426037 |
| Pécoud A and Frei PC | [Developmental trends in allergologic-immunologic research]. | 1986 | Internist (Berl) | pmid:2427469 |
| Raphael GD and Metcalfe DD | Mediators of airway inflammation. | 1986 | Eur J Respir Dis Suppl | pmid:2429857 |
| PAF and leukotrienes '85. Proceedings of the meeting. Paris, September 27th 1985. | 1986 | Pharmacol Res Commun | pmid:3774839 | |
| Vilain B et al. | Pharmacological control of the in vivo passive anaphylactic shock by the PAF-acether antagonist compound BN 52021. | 1986 | Pharmacol Res Commun | pmid:3774840 |
| Hsueh W et al. | Release of leukotriene C4 by isolated, perfused rat small intestine in response to platelet-activating factor. | 1986 | J. Clin. Invest. | pmid:3459734 |
| Bessin P | PAF-acether and leukotriene participation in acute circulatory shock. | 1986 | Pharmacol Res Commun | pmid:3774841 |
| Goldstein RE et al. | Coronary and pulmonary vascular effects of leukotrienes and PAF-acether. | 1986 | Pharmacol Res Commun | pmid:3774842 |
| Plante GE et al. | Hemodynamic effects of PAF-acether. | 1986 | Pharmacol Res Commun | pmid:3774843 |
| Thomas Y et al. | [Synthesis of paf-acether by E. coli K12]. | 1986 | C. R. Acad. Sci. III, Sci. Vie | pmid:3101984 |