| MeSH term | MeSH ID | Detail |
|---|---|---|
| Soft Tissue Injuries | D017695 | 2 associated lipids |
| Optic Nerve Injuries | D020221 | 4 associated lipids |
| Hyperuricemia | D033461 | 4 associated lipids |
| Pneumonia, Pneumococcal | D011018 | 3 associated lipids |
| Dictyocaulus Infections | D004022 | 1 associated lipids |
| Bovine Virus Diarrhea-Mucosal Disease | D001912 | 2 associated lipids |
| Jaundice, Obstructive | D041781 | 2 associated lipids |
| Lymphoma, T-Cell, Cutaneous | D016410 | 4 associated lipids |
| Leukostasis | D018921 | 1 associated lipids |
| Pulmonary Atelectasis | D001261 | 1 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Am. J. Physiol., Cell Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Madi S et al. | Allergen-induced bronchospasm in passively sensitized guinea pigs: influence of new substances in comparison to reference compounds. | 1991 | Agents Actions | pmid:2058463 |
| Will PC et al. | Platelet activating factor as a proinflammatory mediator in acetic-induced colitis in the rat. | 1991 | Agents Actions | pmid:1793026 |
| Vincent D et al. | Dissociation between LPS-induced bronchial hyperreactivity and airway edema in the guinea-pig. | 1991 | Agents Actions | pmid:1793031 |
| Desai S and Barton R | Role of platelet activating factor in the pathogenesis of active and passive models of experimental allergic encephalomyelitis in the rat. | 1990 | Agents Actions | pmid:2285021 |
| Howat DW et al. | An investigation into the possible involvement of platelet activating factor in experimental allergic encephalomyelitis in rats. | 1989 | Agents Actions | pmid:2801340 |
| Appleby P and Bowen JG | Cutaneous inflammatory disorders. | 1990 | Agents Actions | pmid:2117335 |
| Lundgren JD et al. | Platelet activating factor and tracheobronchial respiratory glycoconjugate release in feline and human explants: involvement of the lipoxygenase pathway. | 1990 | Agents Actions | pmid:2117336 |
| Doyle SA et al. | Further studies on the antinociceptive effects of delta 6-THC-7-oic acid. | 1990 | Agents Actions | pmid:2178317 |
| Swingle KF and Reiter MJ | Inhibition of Paf-acether-induced edema of the rat's paw. | 1986 | Agents Actions | pmid:2875631 |
| Flower RJ | Background and discovery of lipocortins. | 1986 | Agents Actions | pmid:2938452 |
| Adnot S et al. | Antagonists of PAF-acether do not suppress thrombin-induced aggregation of ADP-deprived and aspirin-treated human platelets. | 1987 | Agents Actions | pmid:3115070 |
| Montrucchio G et al. | The pattern of cardiovascular alterations induced by infusion of platelet-activating factor in rabbit is modified by pretreatment with H1-H2 receptor antagonists but not by cyclooxygenase inhibition. | 1987 | Agents Actions | pmid:3115072 |
| Morley J | Platelet activating factor and asthma. | 1986 | Agents Actions | pmid:3099555 |
| Cahill M et al. | Effect of des arginine9-bradykinin and other bradykinin fragments on the synthesis of prostacyclin and the binding of bradykinin by vascular cells in culture. | 1988 | Agents Actions | pmid:3051930 |
| Cunha FQ et al. | Failure of PAF-acether to induce in vivo neutrophil migration. | 1988 | Agents Actions | pmid:3055873 |
| Touvay C et al. | Inhibition of antigen-induced lung anaphylaxis in the guinea-pig by BN 52021 a new specific paf-acether receptor antagonist isolated from Ginkgo biloba. | 1986 | Agents Actions | pmid:3754380 |
| Lauri D et al. | Contribution of ADP to the amplification of primary platelet aggregation by platelet activating factor (PAF): modulatory role of aspirin. | 1986 | Agents Actions | pmid:3706054 |
| Kusner EJ et al. | Pharmacologic analysis of 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine-induced increases in cutaneous vascular permeability in the rat. | 1987 | Agents Actions | pmid:3577957 |
| Pirotzky E et al. | Vascular permeability induced by Paf-acether (platelet-activating factor) in the isolated perfused rat kidney. | 1985 | Agents Actions | pmid:4003192 |
| Northover AM | In vitro effects of PAF on venous endothelial cell actin disposition. | 1992 | Agents Actions | pmid:1509977 |
| Miyagawa H et al. | The effect of WEB 2086 on PAF-induced eosinophil chemotaxis and LTC4 production from eosinophils. | 1992 | Agents Actions | pmid:1456179 |
| Benveniste J | Platelet-activating factor (PAF-acether): present status. | 1981 | Agents Actions | pmid:6176101 |
| Northover AM and Northover BJ | Lectin-induced increase in microvascular permeability to colloidal carbon in vitro may involve protein kinase C activation. | 1994 | Agents Actions | pmid:7942320 |
| Tubaro E et al. | In vitro and in vivo impact of a new glycosphingolipid on neutrophils. | 1994 | Agents Actions | pmid:7879694 |
| Raff GW et al. | Procoagulant property of platelet activating factor (PAF). | 1993 | Agents Actions | pmid:8273543 |
| Meats JE et al. | Identification of phospholipase D (PLD) activity in mouse peritoneal macrophages. | 1993 | Agents Actions | pmid:8273553 |
| Thomas TK et al. | Differential antagonism of platelet activating factor-induced neutrophilia and gastric hemorrhage in the rat. | 1993 | Agents Actions | pmid:8273566 |
| Glaser KB et al. | Pharmacological characterization of WAY-121,520: a potent anti-inflammatory indomethacin-based inhibitor of 5-lipoxygenase (5-LO)/phospholipase A2 (PLA2). | 1993 | Agents Actions | pmid:8273577 |
| Perret BA et al. | Binding of bovine factor VIII-coated colloidal gold particles to receptors on platelet membranes. | 1981 | Agents Actions | pmid:6803540 |
| Lecrubier C et al. | Study of platelet aggregation induced by platelet activating factor (PAF) after administration of ticlopidine or aspirin. | 1983 | Agents Actions | pmid:6858789 |
| Mencia-Huerta JM et al. | Is platelet-activating factor (PAF-acether) synthesis by murine peritoneal cells (PC) a two-step process? | 1981 | Agents Actions | pmid:7053072 |
| Borrel MC et al. | Additional techniques for the total synthesis of PAF-acether. | 1982 | Agents Actions | pmid:7164944 |
| Benveniste J et al. | Release of platelet-activating factor (PAF-acether) and 2-lyso PAF-acether from three cell types. | 1982 | Agents Actions | pmid:7164945 |
| Arnoux B et al. | Release of PAF-acether from human blood monocytes. | 1982 | Agents Actions | pmid:7164946 |
| Fouque F et al. | Platelet-activating factor (PAF-acether): thromboxane-independent synergism with adrenaline on human platelets and recent insights into its mode of action. | 1982 | Agents Actions | pmid:7164947 |
| Lefort J et al. | Pharmacological properties of PAF-acether in the guinea-pig: platelet-dependent and independent reactions. | 1982 | Agents Actions | pmid:7164948 |
| Bonnet J et al. | Platelet-activating factor acether (PAF-acether) involvement in acute inflammatory and pain processes. | 1981 | Agents Actions | pmid:7340441 |
| Denjean A et al. | Bronchoconstriction induced by intratracheal administration of platelet-activating factor (PAF-acether) in baboons. | 1981 | Agents Actions | pmid:7340444 |
| Heller R et al. | S35b, a new phenylsulfonylfuroxan compound, inhibits thrombin-induced synthesis of platelet-activating factor and prostacyclin in human endothelial cells. | 1993 | Agents Actions | pmid:7517616 |
| Louis R et al. | Potentiation of histamine release from human leucocytes by PAF. | 1994 | Agents Actions | pmid:7521570 |
| Izzo AA et al. | Platelet activating factor potentiates rat paw oedema induced by different phlogogen agents. | 1994 | Agents Actions | pmid:7524288 |
| Lartigue-Mattei C et al. | Pharmacokinetic study of 3H-labelled PAF-acether II. Comparison with 3H-labelled lyso-PAF-acether after intravenous administration in the rabbit and protein binding. | 1984 | Agents Actions | pmid:6532184 |
| Czarnetzki BM and Benveniste J | Effect of synthetic PAF-acether on human neutrophil function. | 1981 | Agents Actions | pmid:7041568 |
| Camussi G et al. | Neutropenia induced by platelet-activating factor (PAF-acether) released from neutrophils: the inhibitory effect of prostacyclin (PGI2). | 1981 | Agents Actions | pmid:7041569 |
| de Bernardis E et al. | Protective effects of papaverine salicylate in mouse ear dermatitis and PAF-induced rat paw oedema. | 1994 | Agents Actions | pmid:7847181 |
| Kelefiotis D and Vakirtzi-Lemonias C | In vivo responses of mouse blood cells to platelet-activating factor (PAF): role of the mediators of anaphylaxis. | 1993 | Agents Actions | pmid:8023738 |
| Northover AM and Northover BJ | Involvement of protein kinase C in the control of microvascular permeability to colloidal carbon. | 1993 | Agents Actions | pmid:8304240 |
| Morley J et al. | Pharmacological evaluation of prophylactic anti-asthma drugs by reference to the pathological sequelae of exposure to allergen or platelet activating factor. | 1988 | Agents Actions Suppl. | pmid:3262989 |
| Subissi A and Criscuoli M | Effects of LG 30435 on different platelet activating factor-induced responses. | 1988 | Agents Actions Suppl. | pmid:3262990 |
| Hartung HP et al. | Stimulation of the oxidative burst in macrophages with platelet activating factor (PAF-acether). | 1982 | Agents Actions Suppl. | pmid:6960648 |