| MeSH term | MeSH ID | Detail |
|---|---|---|
| Egg Hypersensitivity | D021181 | 1 associated lipids |
| Leukostasis | D018921 | 1 associated lipids |
| Arenaviridae Infections | D001117 | 1 associated lipids |
| Pulmonary Atelectasis | D001261 | 1 associated lipids |
| Neurologic Manifestations | D009461 | 1 associated lipids |
| Leukocyte-Adhesion Deficiency Syndrome | D018370 | 1 associated lipids |
| Dictyocaulus Infections | D004022 | 1 associated lipids |
| Brain Hemorrhage, Traumatic | D020201 | 1 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ozaki Y et al. | A comparative study on the effects of inhibitors of the lipoxygenase pathway on neutrophil function. Inhibitory effects on neutrophil function may not be attributed to inhibition of the lipoxygenase pathway. | 1986 | Biochem. Pharmacol. | pmid:3021173 |
| Huang C et al. | Polymorphic phase behavior of platelet-activating factor. | 1986 | Biophys. J. | pmid:3697472 |
| Vanhoutte PM et al. | Modulation of vascular smooth muscle contraction by the endothelium. | 1986 | Annu. Rev. Physiol. | pmid:2871807 |
| Desquand S et al. | Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig. | 1986 | Eur. J. Pharmacol. | pmid:3019727 |
| Weber N | [A platelet-activating factor--a physiologically active ether lipid]. | 1986 | Pharm Unserer Zeit | pmid:3749211 |
| Berti F et al. | Cardiovascular and pulmonary activity of platelet-activating factor (PAF-acether) and its derivatives. | 1986 | Pharmacol Res Commun | pmid:3749244 |
| Burhop KE et al. | Pulmonary vascular response to platelet-activating factor in awake sheep and the role of cyclooxygenase metabolites. | 1986 | Am. Rev. Respir. Dis. | pmid:3752711 |
| Yasuda K et al. | Platelet-activating factor in normal rat uterus. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3753495 |
| Buxton DB et al. | Specific antagonists of platelet activating factor-mediated vasoconstriction and glycogenolysis in the perfused rat liver. | 1986 | Biochem. Pharmacol. | pmid:3754140 |
| Toyofuku T et al. | Effects of ONO-6240, a platelet-activating factor antagonist, on endotoxin shock in unanesthetized sheep. | 1986 | Prostaglandins | pmid:3754344 |
| Daniel LW et al. | A novel mechanism of diglyceride formation. 12-O-tetradecanoylphorbol-13-acetate stimulates the cyclic breakdown and resynthesis of phosphatidylcholine. | 1986 | J. Biol. Chem. | pmid:3087989 |
| Adnot S et al. | Interference of the PAF-acether antagonist BN 52021 with endotoxin-induced hypotension in the guinea-pig. | 1986 | Prostaglandins | pmid:3562865 |
| Fitzgerald MF et al. | The anaphylactic release of platelet-activating factor from perfused guinea-pig lungs. | 1986 | Br. J. Pharmacol. | pmid:3708213 |
| Chand N et al. | The amplifier role of platelet activating factor (PAF), other chemical mediators and antigen in the induction of airway hyperreactivity to cold. | 1986 | Eur. J. Pharmacol. | pmid:3709669 |
| Osborne JA et al. | In vivo anti-platelet properties of anipamil, a calcium channel blocker, in the rabbit. | 1986 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:3715198 |
| Westwick J et al. | Comparison of the effects of low molecular weight heparin and unfractionated heparin on activation of human platelets in vitro. | 1986 | Thromb. Res. | pmid:3715810 |
| Issekutz AC and Ripley M | The effect of intravascular neutrophil chemotactic factors on blood neutrophil and platelet kinetics. | 1986 | Am. J. Hematol. | pmid:2934975 |
| Brock TA and Gimbrone MA | Platelet activating factors alters calcium homeostasis in cultured vascular endothelial cells. | 1986 | Am. J. Physiol. | pmid:3717361 |
| Piéroni G and Hanahan DJ | Effect of acetylglyceryl ether phosphocholine (platelet-activating factor) and thrombin on acylation of exogenous lysophosphoglycerides in rabbit platelets. | 1986 | Biochim. Biophys. Acta | pmid:3719000 |
| Benhamou M et al. | Decrease in IgE Fc receptor expression on mouse bone marrow-derived mast cells and inhibition of paf-acether formation and of beta-hexosaminidase release by dexamethasone. | 1986 | J. Immunol. | pmid:2935578 |
| Orchard MA et al. | Basophil histamine release induced by a substance from stimulated human platelets. | 1986 | J. Immunol. | pmid:2419428 |
| Tselepis A et al. | Effects of AGEPC on the intracellular levels of ions in Tetrahymena pyriformis. | 1986 | Biochem. Int. | pmid:3099798 |
| Coëffier E et al. | Transient activation of the acetyltransferase necessary for paf-acether biosynthesis in thrombin-activated platelets. | 1986 | Br. J. Haematol. | pmid:3964558 |
| Bachelet M et al. | Changes induced by PAF-acether in diacyl and ether phospholipids from guinea-pig alveolar macrophages. | 1986 | Biochim. Biophys. Acta | pmid:3092866 |
| Alonso F et al. | A cytosolic phospholipase in human neutrophils that hydrolyzes arachidonoyl-containing phosphatidylcholine. | 1986 | Biochim. Biophys. Acta | pmid:3092867 |
| Bourgain RH et al. | Thrombus induction by endogenic paf-acether and its inhibition by Ginkgo Biloba extracts in the guinea pig. | 1986 | Prostaglandins | pmid:3763943 |
| Guinot P et al. | Inhibition of PAF-acether induced weal and flare reaction in man by a specific PAF antagonist. | 1986 | Prostaglandins | pmid:3763944 |
| Scherf H et al. | Hemodynamic effects of platelet activating factor in the dog kidney in vivo. | 1986 | Hypertension | pmid:3744467 |
| Touvay C et al. | Proof of the involvement of platelet activating factor (paf-acether) in pulmonary complex immune systems using a specific paf-acether receptor antagonist: BN 52021. | 1986 | Prog. Lipid Res. | pmid:2827186 |
| Bussolino F et al. | Platelet-activating factor--a powerful lipid autacoid possibly involved in microangiopathy. | 1986 | Acta Haematol. | pmid:3019063 |
| McKean ML et al. | Formation of diacyl- and alkylacylphosphatidylcholine by the membranes of human platelets. | 1986 | FEBS Lett. | pmid:3943622 |
| Dewald B and Baggiolini M | Platelet-activating factor as a stimulus of exocytosis in human neutrophils. | 1986 | Biochim. Biophys. Acta | pmid:3017443 |
| Jackson CV et al. | Platelet-activating factor and the release of a platelet-derived coronary artery vasodilator substance in the canine. | 1986 | Circ. Res. | pmid:2868810 |
| Bussolino F et al. | Interleukin 1 stimulates platelet-activating factor production in cultured human endothelial cells. | 1986 | J. Clin. Invest. | pmid:2872233 |
| Henocq E and Vargaftig BB | Accumulation of eosinophils in response to intracutaneous PAF-acether and allergens in man. | 1986 | Lancet | pmid:2872485 |
| Cuss FM et al. | Effects of inhaled platelet activating factor on pulmonary function and bronchial responsiveness in man. | 1986 | Lancet | pmid:2873440 |
| Montrucchio G et al. | Intravascular release of platelet-activating factor during atrial pacing. | 1986 | Lancet | pmid:2874319 |
| Hackenthal E and Taugner R | Hormonal signals and intracellular messengers for renin secretion. | 1986 | Mol. Cell. Endocrinol. | pmid:2875004 |
| Wallace JL and Whittle BJ | Effects of inhibitors of arachidonic acid metabolism on Paf-induced gastric mucosal necrosis and haemoconcentration. | 1986 | Br. J. Pharmacol. | pmid:3096408 |
| Patterson R et al. | Inhibition of rhesus monkey airway and cutaneous responses to platelet-activating factor (PAF) (AGEPC) with the anti-PAF agent SRI 63-072. | 1986 | Int. Arch. Allergy Appl. Immunol. | pmid:3770978 |
| Smith PF et al. | The responsiveness of rabbit bronchial rings to antigen, AGEPC and histamine. | 1986 | Immunopharmacology | pmid:3771195 |
| Andrikopoulos NK et al. | High-performance liquid chromatographic analysis of platelet activating factor on a cation-exchange column by direct ultraviolet detection. | 1986 | J. Chromatogr. | pmid:3771693 |
| Cordeiro RS et al. | Desensitization to PAF-induced rat paw oedema by repeated intraplantar injections. | 1986 | Life Sci. | pmid:3773645 |
| Cox CP et al. | An extract of rat submandibular glands activates platelets and enhances cutaneous vascular permeability in rats and guinea pigs. | 1986 | Life Sci. | pmid:3773648 |
| Godfroid JJ et al. | Synthesis of ether phospholipids. | 1986 | Pharmacol Res Commun | pmid:3774838 |
| PAF and leukotrienes '85. Proceedings of the meeting. Paris, September 27th 1985. | 1986 | Pharmacol Res Commun | pmid:3774839 | |
| Kester M et al. | Alkylacetylglycerophosphocholine stimulates Na+-Ca2+ exchange, protein phosphorylation and polyphosphoinositide turnover in rat ileal plasmalemmal vesicles. | 1986 | Biochim. Biophys. Acta | pmid:3019423 |
| Voelkel NF et al. | PAF antagonists: different effects on platelets, neutrophils, guinea pig ileum and PAF-induced vasodilation in isolated rat lung. | 1986 | Prostaglandins | pmid:3024235 |
| Zimmerman GA et al. | Thrombin stimulates neutrophil adherence by an endothelial cell-dependent mechanism: characterization of the response and relationship to platelet-activating factor synthesis. | 1986 | Ann. N. Y. Acad. Sci. | pmid:3471149 |
| Küster LJ and Frölich JC | Platelet aggregation and thromboxane release induced by arachidonic acid, collagen, ADP and platelet-activating factor following low dose acetylsalicylic acid in man. | 1986 | Prostaglandins | pmid:3097760 |