| MeSH term | MeSH ID | Detail |
|---|---|---|
| Mouth, Edentulous | D009066 | 1 associated lipids |
| Anthrax | D000881 | 1 associated lipids |
| Egg Hypersensitivity | D021181 | 1 associated lipids |
| Leukostasis | D018921 | 1 associated lipids |
| Arenaviridae Infections | D001117 | 1 associated lipids |
| Pulmonary Atelectasis | D001261 | 1 associated lipids |
| Neurologic Manifestations | D009461 | 1 associated lipids |
| Leukocyte-Adhesion Deficiency Syndrome | D018370 | 1 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Borin ML et al. | [Relation between the changes in Na+/H+-exchange and cytoplasmic Ca levels in platelet activation]. | 1988 | Biull Eksp Biol Med | pmid:2844320 |
| Joseph R et al. | Cytosolic ionized calcium homeostasis in platelets: an abnormal sensitivity to PAF-activation in migraine. | 1988 | Headache | pmid:2844693 |
| Arnoux B et al. | Effect of PAF-acether in non-human primates. | 1988 | Prog. Clin. Biol. Res. | pmid:2837781 |
| Frick KK et al. | Platelet-derived growth factor-induced c-myc RNA expression. Analysis of an inducible pathway independent of protein kinase C. | 1988 | J. Biol. Chem. | pmid:2449430 |
| Dillon PK and Durán WN | Effect of platelet-activating factor on microvascular permselectivity: dose-response relations and pathways of action in the hamster cheek pouch microcirculation. | 1988 | Circ. Res. | pmid:2450695 |
| Okuda Y et al. | Histamine release from human leukocytes by platelet-activating factor. | 1988 | Int. Arch. Allergy Appl. Immunol. | pmid:2450844 |
| Spicer BA et al. | Changes in leucocyte numbers without diapedesis in rats given platelet-activating factor (PAF-acether). | 1988 | Int. Arch. Allergy Appl. Immunol. | pmid:2450847 |
| Vercellotti GM et al. | Platelet-activating factor primes neutrophil responses to agonists: role in promoting neutrophil-mediated endothelial damage. | 1988 | Blood | pmid:2451547 |
| Alessandrì MG et al. | PAF-induced histamine release in the isolated perfused rat kidney. | 1988 | Int J Tissue React | pmid:2456276 |
| Martin TR et al. | Pulmonary responses to bronchoconstrictor agonists in the mouse. | 1988 | J. Appl. Physiol. | pmid:2457008 |
| Bachelet M et al. | Interaction between PAF-acether and drugs that stimulate cyclic AMP in guinea-pig alveolar macrophages. | 1988 | Eur. J. Pharmacol. | pmid:2840303 |
| Trovati M et al. | Insulin directly reduces platelet sensitivity to aggregating agents. Studies in vitro and in vivo. | 1988 | Diabetes | pmid:2838353 |
| Lefort J et al. | Pharmacological profile of 48740 R.P., a PAF-acether antagonist. | 1988 | Eur. J. Pharmacol. | pmid:2843382 |
| Ferrell JE et al. | Membrane bilayer balance and platelet shape: morphological and biochemical responses to amphipathic compounds. | 1988 | Biochim. Biophys. Acta | pmid:3355815 |
| López-Farré A et al. | Glomeruli from ischemic rat kidneys produce increased amounts of platelet activating factor. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3358756 |
| Kuiper J et al. | The induction of glycogenolysis in the perfused liver by platelet activating factor is mediated by prostaglandin D2 from Kupffer cells. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3144970 |
| Valone FH and Epstein LB | Biphasic platelet-activating factor synthesis by human monocytes stimulated with IL-1-beta, tumor necrosis factor, or IFN-gamma. | 1988 | J. Immunol. | pmid:3141509 |
| Anderson G and Fennessy M | Effects of REV 5901, a 5-lipoxygenase inhibitor and leukotriene antagonist, on pulmonary responses to platelet activating factor in the guinea-pig. | 1988 | Br. J. Pharmacol. | pmid:3145088 |
| Grue-Sørensen G et al. | Derivatives of 2-methylenepropane-1,3-diol as new antagonists of platelet activating factor. | 1988 | J. Med. Chem. | pmid:3373485 |
| Pirotzky E et al. | Protection of platelet-activating factor-induced acute renal failure by BN 52021. | 1988 | Br J Exp Pathol | pmid:3377967 |
| Csatò M and Czarnetzki BM | Effect of BN 52021, a platelet activating factor antagonist, on experimental murine contact dermatitis. | 1988 | Br. J. Dermatol. | pmid:3377969 |
| O'Flaherty JT et al. | Mechanism involved in the mobilization of neutrophil calcium by 5-hydroxyeicosatetraenoate. | 1988 | J. Immunol. | pmid:2836511 |
| Hoffman DR et al. | Platelet-activating factor induces glycogen degradation in fetal rabbit lung in utero. | 1988 | J. Biol. Chem. | pmid:3379072 |
| Kertscher HP et al. | [Synthesis and thrombocyte-aggregating action of a structural analog of platelet activating factor with a modified head group]. | 1988 | Pharmazie | pmid:3380866 |
| Smith RJ et al. | Diacylglycerols modulate human polymorphonuclear neutrophil responsiveness: effects on intracellular calcium mobilization, granule exocytosis, and superoxide anion production. | 1988 | J. Leukoc. Biol. | pmid:2836539 |
| Achterrath-Tuckermann U et al. | Azelastine, a new antiallergic/antiasthmatic agent, inhibits PAF-acether-induced platelet aggregation, paw edema and bronchoconstriction. | 1988 | Pharmacology | pmid:3380879 |
| Kornecki E and Ehrlich YH | Neuroregulatory and neuropathological actions of the ether-phospholipid platelet-activating factor. | 1988 | Science | pmid:3381103 |
| Hofmann B et al. | Proaggregatory and inhibitory effects of 2-O-ethyl analogues of platelet-activating factor (PAF) on human and rabbit platelets. | 1988 | Thromb. Res. | pmid:3381200 |
| Rao GH | Measurement of ionized calcium in normal human blood platelets. | 1988 | Anal. Biochem. | pmid:3382012 |
| Lichterfeld A et al. | [Platelet activating factor and its possible role in bronchial asthma]. | 1988 | Prax Klin Pneumol | pmid:3041401 |
| Barnes PJ | Inflammatory mechanisms and nocturnal asthma. | 1988 | Am. J. Med. | pmid:3041827 |
| Camussi G and Salvidio G | Platelet-activating factor in graft rejection. | 1988 | Prog Biochem Pharmacol | pmid:3043426 |
| Hénocq E | PAF-acether and eosinophils. | 1988 | Prog Biochem Pharmacol | pmid:3043428 |
| Serio R and Daniel EE | Thromboxane effects on canine trachealis neuromuscular function. | 1988 | J. Appl. Physiol. | pmid:2839451 |
| Lagente V and Fortes ZB | Role of PAF-acether in the vascular events of inflammation. | 1988 | Prog Biochem Pharmacol | pmid:3043429 |
| Cordeiro RS et al. | Proinflammatory activity of platelet-activating factor: pharmacological modulation and cellular involvement. | 1988 | Prog Biochem Pharmacol | pmid:3043430 |
| Tomooka M et al. | [Azelastine inhibits bronchoconstriction induced by histamine and leukotriene C4]. | 1988 | Arerugi | pmid:2906534 |
| Iwama T et al. | Pharmacological modulation of platelet activating factor (PAF)-induced bronchoconstriction and hypertension in anaesthetized guinea-pigs. | 1988 | J. Pharm. Pharmacol. | pmid:2907007 |
| Hellegouarch A et al. | Effects of BN 52063 and other agents inhibiting platelet-activating factor-induced contractile responses in rat portal vein. | 1988 | J. Pharm. Pharmacol. | pmid:2907020 |
| Subissi A et al. | Effects of anti-asthma drugs on PAF-induced death in mice. | 1988 | Prostaglandins | pmid:2907663 |
| Tamura N et al. | Leukotriene C4 production from human eosinophils in vitro. Role of eosinophil chemotactic factors on eosinophil activation. | 1988 | J. Immunol. | pmid:2848892 |
| Mollinedo F et al. | Intracellular localization of platelet-activating factor synthesis in human neutrophils. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3408495 |
| Hsueh W and Gonzalez-Crussi F | Ischemic bowel necrosis induced by platelet-activating factor: an experimental model. | 1988 | Methods Achiev Exp Pathol | pmid:3045496 |
| Hirafuji M et al. | Transient increase of cytosolic free calcium in cultured human vascular endothelial cells by platelet-activating factor. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3408504 |
| Stahl GL et al. | Salutary consequences of blockade of platelet activating factor in hemorrhagic shock. | 1988 | Eur. J. Pharmacol. | pmid:3409951 |
| Coyle AJ et al. | The effect of the selective PAF antagonist BN 52021 on PAF- and antigen-induced bronchial hyper-reactivity and eosinophil accumulation. | 1988 | Eur. J. Pharmacol. | pmid:3383997 |
| Kroegel C et al. | Platelet-activating factor induces eosinophil peroxidase release from purified human eosinophils. | 1988 | Immunology | pmid:3410498 |
| Tokumura A et al. | Study of platelet activating factor and its antagonists on rat colon strip with a new method avoiding tachyphylaxis. | 1988 | Eur. J. Pharmacol. | pmid:3384001 |
| Takizawa H et al. | Bronchoconstriction induced by platelet-activating factor in the guinea pig and its inhibition by CV-3988, a PAF antagonist: serial changes in findings of lung histology and bronchoalveolar lavage cell population. | 1988 | Int. Arch. Allergy Appl. Immunol. | pmid:3410557 |
| Angle MJ et al. | Platelet-activating factor in the rabbit uterus during early pregnancy. | 1988 | J. Reprod. Fertil. | pmid:3411561 |
| Fukuoka T et al. | [Effect of a platelet activating factor (PAF) antagonist on the hepatic afferent vascular occlusion]. | 1988 | Nihon Geka Gakkai Zasshi | pmid:3412312 |
| Janero DR et al. | Specific binding of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) to the intact canine platelet. | 1988 | Thromb. Res. | pmid:3413730 |
| Altman R et al. | Diltiazem potentiates the inhibitory effect of aspirin on platelet aggregation. | 1988 | Clin. Pharmacol. Ther. | pmid:3416553 |
| Collier M et al. | Biochemical and pharmacological characterization of human embryo-derived platelet activating factor. | 1988 | Hum. Reprod. | pmid:3204154 |
| Gay JC and Stitt ES | Platelet-activating factor induces protein kinase activity in the particulate fraction of human neutrophils. | 1988 | Blood | pmid:2825844 |
| Crouch MF and Lapetina EG | Spacial isolation of protein kinase C activation in thrombin stimulated human platelets. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3178827 |
| Andersson M and Pipkorn U | The effect of platelet activating factor on nasal hypersensitivity. | 1988 | Eur. J. Clin. Pharmacol. | pmid:3181276 |
| Adamus WS et al. | Inhibitory effect of oral WEB 2086, a novel selective PAF-acether antagonist, on ex vivo platelet aggregation. | 1988 | Eur. J. Clin. Pharmacol. | pmid:3181277 |
| Yanoshita R et al. | Hydrolysis of platelet activating factor and its methylated analogs by acetylhydrolases. | 1988 | J. Biochem. | pmid:3182751 |
| Morrison WJ and Shukla SD | Desensitization of receptor-coupled activation of phosphoinositide-specific phospholipase C in platelets: evidence for distinct mechanisms for platelet-activating factor and thrombin. | 1988 | Mol. Pharmacol. | pmid:2827000 |
| Lakin KM | [Problems of a pharmacologic search for inhibitors of platelet aggregation]. | 1988 | Kardiologiia | pmid:3066962 |
| Kawaguchi H et al. | [Effect of platelet-activating factor (PAF) on blood pressure, peripheral, coronary and renovascular system]. | 1988 | Kokyu To Junkan | pmid:3067285 |
| Lang C and Dobrescu C | Attenuation of burn-induced changes in hemodynamics and glucose metabolism by the PAF antagonist SRI 63-675. | 1988 | Eur. J. Pharmacol. | pmid:3071467 |
| Benveniste J | Paf-acether, an ether phospho-lipid with biological activity. | 1988 | Prog. Clin. Biol. Res. | pmid:3071808 |
| Ukena D et al. | Radioligand binding of antagonists of platelet-activating factor to intact human platelets. | 1988 | FEBS Lett. | pmid:3342883 |
| Dulioust A et al. | Immunoregulatory functions of paf-acether (platelet-activating factor). | 1988 | Prog. Clin. Biol. Res. | pmid:3071809 |
| Suzuki Y et al. | Release of acetylhydrolase from platelets on aggregation with platelet-activating factor. | 1988 | Eur. J. Biochem. | pmid:3345757 |
| Romero A et al. | [Effect of corticosteroids, quinacrine and L-652, 731 on experimental aggregation of polymorphonuclear leukocytes induced by complement and platelet activating factor (PAF)]. | 1988 | Rev. Esp. Fisiol. | pmid:3072620 |
| Benveniste J and Leyravaud S | Retention of platelet activating factor by human neutrophils. | 1988 | J. Immunol. | pmid:3346547 |
| Immunomodulation: other approaches. | 1988 | Transplant. Proc. | pmid:3347955 | |
| Lang CH et al. | Platelet-activating factor-induced increases in glucose kinetics. | 1988 | Am. J. Physiol. | pmid:3348371 |
| Molski TF et al. | Intracellular calcium rise produced by platelet-activating factor is deactivated by fMet-Leu-Phe and this requires uninterrupted activation sequence: role of protein kinase C. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3348814 |
| Esplugues JV and Whittle BJ | Gastric mucosal damage induced by local intra-arterial administration of Paf in the rat. | 1988 | Br. J. Pharmacol. | pmid:3349230 |
| Kobayashi T et al. | Metabolism and disposition of (RS)-2-methoxy-3-(octadecylcarbamoyloxy)propyl 2-(3-thiazolio)ethyl phosphate (MOTP) in rats and dogs. | 1988 | Xenobiotica | pmid:3354232 |
| Rees RS et al. | Plasma components are required for platelet activation by the toxin of Loxosceles reclusa. | 1988 | Toxicon | pmid:3245050 |
| Mencia-Huerta JM et al. | [Effect of long-term administration of platelet activating factor on pulmonary response and morphology in the guinea pig]. | 1988 | Allerg Immunol (Paris) | pmid:3245884 |
| Takeuchi N et al. | The antagonist effects of compounds derived from khellactone on platelet-activating factor. | 1988 | Chem. Pharm. Bull. | pmid:3245999 |
| Hasegawa T and Nakajima S | [Recent topics on platelet-activating-factor (PAF)]. | 1988 | Nippon Ika Daigaku Zasshi | pmid:3360909 |
| Kimani G et al. | Stimulation of eosinophil adherence to human vascular endothelial cells in vitro by platelet-activating factor. | 1988 | J. Immunol. | pmid:3361129 |
| Hofmann B et al. | Effect of specific antagonists on PAF-induced platelet aggregation and release of plasminogen activator. | 1988 | Biomed. Biochim. Acta | pmid:3248103 |
| Robertson DA et al. | Negative inotropic effect of platelet-activating factor: association with a decrease in intracellular sodium activity. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3361438 |
| Mest HJ et al. | The arrhythmogenic effect of platelet activating factor (PAF) is inhibited by PAF antagonist and by substances influencing eicosanoids. | 1988 | Biomed. Biochim. Acta | pmid:3248107 |
| Leslie CC et al. | Properties and purification of an arachidonoyl-hydrolyzing phospholipase A2 from a macrophage cell line, RAW 264.7. | 1988 | Biochim. Biophys. Acta | pmid:3143418 |
| Egger M et al. | Human platelet electrorotation change induced by activation: inducer specificity and correlation to serotonin release. | 1988 | Biochim. Biophys. Acta | pmid:3143424 |
| Chung KF and Barnes PJ | PAF antagonists. Their potential therapeutic role in asthma. | 1988 | Drugs | pmid:3281823 |
| Plante GE et al. | Platelet activating factor antagonism with BN52021 protects the kidney against acute ischemic injury. | 1988 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:3231663 |
| Santos JC et al. | Effect of intrarenal infusion of synthetic PAF-acether in dogs. | 1988 | Rev. Esp. Fisiol. | pmid:3231880 |
| Ostermann G et al. | The degradation of platelet-activating factor in serum and its discriminative value in atherosclerotic patients. | 1988 | Thromb. Res. | pmid:3232123 |
| Avdonin PV et al. | Blocking of the receptor-stimulated calcium entry into human platelets by verapamil and nicardipine. | 1988 | Thromb. Res. | pmid:3232128 |
| Kiktev VG et al. | [Calcium metabolism of the thrombocytes in ischemic heart disease]. | 1988 | Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR | pmid:3233156 |
| Yamada K et al. | Highly sensitive gas chromatographic--mass spectrometric method for the determination of platelet-activating factor in human blood. | 1988 | J. Chromatogr. | pmid:3235552 |
| Yoshikawa D and Goto F | [Interactions between platelet activating factor and leukotrienes during endotoxin shock in the rat]. | 1988 | Masui | pmid:3236398 |
| Korth R et al. | Comparison of three paf-acether receptor antagonist ginkgolides. | 1988 | Eur. J. Pharmacol. | pmid:2850196 |
| Valone FH | Interrelationships among platelet-activating factor binding and metabolism and induction of platelet activation. | 1988 | Prog. Clin. Biol. Res. | pmid:2850575 |
| Shukla SD and Morrison WJ | Platelet activating factor receptor occupancy in relation to activation and desensitization of phosphoinositide specific phospholipase C. | 1988 | Prog. Clin. Biol. Res. | pmid:2850576 |
| Chand N et al. | Effect of paf-acether on isoprenaline-induced relaxation in isolated tracheal segments of rats and guinea pigs. | 1988 | Eur. J. Pharmacol. | pmid:2851453 |
| Hayashi H et al. | A novel bioaction of PAF: induction of microbicidal activity in guinea pig bone marrow cells. | 1988 | Lipids | pmid:2852289 |
| Janero DR et al. | Radioligand competitive binding methodology for the evaluation of platelet-activating factor (PAF) and PAF-receptor antagonism using intact canine platelets. | 1988 | J Pharmacol Methods | pmid:2853256 |
| van Delft JL et al. | Specific receptor sites for PAF in iris and ciliary body of the rabbit eye. | 1988 | Curr. Eye Res. | pmid:2854038 |
| Shirinsky VP et al. | Agonist-induced polyphosphoinositide breakdown in cultured human endothelial and vascular smooth muscle cells. | 1988 | Health Psychol | pmid:2854052 |