| MeSH term | MeSH ID | Detail |
|---|---|---|
| Metabolic Syndrome | D024821 | 44 associated lipids |
| Hyperuricemia | D033461 | 4 associated lipids |
| Jaundice, Obstructive | D041781 | 2 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Renal Insufficiency, Chronic | D051436 | 9 associated lipids |
| Mucositis | D052016 | 7 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
| Acute Kidney Injury | D058186 | 34 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Moore TL and Weiss TD | Mediators of inflammation. | 1985 | Semin. Arthritis Rheum. | pmid:3936177 |
| Juhan-Vague I et al. | Possible participation of adenosine 5'-diphosphate, arachidonic acid and paf-acether in the platelet pro-aggregating effect of uncontrolled insulin-dependent diabetic erythrocytes in vitro. | 1985 | Thromb. Res. | pmid:3923649 |
| Steiner M et al. | Biological activity of platelet activating factor-amidophosphonate (PAF-AP), a novel phosphonolipid selective inhibitor of platelet activating factor (PAF). | 1985 | Biochem. Biophys. Res. Commun. | pmid:3936503 |
| Naccache PH et al. | Unique inhibitory profile of platelet activating factor induced calcium mobilization, polyphosphoinositide turnover and granule enzyme secretion in rabbit neutrophils towards pertussis toxin and phorbol ester. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2992480 |
| MacIntyre DE et al. | Regulation of platelet cytosolic free calcium by cyclic nucleotides and protein kinase C. | 1985 | FEBS Lett. | pmid:2993027 |
| Hayashi H et al. | Activation of guinea pig peritoneal macrophages by platelet activating factor (PAF) and its agonists. | 1985 | J. Biochem. | pmid:2993272 |
| Avdonin PV et al. | Stimulation of high-affinity hormone-sensitive GTPase of human platelets by 1-O-alkyl-2-O-acetyl-sn-glyceryl-3-phosphocholine (platelet activating factor). | 1985 | Biochem. Biophys. Res. Commun. | pmid:2994653 |
| Maridonneau-Parini I et al. | Desensitization to PAF-induced bronchoconstriction and to activation of alveolar macrophages by repeated inhalations of PAF in the guinea pig. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2994661 |
| Zukowska-Grojec Z et al. | The adrenergic system and the cardiovascular effects of platelet activating factor (1-0-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine) in SHR and WKY rats. | 1985 | Clin Exp Hypertens A | pmid:2994912 |
| Shen TY et al. | The isolation and characterization of kadsurenone from haifenteng (Piper futokadsura) as an orally active specific receptor antagonist of platelet-activating factor. | 1985 | Int J Tissue React | pmid:2997065 |
| Sánchez Crespo M et al. | Synthesis of platelet-activating factor from human polymorphonuclear leukocytes: regulation and pharmacological approaches. | 1985 | Int J Tissue React | pmid:2997066 |
| Proll MA et al. | Phosphatidate and monooleylphosphatidate inhibition of fibroblast adenylate cyclase is mediated by the inhibitory coupling protein, Ni. | 1985 | Mol. Pharmacol. | pmid:2997592 |
| Murer EH | The role of platelet calcium. | 1985 | Semin. Hematol. | pmid:3901271 |
| Davis JW et al. | Effects of tobacco and non-tobacco cigarette smoking on endothelium and platelets. | 1985 | Clin. Pharmacol. Ther. | pmid:3987176 |
| O'Neill C | Examination of the causes of early pregnancy-associated thrombocytopenia in mice. | 1985 | J. Reprod. Fertil. | pmid:3989801 |
| Kertscher HP and Ostermann G | [Synthesis and biological activity of isomeric structural analogs of platelet activating factor]. | 1985 | Pharmazie | pmid:3991788 |
| Wal F et al. | PAF-acether may not mediate the third pathway of platelet aggregation since self-desensitization reduces the effects of low thrombin but enhances those of convulxin. | 1985 | Thromb. Haemost. | pmid:3992525 |
| Khan SN et al. | Response to platelet-activating factor of platelets from patients with multiple sclerosis. | 1985 | Acta Neurol. Scand. | pmid:3993327 |
| Tamargo J et al. | Electrophysiological effects of platelet-activating factor (PAF-acether) in guinea-pig papillary muscles. | 1985 | Eur. J. Pharmacol. | pmid:3996472 |
| Terashita Z et al. | Is platelet activating factor (PAF) a mediator of endotoxin shock? | 1985 | Eur. J. Pharmacol. | pmid:3996473 |
| Foa R et al. | Release of platelet-activating factor in human leukemia. | 1985 | Cancer Res. | pmid:3861246 |
| Otsuka A et al. | Hypotensive mechanism of acetyl glyceryl ether phosphorylcholine (AGEPC) in dogs. Effects on hemodynamics and humoral factors. | 1985 | Prostaglandins Leukot Med | pmid:3862138 |
| Archer CB et al. | Inflammatory cell accumulation in response to intracutaneous Paf-acether: a mediator of acute and persistent inflammation? | 1985 | Br. J. Dermatol. | pmid:4015978 |
| Morley J et al. | The role of circulating cells in skin reactions. | 1985 | Br. J. Dermatol. | pmid:4015983 |
| Pirotzky E et al. | A role for Paf-acether (platelet-activating factor) in acute skin inflammation? | 1985 | Br. J. Dermatol. | pmid:4015984 |
| Ohno M et al. | An enantioselective synthesis of platelet-activating factors, their enantiomers, and their analogues from D- and L-tartaric acids. | 1985 | Chem. Pharm. Bull. | pmid:4017109 |
| O'Neill C et al. | Maternal blood platelet physiology and luteal-phase endocrinology as a means of monitoring pre- and postimplantation embryo viability following in vitro fertilization. | 1985 | J In Vitro Fert Embryo Transf | pmid:4020241 |
| Heymans F et al. | Structure-activity relationship in PAF-acether. 2. rac-1-O-Octadecyl-2-O-acetyl-3-O-[gamma-(dimethylamino)propyl]glycerol . | 1985 | J. Med. Chem. | pmid:4020830 |
| Touqui L et al. | 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylcholine is the precursor of platelet-activating factor in stimulated rabbit platelets. Evidence for an alkylacetyl-glycerophosphorylcholine cycle. | 1985 | Biochim. Biophys. Acta | pmid:3967037 |
| Suemune H et al. | Synthetic studies on platelet-activating factor (PAF). | 1985 | Chem. Pharm. Bull. | pmid:4028291 |
| Parente L et al. | The release of lyso-PAF from guinea-pig lungs. | 1985 | Eur. J. Pharmacol. | pmid:4029263 |
| Lee TC | Biosynthesis of platelet activating factor. Substrate specificity of 1-alkyl-2-lyso-sn-glycero-3-phosphocholine:acetyl-CoA acetyltransferase in rat spleen microsomes. | 1985 | J. Biol. Chem. | pmid:4030776 |
| Wissner A et al. | Analogues of platelet activating factor (PAF). 2. Some modifications of the glycerine backbone. | 1985 | J. Med. Chem. | pmid:4032422 |
| Wissner A et al. | Analogues of platelet activating factor. 3. Replacement of the phosphate moiety with a sulfonylbismethylene group. | 1985 | J. Med. Chem. | pmid:4032438 |
| Valone FH and Johnson B | Decay of the activating signal after platelet stimulation with 1-0-alkyl-2-acetyl-SN-glycero-3-phosphorylcholine: changes in calcium permeability. | 1985 | Thromb. Res. | pmid:4082115 |
| Scherer GF | 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) stimulates plant H+ transport in vitro and growth. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4084306 |
| Handley DA et al. | Evidence for a direct effect on vascular permeability of platelet-activating factor induced hemoconcentration in the guinea pig. | 1985 | Thromb. Haemost. | pmid:4089809 |
| Hemker HC and Béguin S | The generation of thrombin in whole plasma. Biochemical possibilities and physiological realities. | 1985 | Verh. K. Acad. Geneeskd. Belg. | pmid:4090648 |
| Hallam TJ et al. | Relationship between cytoplasmic free calcium and myosin light chain phosphorylation in intact platelets. | 1985 | Biochem. J. | pmid:4091795 |
| Fouque F and Vargaftig BB | Adrenaline/PAF acether synergism on human platelets: involvement of Hydergine. | 1985 | J Pharmacol | pmid:4094442 |
| Vigo C | Effect of C-reactive protein on platelet-activating factor-induced platelet aggregation and membrane stabilization. | 1985 | J. Biol. Chem. | pmid:3919022 |
| Armstrong RA et al. | Mechanism of the inhibition of platelet aggregation produced by prostaglandin F2 alpha. | 1985 | Prostaglandins | pmid:2988022 |
| Dewald B and Baggiolini M | Activation of NADPH oxidase in human neutrophils. Synergism between fMLP and the neutrophil products PAF and LTB4. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2985075 |
| Peach MJ et al. | Mechanisms of endothelium-dependent vascular smooth muscle relaxation. | 1985 | Biochem. Pharmacol. | pmid:2988558 |
| Orlov SM et al. | [Histamine release from human leukocytes after treatment with 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) and its structural analogs]. | 1985 | Biokhimiia | pmid:2408682 |
| Braquet M et al. | Leukocytic functions in burn-injured patients. | 1985 | Prostaglandins | pmid:2989978 |
| Hallam TJ and Rink TJ | Agonists stimulate divalent cation channels in the plasma membrane of human platelets. | 1985 | FEBS Lett. | pmid:2408921 |
| O'Neill C et al. | Maternal recognition of pregnancy prior to implantation: methods for monitoring embryonic viability in vitro and in vivo. | 1985 | Ann. N. Y. Acad. Sci. | pmid:2409860 |
| Sage SO and Rink TJ | Inhibition by forskolin of cytosolic calcium rise, shape change and aggregation in quin2-loaded human platelets. | 1985 | FEBS Lett. | pmid:2410292 |
| Tou J | Platelet-activating factor promotes arachidonate incorporation into phosphatidylinositol and phosphatidylcholine in neutrophils. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3921017 |