| MeSH term | MeSH ID | Detail |
|---|---|---|
| Metabolic Syndrome | D024821 | 44 associated lipids |
| Hyperuricemia | D033461 | 4 associated lipids |
| Jaundice, Obstructive | D041781 | 2 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Renal Insufficiency, Chronic | D051436 | 9 associated lipids |
| Mucositis | D052016 | 7 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
| Acute Kidney Injury | D058186 | 34 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gálvez J et al. | The intestinal anti-inflammatory activity of UR-12746S on reactivated experimental colitis is mediated through downregulation of cytokine production. | 2003 | Inflamm. Bowel Dis. | pmid:14671485 |
| Saeed SA and Rasheed H | Calcium-dependent synergistic interaction of platelet activating factor and epinephrine in human platelet aggregation. | 2003 | Acta Pharmacol. Sin. | pmid:12511226 |
| Ishizuka S et al. | Effects of rhinovirus infection on the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells. | 2003 | J. Infect. Dis. | pmid:14673774 |
| Koyama N | Platelet activating factor in surfactant-TA is inhibited by coexisting inhibitors. | 2003 | Lung | pmid:14692561 |
| Russo S et al. | Platelet-activating factor mediates CD40-dependent angiogenesis and endothelial-smooth muscle cell interaction. | 2003 | J. Immunol. | pmid:14607955 |
| Slomiany BL and Slomiany A | Biphasic role of platelet-activating factor in oral mucosal ulcer healing. | 2003 | IUBMB Life | pmid:14609204 |
| Shigematsu S et al. | Resveratrol, a red wine constituent polyphenol, prevents superoxide-dependent inflammatory responses induced by ischemia/reperfusion, platelet-activating factor, or oxidants. | 2003 | Free Radic. Biol. Med. | pmid:12654468 |
| Collado MP et al. | Endothelin-1 decreases ethanolamine plasmalogen levels and evokes PAF production in brain microvessels. | 2003 | Microvasc. Res. | pmid:14609525 |
| Odeh AI et al. | Effect of platelet-activating factor (PAF) on stallion sperm motility, capacitation and the acrosome reaction. | 2003 | Reproduction | pmid:14611633 |
| Sugimoto Y et al. | Inhibitory effects of glucocorticoids on rat eosinophil superoxide generation and chemotaxis. | 2003 | Int. Immunopharmacol. | pmid:12781701 |
| Zhu X et al. | Structural determinants of blockade of eosinophil activation, adhesion and secretion by synthetic analogs of phomactin. | 2003 | Life Sci. | pmid:14519449 |
| de Assis EF et al. | Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes. | 2003 | J. Immunol. | pmid:12902515 |
| Gabrijelcic J et al. | Neutrophil airway influx by platelet-activating factor in asthma: role of adhesion molecules and LTB4 expression. | 2003 | Eur. Respir. J. | pmid:12952263 |
| Hu H et al. | Glycoprotein IIb/IIIa inhibition attenuates platelet-activating factor-induced platelet activation by reducing protein kinase C activity. | 2003 | J. Thromb. Haemost. | pmid:12911597 |
| Kalia N and Bardhan KD | Of blood and guts: association between Helicobacter pylori and the gastric microcirculation. | 2003 | J. Gastroenterol. Hepatol. | pmid:12911655 |
| Tokuoka SM et al. | Involvement of platelet-activating factor and LIS1 in neuronal migration. | 2003 | Eur. J. Neurosci. | pmid:12911752 |
| Lupia E et al. | Intra-plaque production of platelet-activating factor correlates with neoangiogenesis in human carotid atherosclerotic lesions. | 2003 | Int. J. Mol. Med. | pmid:12883648 |
| Handa RK et al. | Role of Nitric oxide in the renal and systemic vasodilatory responses to platelet-activating factor in the rat, in vivo. | 2003 | Kidney Blood Press. Res. | pmid:12886044 |
| Taggart DP et al. | Neuroprotection during cardiac surgery: a randomised trial of a platelet activating factor antagonist. | 2003 | Heart | pmid:12860868 |
| Takafuji S et al. | Matrix metalloproteinase-9 release from human leukocytes. | 2003 | J Investig Allergol Clin Immunol | pmid:12861851 |
| Bar-Or D et al. | Copper stimulates the synthesis and release of interleukin-8 in human endothelial cells: a possible early role in systemic inflammatory responses. | 2003 | Shock | pmid:12865660 |
| Kujiraoka T et al. | Altered distribution of plasma PAF-AH between HDLs and other lipoproteins in hyperlipidemia and diabetes mellitus. | 2003 | J. Lipid Res. | pmid:12867534 |
| D'Andrea D et al. | Induction of tissue factor in the arterial wall during recurrent thrombus formation. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12869352 |
| Lupia E et al. | The membrane attack complex of complement contributes to plasmin-induced synthesis of platelet-activating factor by endothelial cells and neutrophils. | 2003 | Immunology | pmid:12871223 |
| Fernandes ES et al. | Mechanisms underlying the modulatory action of platelet activating factor (PAF) on the upregulation of kinin B1 receptors in the rat paw. | 2003 | Br. J. Pharmacol. | pmid:12839871 |
| Saruc M et al. | An experimental model of hemolysis-induced acute pancreatitis. | 2003 | Braz. J. Med. Biol. Res. | pmid:12845374 |
| Nomikos TN et al. | Acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (lyso-PAF AT) activity in cortical and medullary human renal tissue. | 2003 | Eur. J. Biochem. | pmid:12846832 |
| Suzuki M et al. | Actin assembly is a crucial factor for superoxide anion generation from adherent human eosinophils. | 2003 | J. Allergy Clin. Immunol. | pmid:12847489 |
| Liu J et al. | Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor. | 2003 | J. Biol. Chem. | pmid:12949078 |
| Mano T et al. | Novel imidazole compounds as a new series of potent, orally active inhibitors of 5-lipoxygenase. | 2003 | Bioorg. Med. Chem. | pmid:12927848 |
| Talvani A et al. | Experimental Trypanosoma cruzi infection in platelet-activating factor receptor-deficient mice. | 2003 | Microbes Infect. | pmid:12850205 |
| Triggiani M et al. | Secretory phospholipases A2 activate selective functions in human eosinophils. | 2003 | J. Immunol. | pmid:12626587 |
| Strait RT et al. | IL-4 exacerbates anaphylaxis. | 2003 | J. Immunol. | pmid:12646651 |
| Al-Darmaki S et al. | Differential expression of platelet-activating factor acetylhydrolase in macrophages and monocyte-derived dendritic cells. | 2003 | J. Immunol. | pmid:12496397 |
| Lie WJ et al. | Regulation and kinetics of platelet-activating factor and leukotriene C4 synthesis by activated human basophils. | 2003 | Clin. Exp. Allergy | pmid:12911788 |
| Diaper CM et al. | A total synthesis of (+/-)-phomactin A. | 2003 | Org. Biomol. Chem. | pmid:14664384 |
| Beck-Speier I et al. | Sulfur-related air pollutants induce the generation of platelet-activating factor, 5-lipoxygenase- and cyclooxygenase-products in canine alveolar macrophages via activation of phospholipases A2. | 2003 | Prostaglandins Other Lipid Mediat. | pmid:14518563 |
| Antonopoulou S et al. | Hydroxyl-platelet-activating factor exists in blood of healthy volunteers and periodontal patients. | 2003 | Mediators Inflamm. | pmid:14514473 |
| Gödecke A | PAF, PIP(3) and NO: emerging role in reperfusion injury. | 2003 | Cardiovasc. Res. | pmid:14613846 |
| Alloatti G et al. | Phosphoinositide 3-kinase gamma-deficient hearts are protected from the PAF-dependent depression of cardiac contractility. | 2003 | Cardiovasc. Res. | pmid:14613853 |
| Akisu M et al. | Supplementation with Saccharomyces boulardii ameliorates hypoxia/reoxygenation-induced necrotizing enterocolitis in young mice. | 2003 | Eur J Pediatr Surg | pmid:14618522 |
| Zhang X et al. | Age-related increase of plasma platelet-activating factor concentrations in Chinese. | 2003 | Clin. Chim. Acta | pmid:14568193 |
| De Vriese AS and Bourgeois M | Pharmacologic treatment of acute renal failure in sepsis. | 2003 | Curr Opin Crit Care | pmid:14639066 |
| Alviano DS et al. | Differentiation of Fonsecaea pedrosoi mycelial forms into sclerotic cells is induced by platelet-activating factor. | 2003 | Res. Microbiol. | pmid:14643407 |
| Chlopicki S et al. | Obligatory role of lipid mediators in platelet-neutrophil adhesion. | 2003 | Thromb. Res. | pmid:14592550 |
| Montrucchio G et al. | Mechanisms of the priming effect of low doses of lipopoly-saccharides on leukocyte-dependent platelet aggregation in whole blood. | 2003 | Thromb. Haemost. | pmid:14597983 |
| Shabanov VV | [Cytokines and other signal molecules in the pathogenesis of acute pancreatitis]. | 2003 | Vestn. Akad. Med. Nauk SSSR | pmid:14598737 |
| Tonks AJ et al. | Regulation of platelet-activating factor synthesis in human monocytes by dipalmitoyl phosphatidylcholine. | 2003 | J. Leukoc. Biol. | pmid:12832447 |
| Estellés R et al. | Effect of two phenanthrene alkaloids on angiotensin II-induced leukocyte-endothelial cell interactions in vivo. | 2003 | Br. J. Pharmacol. | pmid:14559857 |
| Choi IW et al. | Platelet-activating factor-mediated NF-kappaB dependency of a late anaphylactic reaction. | 2003 | J. Exp. Med. | pmid:12835479 |
| Kell PJ et al. | Inhibition of platelet-activating factor (PAF) acetylhydrolase by methyl arachidonyl fluorophosphonate potentiates PAF synthesis in thrombin-stimulated human coronary artery endothelial cells. | 2003 | J. Pharmacol. Exp. Ther. | pmid:14560038 |
| Denizot Y et al. | Tissue concentrations of platelet-activating factor in colorectal carcinoma: inverse relationships with Dukes' stage of patients. | 2003 | Oncogene | pmid:14562051 |
| Proudfoot JM et al. | Angiotensin II type 1 receptor antagonists inhibit basal as well as low-density lipoprotein and platelet-activating factor-stimulated human monocyte chemoattractant protein-1. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12626661 |
| Fang HY et al. | Cyclooxygenase-2 in human non-small cell lung cancer. | 2003 | Eur J Surg Oncol | pmid:12633561 |
| Witko-Sarsat V et al. | AOPP-induced activation of human neutrophil and monocyte oxidative metabolism: a potential target for N-acetylcysteine treatment in dialysis patients. | 2003 | Kidney Int. | pmid:12787398 |
| Slomiany BL and Slomiany A | Platelet-activating factor modulates gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12788098 |
| Schuster DP et al. | Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: Phase IIb, multicenter, randomized, placebo-controlled, clinical trial. | 2003 | Crit. Care Med. | pmid:12794395 |
| Rabinovici R | Platelet activating factor inhibition in sepsis: the end? | 2003 | Crit. Care Med. | pmid:12794432 |
| Saraf MK et al. | Role of platelet activating factor in triazolobenzodiazepines-induced retrograde amnesia. | 2003 | Behav. Brain Res. | pmid:12798263 |
| Denizot Y et al. | Platelet-activating factor and normal or leukaemic haematopoiesis. | 2003 | Leuk. Lymphoma | pmid:12802913 |
| Olanders K et al. | Protective effects of N-acetyl-L-cysteine and platelet activating factor inhibition are not linked to intercellular adhesion molecule-1 expression after intestinal ischemia and reperfusion injury in rats. | 2003 | Scand. J. Gastroenterol. | pmid:12825870 |
| Adamson RH et al. | PAF- and bradykinin-induced hyperpermeability of rat venules is independent of actin-myosin contraction. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12649070 |
| Haraldsen P et al. | Multimodal management - of value in fulminant acute pancreatitis? | 2003 | Pancreatology | pmid:12649560 |
| Denizot Y et al. | No evidence for a putative involvement of platelet-activating factor in systemic lupus erythematosus without active nephritis. | 2003 | Mediators Inflamm. | pmid:12775360 |
| Yan W et al. | Previously uncharacterized roles of platelet-activating factor acetylhydrolase 1b complex in mouse spermatogenesis. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12775763 |
| Nie ZG and Wang WJ | [Effect of ginkgolide B on platelet-activating factor induced activation of rat polymorphonuclear leukocytes]. | 2003 | Yao Xue Xue Bao | pmid:12778742 |
| Fragopoulou E et al. | Structure elucidation of phenolic compounds from red/white wine with antiatherogenic properties. | 2003 | Biochim. Biophys. Acta | pmid:12782155 |
| Marshall JC | Such stuff as dreams are made on: mediator-directed therapy in sepsis. | 2003 | Nat Rev Drug Discov | pmid:12750742 |
| Zang BX et al. | [Antagonistic effect of myricetin on platelet activing factor]. | 2003 | Yao Xue Xue Bao | pmid:14991995 |
| Mahgoub AA | Thymoquinone protects against experimental colitis in rats. | 2003 | Toxicol. Lett. | pmid:12749817 |
| Mariano F et al. | Platelet-activating factor synthesis by neutrophils, monocytes, and endothelial cells is modulated by nitric oxide production. | 2003 | Shock | pmid:12688545 |
| Thaete LG et al. | Infusion of exogenous platelet-activating factor produces intrauterine growth restriction in the rat. | 2003 | J. Soc. Gynecol. Investig. | pmid:12699876 |
| Simon HU et al. | Interleukin-2 primes eosinophil degranulation in hypereosinophilia and Wells' syndrome. | 2003 | Eur. J. Immunol. | pmid:12672048 |
| Teather LA and Wurtman RJ | Cyclooxygenase-2 mediates platelet-activating factor-induced prostaglandin E2 release from rat primary astrocytes. | 2003 | Neurosci. Lett. | pmid:12672535 |
| Kordan W et al. | Functions of platelet activating factor (PAF) in mammalian reproductive processes: a review. | 2003 | Pol J Vet Sci | pmid:12675470 |
| Loucks EB et al. | Role of platelet activating factor in cardiac dysfunction, apoptosis and nitric oxide synthase mRNA expression in the ischemic-reperfused rabbit heart. | 2003 | Can J Cardiol | pmid:12677282 |
| Ginesta MM et al. | Modulation of the pathology of late xenograft rejection by PAF-antagonist UR-12670 in the hamster-to-rat liver xenotransplant model. | 2003 | APMIS | pmid:12752216 |
| Wu B et al. | Platelet-activating factor promotes mucosal apoptosis via FasL-mediating caspase-9 active pathway in rat small intestine after ischemia-reperfusion. | 2003 | FASEB J. | pmid:12709415 |
| Bussolati B et al. | The long pentraxin PTX3 is synthesized in IgA glomerulonephritis and activates mesangial cells. | 2003 | J. Immunol. | pmid:12538709 |
| Hou X et al. | Increased platelet-activating factor-induced periventricular brain microvascular constriction associated with immaturity. | 2003 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12626359 |
| Hirayama K et al. | Platelet-activating factor, a critical mediator in the pathogenesis of dextran sulfate sodium-induced colitis in rats. | 2003 | Dis. Colon Rectum | pmid:12544529 |
| Balestrieri ML et al. | Modulation by flavonoids of PAF and related phospholipids in endothelial cells during oxidative stress. | 2003 | J. Lipid Res. | pmid:12576520 |
| Biancone L et al. | Platelet-activating factor inactivation by local expression of platelet-activating factor acetyl-hydrolase modifies tumor vascularization and growth. | 2003 | Clin. Cancer Res. | pmid:14519648 |
| Hu G et al. | Neutrophils pretreated with volatile anesthetics lose ability to cause cardiac dysfunction. | 2003 | Anesthesiology | pmid:12606916 |
| Corl CM et al. | Oxidant stress enhances Lyso-PAF-AcT activity by modifying phospholipase D and phosphatidic acid in aortic endothelial cells. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12615078 |
| Dinarello CA | The IL-1 family and inflammatory diseases. | 2002 Sep-Oct | Clin. Exp. Rheumatol. | pmid:14989423 |
| Chłopicki S et al. | Hypoxic pulmonary vasoconstriction in isolated blood-perfused rat lung; modulation by thromboxane A2, platelet-activating factor, cysteinyl leukotrienes and endothelin-1. | 2002 Sep-Oct | Pol J Pharmacol | pmid:12593530 |
| Klabunde RE and Anderson DE | Role of nitric oxide and reactive oxygen species in platelet-activating factor-induced microvascular leakage. | 2002 May-Jun | J. Vasc. Res. | pmid:12097822 |
| Huang JB et al. | Hexokinase translocation during neutrophil activation, chemotaxis, and phagocytosis: disruption by cytochalasin D, dexamethasone, and indomethacin. | 2002 Jul-Aug | Cell. Immunol. | pmid:12470617 |
| Levine AS et al. | A review of the effect of platelet-activating factor on male reproduction and sperm function. | 2002 Jul-Aug | J. Androl. | pmid:12065449 |
| Farbiszewski R et al. | [The role of platelet activating factor (PAF) in physiology and pathology of the central nervous system]. | 2002 Jul-Aug | Neurol. Neurochir. Pol. | pmid:12418143 |
| Teather LA et al. | Platelet-activating factor antagonists decrease the inflammatory nociceptive response in rats. | 2002 | Psychopharmacology (Berl.) | pmid:12373444 |
| Baker PR et al. | Regulation of platelet-activating factor synthesis in human neutrophils by MAP kinases. | 2002 | Biochim. Biophys. Acta | pmid:12379481 |
| McLennan SV et al. | Effects of mesangium glycation on matrix metalloproteinase activities: possible role in diabetic nephropathy. | 2002 | Diabetes | pmid:12145178 |
| Claud EC et al. | Platelet-activating factor regulates chloride transport in colonic epithelial cell monolayers. | 2002 | Pediatr. Res. | pmid:12149490 |
| Benito E and Bosch MA | Role of platelet-activating factor in phosphatidylcholine secretion in primary cultures of rat type II pneumocytes. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12013527 |
| Kato T et al. | Mitochondrial calcium response in human transformed lymphoblastoid cells. | 2002 | Life Sci. | pmid:12052442 |
| Ishii S et al. | Platelet-activating factor receptor. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12432946 |
| Sakamoto H et al. | Overexpression of phospholipid hydroperoxide glutathione peroxidase modulates acetyl-CoA, 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity. | 2002 | J. Biol. Chem. | pmid:12397078 |
| Rivera A et al. | Modulation of Gardos channel activity by cytokines in sickle erythrocytes. | 2002 | Blood | pmid:11756192 |